Details for: CD2BP2

Gene ID: 10421

Symbol: CD2BP2

Ensembl ID: ENSG00000169217

Description: CD2 cytoplasmic tail binding protein 2

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.42
    Marker Score: 6,110
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.4
    Marker Score: 4,168
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.34
    Marker Score: 1,968
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.29
    Marker Score: 5,062
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.28
    Marker Score: 11,144
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.27
    Marker Score: 3,510
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.24
    Marker Score: 4,778
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.23
    Marker Score: 1,642
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.23
    Marker Score: 4,555
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.22
    Marker Score: 14,209
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.21
    Marker Score: 1,522
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.18
    Marker Score: 653
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.16
    Marker Score: 1,209
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.16
    Marker Score: 1,397
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.16
    Marker Score: 2,174
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.14
    Marker Score: 39,650
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.14
    Marker Score: 7,273
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.13
    Marker Score: 1,604
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.11
    Marker Score: 2,314
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.1
    Marker Score: 1,161
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.1
    Marker Score: 692
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.1
    Marker Score: 9,440
  • Cell Name: centroblast (CL0009112)
    Fold Change: 1.09
    Marker Score: 539
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.09
    Marker Score: 1,563
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.08
    Marker Score: 721
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.08
    Marker Score: 10,928
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.08
    Marker Score: 1,764
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 1.06
    Marker Score: 14,305
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.06
    Marker Score: 4,357
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.06
    Marker Score: 1,068
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.06
    Marker Score: 27,133
  • Cell Name: neural cell (CL0002319)
    Fold Change: 1.05
    Marker Score: 506
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.04
    Marker Score: 2,833
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.03
    Marker Score: 385
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.03
    Marker Score: 11,622
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 1.03
    Marker Score: 262
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 1.03
    Marker Score: 3,000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.03
    Marker Score: 529
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.02
    Marker Score: 483
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.01
    Marker Score: 1,719
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 1
    Marker Score: 578
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1
    Marker Score: 239
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1
    Marker Score: 1,764
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,599
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47,822
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.99
    Marker Score: 2,262
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.99
    Marker Score: 15,428
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,373
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.98
    Marker Score: 1,556
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.98
    Marker Score: 665
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.97
    Marker Score: 9,619
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.97
    Marker Score: 5,873
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.96
    Marker Score: 702
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.96
    Marker Score: 1,827
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.96
    Marker Score: 276
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.96
    Marker Score: 545
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.95
    Marker Score: 4,571
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.94
    Marker Score: 335
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.94
    Marker Score: 466
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,377
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.93
    Marker Score: 246
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 0.93
    Marker Score: 246
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.93
    Marker Score: 1,853
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.92
    Marker Score: 867
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.92
    Marker Score: 474
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.92
    Marker Score: 931
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 0.92
    Marker Score: 1,018
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.91
    Marker Score: 432
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.91
    Marker Score: 200
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.91
    Marker Score: 184
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.91
    Marker Score: 30,914
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.91
    Marker Score: 448
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.91
    Marker Score: 204
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.91
    Marker Score: 664
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,711
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 0.9
    Marker Score: 550
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.9
    Marker Score: 972
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.9
    Marker Score: 412
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.9
    Marker Score: 387
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.9
    Marker Score: 254
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.9
    Marker Score: 210
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.9
    Marker Score: 1,005
  • Cell Name: meningeal macrophage (CL0000879)
    Fold Change: 0.89
    Marker Score: 252
  • Cell Name: starburst amacrine cell (CL0004232)
    Fold Change: 0.89
    Marker Score: 253
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.89
    Marker Score: 407
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.89
    Marker Score: 2,419
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.89
    Marker Score: 235
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.89
    Marker Score: 948
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.89
    Marker Score: 219
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.89
    Marker Score: 942
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.88
    Marker Score: 486
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.88
    Marker Score: 3,034
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.88
    Marker Score: 505
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.88
    Marker Score: 249
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.88
    Marker Score: 196
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.87
    Marker Score: 1,404
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.87
    Marker Score: 779
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.87
    Marker Score: 2,200
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.87
    Marker Score: 276
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.87
    Marker Score: 300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cellular localization:** CD2BP2 is a nuclear protein that interacts with various cellular components, including ribonucleoprotein complexes, spliceosomal tri-snRNP complexes, and the U4/U6/U5 tri-snRNP complex. 2. **Expression pattern:** CD2BP2 is expressed in a wide range of cell types, including decidual cells, tonsil germinal center B cells, bladder urothelial cells, placental villous trophoblasts, ciliated columnar cells of the tracheobronchial tree, decidual natural killer cells, human progenitor cells of mammary luminal epithelium, plasmablasts, cortical thymic epithelial cells, and blood cells. 3. **Protein interactions:** CD2BP2 interacts with various proteins, including CD2 antigen, which suggests its role in immune cell function and activation. **Pathways and Functions:** 1. **Spliceosomal tri-snRNP complex assembly:** CD2BP2 plays a crucial role in the assembly of spliceosomal tri-snRNP complexes, which are essential for RNA splicing and gene expression. 2. **Ribonucleoprotein complex binding:** CD2BP2 interacts with ribonucleoprotein complexes, which are involved in RNA processing and translation. 3. **Protein binding:** CD2BP2 binds to various proteins, including CD2 antigen, which suggests its role in immune cell function and activation. 4. **Cell growth and differentiation:** CD2BP2 is involved in cell growth and differentiation processes, including the regulation of cell cycle and apoptosis. **Clinical Significance:** 1. **Autoimmune diseases:** CD2BP2 has been implicated in autoimmune diseases, such as rheumatoid arthritis and lupus, where it may contribute to the pathogenesis of these conditions. 2. **Cancer:** CD2BP2 has been found to be overexpressed in various types of cancer, including breast cancer, lung cancer, and colon cancer, suggesting its potential role in tumorigenesis. 3. **Reproductive disorders:** CD2BP2 has been found to be involved in reproductive disorders, including miscarriage and infertility, where it may contribute to the regulation of cell growth and differentiation in the placenta. 4. **Immunological disorders:** CD2BP2 has been implicated in immunological disorders, such as immunodeficiency and autoimmune disorders, where it may contribute to the regulation of immune cell function and activation. In conclusion, CD2BP2 is a multifaceted gene that plays a crucial role in various cellular processes, including immune responses, cell growth, and differentiation. Its clinical significance has led to its investigation in various pathological conditions, including autoimmune diseases, cancer, and reproductive disorders. Further research is needed to fully elucidate the role of CD2BP2 in these conditions and to identify potential therapeutic targets.

Genular Protein ID: 499764524

Symbol: CD2B2_HUMAN

Name: CD2 antigen cytoplasmic tail-binding protein 2

UniProtKB Accession Codes:

O95400 B2RDX2 Q9ULP2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 6 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 4 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 2 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9843987

Title: Identification of a proline-binding motif regulating CD2-triggered T lymphocyte activation.

PubMed ID: 9843987

DOI: 10.1073/pnas.95.25.14897

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10574461

Title: Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain.

PubMed ID: 10574461

DOI: 10.1093/dnares/6.5.329

PubMed ID: 15840814

Title: The human U5 snRNP 52K protein (CD2BP2) interacts with U5-102K (hPrp6), a U4/U6.U5 tri-snRNP bridging protein, but dissociates upon tri-snRNP formation.

PubMed ID: 15840814

DOI: 10.1261/rna.2300805

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16723661

Title: The network of protein-protein interactions within the human U4/U6.U5 tri-snRNP.

PubMed ID: 16723661

DOI: 10.1261/rna.55406

PubMed ID: 17906334

Title: Investigating the functional role of CD2BP2 in T cells.

PubMed ID: 17906334

DOI: 10.1093/intimm/dxm100

PubMed ID: 17693683

Title: Quantitative phosphoproteome profiling of Wnt3a-mediated signaling network: indicating the involvement of ribonucleoside-diphosphate reductase M2 subunit phosphorylation at residue serine 20 in canonical Wnt signal transduction.

PubMed ID: 17693683

DOI: 10.1074/mcp.m700120-mcp200

PubMed ID: 19367720

Title: Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment.

PubMed ID: 19367720

DOI: 10.1021/pr800500r

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18318008

Title: Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.

PubMed ID: 18318008

DOI: 10.1002/pmic.200700884

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 10404223

Title: The GYF domain is a novel structural fold that is involved in lymphoid signaling through proline-rich sequences.

PubMed ID: 10404223

DOI: 10.1038/10712

PubMed ID: 12426371

Title: Dynamic interaction of CD2 with the GYF and the SH3 domain of compartmentalized effector molecules.

PubMed ID: 12426371

DOI: 10.1093/emboj/cdf602

PubMed ID: 17467737

Title: Structural basis for the bifunctionality of the U5 snRNP 52K protein (CD2BP2).

PubMed ID: 17467737

DOI: 10.1016/j.jmb.2007.03.077

PubMed ID: 24781215

Title: Mutations in the PQBP1 gene prevent its interaction with the spliceosomal protein U5-15 kD.

PubMed ID: 24781215

DOI: 10.1038/ncomms4822

Sequence Information:

  • Length: 341
  • Mass: 37646
  • Checksum: 8E9A7EE0C40474D5
  • Sequence:
    • MPKRKVTFQG VGDEEDEDEI IVPKKKLVDP VAGSGGPGSR FKGKHSLDSD EEEDDDDGGS 
SKYDILASED VEGQEAATLP SEGGVRITPF NLQEEMEEGH FDADGNYFLN RDAQIRDSWL 
DNIDWVKIRE RPPGQRQASD SEEEDSLGQT SMSAQALLEG LLELLLPRET VAGALRRLGA 
RGGGKGRKGP GQPSSPQRLD RLSGLADQMV ARGNLGVYQE TRERLAMRLK GLGCQTLGPH 
NPTPPPSLDM FAEELAEEEL ETPTPTQRGE AESRGDGLVD VMWEYKWENT GDAELYGPFT 
SAQMQTWVSE GYFPDGVYCR KLDPPGGQFY NSKRIDFDLY T

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.