Details for: RAPGEF3

Gene ID: 10411

Symbol: RAPGEF3

Ensembl ID: ENSG00000079337

Description: Rap guanine nucleotide exchange factor 3

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 2.02
    Marker Score: 1,326
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.97
    Marker Score: 42,022
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.63
    Marker Score: 590
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.56
    Marker Score: 3,942
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.54
    Marker Score: 1,562
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.5
    Marker Score: 470
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1.48
    Marker Score: 1,142
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168,922
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.19
    Marker Score: 695
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.19
    Marker Score: 18,607
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.16
    Marker Score: 1,563
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4,802
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.11
    Marker Score: 266
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.09
    Marker Score: 2,215
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 1.07
    Marker Score: 248
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.04
    Marker Score: 2,459
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251,794
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.03
    Marker Score: 1,456
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.03
    Marker Score: 612
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.01
    Marker Score: 1,706
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,812
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,036
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 506
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,407
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.98
    Marker Score: 849
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 460
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.97
    Marker Score: 401
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,411
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.92
    Marker Score: 870
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5,232
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,734
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.91
    Marker Score: 1,000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 324
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.9
    Marker Score: 3,192
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,282
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.86
    Marker Score: 1,720
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.83
    Marker Score: 305
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.82
    Marker Score: 625
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.8
    Marker Score: 382
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.8
    Marker Score: 170
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.79
    Marker Score: 204
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.78
    Marker Score: 313
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.78
    Marker Score: 740
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1,257
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.77
    Marker Score: 690
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 395
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.75
    Marker Score: 686
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.73
    Marker Score: 1,754
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.73
    Marker Score: 786
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.72
    Marker Score: 650
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.72
    Marker Score: 1,926
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.7
    Marker Score: 1,022
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.7
    Marker Score: 224
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.68
    Marker Score: 733
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.68
    Marker Score: 1,661
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.67
    Marker Score: 406
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.66
    Marker Score: 6,203
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.62
    Marker Score: 1,022
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.61
    Marker Score: 417
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.61
    Marker Score: 5,373
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6
    Marker Score: 386
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.57
    Marker Score: 453
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 0.55
    Marker Score: 1,397
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.54
    Marker Score: 1,457
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.52
    Marker Score: 18,088
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.52
    Marker Score: 105
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.51
    Marker Score: 545
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.47
    Marker Score: 313
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.46
    Marker Score: 555
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.46
    Marker Score: 325
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.45
    Marker Score: 206
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.44
    Marker Score: 827
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: 0.43
    Marker Score: 110
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 0.43
    Marker Score: 370
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.43
    Marker Score: 822
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.42
    Marker Score: 223
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.42
    Marker Score: 16,027
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.42
    Marker Score: 493
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.42
    Marker Score: 756
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.41
    Marker Score: 1,688
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.4
    Marker Score: 407
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.39
    Marker Score: 896
  • Cell Name: vasa recta descending limb cell (CL1001285)
    Fold Change: 0.39
    Marker Score: 108
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.38
    Marker Score: 331
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.38
    Marker Score: 1,559
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.38
    Marker Score: 402
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.38
    Marker Score: 83
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.38
    Marker Score: 256
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.38
    Marker Score: 156
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.37
    Marker Score: 244
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.35
    Marker Score: 1,484
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 0.35
    Marker Score: 506
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.35
    Marker Score: 510
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.34
    Marker Score: 133
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 0.34
    Marker Score: 79
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.34
    Marker Score: 167
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.34
    Marker Score: 2,194
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.34
    Marker Score: 1,404
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.33
    Marker Score: 115

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key characteristics** RAPGEF3 is a guanine nucleotide exchange factor (GEF) that specifically activates Rap1, a small GTPase involved in various cellular processes. The RAPGEF3 protein is characterized by its ability to bind to Rap1 and stimulate its GTPase activity, leading to the activation of downstream signaling pathways. RAPGEF3 is also involved in the regulation of the actin cytoskeleton, cell adhesion, and cell migration. The protein exhibits a high degree of specificity for Rap1, suggesting that RAPGEF3 plays a critical role in regulating Rap1-mediated signaling. **Pathways and functions** RAPGEF3 is involved in a wide range of cellular signaling pathways, including: 1. **Adaptive immune response**: RAPGEF3 regulates the activity of immune cells, such as T cells and B cells, by activating Rap1 and modulating the expression of immune-related genes. 2. **Angiogenesis**: RAPGEF3 promotes the formation of new blood vessels by regulating the activity of endothelial cells and the expression of angiogenic factors. 3. **Integrin signaling**: RAPGEF3 modulates the activity of integrins, which are transmembrane receptors involved in cell adhesion and migration. 4. **Ras protein signal transduction**: RAPGEF3 interacts with Ras proteins, which are key regulators of cell growth and differentiation. 5. **Insulin secretion**: RAPGEF3 regulates the expression of glucagon-like peptide-1 (GLP-1), which is involved in glucose metabolism and insulin secretion. RAPGEF3 also plays a role in the regulation of the actin cytoskeleton, cell adhesion, and cell migration. The protein is involved in the formation of filopodia and lamellipodia, which are structures involved in cell migration and adhesion. **Clinical significance** Dysregulation of RAPGEF3 has been implicated in various diseases, including: 1. **Cancer**: Overexpression of RAPGEF3 has been observed in certain types of cancer, including breast and lung cancer. 2. **Neurodegenerative diseases**: RAPGEF3 has been implicated in the pathogenesis of neurodegenerative diseases, such as Alzheimer's and Parkinson's disease. 3. **Cardiovascular disease**: RAPGEF3 regulates the activity of endothelial cells and the expression of angiogenic factors, which are involved in the development of cardiovascular disease. 4. **Immunological disorders**: RAPGEF3 plays a role in regulating the activity of immune cells and the expression of immune-related genes, which are involved in the development of immunological disorders, such as rheumatoid arthritis and multiple sclerosis. In conclusion, RAPGEF3 is a critical regulator of various cellular signaling pathways, including those involved in immune function, angiogenesis, and cell growth and differentiation. Dysregulation of RAPGEF3 has been implicated in various diseases, highlighting the importance of this gene in human health and disease.

Genular Protein ID: 334721487

Symbol: RPGF3_HUMAN

Name: Rap guanine nucleotide exchange factor 3

UniProtKB Accession Codes:

O95398 A8K2G5 E7EQC8 O95634 Q8WVN0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 4 CTD 1 ChEBI 2 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 5 ExpressionAtlas 1 GO 29 Gene3D 5 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 13 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 1 PRINTS 1 PRO 1 PROSITE 5 PROSITE-ProRule 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 4 RefSeq 2 SASBDB 1 SIGNOR 1 SMART 4 SMR 1 STRING 1 SUPFAM 4 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9856955

Title: A family of cAMP-binding proteins that directly activate rap1.

PubMed ID: 9856955

DOI: 10.1126/science.282.5397.2275

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9853756

Title: Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP.

PubMed ID: 9853756

DOI: 10.1038/24884

PubMed ID: 10777494

Title: Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs.

PubMed ID: 10777494

DOI: 10.1074/jbc.m001113200

PubMed ID: 12469113

Title: Structure and regulation of the cAMP-binding domains of Epac2.

PubMed ID: 12469113

DOI: 10.1038/nsb878

PubMed ID: 21840392

Title: Epac1 and PDZ-GEF cooperate in Rap1 mediated endothelial junction control.

PubMed ID: 21840392

DOI: 10.1016/j.cellsig.2011.07.022

PubMed ID: 21393242

Title: A phosphodiesterase 3B-based signaling complex integrates exchange protein activated by cAMP 1 and phosphatidylinositol 3-kinase signals in human arterial endothelial cells.

PubMed ID: 21393242

DOI: 10.1074/jbc.m110.217026

Sequence Information:

  • Length: 923
  • Mass: 103751
  • Checksum: 8B3A24341F20515F
  • Sequence:
    • MKVGWPGESC WQVGLAVEDS PALGAPRVGA LPDVVPEGTL LNMVLRRMHR PRSCSYQLLL 
EHQRPSCIQG LRWTPLTNSE ESLDFSESLE QASTERVLRA GRQLHRHLLA TCPNLIRDRK 
YHLRLYRQCC SGRELVDGIL ALGLGVHSRS QVVGICQVLL DEGALCHVKH DWAFQDRDAQ 
FYRFPGPEPE PVRTHEMEEE LAEAVALLSQ RGPDALLTVA LRKPPGQRTD EELDLIFEEL 
LHIKAVAHLS NSVKRELAAV LLFEPHSKAG TVLFSQGDKG TSWYIIWKGS VNVVTHGKGL 
VTTLHEGDDF GQLALVNDAP RAATIILRED NCHFLRVDKQ DFNRIIKDVE AKTMRLEEHG 
KVVLVLERAS QGAGPSRPPT PGRNRYTVMS GTPEKILELL LEAMGPDSSA HDPTETFLSD 
FLLTHRVFMP SAQLCAALLH HFHVEPAGGS EQERSTYVCN KRQQILRLVS QWVALYGSML 
HTDPVATSFL QKLSDLVGRD TRLSNLLREQ WPERRRCHRL ENGCGNASPQ MKARNLPVWL 
PNQDEPLPGS SCAIQVGDKV PYDICRPDHS VLTLQLPVTA SVREVMAALA QEDGWTKGQV 
LVKVNSAGDA IGLQPDARGV ATSLGLNERL FVVNPQEVHE LIPHPDQLGP TVGSAEGLDL 
VSAKDLAGQL TDHDWSLFNS IHQVELIHYV LGPQHLRDVT TANLERFMRR FNELQYWVAT 
ELCLCPVPGP RAQLLRKFIK LAAHLKEQKN LNSFFAVMFG LSNSAISRLA HTWERLPHKV 
RKLYSALERL LDPSWNHRVY RLALAKLSPP VIPFMPLLLK DMTFIHEGNH TLVENLINFE 
KMRMMARAAR MLHHCRSHNP VPLSPLRSRV SHLHEDSQVA RISTCSEQSL STRSPASTWA 
YVQQLKVIDN QRELSRLSRE LEP

Genular Protein ID: 119415829

Symbol: Q99777_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q99777

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 Genevisible 1 GenomeRNAi 1 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 RefSeq 3 SAM 1

Citations:

PubMed ID: 8619474

Title: A "double adaptor" method for improved shotgun library construction.

PubMed ID: 8619474

DOI: 10.1006/abio.1996.0138

PubMed ID: 9110174

Title: Large-scale concatenation cDNA sequencing.

PubMed ID: 9110174

Sequence Information:

  • Length: 133
  • Mass: 14107
  • Checksum: C2F62AD19A480181
  • Sequence:
    • GAGVLHQHFS SGHIYVLMGL LPPPWTISFT VQTTLQPPGG LPAAPVSGRM AFEPVGRDLA 
RRMVPRAGKR TQTLGARRVA AQGARPLPED RRPKSGERLH VTVAPCWEFV LPSVSLTAQA 
WGGVGQEASS GVP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.