Details for: PGRMC2

Gene ID: 10424

Symbol: PGRMC2

Ensembl ID: ENSG00000164040

Description: progesterone receptor membrane component 2

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.82
    Marker Score: 8,750
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 1.82
    Marker Score: 7,569
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.79
    Marker Score: 11,420
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.76
    Marker Score: 3,123
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.69
    Marker Score: 2,483
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.58
    Marker Score: 1,074
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.55
    Marker Score: 886
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.55
    Marker Score: 3,536
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 1.55
    Marker Score: 1,167
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.51
    Marker Score: 632
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.5
    Marker Score: 5,908
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 1.49
    Marker Score: 1,459
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.49
    Marker Score: 342
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.46
    Marker Score: 12,590
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.44
    Marker Score: 3,258
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 1.38
    Marker Score: 4,532
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.37
    Marker Score: 46,550
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 1.34
    Marker Score: 947
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.34
    Marker Score: 46,433
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.32
    Marker Score: 1,401
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 1.31
    Marker Score: 571
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 1.29
    Marker Score: 1,984
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.25
    Marker Score: 837
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.24
    Marker Score: 5,365
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.23
    Marker Score: 2,595
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.22
    Marker Score: 1,293
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 1.21
    Marker Score: 1,164
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.2
    Marker Score: 1,285
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.2
    Marker Score: 2,507
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.19
    Marker Score: 4,604
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.19
    Marker Score: 280
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.19
    Marker Score: 4,237
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.19
    Marker Score: 2,818
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.18
    Marker Score: 20,948
  • Cell Name: PP cell (CL0000696)
    Fold Change: 1.18
    Marker Score: 265
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.16
    Marker Score: 3,102
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.16
    Marker Score: 431
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.15
    Marker Score: 12,920
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.15
    Marker Score: 3,121
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.14
    Marker Score: 339
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.12
    Marker Score: 1,307
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 1.11
    Marker Score: 943
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.09
    Marker Score: 2,862
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 1.09
    Marker Score: 617
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.09
    Marker Score: 1,129
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 1.08
    Marker Score: 365
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 1.08
    Marker Score: 927
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.07
    Marker Score: 1,150
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 1.07
    Marker Score: 209
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.06
    Marker Score: 262
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.06
    Marker Score: 9,077
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 1.05
    Marker Score: 236
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.05
    Marker Score: 1,103
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.04
    Marker Score: 4,252
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.04
    Marker Score: 392
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1.04
    Marker Score: 4,018
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.03
    Marker Score: 690
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 1.03
    Marker Score: 643
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 1.03
    Marker Score: 326
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.03
    Marker Score: 9,762
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.03
    Marker Score: 2,084
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.02
    Marker Score: 1,924
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.02
    Marker Score: 594
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.02
    Marker Score: 15,896
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.02
    Marker Score: 252
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 1.01
    Marker Score: 980
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.01
    Marker Score: 1,027
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.01
    Marker Score: 639
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,625
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1
    Marker Score: 1,285
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47,847
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.98
    Marker Score: 342
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,377
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.97
    Marker Score: 2,293
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.97
    Marker Score: 1,650
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 0.96
    Marker Score: 350
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.96
    Marker Score: 496
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.95
    Marker Score: 650
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.95
    Marker Score: 492
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.95
    Marker Score: 1,528
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.95
    Marker Score: 2,397
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.95
    Marker Score: 58,345
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 0.95
    Marker Score: 327
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.95
    Marker Score: 9,534
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.95
    Marker Score: 9,768
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.94
    Marker Score: 229
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.94
    Marker Score: 1,497
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.94
    Marker Score: 937
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,387
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.93
    Marker Score: 7,288
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.93
    Marker Score: 466
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.93
    Marker Score: 649
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.93
    Marker Score: 1,545
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.93
    Marker Score: 800
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.93
    Marker Score: 1,848
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.92
    Marker Score: 267
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.92
    Marker Score: 475
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.92
    Marker Score: 235
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.91
    Marker Score: 432
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.91
    Marker Score: 293

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PGRMC2 is a transmembrane protein that belongs to the progesterone receptor family. It is characterized by its unique structure, comprising two transmembrane domains and a cytoplasmic domain. This protein is specifically expressed in enterocytes, GABAergic neurons, and other cell types involved in steroid hormone-mediated signaling pathways. PGRMC2 has been shown to interact with various signaling molecules, including G-proteins, and plays a crucial role in modulating cellular responses to stimuli. **Pathways and Functions:** PGRMC2 is involved in several signaling pathways that regulate cellular processes, including: 1. **Adipose tissue development:** PGRMC2 has been implicated in the regulation of adipogenesis, the process by which preadipocytes differentiate into mature adipocytes. 2. **Steroid hormone-mediated signaling:** PGRMC2 acts as a cofactor for the progesterone receptor, facilitating the translocation of the receptor to the nucleus and the regulation of gene expression. 3. **G-protein coupled receptor signaling:** PGRMC2 interacts with G-proteins, modulating the activity of various G-protein coupled receptors. 4. **Rho GTPase signaling:** PGRMC2 has been shown to interact with Rho GTPases, regulating cellular processes such as cell migration and proliferation. **Clinical Significance:** PGRMC2 has been implicated in various diseases, including: 1. **Breast cancer:** Abnormal expression of PGRMC2 has been observed in breast cancer cells, suggesting its potential role in tumor development and progression. 2. **Adipose tissue disorders:** Alterations in PGRMC2 expression have been linked to adipose tissue disorders, such as obesity and metabolic syndrome. 3. **Neurological disorders:** PGRMC2 has been implicated in the pathogenesis of neurological disorders, including epilepsy and Parkinson's disease. In conclusion, PGRMC2 is a complex protein that plays a critical role in various cellular processes, including adipose tissue development, steroid hormone-mediated signaling, and Rho GTPase signaling. Further research is needed to fully elucidate the functions of PGRMC2 and its potential applications in the treatment of various diseases. **Future Directions:** To further understand the biology of PGRMC2, future studies should focus on: 1. **Functional characterization:** Investigate the functional roles of PGRMC2 in different cell types and tissues. 2. **Molecular mechanisms:** Elucidate the molecular mechanisms underlying the interactions between PGRMC2 and other signaling molecules. 3. **Clinical applications:** Explore the potential clinical applications of PGRMC2 in the treatment of various diseases, including breast cancer and adipose tissue disorders.

Genular Protein ID: 3124115906

Symbol: PGRC2_HUMAN

Name: Progesterone membrane-binding protein

UniProtKB Accession Codes:

O15173 Q569H1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 5 EPD 1 Ensembl 3 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 5 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TopDownProteomics 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9705155

Title: Cloning and tissue expression of two putative steroid membrane receptors.

PubMed ID: 9705155

DOI: 10.1515/bchm.1998.379.7.907

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18318008

Title: Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.

PubMed ID: 18318008

DOI: 10.1002/pmic.200700884

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 23793472

Title: Expression patterns of progesterone receptor membrane components 1 and 2 in endometria from women with and without endometriosis.

PubMed ID: 23793472

DOI: 10.1177/1933719113492208

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27754849

Title: Identification of a novel putative interaction partner of the nucleoporin ALADIN.

PubMed ID: 27754849

DOI: 10.1242/bio.021162

PubMed ID: 28111073

Title: Ligand and Target Discovery by Fragment-Based Screening in Human Cells.

PubMed ID: 28111073

DOI: 10.1016/j.cell.2016.12.029

PubMed ID: 28396637

Title: Membrane associated progesterone receptors: promiscuous proteins with pleiotropic functions - focus on interactions with cytochromes P450.

PubMed ID: 28396637

DOI: 10.3389/fphar.2017.00159

PubMed ID: 37453717

Title: Mapping the Human Chondroitin Sulfate Glycoproteome Reveals an Unexpected Correlation Between Glycan Sulfation and Attachment Site Characteristics.

PubMed ID: 37453717

DOI: 10.1016/j.mcpro.2023.100617

Sequence Information:

  • Length: 223
  • Mass: 23818
  • Checksum: BE36229EDF0FF3AD
  • Sequence:
    • MAAGDGDVKL GTLGSGSESS NDGGSESPGD AGAAAEGGGW AAAALALLTG GGEMLLNVAL 
VALVLLGAYR LWVRWGRRGL GAGAGAGEES PATSLPRMKK RDFSLEQLRQ YDGSRNPRIL 
LAVNGKVFDV TKGSKFYGPA GPYGIFAGRD ASRGLATFCL DKDALRDEYD DLSDLNAVQM 
ESVREWEMQF KEKYDYVGRL LKPGEEPSEY TDEEDTKDHN KQD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.