Details for: YAP1

Gene ID: 10413

Symbol: YAP1

Ensembl ID: ENSG00000137693

Description: Yes1 associated transcriptional regulator

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 4.49
    Marker Score: 3,685
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 4.39
    Marker Score: 18,295
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 3.97
    Marker Score: 2,208
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 3.54
    Marker Score: 3,139
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 3.38
    Marker Score: 2,923
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 3.38
    Marker Score: 28,610
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 3.15
    Marker Score: 3,573
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 2.98
    Marker Score: 2,071
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.68
    Marker Score: 57,219
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 2.59
    Marker Score: 1,999
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 2.59
    Marker Score: 4,983
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 2.58
    Marker Score: 2,464
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.48
    Marker Score: 39,775
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 2.44
    Marker Score: 1,423
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 2.43
    Marker Score: 711
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 2.39
    Marker Score: 3,215
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.37
    Marker Score: 1,386
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 2.33
    Marker Score: 2,819
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.32
    Marker Score: 9,707
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 2.31
    Marker Score: 599
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.29
    Marker Score: 2,634
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 2.28
    Marker Score: 4,996
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 2.17
    Marker Score: 1,178
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 2.15
    Marker Score: 2,379
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.14
    Marker Score: 2,256
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 2.11
    Marker Score: 608
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.99
    Marker Score: 629
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 1.96
    Marker Score: 718
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.93
    Marker Score: 491
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.88
    Marker Score: 1,049
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.81
    Marker Score: 952
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.8
    Marker Score: 1,824
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.78
    Marker Score: 1,920
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 1.75
    Marker Score: 763
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.74
    Marker Score: 1,037
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 1.73
    Marker Score: 4,963
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.71
    Marker Score: 38,171
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.65
    Marker Score: 10,752
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.63
    Marker Score: 1,109
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.61
    Marker Score: 584
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.6
    Marker Score: 1,054
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.6
    Marker Score: 6,276
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.58
    Marker Score: 583
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.57
    Marker Score: 2,783
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 1.56
    Marker Score: 314
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.55
    Marker Score: 2,001
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.54
    Marker Score: 1,338
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.52
    Marker Score: 51,661
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.48
    Marker Score: 733
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.48
    Marker Score: 2,184
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.47
    Marker Score: 837
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.46
    Marker Score: 549
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.45
    Marker Score: 1,808
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.43
    Marker Score: 536
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.43
    Marker Score: 832
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.42
    Marker Score: 6,953
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.39
    Marker Score: 3,474
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.38
    Marker Score: 469
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 1.36
    Marker Score: 894
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.35
    Marker Score: 8,703
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.34
    Marker Score: 3,157
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.34
    Marker Score: 849
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.33
    Marker Score: 8,673
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.32
    Marker Score: 1,370
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.31
    Marker Score: 2,996
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.31
    Marker Score: 5,644
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.3
    Marker Score: 619
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 1.3
    Marker Score: 4,251
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.28
    Marker Score: 2,907
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.28
    Marker Score: 1,811
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.28
    Marker Score: 1,358
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.27
    Marker Score: 616
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.26
    Marker Score: 6,620
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.24
    Marker Score: 4,397
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.24
    Marker Score: 19,350
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.23
    Marker Score: 3,109
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.23
    Marker Score: 3,302
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.23
    Marker Score: 4,561
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.22
    Marker Score: 1,960
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.21
    Marker Score: 6,505
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 1.2
    Marker Score: 379
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.2
    Marker Score: 1,738
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.2
    Marker Score: 1,264
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.18
    Marker Score: 276
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.17
    Marker Score: 1,247
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 1.17
    Marker Score: 395
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.16
    Marker Score: 1,363
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.16
    Marker Score: 774
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 1.15
    Marker Score: 821
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.15
    Marker Score: 2,100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.15
    Marker Score: 20,390
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.15
    Marker Score: 9,896
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 1.14
    Marker Score: 433
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.14
    Marker Score: 367
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.14
    Marker Score: 2,146
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.14
    Marker Score: 2,680
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.14
    Marker Score: 759
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 1.13
    Marker Score: 1,476
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.13
    Marker Score: 260
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.13
    Marker Score: 1,315

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** YAP1 is a transcriptional coactivator that belongs to the YAP/TAZ family of transcriptional regulators. It is characterized by its ability to interact with transcription factors and coactivators to regulate gene expression. YAP1 is primarily expressed in the nucleus and is involved in various signaling pathways, including the Hippo signaling pathway, Wnt signaling pathway, and ERBB4 signaling pathway. The gene is highly conserved across species and has been identified as a key regulator of cellular processes. **Pathways and Functions** YAP1 is involved in various signaling pathways that regulate cellular processes, including: 1. **Hippo Signaling Pathway**: YAP1 is a key effector of the Hippo signaling pathway, which regulates organ size and tissue homeostasis. 2. **Wnt Signaling Pathway**: YAP1 is a positive regulator of the Wnt signaling pathway, which is involved in cell proliferation and differentiation. 3. **ERBB4 Signaling Pathway**: YAP1 is a positive regulator of the ERBB4 signaling pathway, which is involved in cell growth and differentiation. 4. **Cell Proliferation**: YAP1 regulates cell proliferation by interacting with transcription factors and coactivators to activate gene expression. 5. **Differentiation**: YAP1 regulates cell differentiation by interacting with transcription factors and coactivators to activate gene expression. 6. **Apoptosis**: YAP1 regulates apoptosis by interacting with transcription factors and coactivators to inhibit gene expression. **Clinical Significance** Dysregulation of YAP1 has been implicated in various diseases, including: 1. **Cancer**: YAP1 is often overexpressed in cancer cells and is involved in tumor progression and metastasis. 2. **Cardiovascular Disease**: YAP1 is involved in cardiac hypertrophy and fibrosis, which are common features of cardiovascular disease. 3. **Neurodegenerative Disorders**: YAP1 is involved in neurogenesis and neuronal differentiation, and its dysregulation has been implicated in neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease. 4. **Metabolic Disorders**: YAP1 is involved in glucose and lipid metabolism, and its dysregulation has been implicated in metabolic disorders such as diabetes and obesity. In conclusion, YAP1 is a critical gene involved in various cellular processes, including cell proliferation, differentiation, and survival. Its dysregulation has been implicated in various diseases, including cancer, cardiovascular disease, and neurodegenerative disorders. Further research is needed to fully understand the role of YAP1 in human disease and to develop novel therapeutic strategies to target this gene.

Genular Protein ID: 4291393046

Symbol: YAP1_HUMAN

Name: Transcriptional coactivator YAP1

UniProtKB Accession Codes:

P46937 B4DTY1 B7ZA01 E3WEB5 E3WEB6 E9PRV2 F5H202 K0KQ18 K0KYZ8 K0L195 K0L1G3 Q7Z574 Q8IUY9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 8 CDD 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 ELM 1 EMBL 16 EPD 1 Ensembl 8 EvolutionaryTrace 1 ExpressionAtlas 1 GO 73 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 MoonProt 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 47 PDBsum 38 PIR 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 6 Pumba 1 RNAct 1 Reactome 9 RefSeq 8 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7782338

Title: Characterization of the mammalian YAP (Yes-associated protein) gene and its role in defining a novel protein module, the WW domain.

PubMed ID: 7782338

DOI: 10.1074/jbc.270.24.14733

PubMed ID: 12807903

Title: WW domain-containing protein YAP associates with ErbB-4 and acts as a co-transcriptional activator for the carboxyl-terminal fragment of ErbB-4 that translocates to the nucleus.

PubMed ID: 12807903

DOI: 10.1074/jbc.m305597200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 22939869

Title: Identification, basic characterization and evolutionary analysis of differentially spliced mRNA isoforms of human YAP1 gene.

PubMed ID: 22939869

DOI: 10.1016/j.gene.2012.08.025

PubMed ID: 9202023

Title: Characterization of the WW domain of human Yes-associated protein and its polyproline containing ligands.

PubMed ID: 9202023

DOI: 10.1074/jbc.272.27.17070

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16461361

Title: Transcriptional repression induces a slowly progressive atypical neuronal death associated with changes of YAP isoforms and p73.

PubMed ID: 16461361

DOI: 10.1083/jcb.200509132

PubMed ID: 17535448

Title: Regulation of p73 by Hck through kinase-dependent and independent mechanisms.

PubMed ID: 17535448

DOI: 10.1186/1471-2199-8-45

PubMed ID: 17974916

Title: Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control.

PubMed ID: 17974916

DOI: 10.1101/gad.1602907

PubMed ID: 17502622

Title: Proline-rich Gla protein 2 is a cell-surface vitamin K-dependent protein that binds to the transcriptional coactivator Yes-associated protein.

PubMed ID: 17502622

DOI: 10.1073/pnas.0703195104

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18579750

Title: TEAD mediates YAP-dependent gene induction and growth control.

PubMed ID: 18579750

DOI: 10.1101/gad.1664408

PubMed ID: 18158288

Title: Tumor suppressor LATS1 is a negative regulator of oncogene YAP.

PubMed ID: 18158288

DOI: 10.1074/jbc.m709037200

PubMed ID: 18280240

Title: Yap1 phosphorylation by c-Abl is a critical step in selective activation of proapoptotic genes in response to DNA damage.

PubMed ID: 18280240

DOI: 10.1016/j.molcel.2007.12.022

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21364637

Title: JNK phosphorylates Yes-associated protein (YAP) to regulate apoptosis.

PubMed ID: 21364637

DOI: 10.1038/cddis.2010.7

PubMed ID: 21145499

Title: The Crumbs complex couples cell density sensing to Hippo-dependent control of the TGF-beta-SMAD pathway.

PubMed ID: 21145499

DOI: 10.1016/j.devcel.2010.11.012

PubMed ID: 20048001

Title: A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF(beta-TRCP).

PubMed ID: 20048001

DOI: 10.1101/gad.1843810

PubMed ID: 20123908

Title: Structural basis of YAP recognition by TEAD4 in the hippo pathway.

PubMed ID: 20123908

DOI: 10.1101/gad.1865310

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23873930

Title: Cellular localization and characterization of cytosolic binding partners for Gla domain-containing proteins PRRG4 and PRRG2.

PubMed ID: 23873930

DOI: 10.1074/jbc.m113.484683

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 22525271

Title: PTPN14 interacts with and negatively regulates the oncogenic function of YAP.

PubMed ID: 22525271

DOI: 10.1038/onc.2012.147

PubMed ID: 24462371

Title: Heterozygous loss-of-function mutations in YAP1 cause both isolated and syndromic optic fissure closure defects.

PubMed ID: 24462371

DOI: 10.1016/j.ajhg.2014.01.001

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25778702

Title: YAP is essential for tissue tension to ensure vertebrate 3D body shape.

PubMed ID: 25778702

DOI: 10.1038/nature14215

PubMed ID: 25849865

Title: Actin remodelling factors control ciliogenesis by regulating YAP/TAZ activity and vesicle trafficking.

PubMed ID: 25849865

DOI: 10.1038/ncomms7781

PubMed ID: 28169360

Title: Loss of DLG5 promotes breast cancer malignancy by inhibiting the Hippo signaling pathway.

PubMed ID: 28169360

DOI: 10.1038/srep42125

PubMed ID: 29400695

Title: Claudin-18-mediated YAP activity regulates lung stem and progenitor cell homeostasis and tumorigenesis.

PubMed ID: 29400695

DOI: 10.1172/jci90429

PubMed ID: 30447097

Title: Identification of genes involved in the regulation of TERT in hepatocellular carcinoma.

PubMed ID: 30447097

DOI: 10.1111/cas.13884

PubMed ID: 11743730

Title: Solution structures of the YAP65 WW domain and the variant L30 K in complex with the peptides GTPPPPYTVG, N-(n-octyl)-GPPPY and PLPPY and the application of peptide libraries reveal a minimal binding epitope.

PubMed ID: 11743730

DOI: 10.1006/jmbi.2000.5199

PubMed ID: 11687614

Title: Using flexible loop mimetics to extend phi-value analysis to secondary structure interactions.

PubMed ID: 11687614

DOI: 10.1073/pnas.221467398

PubMed ID: 20123905

Title: Structural insights into the YAP and TEAD complex.

PubMed ID: 20123905

DOI: 10.1101/gad.1865810

PubMed ID: 21685363

Title: A Smad action turnover switch operated by WW domain readers of a phosphoserine code.

PubMed ID: 21685363

DOI: 10.1101/gad.2060811

Sequence Information:

  • Length: 504
  • Mass: 54462
  • Checksum: 6145F7049ED338AE
  • Sequence:
    • MDPGQQPPPQ PAPQGQGQPP SQPPQGQGPP SGPGQPAPAA TQAAPQAPPA GHQIVHVRGD 
SETDLEALFN AVMNPKTANV PQTVPMRLRK LPDSFFKPPE PKSHSRQAST DAGTAGALTP 
QHVRAHSSPA SLQLGAVSPG TLTPTGVVSG PAATPTAQHL RQSSFEIPDD VPLPAGWEMA 
KTSSGQRYFL NHIDQTTTWQ DPRKAMLSQM NVTAPTSPPV QQNMMNSASG PLPDGWEQAM 
TQDGEIYYIN HKNKTTSWLD PRLDPRFAMN QRISQSAPVK QPPPLAPQSP QGGVMGGSNS 
NQQQQMRLQQ LQMEKERLRL KQQELLRQAM RNINPSTANS PKCQELALRS QLPTLEQDGG 
TQNPVSSPGM SQELRTMTTN SSDPFLNSGT YHSRDESTDS GLSMSSYSVP RTPDDFLNSV 
DEMDTGDTIN QSTLPSQQNR FPDYLEAIPG TNVDLGTLEG DGMNIEGEEL MPSLQEALSS 
DILNDMESVL AATKLDKESF LTWL

Genular Protein ID: 823182996

Symbol: Q86T74_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q86T74

Database IDs:

ARBA 7 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 2 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PeptideAtlas 1 Pfam 1 RefSeq 9 SAM 1 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 397
  • Mass: 43281
  • Checksum: FDDC41A561116EF0
  • Sequence:
    • TDAGTAGALT PQHVRAHSSP ASLQLGAVSP GTLTPTGVVS GPAATPTAQH LRQSSFEIPD 
DVPLPAGWEM AKTSSGQRYF LNHIDQTTTW QDPRKAMLSQ MNVTAPTSPP VQQNMMNSAS 
GPLPDGWEQA MTQDGEIYYI NHKNKTTSWL DPRLDPRFGK AMNQRISQSA PVKQPPPLAP 
QSPQGGVMGG SNSNQQQQMR LQQLQMEKER LRLKQQELLR QAMRNINPST ANSPKCQELA 
LRSQLPTLEQ DGGTQNPVSS PGMSQELRTM TTNSSDPFLN SGTYHSRDES TDSGLSMSSY 
SVPRTPDDFL NSVDEMDTGD TINQSTLPSQ QNRFPDYLEA IPGTNVDLGT LEGDGMNIEG 
EELMPSLQEA LSSDILNDME SVLAATKLDK ESFLTWL

Genular Protein ID: 3263209330

Symbol: K0KVU2_HUMAN

Name: N/A

UniProtKB Accession Codes:

K0KVU2

Database IDs:

ARBA 7 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 Gene3D 1 GenomeRNAi 1 InterPro 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PeptideAtlas 1 Pfam 1 RefSeq 1 SAM 1 SMART 1 SUPFAM 1

Citations:

Title: Identification, basic characterization and evolutionary analysis of differentially spliced mRNA isoforms of human YAP1 gene.

DOI: 10.1016/j.gene.2012.08.025

Sequence Information:

  • Length: 168
  • Mass: 18714
  • Checksum: 39A890B3505370A7
  • Sequence:
    • MLSQMNVTAP TSPPVQQNMM NSASGPLPDG WEQAMTQDGE IYYINHKNKT TSWLDPRLDP 
RFAMNQRISQ SAPVKQPPPL APQSPQGGVM GGSNSNQQQQ MRLQQLQMEK ERLRLKQQEL 
LRQVRPQAMR NINPSTANSP KCQELALRSQ LPTLEQDGGT QNPVSSPG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.