Details for: PRMT5

Gene ID: 10419

Symbol: PRMT5

Ensembl ID: ENSG00000100462

Description: protein arginine methyltransferase 5

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 1.83
    Marker Score: 1,464
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.48
    Marker Score: 2,128
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 1.4
    Marker Score: 1,462
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.23
    Marker Score: 2,562
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.22
    Marker Score: 1,530
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.15
    Marker Score: 783
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.13
    Marker Score: 1,193
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.11
    Marker Score: 1,180
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.1
    Marker Score: 736
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.02
    Marker Score: 4,010
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.02
    Marker Score: 1,097
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.01
    Marker Score: 1,722
  • Cell Name: oocyte (CL0000023)
    Fold Change: 1.01
    Marker Score: 249
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,743
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,967
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,398
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,401
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.94
    Marker Score: 14,733
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.94
    Marker Score: 2,562
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 481
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 436
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.92
    Marker Score: 1,741
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2,709
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.9
    Marker Score: 961
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.89
    Marker Score: 490
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.89
    Marker Score: 5,058
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.87
    Marker Score: 7,477
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,245
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.86
    Marker Score: 871
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.85
    Marker Score: 200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 306
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.85
    Marker Score: 3,654
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.83
    Marker Score: 3,397
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.82
    Marker Score: 618
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.81
    Marker Score: 1,077
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.81
    Marker Score: 1,922
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.8
    Marker Score: 1,882
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.79
    Marker Score: 5,110
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,266
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.78
    Marker Score: 2,672
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.77
    Marker Score: 646
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.76
    Marker Score: 810
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.76
    Marker Score: 712
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.76
    Marker Score: 237
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.75
    Marker Score: 571
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.74
    Marker Score: 298
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.74
    Marker Score: 238
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.74
    Marker Score: 237
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.73
    Marker Score: 6,325
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.73
    Marker Score: 415
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.73
    Marker Score: 383
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.72
    Marker Score: 208
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 373
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.72
    Marker Score: 7,221
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.71
    Marker Score: 444
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.7
    Marker Score: 641
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.7
    Marker Score: 443
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.69
    Marker Score: 23,576
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.69
    Marker Score: 1,214
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.68
    Marker Score: 341
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2,858
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.68
    Marker Score: 8,929
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.66
    Marker Score: 170
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.66
    Marker Score: 1,016
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.66
    Marker Score: 1,788
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.65
    Marker Score: 7,279
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.64
    Marker Score: 342
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.64
    Marker Score: 1,047
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.64
    Marker Score: 3,130
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.64
    Marker Score: 1,295
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.62
    Marker Score: 1,421
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.62
    Marker Score: 917
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.62
    Marker Score: 414
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.61
    Marker Score: 391
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.61
    Marker Score: 289
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.61
    Marker Score: 629
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.6
    Marker Score: 117
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6
    Marker Score: 20,666
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.59
    Marker Score: 6,000
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.59
    Marker Score: 1,121
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.59
    Marker Score: 427
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.59
    Marker Score: 205
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.58
    Marker Score: 154
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.58
    Marker Score: 1,361
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.58
    Marker Score: 147
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.57
    Marker Score: 162
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.56
    Marker Score: 1,379
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.55
    Marker Score: 365
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 439
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.54
    Marker Score: 327
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.54
    Marker Score: 193
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.54
    Marker Score: 259
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.54
    Marker Score: 3,211
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.54
    Marker Score: 3,240
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.53
    Marker Score: 559
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.53
    Marker Score: 618
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.52
    Marker Score: 357
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.52
    Marker Score: 2,019
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.52
    Marker Score: 480
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.52
    Marker Score: 1,929

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Methyltransferase Activity:** PRMT5 is a histone arginine methyltransferase (HART) that catalyzes the methylation of arginine residues on histones and non-histone proteins, leading to changes in protein function and gene expression. 2. **Dual-Specificity Methyltransferase (DSMT):** PRMT5 possesses dual specificity, allowing it to methylate both arginine and lysine residues, which distinguishes it from other PRMT enzymes. 3. **Heterodimerization:** PRMT5 can form heterodimers with other proteins, including TP53, to regulate gene expression and signal transduction. 4. **Regulation of Gene Expression:** PRMT5 has been shown to regulate various aspects of gene expression, including transcription initiation, elongation, and termination, as well as mRNA splicing and stability. **Pathways and Functions:** 1. **Chromatin Remodeling:** PRMT5 plays a crucial role in chromatin remodeling by modifying histones and other chromatin-associated proteins, leading to changes in gene expression and cellular differentiation. 2. **Transcriptional Regulation:** PRMT5 regulates transcriptional initiation and elongation by modifying histones and other transcriptional regulators, such as TP53 and p53 class mediator. 3. **Signal Transduction:** PRMT5 interacts with various signaling pathways, including the Erk1/2 and p53 pathways, to regulate cellular responses to stress and growth factors. 4. **Cellular Differentiation:** PRMT5 is involved in the regulation of cellular differentiation, particularly in the context of hematopoiesis and neural development. 5. **Circadian Rhythm Regulation:** PRMT5 has been implicated in the regulation of circadian rhythms by modifying clock genes and influencing the expression of circadian-regulated genes. **Clinical Significance:** 1. **Cancer:** PRMT5 has been identified as a potential therapeutic target in cancer, where its dysregulation is associated with tumorigenesis and poor prognosis. 2. **Neurological Disorders:** PRMT5 has been implicated in the pathogenesis of neurological disorders, such as Alzheimer's disease, Parkinson's disease, and Huntington's disease, where its dysregulation is associated with neurodegeneration. 3. **Immunological Disorders:** PRMT5 has been shown to regulate immune responses, particularly in the context of autoimmune diseases, where its dysregulation is associated with inflammation and tissue damage. 4. **Regenerative Medicine:** PRMT5 has been identified as a potential therapeutic target in regenerative medicine, where its dysregulation is associated with tissue injury and repair. In conclusion, PRMT5 is a complex and multifaceted enzyme that plays a critical role in regulating gene expression, cellular differentiation, and signal transduction. Further research is necessary to elucidate its precise mechanisms of action and to explore its therapeutic potential in various diseases.

Genular Protein ID: 1147159091

Symbol: ANM5_HUMAN

Name: Protein arginine N-methyltransferase 5

UniProtKB Accession Codes:

O14744 A8MTP3 A8MZ91 B4DX49 B4DY30 B5BU10 D3DS33 E2QRE7 Q6IBR1 Q9UKH1

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 5 CDD 1 CORUM 1 CTD 1 ChEBI 15 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DNASU 1 DisGeNET 1 EC 1 EMBL 15 EMDB 5 EPD 1 Ensembl 5 ExpressionAtlas 1 GO 40 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 70 PDBsum 54 PIR 1 PIRSF 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 3 RefSeq 5 Rhea 3 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9556550

Title: pICln binds to a mammalian homolog of a yeast protein involved in regulation of cell morphology.

PubMed ID: 9556550

DOI: 10.1074/jbc.273.18.10811

PubMed ID: 9843966

Title: Negative regulation of mitosis in fission yeast by the shk1 interacting protein skb1 and its human homolog, Skb1Hs.

PubMed ID: 9843966

DOI: 10.1073/pnas.95.25.14781

PubMed ID: 10531356

Title: The human homologue of the yeast proteins Skb1 and Hsl7p interacts with Jak kinases and contains protein methyltransferase activity.

PubMed ID: 10531356

DOI: 10.1074/jbc.274.44.31531

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 19054851

Title: Human protein factory for converting the transcriptome into an in vitro-expressed proteome.

PubMed ID: 19054851

DOI: 10.1038/nmeth.1273

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21917714

Title: Protein arginine methyltransferase 5 regulates ERK1/2 signal transduction amplitude and cell fate through CRAF.

PubMed ID: 21917714

DOI: 10.1126/scisignal.2001936

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 12411503

Title: Assisted RNP assembly: SMN and PRMT5 complexes cooperate in the formation of spliceosomal UsnRNPs.

PubMed ID: 12411503

DOI: 10.1093/emboj/cdf585

PubMed ID: 15737618

Title: The tumor suppressor DAL-1/4.1B modulates protein arginine N-methyltransferase 5 activity in a substrate-specific manner.

PubMed ID: 15737618

DOI: 10.1016/j.bbrc.2005.01.153

PubMed ID: 16087681

Title: Toward an assembly line for U7 snRNPs: interactions of U7-specific Lsm proteins with PRMT5 and SMN complexes.

PubMed ID: 16087681

DOI: 10.1074/jbc.m505077200

PubMed ID: 10734105

Title: Interaction of the somatostatin receptor subtype 1 with the human homolog of the Shk1 kinase-binding protein from yeast.

PubMed ID: 10734105

DOI: 10.1074/jbc.275.13.9557

PubMed ID: 11152681

Title: Prmt5, which forms distinct homo-oligomers, is a member of the protein-arginine methyltransferase family.

PubMed ID: 11152681

DOI: 10.1074/jbc.m008660200

PubMed ID: 11747828

Title: Methylation of Sm proteins by a complex containing PRMT5 and the putative U snRNP assembly factor pICln.

PubMed ID: 11747828

DOI: 10.1016/s0960-9822(01)00592-9

PubMed ID: 12101096

Title: Negative regulation of transcription by the type II arginine methyltransferase PRMT5.

PubMed ID: 12101096

DOI: 10.1093/embo-reports/kvf136

PubMed ID: 12718890

Title: Methylation of SPT5 regulates its interaction with RNA polymerase II and transcriptional elongation properties.

PubMed ID: 12718890

DOI: 10.1016/s1097-2765(03)00101-1

PubMed ID: 15485929

Title: Human SWI/SNF-associated PRMT5 methylates histone H3 arginine 8 and negatively regulates expression of ST7 and NM23 tumor suppressor genes.

PubMed ID: 15485929

DOI: 10.1128/mcb.24.21.9630-9645.2004

PubMed ID: 16428440

Title: MBD2/NuRD and MBD3/NuRD, two distinct complexes with different biochemical and functional properties.

PubMed ID: 16428440

DOI: 10.1128/mcb.26.3.843-851.2006

PubMed ID: 17184735

Title: A putative transcriptional elongation factor hIws1 is essential for mammalian cell proliferation.

PubMed ID: 17184735

DOI: 10.1016/j.bbrc.2006.11.133

PubMed ID: 17709427

Title: Two distinct arginine methyltransferases are required for biogenesis of Sm-class ribonucleoproteins.

PubMed ID: 17709427

DOI: 10.1083/jcb.200702147

PubMed ID: 18984161

Title: An assembly chaperone collaborates with the SMN complex to generate spliceosomal SnRNPs.

PubMed ID: 18984161

DOI: 10.1016/j.cell.2008.09.020

PubMed ID: 18404153

Title: The histone-binding protein COPR5 is required for nuclear functions of the protein arginine methyltransferase PRMT5.

PubMed ID: 18404153

DOI: 10.1038/embor.2008.45

PubMed ID: 19011621

Title: Arginine methylation regulates the p53 response.

PubMed ID: 19011621

DOI: 10.1038/ncb1802

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20421892

Title: PRMT5 regulates Golgi apparatus structure through methylation of the golgin GM130.

PubMed ID: 20421892

DOI: 10.1038/cr.2010.56

PubMed ID: 20159986

Title: Methylation of ribosomal protein S10 by protein-arginine methyltransferase 5 regulates ribosome biogenesis.

PubMed ID: 20159986

DOI: 10.1074/jbc.m110.103911

PubMed ID: 20810653

Title: srGAP2 arginine methylation regulates cell migration and cell spreading through promoting dimerization.

PubMed ID: 20810653

DOI: 10.1074/jbc.m110.153429

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21081503

Title: RioK1, a new interactor of protein arginine methyltransferase 5 (PRMT5), competes with pICln for binding and modulates PRMT5 complex composition and substrate specificity.

PubMed ID: 21081503

DOI: 10.1074/jbc.m110.148486

PubMed ID: 21258366

Title: Crosstalk between Arg 1175 methylation and Tyr 1173 phosphorylation negatively modulates EGFR-mediated ERK activation.

PubMed ID: 21258366

DOI: 10.1038/ncb2158

PubMed ID: 22269951

Title: HOXA9 methylation by PRMT5 is essential for endothelial cell expression of leukocyte adhesion molecules.

PubMed ID: 22269951

DOI: 10.1128/mcb.05977-11

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 25284789

Title: 5-Hydroxymethylcytosine plays a critical role in glioblastomagenesis by recruiting the CHTOP-methylosome complex.

PubMed ID: 25284789

DOI: 10.1016/j.celrep.2014.08.071

PubMed ID: 25092918

Title: Human fetal globin gene expression is regulated by LYAR.

PubMed ID: 25092918

DOI: 10.1093/nar/gku718

PubMed ID: 26700805

Title: SMN and symmetric arginine dimethylation of RNA polymerase II C-terminal domain control termination.

PubMed ID: 26700805

DOI: 10.1038/nature16469

PubMed ID: 33376131

Title: The uncharacterized protein FAM47E interacts with PRMT5 and regulates its functions.

PubMed ID: 33376131

DOI: 10.26508/lsa.202000699

PubMed ID: 23071334

Title: Crystal structure of the human PRMT5:MEP50 complex.

PubMed ID: 23071334

DOI: 10.1073/pnas.1209814109

Sequence Information:

  • Length: 637
  • Mass: 72684
  • Checksum: 522E255B384F25E7
  • Sequence:
    • MAAMAVGGAG GSRVSSGRDL NCVPEIADTL GAVAKQGFDF LCMPVFHPRF KREFIQEPAK 
NRPGPQTRSD LLLSGRDWNT LIVGKLSPWI RPDSKVEKIR RNSEAAMLQE LNFGAYLGLP 
AFLLPLNQED NTNLARVLTN HIHTGHHSSM FWMRVPLVAP EDLRDDIIEN APTTHTEEYS 
GEEKTWMWWH NFRTLCDYSK RIAVALEIGA DLPSNHVIDR WLGEPIKAAI LPTSIFLTNK 
KGFPVLSKMH QRLIFRLLKL EVQFIITGTN HHSEKEFCSY LQYLEYLSQN RPPPNAYELF 
AKGYEDYLQS PLQPLMDNLE SQTYEVFEKD PIKYSQYQQA IYKCLLDRVP EEEKDTNVQV 
LMVLGAGRGP LVNASLRAAK QADRRIKLYA VEKNPNAVVT LENWQFEEWG SQVTVVSSDM 
REWVAPEKAD IIVSELLGSF ADNELSPECL DGAQHFLKDD GVSIPGEYTS FLAPISSSKL 
YNEVRACREK DRDPEAQFEM PYVVRLHNFH QLSAPQPCFT FSHPNRDPMI DNNRYCTLEF 
PVEVNTVLHG FAGYFETVLY QDITLSIRPE THSPGMFSWF PILFPIKQPI TVREGQTICV 
RFWRCSNSKK VWYEWAVTAP VCSAIHNPTG RSYTIGL

Genular Protein ID: 2720820659

Symbol: B4DV00_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DV00

Database IDs:

ARBA 7 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 9 DNASU 1 EC 1 EMBL 2 EPD 1 GO 4 Gene3D 3 GenomeRNAi 1 InterPro 6 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRNR 1 PIRSF 1 PIRSR 3 PROSITE 1 PeptideAtlas 1 Pfam 6 ProteomicsDB 1 RefSeq 2 Rhea 3 SUPFAM 1

Sequence Information:

  • Length: 531
  • Mass: 61108
  • Checksum: 223B66796E0FD47A
  • Sequence:
    • MLQELNFGAY LGLPAFLLPL NQEDNTNLAR VLTNHIHTGH HSSMFWMRVP LVAPEDLRDD 
IIENAPTTHT EEYSGEEKTW MWWHNFRTLC DYSKRIAVAL EIGADLPSNH VIDRWLGEPI 
KAAILPTSIF LTNKKGFPVL SKMHQRLIFR LLKLEVQFII TGTNHHSEKE FCSYLQYLEY 
LSQNRPPPNA YELFAKGYED YLQSPLQPLM DNLESQTYEV FEKDPIKYSQ YQQAIYKCLL 
DRVPEEEKDT NVQVLMVLGA GRGPLVNASL RAAKQADRRI KLYAVEKNPN AVVTLENWQF 
EEWGSQVTVV SSDMREWVAP EKADIIVSEL LGSFADNELS PECLDGAQHF LKDDGVSIPG 
EYTSFLAPIS SSKLYNEVRA CREKDRDPEA QFEMPYVVRL HNFHQLSAPQ PCFTFSHPNR 
DPMIDNNRYC TLEFPVEVNT VLHGFAGYFE TVLYQDITLS IRPETHSPGM FSWFPILFPI 
KQPITVREGQ TICVRFWRCS NSKKVWYEWA VTAPVCSAIH NPTGRSYTIG L

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.