SPON1 | ENSG00000262655 | NCBI 10418

Details for: SPON1

Gene ID: 10418

Symbol: SPON1

Ensembl ID: ENSG00000262655

Description: spondin 1

Associated with

Defective b3galtl causes pps
(R-HSA-5083635)
Disease
(R-HSA-1643685)
Diseases associated with o-glycosylation of proteins
(R-HSA-3906995)
Diseases of glycosylation
(R-HSA-3781865)
Diseases of metabolism
(R-HSA-5668914)
Metabolism of proteins
(R-HSA-392499)
O-glycosylation of tsr domain-containing proteins
(R-HSA-5173214)
O-linked glycosylation
(R-HSA-5173105)
Post-translational protein modification
(R-HSA-597592)
Cell adhesion
(GO:0007155)
Collagen-containing extracellular matrix
(GO:0062023)
Endoplasmic reticulum lumen
(GO:0005788)
Extracellular matrix
(GO:0031012)
Extracellular matrix structural constituent
(GO:0005201)
Extracellular space
(GO:0005615)
Lbd domain binding
(GO:0050693)
Metal ion binding
(GO:0046872)
Negative regulation of amyloid-beta formation
(GO:1902430)
Positive regulation of amyloid precursor protein catabolic process
(GO:1902993)
Positive regulation of protein processing
(GO:0010954)
Protein binding
(GO:0005515)
Protein processing
(GO:0016485)

Other Information

Proteins

Spondin-1

Genular Protein ID: 3669775279

Symbol: SPON1_HUMAN

Name: Spondin-1

UniProtKB Accession Codes:

Q9HCB6 A8K6W5 O94862 Q8NCD7 Q8WUR5

Database IDs:

Citations:

PubMed ID: 11368520

Title: Isolation and characterization of vascular smooth muscle cell growth promoting factor from bovine ovarian follicular fluid and its cDNA cloning from bovine and human ovary.

PubMed ID: 11368520

DOI: 10.1006/abbi.2001.2367

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9872452

Title: Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 9872452

DOI: 10.1093/dnares/5.5.277

PubMed ID: 12168954

Title: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

PubMed ID: 12168954

DOI: 10.1093/dnares/9.3.99

PubMed ID: 12096136

Title: C-mannosylation and O-fucosylation of thrombospondin type 1 repeats.

PubMed ID: 12096136

DOI: 10.1074/mcp.m100011-mcp200

PubMed ID: 19020352

Title: Structure of the F-spondin reeler domain reveals a unique beta-sandwich fold with a deformable disulfide-bonded loop.

PubMed ID: 19020352

DOI: 10.1107/s0907444908028308

PubMed ID: 18602404

Title: The crystal structure of the heparin-binding reelin-N domain of f-spondin.

PubMed ID: 18602404

DOI: 10.1016/j.jmb.2008.06.045

PubMed ID: 21569239

Title: The structure of the Ca+-binding, glycosylated F-spondin domain of F-spondin - A C2-domain variant in an extracellular matrix protein.

PubMed ID: 21569239

DOI: 10.1186/1472-6807-11-22

Sequence Information:

Length: 807
Mass: 90973
Checksum: CEA84A83F206A5A5
Sequence:

MRLSPAPLKL SRTPALLALA LPLAAALAFS DETLDKVPKS EGYCSRILRA QGTRREGYTE 
FSLRVEGDPD FYKPGTSYRV TLSAAPPSYF RGFTLIALRE NREGDKEEDH AGTFQIIDEE 
ETQFMSNCPV AVTESTPRRR TRIQVFWIAP PAGTGCVILK ASIVQKRIIY FQDEGSLTKK 
LCEQDSTFDG VTDKPILDCC ACGTAKYRLT FYGNWSEKTH PKDYPRRANH WSAIIGGSHS 
KNYVLWEYGG YASEGVKQVA ELGSPVKMEE EIRQQSDEVL TVIKAKAQWP AWQPLNVRAA 
PSAEFSVDRT RHLMSFLTMM GPSPDWNVGL SAEDLCTKEC GWVQKVVQDL IPWDAGTDSG 
VTYESPNKPT IPQEKIRPLT SLDHPQSPFY DPEGGSITQV ARVVIERIAR KGEQCNIVPD 
NVDDIVADLA PEEKDEDDTP ETCIYSNWSP WSACSSSTCD KGKRMRQRML KAQLDLSVPC 
PDTQDFQPCM GPGCSDEDGS TCTMSEWITW SPCSISCGMG MRSRERYVKQ FPEDGSVCTL 
PTEETEKCTV NEECSPSSCL MTEWGEWDEC SATCGMGMKK RHRMIKMNPA DGSMCKAETS 
QAEKCMMPEC HTIPCLLSPW SEWSDCSVTC GKGMRTRQRM LKSLAELGDC NEDLEQVEKC 
MLPECPIDCE LTEWSQWSEC NKSCGKGHVI RTRMIQMEPQ FGGAPCPETV QRKKCRIRKC 
LRNPSIQKLR WREARESRRS EQLKEESEGE QFPGCRMRPW TAWSECTKLC GGGIQERYMT 
VKKRFKSSQF TSCKDKKEIR ACNVHPC

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: SPON1

Associated with

Other Information

Isolation and characterization of vascular smooth muscle cell growth promoting factor from bovine ovarian follicular fluid and its cDNA cloning from bovine and human ovary. PubMed ID: 11368520

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. PubMed ID: 9872452

Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. PubMed ID: 12168954

C-mannosylation and O-fucosylation of thrombospondin type 1 repeats. PubMed ID: 12096136

Structure of the F-spondin reeler domain reveals a unique beta-sandwich fold with a deformable disulfide-bonded loop. PubMed ID: 19020352

The crystal structure of the heparin-binding reelin-N domain of f-spondin. PubMed ID: 18602404

The structure of the Ca+-binding, glycosylated F-spondin domain of F-spondin - A C2-domain variant in an extracellular matrix protein. PubMed ID: 21569239