Genular: Defining Cellular Identity and Function

Details for: SPON1

Gene ID: 10418

Symbol: SPON1

Ensembl ID: ENSG00000262655

Description: spondin 1

Associated with

Defective b3galtl causes pps
(R-HSA-5083635)
Disease
(R-HSA-1643685)
Diseases associated with o-glycosylation of proteins
(R-HSA-3906995)
Diseases of glycosylation
(R-HSA-3781865)
Diseases of metabolism
(R-HSA-5668914)
Metabolism of proteins
(R-HSA-392499)
O-glycosylation of tsr domain-containing proteins
(R-HSA-5173214)
O-linked glycosylation
(R-HSA-5173105)
Post-translational protein modification
(R-HSA-597592)
Cell adhesion
(GO:0007155)
Collagen-containing extracellular matrix
(GO:0062023)
Endoplasmic reticulum lumen
(GO:0005788)
Extracellular matrix
(GO:0031012)
Extracellular matrix structural constituent
(GO:0005201)
Extracellular space
(GO:0005615)
Lbd domain binding
(GO:0050693)
Metal ion binding
(GO:0046872)
Negative regulation of amyloid-beta formation
(GO:1902430)
Positive regulation of amyloid precursor protein catabolic process
(GO:1902993)
Positive regulation of protein processing
(GO:0010954)
Protein binding
(GO:0005515)
Protein processing
(GO:0016485)

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 3.93
Marker Score: 1,909
Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 3.36
Marker Score: 6,455
Cell Name: alveolar type 2 fibroblast cell (CL4028006)
Fold Change: 3.35
Marker Score: 1,861
Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: 3.09
Marker Score: 6,397
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 2.83
Marker Score: 60,468
Cell Name: subcutaneous fat cell (CL0002521)
Fold Change: 2.77
Marker Score: 1,012
Cell Name: thymocyte (CL0000893)
Fold Change: 2.61
Marker Score: 2,734
Cell Name: fat cell (CL0000136)
Fold Change: 2.49
Marker Score: 1,391
Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: 2.33
Marker Score: 6,650
Cell Name: mature astrocyte (CL0002627)
Fold Change: 2.09
Marker Score: 1,375
Cell Name: fibroblast of lung (CL0002553)
Fold Change: 1.73
Marker Score: 4,541
Cell Name: cell in vitro (CL0001034)
Fold Change: 1.7
Marker Score: 59,004
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 1.62
Marker Score: 15,221
Cell Name: Mueller cell (CL0000636)
Fold Change: 1.47
Marker Score: 2,044
Cell Name: mural cell (CL0008034)
Fold Change: 1.47
Marker Score: 169,002
Cell Name: skin fibroblast (CL0002620)
Fold Change: 1.47
Marker Score: 382
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.46
Marker Score: 16,457
Cell Name: corneal endothelial cell (CL0000132)
Fold Change: 1.34
Marker Score: 781
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 1.34
Marker Score: 455
Cell Name: bronchus fibroblast of lung (CL2000093)
Fold Change: 1.34
Marker Score: 1,836
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 1.29
Marker Score: 2,614
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 1.18
Marker Score: 2,778
Cell Name: cardiac muscle cell (CL0000746)
Fold Change: 1.11
Marker Score: 14,797
Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 1.1
Marker Score: 1,189
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.06
Marker Score: 16,626
Cell Name: stromal cell (CL0000499)
Fold Change: 1.04
Marker Score: 1,218
Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
Fold Change: 1.03
Marker Score: 272
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 1.03
Marker Score: 620
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 1.02
Marker Score: 1,574
Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
Fold Change: 1.02
Marker Score: 423
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 1.01
Marker Score: 6,087
Cell Name: astrocyte (CL0000127)
Fold Change: 1.01
Marker Score: 877
Cell Name: pyramidal neuron (CL0000598)
Fold Change: 0.98
Marker Score: 1,649
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30,405
Cell Name: goblet cell (CL0000160)
Fold Change: 0.97
Marker Score: 6,441
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.97
Marker Score: 498
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.95
Marker Score: 451
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2,409
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 0.95
Marker Score: 2,367
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.93
Marker Score: 5,312
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 0.92
Marker Score: 18,243
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2,728
Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 0.9
Marker Score: 284
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.88
Marker Score: 316
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5,275
Cell Name: migratory enteric neural crest cell (CL0002607)
Fold Change: 0.85
Marker Score: 802
Cell Name: neural crest cell (CL0011012)
Fold Change: 0.85
Marker Score: 904
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.83
Marker Score: 1,355
Cell Name: pancreatic stellate cell (CL0002410)
Fold Change: 0.82
Marker Score: 516
Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.81
Marker Score: 3,142
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.77
Marker Score: 590
Cell Name: brush cell (CL0002204)
Fold Change: 0.76
Marker Score: 697
Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 0.76
Marker Score: 1,863
Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 0.75
Marker Score: 643
Cell Name: endocardial cell (CL0002350)
Fold Change: 0.75
Marker Score: 426
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.74
Marker Score: 297
Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.74
Marker Score: 237
Cell Name: decidual cell (CL2000002)
Fold Change: 0.73
Marker Score: 3,162
Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: 0.73
Marker Score: 185
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.71
Marker Score: 455
Cell Name: fibroblast (CL0000057)
Fold Change: 0.71
Marker Score: 682
Cell Name: macroglial cell (CL0000126)
Fold Change: 0.71
Marker Score: 1,621
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.69
Marker Score: 201
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: 0.68
Marker Score: 216
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.68
Marker Score: 2,858
Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: 0.68
Marker Score: 426
Cell Name: mature microglial cell (CL0002629)
Fold Change: 0.67
Marker Score: 242
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.67
Marker Score: 171
Cell Name: fibroblast of connective tissue of prostate (CL1000299)
Fold Change: 0.66
Marker Score: 164
Cell Name: preosteoblast (CL0007010)
Fold Change: 0.66
Marker Score: 186
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.65
Marker Score: 312
Cell Name: prostate stromal cell (CL0002622)
Fold Change: 0.65
Marker Score: 164
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.65
Marker Score: 647
Cell Name: nephron tubule epithelial cell (CL1000494)
Fold Change: 0.64
Marker Score: 150
Cell Name: kidney cell (CL1000497)
Fold Change: 0.63
Marker Score: 421
Cell Name: enteric neuron (CL0007011)
Fold Change: 0.61
Marker Score: 324
Cell Name: stem cell (CL0000034)
Fold Change: 0.61
Marker Score: 1,437
Cell Name: myofibroblast cell (CL0000186)
Fold Change: 0.6
Marker Score: 738
Cell Name: neuron (CL0000540)
Fold Change: 0.6
Marker Score: 2,424
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 0.59
Marker Score: 3,819
Cell Name: tracheobronchial smooth muscle cell (CL0019019)
Fold Change: 0.57
Marker Score: 168
Cell Name: cerebellar granule cell precursor (CL0002362)
Fold Change: 0.57
Marker Score: 317
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 0.56
Marker Score: 863
Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 0.56
Marker Score: 494
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.56
Marker Score: 443
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.54
Marker Score: 170
Cell Name: Bergmann glial cell (CL0000644)
Fold Change: 0.54
Marker Score: 221
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.54
Marker Score: 142
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.54
Marker Score: 222
Cell Name: CNS interneuron (CL0000402)
Fold Change: 0.53
Marker Score: 257
Cell Name: osteoblast (CL0000062)
Fold Change: 0.52
Marker Score: 282
Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 0.52
Marker Score: 645
Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
Fold Change: 0.52
Marker Score: 117
Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: 0.51
Marker Score: 342
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.51
Marker Score: 2,138
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 0.51
Marker Score: 123,715
Cell Name: fibroblast of breast (CL4006000)
Fold Change: 0.51
Marker Score: 289
Cell Name: neural cell (CL0002319)
Fold Change: 0.5
Marker Score: 242
Cell Name: glial cell (CL0000125)
Fold Change: 0.5
Marker Score: 545
Cell Name: skeletal muscle satellite cell (CL0000594)
Fold Change: 0.49
Marker Score: 329

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

**Key Characteristics:** 1. **Cellular Localization:** SPON1 is expressed in various cell types, including epicardial adipocytes, kidney interstitial fibroblasts, alveolar type 2 fibroblasts, and thymocytes, suggesting its role in tissue-specific functions. 2. **Protein Structure:** SPON1 belongs to the spondin family, characterized by a unique LBD (leucine-rich repeat and domain-binding) domain, which plays a crucial role in protein-protein interactions. 3. **Glycosylation:** SPON1 is subject to O-glycosylation, a post-translational modification that affects protein function and stability. **Pathways and Functions:** 1. **Cell Adhesion:** SPON1 interacts with various proteins, including integrins and cadherins, to regulate cell adhesion and migration. 2. **Protein Processing:** SPON1 modulates protein processing through interactions with enzymes involved in protein cleavage and modification. 3. **Post-translational Modifications:** SPON1 is involved in the regulation of post-translational modifications, including O-glycosylation and protein binding. 4. **Immune Regulation:** SPON1 plays a crucial role in immune regulation, particularly in thymocyte development and function. 5. **Metabolic Processes:** SPON1 is involved in metabolic processes, including the regulation of amyloid precursor protein catabolic process and protein metabolism. **Clinical Significance:** 1. **Autoimmune Diseases:** Alterations in SPON1 expression have been linked to autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis, highlighting its potential as a therapeutic target. 2. **Cancer:** SPON1's role in cell adhesion and migration makes it a potential biomarker for cancer diagnosis and progression. 3. **Metabolic Disorders:** SPON1's involvement in protein processing and metabolism suggests its potential as a therapeutic target for metabolic disorders, such as diabetes and obesity. 4. **Neurodegenerative Diseases:** SPON1's role in amyloid precursor protein catabolic process makes it a potential therapeutic target for neurodegenerative diseases, such as Alzheimer's disease. In conclusion, SPON1 is a multifunctional protein with a wide range of biological activities, including cell adhesion, protein processing, and post-translational modifications. Its involvement in immune regulation and metabolic processes makes it a crucial player in various diseases, including autoimmune disorders, cancer, metabolic disorders, and neurodegenerative diseases. Further research is needed to fully elucidate the mechanisms of SPON1's functions and to explore its therapeutic potential.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Spondin-1

Genular Protein ID: 3669775279

Symbol: SPON1_HUMAN

Name: Spondin-1

UniProtKB Accession Codes:

Q9HCB6 A8K6W5 O94862 Q8NCD7 Q8WUR5

Database IDs:

Citations:

PubMed ID: 11368520

Title: Isolation and characterization of vascular smooth muscle cell growth promoting factor from bovine ovarian follicular fluid and its cDNA cloning from bovine and human ovary.

PubMed ID: 11368520

DOI: 10.1006/abbi.2001.2367

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9872452

Title: Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 9872452

DOI: 10.1093/dnares/5.5.277

PubMed ID: 12168954

Title: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

PubMed ID: 12168954

DOI: 10.1093/dnares/9.3.99

PubMed ID: 12096136

Title: C-mannosylation and O-fucosylation of thrombospondin type 1 repeats.

PubMed ID: 12096136

DOI: 10.1074/mcp.m100011-mcp200

PubMed ID: 19020352

Title: Structure of the F-spondin reeler domain reveals a unique beta-sandwich fold with a deformable disulfide-bonded loop.

PubMed ID: 19020352

DOI: 10.1107/s0907444908028308

PubMed ID: 18602404

Title: The crystal structure of the heparin-binding reelin-N domain of f-spondin.

PubMed ID: 18602404

DOI: 10.1016/j.jmb.2008.06.045

PubMed ID: 21569239

Title: The structure of the Ca+-binding, glycosylated F-spondin domain of F-spondin - A C2-domain variant in an extracellular matrix protein.

PubMed ID: 21569239

DOI: 10.1186/1472-6807-11-22

Sequence Information:

Length: 807
Mass: 90973
Checksum: CEA84A83F206A5A5
Sequence:

MRLSPAPLKL SRTPALLALA LPLAAALAFS DETLDKVPKS EGYCSRILRA QGTRREGYTE 
FSLRVEGDPD FYKPGTSYRV TLSAAPPSYF RGFTLIALRE NREGDKEEDH AGTFQIIDEE 
ETQFMSNCPV AVTESTPRRR TRIQVFWIAP PAGTGCVILK ASIVQKRIIY FQDEGSLTKK 
LCEQDSTFDG VTDKPILDCC ACGTAKYRLT FYGNWSEKTH PKDYPRRANH WSAIIGGSHS 
KNYVLWEYGG YASEGVKQVA ELGSPVKMEE EIRQQSDEVL TVIKAKAQWP AWQPLNVRAA 
PSAEFSVDRT RHLMSFLTMM GPSPDWNVGL SAEDLCTKEC GWVQKVVQDL IPWDAGTDSG 
VTYESPNKPT IPQEKIRPLT SLDHPQSPFY DPEGGSITQV ARVVIERIAR KGEQCNIVPD 
NVDDIVADLA PEEKDEDDTP ETCIYSNWSP WSACSSSTCD KGKRMRQRML KAQLDLSVPC 
PDTQDFQPCM GPGCSDEDGS TCTMSEWITW SPCSISCGMG MRSRERYVKQ FPEDGSVCTL 
PTEETEKCTV NEECSPSSCL MTEWGEWDEC SATCGMGMKK RHRMIKMNPA DGSMCKAETS 
QAEKCMMPEC HTIPCLLSPW SEWSDCSVTC GKGMRTRQRM LKSLAELGDC NEDLEQVEKC 
MLPECPIDCE LTEWSQWSEC NKSCGKGHVI RTRMIQMEPQ FGGAPCPETV QRKKCRIRKC 
LRNPSIQKLR WREARESRRS EQLKEESEGE QFPGCRMRPW TAWSECTKLC GGGIQERYMT 
VKKRFKSSQF TSCKDKKEIR ACNVHPC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: SPON1

Associated with

Cells (max top 100)

Other Information

Isolation and characterization of vascular smooth muscle cell growth promoting factor from bovine ovarian follicular fluid and its cDNA cloning from bovine and human ovary. PubMed ID: 11368520

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. PubMed ID: 9872452

Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. PubMed ID: 12168954

C-mannosylation and O-fucosylation of thrombospondin type 1 repeats. PubMed ID: 12096136

Structure of the F-spondin reeler domain reveals a unique beta-sandwich fold with a deformable disulfide-bonded loop. PubMed ID: 19020352

The crystal structure of the heparin-binding reelin-N domain of f-spondin. PubMed ID: 18602404

The structure of the Ca+-binding, glycosylated F-spondin domain of F-spondin - A C2-domain variant in an extracellular matrix protein. PubMed ID: 21569239