Details for: IFITM3

Gene ID: 10410

Symbol: IFITM3

Ensembl ID: ENSG00000142089

Description: interferon induced transmembrane protein 3

Associated with

Other Information

Genular Protein ID: 597334777

Symbol: IFM3_HUMAN

Name: Dispanin subfamily A member 2b

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 1906403

Title: Molecular analysis of a human interferon-inducible gene family.

PubMed ID: 1906403

DOI: 10.1111/j.1432-1033.1991.tb16139.x

PubMed ID: 22446628

Title: IFITM3 restricts the morbidity and mortality associated with influenza.

PubMed ID: 22446628

DOI: 10.1038/nature10921

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 20064371

Title: The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus.

PubMed ID: 20064371

DOI: 10.1016/j.cell.2009.12.017

PubMed ID: 20534863

Title: Identification of five interferon-induced cellular proteins that inhibit west nile virus and dengue virus infections.

PubMed ID: 20534863

DOI: 10.1128/jvi.02199-09

PubMed ID: 20943977

Title: Interferon-induced cell membrane proteins, IFITM3 and tetherin, inhibit vesicular stomatitis virus infection via distinct mechanisms.

PubMed ID: 20943977

DOI: 10.1128/jvi.01328-10

PubMed ID: 19901966

Title: Interferon-induced transmembrane 3 binds osteopontin in vitro: expressed in vivo IFITM3 reduced OPN expression.

PubMed ID: 19901966

DOI: 10.1038/onc.2009.379

PubMed ID: 20601941

Title: Palmitoylome profiling reveals S-palmitoylation-dependent antiviral activity of IFITM3.

PubMed ID: 20601941

DOI: 10.1038/nchembio.405

PubMed ID: 21166591

Title: The small interferon-induced transmembrane genes and proteins.

PubMed ID: 21166591

DOI: 10.1089/jir.2010.0112

PubMed ID: 21177806

Title: The IFITM proteins inhibit HIV-1 infection.

PubMed ID: 21177806

DOI: 10.1128/jvi.01531-10

PubMed ID: 22046135

Title: IFITM3 inhibits influenza A virus infection by preventing cytosolic entry.

PubMed ID: 22046135

DOI: 10.1371/journal.ppat.1002337

PubMed ID: 21253575

Title: Distinct patterns of IFITM-mediated restriction of filoviruses, SARS coronavirus, and influenza A virus.

PubMed ID: 21253575

DOI: 10.1371/journal.ppat.1001258

PubMed ID: 22511783

Title: S-palmitoylation and ubiquitination differentially regulate interferon-induced transmembrane protein 3 (IFITM3)-mediated resistance to influenza virus.

PubMed ID: 22511783

DOI: 10.1074/jbc.m112.362095

PubMed ID: 22479637

Title: IFITM proteins restrict antibody-dependent enhancement of dengue virus infection.

PubMed ID: 22479637

DOI: 10.1371/journal.pone.0034508

PubMed ID: 22363774

Title: The dispanins: a novel gene family of ancient origin that contains 14 human members.

PubMed ID: 22363774

DOI: 10.1371/journal.pone.0031961

PubMed ID: 23601107

Title: The antiviral effector IFITM3 disrupts intracellular cholesterol homeostasis to block viral entry.

PubMed ID: 23601107

DOI: 10.1016/j.chom.2013.03.006

PubMed ID: 26354436

Title: The Interferon-induced Transmembrane Proteins, IFITM1, IFITM2, and IFITM3 Inhibit Hepatitis C Virus Entry.

PubMed ID: 26354436

DOI: 10.1074/jbc.m115.657346

PubMed ID: 30983867

Title: Identification of IFITM3 and MGAT1 as novel interaction partners of BRI3 by yeast two-hybrid screening.

PubMed ID: 30983867

DOI: 10.3906/biy-1805-47

PubMed ID: 33239446

Title: Cholesterol 25-hydroxylase suppresses SARS-CoV-2 replication by blocking membrane fusion.

PubMed ID: 33239446

DOI: 10.1073/pnas.2012197117

PubMed ID: 33270927

Title: Opposing activities of IFITM proteins in SARS-CoV-2 infection.

PubMed ID: 33270927

DOI: 10.15252/embj.2020106501

Sequence Information:

  • Length: 133
  • Mass: 14632
  • Checksum: 9FFB2E4623F7A1DD
  • Sequence:
  • MNHTVQTFFS PVNSGQPPNY EMLKEEHEVA VLGAPHNPAP PTSTVIHIRS ETSVPDHVVW 
    SLFNTLFMNP CCLGFIAFAY SVKSRDRKMV GDVTGAQAYA STAKCLNIWA LILGILMTIL 
    LIVIPVLIFQ AYG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.