RAPGEF3 | ENSG00000079337 | NCBI 10411

Details for: RAPGEF3

Gene ID: 10411

Symbol: RAPGEF3

Ensembl ID: ENSG00000079337

Description: Rap guanine nucleotide exchange factor 3

Associated with

Adaptive immune system
(R-HSA-1280218)
Glucagon-like peptide-1 (glp1) regulates insulin secretion
(R-HSA-381676)
Hemostasis
(R-HSA-109582)
Immune system
(R-HSA-168256)
Integration of energy metabolism
(R-HSA-163685)
Integrin signaling
(R-HSA-354192)
Metabolism
(R-HSA-1430728)
Platelet activation, signaling and aggregation
(R-HSA-76002)
Platelet aggregation (plug formation)
(R-HSA-76009)
Rap1 signalling
(R-HSA-392517)
Regulation of insulin secretion
(R-HSA-422356)
Adaptive immune response
(GO:0002250)
Angiogenesis
(GO:0001525)
Associative learning
(GO:0008306)
Camp-mediated signaling
(GO:0019933)
Camp binding
(GO:0030552)
Cellular response to camp
(GO:0071320)
Cortical actin cytoskeleton
(GO:0030864)
Endomembrane system
(GO:0012505)
Establishment of endothelial barrier
(GO:0061028)
Extracellular exosome
(GO:0070062)
Filopodium
(GO:0030175)
Guanyl-nucleotide exchange factor activity
(GO:0005085)
Intracellular signal transduction
(GO:0035556)
Lamellipodium
(GO:0030027)
Membrane
(GO:0016020)
Microvillus
(GO:0005902)
Negative regulation of syncytium formation by plasma membrane fusion
(GO:0034242)
Plasma membrane
(GO:0005886)
Positive regulation of angiogenesis
(GO:0045766)
Positive regulation of gtpase activity
(GO:0043547)
Positive regulation of protein export from nucleus
(GO:0046827)
Positive regulation of stress fiber assembly
(GO:0051496)
Positive regulation of syncytium formation by plasma membrane fusion
(GO:0060143)
Protein binding
(GO:0005515)
Protein domain specific binding
(GO:0019904)
Rap protein signal transduction
(GO:0032486)
Ras protein signal transduction
(GO:0007265)
Regulation of actin cytoskeleton organization
(GO:0032956)
Regulation of angiogenesis
(GO:0045765)
Regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0051896)
Signal transduction
(GO:0007165)

Other Information

Proteins

Rap guanine nucleotide exchange factor 3
Q99777_HUMAN

Genular Protein ID: 334721487

Symbol: RPGF3_HUMAN

Name: Rap guanine nucleotide exchange factor 3

UniProtKB Accession Codes:

O95398 A8K2G5 E7EQC8 O95634 Q8WVN0

Database IDs:

Citations:

PubMed ID: 9856955

Title: A family of cAMP-binding proteins that directly activate rap1.

PubMed ID: 9856955

DOI: 10.1126/science.282.5397.2275

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9853756

Title: Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP.

PubMed ID: 9853756

DOI: 10.1038/24884

PubMed ID: 10777494

Title: Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs.

PubMed ID: 10777494

DOI: 10.1074/jbc.m001113200

PubMed ID: 12469113

Title: Structure and regulation of the cAMP-binding domains of Epac2.

PubMed ID: 12469113

DOI: 10.1038/nsb878

PubMed ID: 21840392

Title: Epac1 and PDZ-GEF cooperate in Rap1 mediated endothelial junction control.

PubMed ID: 21840392

DOI: 10.1016/j.cellsig.2011.07.022

PubMed ID: 21393242

Title: A phosphodiesterase 3B-based signaling complex integrates exchange protein activated by cAMP 1 and phosphatidylinositol 3-kinase signals in human arterial endothelial cells.

PubMed ID: 21393242

DOI: 10.1074/jbc.m110.217026

Sequence Information:

Length: 923
Mass: 103751
Checksum: 8B3A24341F20515F
Sequence:

MKVGWPGESC WQVGLAVEDS PALGAPRVGA LPDVVPEGTL LNMVLRRMHR PRSCSYQLLL 
EHQRPSCIQG LRWTPLTNSE ESLDFSESLE QASTERVLRA GRQLHRHLLA TCPNLIRDRK 
YHLRLYRQCC SGRELVDGIL ALGLGVHSRS QVVGICQVLL DEGALCHVKH DWAFQDRDAQ 
FYRFPGPEPE PVRTHEMEEE LAEAVALLSQ RGPDALLTVA LRKPPGQRTD EELDLIFEEL 
LHIKAVAHLS NSVKRELAAV LLFEPHSKAG TVLFSQGDKG TSWYIIWKGS VNVVTHGKGL 
VTTLHEGDDF GQLALVNDAP RAATIILRED NCHFLRVDKQ DFNRIIKDVE AKTMRLEEHG 
KVVLVLERAS QGAGPSRPPT PGRNRYTVMS GTPEKILELL LEAMGPDSSA HDPTETFLSD 
FLLTHRVFMP SAQLCAALLH HFHVEPAGGS EQERSTYVCN KRQQILRLVS QWVALYGSML 
HTDPVATSFL QKLSDLVGRD TRLSNLLREQ WPERRRCHRL ENGCGNASPQ MKARNLPVWL 
PNQDEPLPGS SCAIQVGDKV PYDICRPDHS VLTLQLPVTA SVREVMAALA QEDGWTKGQV 
LVKVNSAGDA IGLQPDARGV ATSLGLNERL FVVNPQEVHE LIPHPDQLGP TVGSAEGLDL 
VSAKDLAGQL TDHDWSLFNS IHQVELIHYV LGPQHLRDVT TANLERFMRR FNELQYWVAT 
ELCLCPVPGP RAQLLRKFIK LAAHLKEQKN LNSFFAVMFG LSNSAISRLA HTWERLPHKV 
RKLYSALERL LDPSWNHRVY RLALAKLSPP VIPFMPLLLK DMTFIHEGNH TLVENLINFE 
KMRMMARAAR MLHHCRSHNP VPLSPLRSRV SHLHEDSQVA RISTCSEQSL STRSPASTWA 
YVQQLKVIDN QRELSRLSRE LEP

Genular Protein ID: 119415829

Symbol: Q99777_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q99777

Database IDs:

Citations:

PubMed ID: 8619474

Title: A "double adaptor" method for improved shotgun library construction.

PubMed ID: 8619474

DOI: 10.1006/abio.1996.0138

PubMed ID: 9110174

Title: Large-scale concatenation cDNA sequencing.

PubMed ID: 9110174

Sequence Information:

Length: 133
Mass: 14107
Checksum: C2F62AD19A480181
Sequence:

GAGVLHQHFS SGHIYVLMGL LPPPWTISFT VQTTLQPPGG LPAAPVSGRM AFEPVGRDLA 
RRMVPRAGKR TQTLGARRVA AQGARPLPED RRPKSGERLH VTVAPCWEFV LPSVSLTAQA 
WGGVGQEASS GVP

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: RAPGEF3

Associated with

Other Information

A family of cAMP-binding proteins that directly activate rap1. PubMed ID: 9856955

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The finished DNA sequence of human chromosome 12. PubMed ID: 16541075

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP. PubMed ID: 9853756

Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs. PubMed ID: 10777494

Structure and regulation of the cAMP-binding domains of Epac2. PubMed ID: 12469113

Epac1 and PDZ-GEF cooperate in Rap1 mediated endothelial junction control. PubMed ID: 21840392

A phosphodiesterase 3B-based signaling complex integrates exchange protein activated by cAMP 1 and phosphatidylinositol 3-kinase signals in human arterial endothelial cells. PubMed ID: 21393242

A "double adaptor" method for improved shotgun library construction. PubMed ID: 8619474

Large-scale concatenation cDNA sequencing. PubMed ID: 9110174