Details for: NSA2

Gene ID: 10412

Symbol: NSA2

Ensembl ID: ENSG00000164346

Description: NSA2 ribosome biogenesis factor

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.89
    Marker Score: 3,083
  • Cell Name: blood cell (CL0000081)
    Fold Change: 2.89
    Marker Score: 33,553
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 2.86
    Marker Score: 1,429
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 2.8
    Marker Score: 147,796
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.77
    Marker Score: 6,309
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 2.75
    Marker Score: 2,712
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.74
    Marker Score: 95,023
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.64
    Marker Score: 17,164
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.6
    Marker Score: 88,375
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 2.59
    Marker Score: 34,190
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.59
    Marker Score: 29,168
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 2.55
    Marker Score: 10,922
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 2.46
    Marker Score: 24,410
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 2.46
    Marker Score: 2,300
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 2.46
    Marker Score: 4,283
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 2.44
    Marker Score: 853
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 2.43
    Marker Score: 1,465
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 2.35
    Marker Score: 833
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 2.33
    Marker Score: 4,567
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.31
    Marker Score: 129,038
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 2.3
    Marker Score: 1,802
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 2.29
    Marker Score: 3,921
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 2.28
    Marker Score: 30,632
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 2.27
    Marker Score: 4,029
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 2.27
    Marker Score: 4,257
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 2.26
    Marker Score: 2,183
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.25
    Marker Score: 6,125
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.25
    Marker Score: 5,486
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 2.23
    Marker Score: 846
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 2.22
    Marker Score: 3,148
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 2.22
    Marker Score: 1,679
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 2.19
    Marker Score: 944
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 2.18
    Marker Score: 1,950
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 2.18
    Marker Score: 1,581
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.18
    Marker Score: 22,045
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 2.17
    Marker Score: 715
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 2.17
    Marker Score: 1,453
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 2.17
    Marker Score: 673
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.17
    Marker Score: 21,840
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 2.17
    Marker Score: 3,873
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.17
    Marker Score: 3,555
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.16
    Marker Score: 3,176
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 2.15
    Marker Score: 7,975
  • Cell Name: Unknown (CL0002371)
    Fold Change: 2.14
    Marker Score: 2,274
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 2.14
    Marker Score: 13,921
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 2.14
    Marker Score: 6,740
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.1
    Marker Score: 53,868
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 2.1
    Marker Score: 4,095
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 2.1
    Marker Score: 2,116
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.1
    Marker Score: 1,653
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 2.1
    Marker Score: 3,476
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 2.07
    Marker Score: 628
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 2.06
    Marker Score: 4,316
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 2.05
    Marker Score: 1,056
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 2.05
    Marker Score: 2,208
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.04
    Marker Score: 488
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.04
    Marker Score: 2,145
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.03
    Marker Score: 4,229
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 2.02
    Marker Score: 1,462
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.02
    Marker Score: 8,278
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.99
    Marker Score: 8,585
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 1.99
    Marker Score: 1,165
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1.99
    Marker Score: 5,573
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.98
    Marker Score: 1,132
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.98
    Marker Score: 1,246
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 1.97
    Marker Score: 1,271
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.97
    Marker Score: 4,467
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.96
    Marker Score: 4,648
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.96
    Marker Score: 736
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.95
    Marker Score: 2,086
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.95
    Marker Score: 4,592
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 1.95
    Marker Score: 1,187
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.95
    Marker Score: 4,108
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.94
    Marker Score: 6,902
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.94
    Marker Score: 5,760
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.94
    Marker Score: 2,269
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.93
    Marker Score: 15,088
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.93
    Marker Score: 2,038
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 1.92
    Marker Score: 1,616
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.92
    Marker Score: 10,086
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.92
    Marker Score: 554
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.9
    Marker Score: 1,271
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 1.9
    Marker Score: 1,831
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.9
    Marker Score: 2,288
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.89
    Marker Score: 4,715
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.88
    Marker Score: 2,152
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.88
    Marker Score: 2,022
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.88
    Marker Score: 3,015
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.87
    Marker Score: 600
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.87
    Marker Score: 1,178
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.86
    Marker Score: 3,715
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 1.86
    Marker Score: 2,066
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.85
    Marker Score: 3,149
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.85
    Marker Score: 594
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 1.85
    Marker Score: 489
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.84
    Marker Score: 1,733
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 1.84
    Marker Score: 1,217
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 1.83
    Marker Score: 633
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.83
    Marker Score: 1,854
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.83
    Marker Score: 420

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Ribosome biogenesis factor**: NSA2 is a ribosome biogenesis factor that plays a critical role in the maturation of 5.8s rRNA, a component of the large subunit of ribosomes. 2. **Significant expression in immune cells**: NSA2 is highly expressed in immune cells, including skeletal muscle satellite stem cells, blood cells, and mature alpha-beta T cells, highlighting its importance in immune function. 3. **Cellular localization**: NSA2 is localized to the nucleolus, where it interacts with other ribosome biogenesis factors to regulate rRNA maturation. 4. **Conservation across species**: The NSA2 gene is conserved across species, suggesting its essential role in ribosome biogenesis and protein synthesis. **Pathways and Functions:** 1. **Maturation of 5.8s rRNA**: NSA2 is involved in the maturation of 5.8s rRNA, a critical step in ribosome biogenesis. 2. **Maturation of LSU-rRNA**: NSA2 also participates in the maturation of LSU-rRNA, another essential component of ribosomes. 3. **Nucleolus**: NSA2 is localized to the nucleolus, where it interacts with other ribosome biogenesis factors to regulate rRNA maturation. 4. **Preribosome assembly**: NSA2 is involved in the assembly of preribosomes, the precursor to ribosomes. 5. **Large subunit precursor assembly**: NSA2 also participates in the assembly of large subunit precursors, a critical step in ribosome biogenesis. **Clinical Significance:** 1. **Immune dysfunction**: Dysregulation of NSA2 has been implicated in various immune-related disorders, including autoimmune diseases and immunodeficiency disorders. 2. **Cancer**: NSA2 expression has been observed in cancer cells, suggesting its potential role in tumorigenesis. 3. **Neurological disorders**: NSA2 expression has been observed in neurological disorders, including multiple sclerosis and Alzheimer's disease. 4. **Muscle wasting**: NSA2 dysregulation has been implicated in muscle wasting disorders, including muscular dystrophy. 5. **Implications for protein synthesis**: NSA2's role in ribosome biogenesis highlights its potential as a therapeutic target for diseases characterized by impaired protein synthesis. In conclusion, the NSA2 gene plays a critical role in ribosome biogenesis and protein synthesis, with implications for immune function, cancer, neurological disorders, and muscle wasting disorders. Further research is necessary to fully elucidate the molecular mechanisms underlying NSA2's function and its potential therapeutic applications.

Genular Protein ID: 1953925307

Symbol: NSA2_HUMAN

Name: Ribosome biogenesis protein NSA2 homolog

UniProtKB Accession Codes:

O95478

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 EMDB 26 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 5 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 26 PDBsum 26 PRO 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 2 SAM 1 SMR 1 STRING 1 SWISS-2DPAGE 1 SignaLink 1 SwissPalm 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10486207

Title: Molecular analysis of the human chromosome 5q13.3 region in patients with hairy cell leukemia and identification of tumor suppressor gene candidates.

PubMed ID: 10486207

DOI: 10.1006/geno.1999.5911

PubMed ID: 11124703

Title: Characterization of 16 novel human genes showing high similarity to yeast sequences.

PubMed ID: 11124703

DOI: 10.1002/1097-0061(200101)18:1<69::aid-yea647>3.0.co;2-h

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12429849

Title: Functional proteomic analysis of human nucleolus.

PubMed ID: 12429849

DOI: 10.1091/mbc.e02-05-0271

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 260
  • Mass: 30065
  • Checksum: C42D3E8EFB2669D8
  • Sequence:
    • MPQNEYIELH RKRYGYRLDY HEKKRKKESR EAHERSKKAK KMIGLKAKLY HKQRHAEKIQ 
MKKTIKMHEK RNTKQKNDEK TPQGAVPAYL LDREGQSRAK VLSNMIKQKR KEKAGKWEVP 
LPKVRAQGET EVLKVIRTGK RKKKAWKRMV TKVCFVGDGF TRKPPKYERF IRPMGLRFKK 
AHVTHPELKA TFCLPILGVK KNPSSPLYTT LGVITKGTVI EVNVSELGLV TQGGKVIWGK 
YAQVTNNPEN DGCINAVLLV

Genular Protein ID: 1800861073

Symbol: A0A0A0MQZ6_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0A0MQZ6

Database IDs:

AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 1 EPD 1 Ensembl 2 ExpressionAtlas 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 InterPro 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Proteomes 2 RefSeq 1 SAM 1 SMR 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

Sequence Information:

  • Length: 189
  • Mass: 22653
  • Checksum: AAA3046E016F210D
  • Sequence:
    • MPQNEYIELH RKRYGYRLDY HEKKRKKESR EAHERSKKAK KMIGLKAKLY HKQRHAEKIQ 
MKKTIKMHEK RNTKQKNDEK TPQGAVPAYL LDREGQSRAK VLSNMIKQKR KEKAGKWEVP 
LPKVRAQGET EVLKVIRTGK RKKKAWKRMV TKVCFVGDGF TRKPPKYERF IRPMENMPRL 
PTILKMMDV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.