Details for: TESK2

Gene ID: 10420

Symbol: TESK2

Ensembl ID: ENSG00000070759

Description: testis associated actin remodelling kinase 2

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.85
    Marker Score: 39,421
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.49
    Marker Score: 1,038
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 169,071
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.41
    Marker Score: 2,877
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.33
    Marker Score: 878
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.22
    Marker Score: 2,125
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.19
    Marker Score: 1,055
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.15
    Marker Score: 1,301
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.11
    Marker Score: 359
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 1.08
    Marker Score: 888
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.04
    Marker Score: 16,257
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,785
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,009
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.99
    Marker Score: 453
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.99
    Marker Score: 2,326
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,404
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.97
    Marker Score: 304
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 493
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,409
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 447
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.92
    Marker Score: 1,772
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,728
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.91
    Marker Score: 1,472
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.9
    Marker Score: 721
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.89
    Marker Score: 5,086
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.89
    Marker Score: 388
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.88
    Marker Score: 512
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 315
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,295
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.84
    Marker Score: 2,744
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.79
    Marker Score: 684
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.78
    Marker Score: 471
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.77
    Marker Score: 585
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.74
    Marker Score: 384
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.72
    Marker Score: 4,617
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.71
    Marker Score: 144
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.7
    Marker Score: 5,375
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.69
    Marker Score: 277
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.69
    Marker Score: 630
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.69
    Marker Score: 2,974
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.69
    Marker Score: 4,122
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.68
    Marker Score: 984
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.68
    Marker Score: 323
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 172
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.66
    Marker Score: 2,755
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.65
    Marker Score: 751
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 0.63
    Marker Score: 341
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.61
    Marker Score: 158
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.6
    Marker Score: 1,378
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6
    Marker Score: 36,605
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.58
    Marker Score: 2,077
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.58
    Marker Score: 1,453
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.57
    Marker Score: 3,046
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 433
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.53
    Marker Score: 7,902
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.51
    Marker Score: 4,869
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.5
    Marker Score: 19,028
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.5
    Marker Score: 432
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.48
    Marker Score: 5,007
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.48
    Marker Score: 361
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.48
    Marker Score: 518
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.48
    Marker Score: 122
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.47
    Marker Score: 301
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.47
    Marker Score: 503
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.47
    Marker Score: 447
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 279
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.46
    Marker Score: 204
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.46
    Marker Score: 304
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.46
    Marker Score: 165
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.45
    Marker Score: 1,895
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.44
    Marker Score: 679
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.44
    Marker Score: 289
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.44
    Marker Score: 164
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.41
    Marker Score: 604
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.4
    Marker Score: 502
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.39
    Marker Score: 113
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.39
    Marker Score: 387
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.38
    Marker Score: 6,159
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.38
    Marker Score: 320
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.38
    Marker Score: 479
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.38
    Marker Score: 265
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.38
    Marker Score: 633
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.38
    Marker Score: 2,798
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.37
    Marker Score: 3,150
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.36
    Marker Score: 620
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.35
    Marker Score: 131
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.35
    Marker Score: 353
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.35
    Marker Score: 122
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.35
    Marker Score: 422
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.34
    Marker Score: 326
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.33
    Marker Score: 154
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.33
    Marker Score: 347
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.33
    Marker Score: 6,550
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.33
    Marker Score: 165
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.32
    Marker Score: 471
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.32
    Marker Score: 612
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.32
    Marker Score: 155
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.32
    Marker Score: 178
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.32
    Marker Score: 908
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.32
    Marker Score: 133

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TESK2 is a unique kinase enzyme that exhibits dual specificity, with the ability to phosphorylate both serine and threonine residues on target proteins. This characteristic enables TESK2 to regulate a wide range of cellular processes, including actin cytoskeleton dynamics, protein stability, and cell signaling pathways. TESK2 is predominantly expressed in cells of the nervous system, reproductive system, and immune cells, suggesting its involvement in neurodevelopment, spermatogenesis, and immune homeostasis. **Pathways and Functions:** TESK2 is implicated in several key signaling pathways, including: 1. **Actin cytoskeleton organization**: TESK2 regulates actin filament dynamics, which is essential for cell shape, movement, and division. 2. **Protein phosphorylation**: TESK2 phosphorylates and modulates the activity of various proteins, including those involved in cell signaling, protein degradation, and protein stability. 3. **Spermatogenesis**: TESK2 plays a crucial role in the regulation of spermatogenesis, a complex process involving the development of sperm cells from spermatogonia. 4. **Immune cell function**: TESK2 is expressed in immune cells, including immature innate lymphoid cells, and regulates their activation, proliferation, and differentiation. **Clinical Significance:** TESK2 has been implicated in several human diseases, including: 1. **Neurodevelopmental disorders**: Mutations in TESK2 have been associated with neurodevelopmental disorders, such as autism spectrum disorder and schizophrenia. 2. **Reproductive disorders**: TESK2 dysfunction has been linked to male infertility and abnormal spermatogenesis. 3. **Immune-mediated diseases**: TESK2 plays a critical role in regulating immune cell function, and dysregulation of TESK2 has been implicated in autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. In conclusion, TESK2 is a multifunctional kinase enzyme that plays a crucial role in various cellular processes, including actin cytoskeleton organization, protein phosphorylation, and spermatogenesis. Its dysregulation has been implicated in human diseases, highlighting the importance of TESK2 in human health and disease. Further research is necessary to fully elucidate the mechanisms of TESK2 and its role in human disease.

Genular Protein ID: 1364049895

Symbol: TESK2_HUMAN

Name: Dual specificity testis-specific protein kinase 2

UniProtKB Accession Codes:

Q96S53 Q5T422 Q5T423 Q8N520 Q9Y3Q6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 19 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 4 EMBL 7 EPD 1 Ensembl 2 GO 15 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 3 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 RefSeq 4 Rhea 9 SAM 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10512679

Title: Identification and characterization of TESK2, a novel member of the LIMK/TESK family of protein kinases, predominantly expressed in testis.

PubMed ID: 10512679

DOI: 10.1006/geno.1999.5922

PubMed ID: 11418599

Title: Cofilin phosphorylation and actin reorganization activities of testicular protein kinase 2 and its predominant expression in testicular Sertoli cells.

PubMed ID: 11418599

DOI: 10.1074/jbc.m102988200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 571
  • Mass: 63639
  • Checksum: D83B0E58321A46FA
  • Sequence:
    • MDRSKRNSIA GFPPRVERLE EFEGGGGGEG NVSQVGRVWP SSYRALISAF SRLTRLDDFT 
CEKIGSGFFS EVFKVRHRAS GQVMALKMNT LSSNRANMLK EVQLMNRLSH PNILRFMGVC 
VHQGQLHALT EYINSGNLEQ LLDSNLHLPW TVRVKLAYDI AVGLSYLHFK GIFHRDLTSK 
NCLIKRDENG YSAVVADFGL AEKIPDVSMG SEKLAVVGSP FWMAPEVLRD EPYNEKADVF 
SYGIILCEII ARIQADPDYL PRTENFGLDY DAFQHMVGDC PPDFLQLTFN CCNMDPKLRP 
SFVEIGKTLE EILSRLQEEE QERDRKLQPT ARGLLEKAPG VKRLSSLDDK IPHKSPCPRR 
TIWLSRSQSD IFSRKPPRTV SVLDPYYRPR DGAARTPKVN PFSARQDLMG GKIKFFDLPS 
KSVISLVFDL DAPGPGTMPL ADWQEPLAPP IRRWRSLPGS PEFLHQEACP FVGREESLSD 
GPPPRLSSLK YRVKEIPPFR ASALPAAQAH EAMDCSILQE ENGFGSRPQG TSPCPAGASE 
EMEVEERPAG STPATFSTSG IGLQTQGKQD G

Genular Protein ID: 3221474188

Symbol: B4DFN2_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DFN2

Database IDs:

ARBA 8 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 17 DNASU 1 EC 3 EMBL 2 GO 3 Gene3D 1 GenomeRNAi 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 PeptideAtlas 1 Pfam 1 RefSeq 1 Rhea 9 SAM 1 SUPFAM 1

Sequence Information:

  • Length: 488
  • Mass: 54393
  • Checksum: 4EB214C5FFCFB015
  • Sequence:
    • MALKMNTLSS NRANMLKEVQ LMNRLSHPNI LRFMGVCVHQ GQLHALTEYI NSGNLEQLLD 
SNLHLPWTVR VKLAYDIAVG LSYLHFKGIF HRDLTSKNCL IKRDENGYSA VVADFGLAEK 
IPDVSMGSEK LAVVGSPFWM APEVLRDEPY NEKADVFSYG IILCEIIARI QADPDYLPRT 
ENFGLDYDAF QHMVGDCPPD FLQLTFNCCN MDPKLRPSFV EIGKTLEEIL SRLQEEEQER 
DRKLQPTARG LLEKAPGVKR LSSLDDKIPH KSPCPRRTIW LSRSQSDIFS RKPPRTVSVL 
DPYYRPRDGA ARTPKVNPFS ARQDLMGGKI KFFDLPSKSV ISLVFDLDAP GPGTMPLADW 
QEPLAPPIRR WCSLPGSPEF LHQEACPFVG REESLSDGPP PRLSSLKYRV KEIPPFRASA 
LPAAQAHEAM DCSILQEENG FGSRPQGTSP CPAGASEEME VEERPAGSTP ATFSTSGIGL 
QTQGKQDG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.