Details for: IFITM3

Gene ID: 10410

Symbol: IFITM3

Ensembl ID: ENSG00000142089

Description: interferon induced transmembrane protein 3

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 5.92
    Marker Score: 15,053
  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 5.27
    Marker Score: 2,970
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 4.83
    Marker Score: 6,290
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 4.71
    Marker Score: 7,257
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 4.65
    Marker Score: 6,725
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 4.25
    Marker Score: 3,657
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 4.23
    Marker Score: 55,859
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 4.19
    Marker Score: 6,093
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 4.18
    Marker Score: 4,465
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 4.1
    Marker Score: 2,319
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 4.02
    Marker Score: 7,557
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.95
    Marker Score: 220,768
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.92
    Marker Score: 133,426
  • Cell Name: theca cell (CL0000503)
    Fold Change: 3.9
    Marker Score: 2,795
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 3.84
    Marker Score: 1,232
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 3.8
    Marker Score: 2,700
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 3.79
    Marker Score: 19,919
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 3.78
    Marker Score: 5,190
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 3.71
    Marker Score: 24,125
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 3.68
    Marker Score: 3,134
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 3.65
    Marker Score: 9,564
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 3.64
    Marker Score: 4,493
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 3.63
    Marker Score: 7,259
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 3.41
    Marker Score: 8,222
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 3.41
    Marker Score: 20,202
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 3.39
    Marker Score: 2,653
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 3.37
    Marker Score: 3,630
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 3.33
    Marker Score: 775
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 3.33
    Marker Score: 6,489
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 3.31
    Marker Score: 24,625
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 3.31
    Marker Score: 5,596
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 3.3
    Marker Score: 21,515
  • Cell Name: blood cell (CL0000081)
    Fold Change: 3.3
    Marker Score: 38,365
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 3.29
    Marker Score: 3,963
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.27
    Marker Score: 7,990
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 3.27
    Marker Score: 3,159
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 3.19
    Marker Score: 1,329
  • Cell Name: pericyte (CL0000669)
    Fold Change: 3.19
    Marker Score: 1,864
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 3.17
    Marker Score: 2,089
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 3.11
    Marker Score: 5,005
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 3.1
    Marker Score: 2,777
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 3.09
    Marker Score: 5,073
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 3.07
    Marker Score: 34,622
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 3.05
    Marker Score: 1,740
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.95
    Marker Score: 11,389
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 2.93
    Marker Score: 2,931
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.91
    Marker Score: 12,552
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 2.91
    Marker Score: 1,309
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 2.88
    Marker Score: 1,238
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.86
    Marker Score: 7,773
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 2.84
    Marker Score: 2,706
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 2.8
    Marker Score: 7,726
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.76
    Marker Score: 27,803
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 2.73
    Marker Score: 2,766
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 2.67
    Marker Score: 1,377
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 2.64
    Marker Score: 4,675
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 2.62
    Marker Score: 1,017
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 2.6
    Marker Score: 1,083
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 2.59
    Marker Score: 4,731
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 2.58
    Marker Score: 581
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 2.58
    Marker Score: 1,070
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 2.56
    Marker Score: 4,077
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.56
    Marker Score: 2,578
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 2.56
    Marker Score: 2,410
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 2.55
    Marker Score: 721
  • Cell Name: club cell (CL0000158)
    Fold Change: 2.54
    Marker Score: 2,971
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.54
    Marker Score: 5,298
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 2.53
    Marker Score: 2,893
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 2.53
    Marker Score: 12,411
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 2.53
    Marker Score: 6,368
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 2.52
    Marker Score: 1,827
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 2.52
    Marker Score: 1,657
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 2.5
    Marker Score: 1,044
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 2.47
    Marker Score: 1,561
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 2.47
    Marker Score: 6,624
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 2.45
    Marker Score: 2,005
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 2.43
    Marker Score: 604
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 2.42
    Marker Score: 530
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.41
    Marker Score: 83,487
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 2.41
    Marker Score: 2,173
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 2.41
    Marker Score: 604
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 2.41
    Marker Score: 1,436
  • Cell Name: Unknown (CL0002371)
    Fold Change: 2.39
    Marker Score: 2,539
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 2.37
    Marker Score: 546
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 2.32
    Marker Score: 658
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 2.31
    Marker Score: 875
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 2.31
    Marker Score: 2,708
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 2.3
    Marker Score: 585
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 2.29
    Marker Score: 2,467
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 2.29
    Marker Score: 1,332
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.28
    Marker Score: 1,524
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 2.26
    Marker Score: 825
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 2.25
    Marker Score: 5,307
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 2.25
    Marker Score: 799
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 2.23
    Marker Score: 2,357
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 2.22
    Marker Score: 1,222
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.22
    Marker Score: 35,589
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 2.21
    Marker Score: 3,131
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.21
    Marker Score: 2,539
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 2.2
    Marker Score: 5,707

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Antiviral Function:** IFITM3 has been shown to have antiviral properties, inhibiting the entry of viruses such as HIV, influenza, and Ebola into host cells. 2. **Type I Interferon Signaling:** IFITM3 is a downstream effector of type I interferons, which are critical for the activation of the innate immune response against viral infections. 3. **Cellular Expression:** IFITM3 is highly expressed in various cell types, including endothelial cells, epithelial cells, and immune cells, making it a key component of the innate immune response. 4. **Membrane Localization:** IFITM3 is a transmembrane protein, with its N-terminal domain being located in the cytoplasm and its C-terminal domain being embedded in the plasma membrane. **Pathways and Functions:** IFITM3 is involved in the following pathways: 1. **Cytokine Signaling in Immune System:** IFITM3 is a downstream effector of type I interferons, which are critical for the activation of the innate immune response against viral infections. 2. **Defense Response to Virus:** IFITM3 has been shown to inhibit the entry of viruses such as HIV, influenza, and Ebola into host cells, thereby preventing viral replication and transmission. 3. **Negative Regulation of Viral Entry:** IFITM3 has been shown to inhibit the entry of viruses into host cells by interacting with viral proteins and disrupting viral entry mechanisms. 4. **Negative Regulation of Viral Genome Replication:** IFITM3 has been shown to inhibit the replication of viral genomes by interacting with viral proteins and disrupting viral replication mechanisms. **Clinical Significance:** IFITM3 has significant clinical implications in the prevention and treatment of viral infections. Its antiviral properties make it a potential therapeutic target for the treatment of viral diseases such as HIV, influenza, and Ebola. Additionally, IFITM3's role in the innate immune response against viral infections makes it a potential biomarker for the diagnosis and monitoring of viral infections. In conclusion, IFITM3 is a critical component of the human immune response against viral infections, and its antiviral properties make it a potential therapeutic target for the treatment of viral diseases. Further research is needed to fully understand the mechanisms of IFITM3 and its role in the innate immune response against viral infections.

Genular Protein ID: 597334777

Symbol: IFM3_HUMAN

Name: Dispanin subfamily A member 2b

UniProtKB Accession Codes:

Q01628 Q53Y76 Q96HK8 Q96J15

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 57 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 16 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 2 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 STRING 1 SignaLink 1 SwissPalm 1 TCDB 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1906403

Title: Molecular analysis of a human interferon-inducible gene family.

PubMed ID: 1906403

DOI: 10.1111/j.1432-1033.1991.tb16139.x

PubMed ID: 22446628

Title: IFITM3 restricts the morbidity and mortality associated with influenza.

PubMed ID: 22446628

DOI: 10.1038/nature10921

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 20064371

Title: The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus.

PubMed ID: 20064371

DOI: 10.1016/j.cell.2009.12.017

PubMed ID: 20534863

Title: Identification of five interferon-induced cellular proteins that inhibit west nile virus and dengue virus infections.

PubMed ID: 20534863

DOI: 10.1128/jvi.02199-09

PubMed ID: 20943977

Title: Interferon-induced cell membrane proteins, IFITM3 and tetherin, inhibit vesicular stomatitis virus infection via distinct mechanisms.

PubMed ID: 20943977

DOI: 10.1128/jvi.01328-10

PubMed ID: 19901966

Title: Interferon-induced transmembrane 3 binds osteopontin in vitro: expressed in vivo IFITM3 reduced OPN expression.

PubMed ID: 19901966

DOI: 10.1038/onc.2009.379

PubMed ID: 20601941

Title: Palmitoylome profiling reveals S-palmitoylation-dependent antiviral activity of IFITM3.

PubMed ID: 20601941

DOI: 10.1038/nchembio.405

PubMed ID: 21166591

Title: The small interferon-induced transmembrane genes and proteins.

PubMed ID: 21166591

DOI: 10.1089/jir.2010.0112

PubMed ID: 21177806

Title: The IFITM proteins inhibit HIV-1 infection.

PubMed ID: 21177806

DOI: 10.1128/jvi.01531-10

PubMed ID: 22046135

Title: IFITM3 inhibits influenza A virus infection by preventing cytosolic entry.

PubMed ID: 22046135

DOI: 10.1371/journal.ppat.1002337

PubMed ID: 21253575

Title: Distinct patterns of IFITM-mediated restriction of filoviruses, SARS coronavirus, and influenza A virus.

PubMed ID: 21253575

DOI: 10.1371/journal.ppat.1001258

PubMed ID: 22511783

Title: S-palmitoylation and ubiquitination differentially regulate interferon-induced transmembrane protein 3 (IFITM3)-mediated resistance to influenza virus.

PubMed ID: 22511783

DOI: 10.1074/jbc.m112.362095

PubMed ID: 22479637

Title: IFITM proteins restrict antibody-dependent enhancement of dengue virus infection.

PubMed ID: 22479637

DOI: 10.1371/journal.pone.0034508

PubMed ID: 22363774

Title: The dispanins: a novel gene family of ancient origin that contains 14 human members.

PubMed ID: 22363774

DOI: 10.1371/journal.pone.0031961

PubMed ID: 23601107

Title: The antiviral effector IFITM3 disrupts intracellular cholesterol homeostasis to block viral entry.

PubMed ID: 23601107

DOI: 10.1016/j.chom.2013.03.006

PubMed ID: 26354436

Title: The Interferon-induced Transmembrane Proteins, IFITM1, IFITM2, and IFITM3 Inhibit Hepatitis C Virus Entry.

PubMed ID: 26354436

DOI: 10.1074/jbc.m115.657346

PubMed ID: 30983867

Title: Identification of IFITM3 and MGAT1 as novel interaction partners of BRI3 by yeast two-hybrid screening.

PubMed ID: 30983867

DOI: 10.3906/biy-1805-47

PubMed ID: 33239446

Title: Cholesterol 25-hydroxylase suppresses SARS-CoV-2 replication by blocking membrane fusion.

PubMed ID: 33239446

DOI: 10.1073/pnas.2012197117

PubMed ID: 33270927

Title: Opposing activities of IFITM proteins in SARS-CoV-2 infection.

PubMed ID: 33270927

DOI: 10.15252/embj.2020106501

Sequence Information:

  • Length: 133
  • Mass: 14632
  • Checksum: 9FFB2E4623F7A1DD
  • Sequence:
    • MNHTVQTFFS PVNSGQPPNY EMLKEEHEVA VLGAPHNPAP PTSTVIHIRS ETSVPDHVVW 
SLFNTLFMNP CCLGFIAFAY SVKSRDRKMV GDVTGAQAYA STAKCLNIWA LILGILMTIL 
LIVIPVLIFQ AYG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.