Genular: Defining Cellular Identity and Function

Details for: SPON2

Gene ID: 10417

Symbol: SPON2

Ensembl ID: ENSG00000159674

Description: spondin 2

Associated with

Defective b3galtl causes pps
(R-HSA-5083635)
Disease
(R-HSA-1643685)
Diseases associated with o-glycosylation of proteins
(R-HSA-3906995)
Diseases of glycosylation
(R-HSA-3781865)
Diseases of metabolism
(R-HSA-5668914)
Metabolism of proteins
(R-HSA-392499)
O-glycosylation of tsr domain-containing proteins
(R-HSA-5173214)
O-linked glycosylation
(R-HSA-5173105)
Post-translational protein modification
(R-HSA-597592)
Antigen binding
(GO:0003823)
Cell adhesion
(GO:0007155)
Cellular response to lipopolysaccharide
(GO:0071222)
Defense response to fungus
(GO:0050832)
Defense response to virus
(GO:0051607)
Extracellular exosome
(GO:0070062)
Extracellular matrix
(GO:0031012)
Induction of bacterial agglutination
(GO:0043152)
Innate immune response
(GO:0045087)
Lipopolysaccharide binding
(GO:0001530)
Mast cell mediated immunity
(GO:0002448)
Metal ion binding
(GO:0046872)
Opsonization
(GO:0008228)
Positive regulation of interleukin-6 production
(GO:0032755)
Positive regulation of macrophage cytokine production
(GO:0060907)
Positive regulation of tumor necrosis factor production
(GO:0032760)
Protein binding
(GO:0005515)

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
Fold Change: 4.33
Marker Score: 12,644
Cell Name: decidual cell (CL2000002)
Fold Change: 2.71
Marker Score: 11,698
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 2.44
Marker Score: 27,430
Cell Name: bronchus fibroblast of lung (CL2000093)
Fold Change: 2.3
Marker Score: 3,168
Cell Name: mesodermal cell (CL0000222)
Fold Change: 2.26
Marker Score: 29,793
Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: 2.17
Marker Score: 6,839
Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: 2.12
Marker Score: 917
Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
Fold Change: 1.91
Marker Score: 430
Cell Name: fibroblast of lung (CL0002553)
Fold Change: 1.85
Marker Score: 4,856
Cell Name: pancreatic stellate cell (CL0002410)
Fold Change: 1.76
Marker Score: 1,112
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 1.68
Marker Score: 5,954
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 1.65
Marker Score: 56,120
Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
Fold Change: 1.59
Marker Score: 662
Cell Name: uterine smooth muscle cell (CL0002601)
Fold Change: 1.59
Marker Score: 2,068
Cell Name: interstitial cell of Cajal (CL0002088)
Fold Change: 1.55
Marker Score: 536
Cell Name: mural cell (CL0008034)
Fold Change: 1.47
Marker Score: 168,304
Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
Fold Change: 1.45
Marker Score: 1,278
Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
Fold Change: 1.45
Marker Score: 2,134
Cell Name: myofibroblast cell (CL0000186)
Fold Change: 1.42
Marker Score: 1,750
Cell Name: fibroblast of connective tissue of prostate (CL1000299)
Fold Change: 1.39
Marker Score: 347
Cell Name: prostate stromal cell (CL0002622)
Fold Change: 1.38
Marker Score: 347
Cell Name: ILC1, human (CL0001077)
Fold Change: 1.33
Marker Score: 336
Cell Name: skin fibroblast (CL0002620)
Fold Change: 1.29
Marker Score: 335
Cell Name: fibroblast (CL0000057)
Fold Change: 1.28
Marker Score: 1,236
Cell Name: theca cell (CL0000503)
Fold Change: 1.25
Marker Score: 895
Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 1.17
Marker Score: 998
Cell Name: subcutaneous fat cell (CL0002521)
Fold Change: 1.16
Marker Score: 425
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 1.11
Marker Score: 666
Cell Name: natural killer cell (CL0000623)
Fold Change: 1.11
Marker Score: 1,434
Cell Name: double negative thymocyte (CL0002489)
Fold Change: 1.09
Marker Score: 1,507
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.06
Marker Score: 16,537
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 1.05
Marker Score: 2,932
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71,737
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 47,962
Cell Name: midzonal region hepatocyte (CL0019028)
Fold Change: 0.99
Marker Score: 4,268
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30,400
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.98
Marker Score: 1,856
Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
Fold Change: 0.98
Marker Score: 756
Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
Fold Change: 0.97
Marker Score: 1,410
Cell Name: pericyte (CL0000669)
Fold Change: 0.97
Marker Score: 567
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.95
Marker Score: 490
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2,406
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.94
Marker Score: 5,665
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.94
Marker Score: 445
Cell Name: Unknown (CL0000548)
Fold Change: 0.93
Marker Score: 675
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 0.91
Marker Score: 5,940
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 0.91
Marker Score: 5,845
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2,720
Cell Name: eukaryotic cell (CL0000255)
Fold Change: 0.9
Marker Score: 465
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.9
Marker Score: 360
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5,296
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.87
Marker Score: 314
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.87
Marker Score: 4,975
Cell Name: fibroblast of breast (CL4006000)
Fold Change: 0.87
Marker Score: 495
Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
Fold Change: 0.86
Marker Score: 760
Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
Fold Change: 0.86
Marker Score: 705
Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 0.85
Marker Score: 4,596
Cell Name: supporting cell (CL0000630)
Fold Change: 0.85
Marker Score: 1,603
Cell Name: lung secretory cell (CL1000272)
Fold Change: 0.82
Marker Score: 729
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.82
Marker Score: 1,923
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.81
Marker Score: 8,224
Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
Fold Change: 0.8
Marker Score: 182
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.79
Marker Score: 601
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1,267
Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 0.78
Marker Score: 654
Cell Name: fat cell (CL0000136)
Fold Change: 0.78
Marker Score: 434
Cell Name: double negative T regulatory cell (CL0011024)
Fold Change: 0.77
Marker Score: 747
Cell Name: parietal epithelial cell (CL1000452)
Fold Change: 0.77
Marker Score: 280
Cell Name: adventitial cell (CL0002503)
Fold Change: 0.77
Marker Score: 189
Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: 0.76
Marker Score: 237
Cell Name: hepatic stellate cell (CL0000632)
Fold Change: 0.76
Marker Score: 288
Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 0.75
Marker Score: 363
Cell Name: blood cell (CL0000081)
Fold Change: 0.74
Marker Score: 8,584
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.74
Marker Score: 381
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.74
Marker Score: 3,084
Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
Fold Change: 0.73
Marker Score: 404
Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
Fold Change: 0.72
Marker Score: 159
Cell Name: brush cell (CL0002204)
Fold Change: 0.71
Marker Score: 649
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.71
Marker Score: 1,434
Cell Name: lung ciliated cell (CL1000271)
Fold Change: 0.69
Marker Score: 329
Cell Name: alveolar type 2 fibroblast cell (CL4028006)
Fold Change: 0.69
Marker Score: 384
Cell Name: mature T cell (CL0002419)
Fold Change: 0.69
Marker Score: 6,802
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.68
Marker Score: 173
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: 0.67
Marker Score: 668
Cell Name: reticular cell (CL0000432)
Fold Change: 0.67
Marker Score: 243
Cell Name: epithelial cell of glomerular capsule (CL1000450)
Fold Change: 0.66
Marker Score: 168
Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
Fold Change: 0.66
Marker Score: 1,605
Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.66
Marker Score: 211
Cell Name: keratocyte (CL0002363)
Fold Change: 0.63
Marker Score: 146
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.63
Marker Score: 301
Cell Name: gamma-delta T cell (CL0000798)
Fold Change: 0.63
Marker Score: 424
Cell Name: type I NK T cell (CL0000921)
Fold Change: 0.62
Marker Score: 487
Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
Fold Change: 0.61
Marker Score: 197
Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 0.6
Marker Score: 1,158
Cell Name: lymphocyte (CL0000542)
Fold Change: 0.6
Marker Score: 302
Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
Fold Change: 0.59
Marker Score: 1,163
Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
Fold Change: 0.59
Marker Score: 960
Cell Name: hepatocyte (CL0000182)
Fold Change: 0.58
Marker Score: 398
Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
Fold Change: 0.58
Marker Score: 3,055
Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
Fold Change: 0.58
Marker Score: 190

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

**Key Characteristics:** SPON2 belongs to the spondin family of proteins, which have been implicated in various biological processes, including immune response and cell adhesion. The protein exhibits a unique structure, characterized by a TSR (tumor necrosis factor receptor-associated protein with interspersed SH3 domains) domain, which is crucial for its function. SPON2 is also known to undergo O-glycosylation, a post-translational modification that plays a significant role in protein-protein interactions and cell signaling. **Pathways and Functions:** SPON2 is involved in several key immune-related pathways, including: 1. **Antigen Binding and Cell Adhesion:** SPON2 interacts with various ligands, including lipopolysaccharides, to regulate cell adhesion and immune response. 2. **Innate Immune Response:** SPON2 plays a crucial role in the recognition and clearance of pathogens, particularly fungi and viruses, through its interaction with pattern recognition receptors. 3. **O-Glycosylation of TSR Domain-Containing Proteins:** SPON2 is involved in the O-glycosylation of TSR domain-containing proteins, which is essential for their function in immune response and cell adhesion. 4. **Protein Binding and Post-Translational Modification:** SPON2 exhibits metal ion binding properties and undergoes O-linked glycosylation, which are critical for its interactions with other proteins and regulation of immune response. **Clinical Significance:** Dysregulation of SPON2 has been implicated in various diseases, including: 1. **Diseases associated with O-glycosylation of proteins:** Altered glycosylation patterns, including O-glycosylation, have been linked to several diseases, including cancer, autoimmune disorders, and infectious diseases. 2. **Innate Immune Response Defects:** SPON2 dysfunction has been associated with impaired innate immune response, making individuals more susceptible to infections and autoimmune diseases. 3. **Cancer and Metabolic Disorders:** Altered glycosylation patterns, including O-glycosylation, have been implicated in cancer progression and metabolic disorders, highlighting the importance of SPON2 in disease pathogenesis. In conclusion, SPON2 is a crucial protein involved in immune response, cell adhesion, and disease pathogenesis. Further research is necessary to elucidate the mechanisms underlying SPON2 function and its role in various diseases, ultimately leading to the development of novel therapeutic strategies.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Spondin-2

Genular Protein ID: 512615404

Symbol: SPON2_HUMAN

Name: Spondin-2

UniProtKB Accession Codes:

Q9BUD6 D3DVN9 Q4W5N4 Q9ULW1

Database IDs:

Citations:

PubMed ID: 10512675

Title: Identification of genes (SPON2 and C20orf2) differentially expressed between cancerous and noncancerous lung cells by mRNA differential display.

PubMed ID: 10512675

DOI: 10.1006/geno.1999.5939

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19153605

Title: Structure of the F-spondin domain of mindin, an integrin ligand and pattern recognition molecule.

PubMed ID: 19153605

DOI: 10.1038/emboj.2008.288

Sequence Information:

Length: 331
Mass: 35788
Checksum: 3ABB49FEC45579EC
Sequence:

MENPSPAAAL GKALCALLLA TLGAAGQPLG GESICSARAL AKYSITFTGK WSQTAFPKQY 
PLFRPPAQWS SLLGAAHSSD YSMWRKNQYV SNGLRDFAER GEAWALMKEI EAAGEALQSV 
HAVFSAPAVP SGTGQTSAEL EVQRRHSLVS FVVRIVPSPD WFVGVDSLDL CDGDRWREQA 
ALDLYPYDAG TDSGFTFSSP NFATIPQDTV TEITSSSPSH PANSFYYPRL KALPPIARVT 
LVRLRQSPRA FIPPAPVLPS RDNEIVDSAS VPETPLDCEV SLWSSWGLCG GHCGRLGTKS 
RTRYVRVQPA NNGSPCPELE EEAECVPDNC V

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: SPON2

Associated with

Cells (max top 100)

Other Information

Identification of genes (SPON2 and C20orf2) differentially expressed between cancerous and noncancerous lung cells by mRNA differential display. PubMed ID: 10512675

The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. PubMed ID: 12975309

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. PubMed ID: 15815621

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334