Details for: BASP1

Gene ID: 10409

Symbol: BASP1

Ensembl ID: ENSG00000176788

Description: brain abundant membrane attached signal protein 1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 5.61
    Marker Score: 23,379
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 4.84
    Marker Score: 25,367
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 4.41
    Marker Score: 17,060
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 4.25
    Marker Score: 5,975
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 3.74
    Marker Score: 126,428
  • Cell Name: granule cell (CL0000120)
    Fold Change: 3.63
    Marker Score: 27,397
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 3.32
    Marker Score: 4,004
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 3.06
    Marker Score: 7,024
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 3.01
    Marker Score: 6,113
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 3
    Marker Score: 10,043
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 2.96
    Marker Score: 2,792
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 2.87
    Marker Score: 15,418
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 2.73
    Marker Score: 12,619
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 2.7
    Marker Score: 1,644
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.67
    Marker Score: 2,994
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.64
    Marker Score: 29,709
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 2.6
    Marker Score: 5,715
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.47
    Marker Score: 10,643
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.41
    Marker Score: 81,983
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.38
    Marker Score: 82,573
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.36
    Marker Score: 46,884
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 2.34
    Marker Score: 3,243
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.34
    Marker Score: 17,913
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 2.33
    Marker Score: 8,010
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.33
    Marker Score: 88,417
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 2.33
    Marker Score: 5,719
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.28
    Marker Score: 6,770
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 2.23
    Marker Score: 19,390
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 2.22
    Marker Score: 747
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 2.19
    Marker Score: 8,113
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.19
    Marker Score: 1,281
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 2.19
    Marker Score: 1,299
  • Cell Name: centroblast (CL0009112)
    Fold Change: 2.18
    Marker Score: 1,074
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 2.17
    Marker Score: 1,263
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 2.16
    Marker Score: 1,256
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 2.14
    Marker Score: 6,113
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 2.13
    Marker Score: 1,285
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.13
    Marker Score: 20,041
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.12
    Marker Score: 8,203
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 2.11
    Marker Score: 883
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.11
    Marker Score: 8,736
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.05
    Marker Score: 126,136
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.03
    Marker Score: 30,352
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 2
    Marker Score: 20,697
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.95
    Marker Score: 25,774
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.95
    Marker Score: 7,955
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.94
    Marker Score: 3,263
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.94
    Marker Score: 3,690
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.91
    Marker Score: 5,195
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.9
    Marker Score: 18,074
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.86
    Marker Score: 15,988
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.83
    Marker Score: 67,505
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.83
    Marker Score: 1,828
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.81
    Marker Score: 1,233
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.78
    Marker Score: 686
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.77
    Marker Score: 1,742
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 1.77
    Marker Score: 2,204
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 1.76
    Marker Score: 832
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 1.75
    Marker Score: 2,401
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.73
    Marker Score: 3,278
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.72
    Marker Score: 983
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 1.72
    Marker Score: 409
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.71
    Marker Score: 1,082
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.71
    Marker Score: 4,267
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 1.71
    Marker Score: 22,947
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.69
    Marker Score: 6,659
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1.64
    Marker Score: 580
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.63
    Marker Score: 3,845
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 1.63
    Marker Score: 1,231
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.62
    Marker Score: 1,401
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.6
    Marker Score: 2,468
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 1.6
    Marker Score: 541
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.58
    Marker Score: 433
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.58
    Marker Score: 507
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.58
    Marker Score: 1,674
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.55
    Marker Score: 867
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.5
    Marker Score: 1,860
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.45
    Marker Score: 2,939
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.44
    Marker Score: 9,380
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.44
    Marker Score: 683
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 1.43
    Marker Score: 435
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 1.43
    Marker Score: 456
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 1.42
    Marker Score: 320
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.42
    Marker Score: 732
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 1.42
    Marker Score: 1,266
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 1.39
    Marker Score: 670
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.37
    Marker Score: 937
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 1.32
    Marker Score: 419
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.27
    Marker Score: 2,450
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 1.27
    Marker Score: 2,313
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.26
    Marker Score: 624
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 1.23
    Marker Score: 533
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 1.23
    Marker Score: 12,464
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.22
    Marker Score: 1,880
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 1.22
    Marker Score: 1,000
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.21
    Marker Score: 7,377
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.21
    Marker Score: 1,413
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 1.2
    Marker Score: 300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.2
    Marker Score: 12,113
  • Cell Name: B cell (CL0000236)
    Fold Change: 1.2
    Marker Score: 1,143

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** BASP1 is a membrane-associated protein that belongs to the family of brain abundant soluble proteins. It contains a unique structure, consisting of multiple domains, including a GTPase-activating protein (GAP) domain, a Rho GTPase-specific interaction domain, and a protein-binding domain. This protein is highly expressed in the brain, where it is predominantly found in neurons and neural progenitor cells. BASP1 is also expressed in other tissues, including the pancreas and the thyroid gland, where it plays a role in the regulation of cell growth and differentiation. **Pathways and Functions:** BASP1 is involved in several signaling pathways, including those mediated by Rho GTPases, which are essential for cell migration, adhesion, and proliferation. The BASP1 protein interacts with Rho GTPases, such as Rhobt3, Miro, and Rho GTPases, to regulate their activity and influence downstream signaling pathways. BASP1 has also been implicated in the regulation of transcription, particularly in the context of neuronal development and plasticity. The protein interacts with transcription factors and co-repressors to regulate the expression of genes involved in neuronal development and function. In addition to its role in signaling and transcription regulation, BASP1 is also involved in the organization of the cytoskeleton, particularly in the context of neuronal migration and axon guidance. The protein interacts with cytoskeletal proteins, such as actin and myosin, to regulate their activity and influence cell shape and movement. **Clinical Significance:** Dysregulation of BASP1 has been implicated in several neurological disorders, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). In Alzheimer's disease, BASP1 has been shown to be decreased in the brain, leading to impaired neuronal function and cognitive decline. In Parkinson's disease, BASP1 has been implicated in the regulation of dopamine signaling, and its dysregulation has been linked to the development of motor symptoms. In ALS, BASP1 has been shown to be decreased in the brain, leading to impaired neuronal function and motor dysfunction. In addition to its role in neurological disorders, BASP1 has also been implicated in the development of cancer. The protein has been shown to be overexpressed in several types of cancer, including breast cancer and lung cancer, and its dysregulation has been linked to the development of metastasis and poor prognosis. In conclusion, BASP1 is a multifunctional protein that plays a critical role in the regulation of cellular processes, including signaling, transcription regulation, and cytoskeletal organization. Its dysregulation has been implicated in several neurological disorders and cancers, highlighting the importance of BASP1 in maintaining normal brain function and preventing disease. Further research is needed to fully elucidate the functions and significance of BASP1 and to explore its potential as a therapeutic target for neurological and cancer disorders.

Genular Protein ID: 684098841

Symbol: BASP1_HUMAN

Name: Brain acid soluble protein 1

UniProtKB Accession Codes:

P80723 B4DJA8 D3DTD5 O43596 Q5U0S0 Q9BWA5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CPTAC 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 7 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 25 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SAM 1 STRING 1 SignaLink 1 SwissPalm 1 TCDB 1 TopDownProteomics 2 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9749536

Title: Characterization of bovine and human cDNAs encoding NAP-22 (22 kDa neuronal tissue-enriched acidic protein) homologs.

PubMed ID: 9749536

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9310187

Title: The BASP1 family of myristoylated proteins abundant in axonal termini. Primary structure analysis and physico-chemical properties.

PubMed ID: 9310187

DOI: 10.1016/s0300-9084(97)80032-6

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25255805

Title: Global profiling of co- and post-translationally N-myristoylated proteomes in human cells.

PubMed ID: 25255805

DOI: 10.1038/ncomms5919

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 227
  • Mass: 22693
  • Checksum: 56FFFCEA441062AB
  • Sequence:
    • MGGKLSKKKK GYNVNDEKAK EKDKKAEGAA TEEEGTPKES EPQAAAEPAE AKEGKEKPDQ 
DAEGKAEEKE GEKDAAAAKE EAPKAEPEKT EGAAEAKAEP PKAPEQEQAA PGPAAGGEAP 
KAAEAAAAPA ESAAPAAGEE PSKEEGEPKK TEAPAAPAAQ ETKSDGAPAS DSKPGSSEAA 
PSSKETPAAT EAPSSTPKAQ GPAASAEEPK PVEAPAANSD QTVTVKE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.