Details for: MYCNOS

Gene ID: 10408

Symbol: MYCNOS

Ensembl ID: ENSG00000233718

Description: MYCN opposite strand

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 2.63
    Marker Score: 10,171
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1,172
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.15
    Marker Score: 7,675
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4,819
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.09
    Marker Score: 693
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.02
    Marker Score: 691
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,831
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,056
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 510
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,409
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 463
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.96
    Marker Score: 399
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,354
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.94
    Marker Score: 375
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2,742
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 327
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.9
    Marker Score: 414
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,289
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.85
    Marker Score: 650
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.83
    Marker Score: 1,579
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,264
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 710
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 398
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.62
    Marker Score: 412
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6
    Marker Score: 383
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.58
    Marker Score: 463
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 174
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.47
    Marker Score: 818
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 278
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.41
    Marker Score: 6,492
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.41
    Marker Score: 394
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.39
    Marker Score: 152
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.39
    Marker Score: 226
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.38
    Marker Score: 772
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.36
    Marker Score: 375
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.31
    Marker Score: 391
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.28
    Marker Score: 115
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.24
    Marker Score: 164
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 74
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.21
    Marker Score: 56
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.21
    Marker Score: 300
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.19
    Marker Score: 85
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.18
    Marker Score: 127
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.18
    Marker Score: 228
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.17
    Marker Score: 70
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 43
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.17
    Marker Score: 81
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.15
    Marker Score: 46
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.13
    Marker Score: 96
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.13
    Marker Score: 75
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.13
    Marker Score: 182
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.13
    Marker Score: 120
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.12
    Marker Score: 133
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.12
    Marker Score: 74
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.12
    Marker Score: 83
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.12
    Marker Score: 121
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.12
    Marker Score: 323
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.12
    Marker Score: 80
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.11
    Marker Score: 72
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.11
    Marker Score: 54
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.11
    Marker Score: 188
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.11
    Marker Score: 31
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.11
    Marker Score: 59
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 0.11
    Marker Score: 71
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1
    Marker Score: 126
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.1
    Marker Score: 431
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.1
    Marker Score: 101
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.1
    Marker Score: 48
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.1
    Marker Score: 19
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.09
    Marker Score: 5,685
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.09
    Marker Score: 138
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.09
    Marker Score: 325
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.09
    Marker Score: 114
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.09
    Marker Score: 107
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.09
    Marker Score: 71
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.08
    Marker Score: 89
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.08
    Marker Score: 91
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.08
    Marker Score: 92
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.08
    Marker Score: 165
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.08
    Marker Score: 19
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.08
    Marker Score: 43
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.08
    Marker Score: 111
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.08
    Marker Score: 2,929
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.08
    Marker Score: 27
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.08
    Marker Score: 47
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.08
    Marker Score: 768
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.08
    Marker Score: 35
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.07
    Marker Score: 97
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.07
    Marker Score: 309
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.07
    Marker Score: 16
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.07
    Marker Score: 65
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.07
    Marker Score: 40
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.07
    Marker Score: 42
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.07
    Marker Score: 150
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.07
    Marker Score: 19
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.07
    Marker Score: 36
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.07
    Marker Score: 65

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MYCNOS is a transcription factor that exhibits characteristics of a negative regulator of kinase activity. Its expression is tightly regulated, and its absence or dysregulation has been linked to various diseases. The gene's ability to bind to specific DNA sequences and regulate protein stability makes it an essential player in cellular signaling pathways. Furthermore, its expression in neural progenitor cells, goblet cells, and stem cells from the intestinal crypt suggests a role in development and tissue homeostasis. **Pathways and Functions:** The MYCNOS gene is involved in several key pathways, including: 1. **Negative regulation of kinase activity:** MYCNOS acts as a negative regulator of kinase activity, which is essential for maintaining cellular homeostasis and preventing excessive signaling. 2. **Protein binding:** MYCNOS binds to specific DNA sequences, regulating the expression of target genes involved in various cellular processes. 3. **Regulation of protein stability:** MYCNOS influences the stability of target proteins, thereby modulating cellular signaling pathways. 4. **Cytoplasmic and nuclear regulation:** MYCNOS regulates cellular processes in both the cytoplasm and nucleus, highlighting its role in maintaining cellular homeostasis. **Functions:** The MYCNOS gene has been implicated in various cellular processes, including: 1. **Immune regulation:** MYCNOS plays a crucial role in regulating immune responses, particularly in the development and function of immune cells such as goblet cells and granulocyte-monocyte progenitor cells. 2. **Developmental processes:** MYCNOS is essential for the development and maintenance of neural progenitor cells, goblet cells, and stem cells from the intestinal crypt. 3. **Tissue homeostasis:** MYCNOS regulates the expression of genes involved in tissue homeostasis, ensuring the proper functioning of various tissues and organs. **Clinical Significance:** Dysregulation of the MYCNOS gene has been linked to various diseases, including cancer and immune disorders. For instance, alterations in MYCNOS expression have been observed in neurodevelopmental disorders, such as autism spectrum disorder. Furthermore, MYCNOS has been implicated in the development of various cancers, including colon cancer, where its dysregulation can lead to uncontrolled cell growth and tumor formation. Understanding the role of MYCNOS in immune regulation and development is crucial for the development of novel therapeutic strategies and the treatment of related diseases. In conclusion, the MYCNOS gene is a complex transcription factor that plays a pivotal role in regulating various cellular processes, including immune regulation, development, and tissue homeostasis. Further research is necessary to fully elucidate the mechanisms by which MYCNOS influences cellular signaling pathways and to explore its therapeutic potential in various diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.