Details for: CD52

Gene ID: 1043

Symbol: CD52

Ensembl ID: ENSG00000169442

Description: CD52 molecule

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 121.7995
    Cell Significance Index: -50.1800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 118.0779
    Cell Significance Index: -47.9700
  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 116.3970
    Cell Significance Index: -18.1100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 92.2655
    Cell Significance Index: -47.4600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 69.5582
    Cell Significance Index: -32.8400
  • Cell Name: centroblast (CL0009112)
    Fold Change: 28.9191
    Cell Significance Index: 67.4700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 14.1524
    Cell Significance Index: 415.6400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 13.4028
    Cell Significance Index: -16.5300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 10.5553
    Cell Significance Index: -32.4200
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 10.3733
    Cell Significance Index: 31.6200
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 8.2648
    Cell Significance Index: 36.9600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 7.7164
    Cell Significance Index: 142.6200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.1717
    Cell Significance Index: -28.3000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 5.8570
    Cell Significance Index: 690.7200
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 4.9328
    Cell Significance Index: 20.5300
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.5283
    Cell Significance Index: 9.2300
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.4027
    Cell Significance Index: 14.0700
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 1.3967
    Cell Significance Index: 14.8400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.1914
    Cell Significance Index: 226.7300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.0146
    Cell Significance Index: 65.4600
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.9535
    Cell Significance Index: 8.3400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.8442
    Cell Significance Index: 83.5100
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.8196
    Cell Significance Index: 4.1000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7577
    Cell Significance Index: 684.1700
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 0.6846
    Cell Significance Index: 4.3700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.5084
    Cell Significance Index: 13.6000
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.4328
    Cell Significance Index: 2.3600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3835
    Cell Significance Index: 62.3800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1745
    Cell Significance Index: 18.9800
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 0.1008
    Cell Significance Index: 0.7500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0333
    Cell Significance Index: 25.1800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0231
    Cell Significance Index: 14.4400
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.0198
    Cell Significance Index: 0.2900
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.0039
    Cell Significance Index: -0.0300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0099
    Cell Significance Index: -4.3700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0144
    Cell Significance Index: -27.0800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0161
    Cell Significance Index: -11.9600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0164
    Cell Significance Index: -30.3300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0186
    Cell Significance Index: -0.9400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0198
    Cell Significance Index: -30.4800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0225
    Cell Significance Index: -30.5500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0248
    Cell Significance Index: -14.0100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0261
    Cell Significance Index: -1.0700
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0313
    Cell Significance Index: -0.5400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0352
    Cell Significance Index: -0.9000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0357
    Cell Significance Index: -7.5200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0496
    Cell Significance Index: -1.2400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0517
    Cell Significance Index: -28.2400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0590
    Cell Significance Index: -1.7000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0651
    Cell Significance Index: -4.5000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0681
    Cell Significance Index: -49.9500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0784
    Cell Significance Index: -49.7900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0862
    Cell Significance Index: -30.9200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0890
    Cell Significance Index: -4.0400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0938
    Cell Significance Index: -42.5800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0960
    Cell Significance Index: -2.0800
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.1090
    Cell Significance Index: -1.0200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1095
    Cell Significance Index: -18.7000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1157
    Cell Significance Index: -22.9700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1222
    Cell Significance Index: -15.6700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1295
    Cell Significance Index: -37.2600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1312
    Cell Significance Index: -26.3200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1439
    Cell Significance Index: -14.7000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1499
    Cell Significance Index: -4.8000
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: -0.1501
    Cell Significance Index: -1.4700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1566
    Cell Significance Index: -17.9400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1847
    Cell Significance Index: -25.3700
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.1884
    Cell Significance Index: -3.2000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1897
    Cell Significance Index: -8.2500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.1921
    Cell Significance Index: -34.6300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1979
    Cell Significance Index: -23.0600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2444
    Cell Significance Index: -27.9000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2540
    Cell Significance Index: -5.2700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2760
    Cell Significance Index: -16.9200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2845
    Cell Significance Index: -36.7500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.3045
    Cell Significance Index: -37.4400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.3155
    Cell Significance Index: -18.9400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3260
    Cell Significance Index: -15.3200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3401
    Cell Significance Index: -49.4400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3884
    Cell Significance Index: -20.2300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3983
    Cell Significance Index: -30.5700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.4057
    Cell Significance Index: -28.6900
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.4082
    Cell Significance Index: -3.8700
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.4301
    Cell Significance Index: -3.9800
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.4467
    Cell Significance Index: -3.7700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4738
    Cell Significance Index: -31.8600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.4962
    Cell Significance Index: -36.9800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.5296
    Cell Significance Index: -33.3800
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.5307
    Cell Significance Index: -7.2200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.5637
    Cell Significance Index: -29.2800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.5761
    Cell Significance Index: -32.3300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.5930
    Cell Significance Index: -36.4500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.6222
    Cell Significance Index: -29.0100
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.6347
    Cell Significance Index: -5.4100
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.6674
    Cell Significance Index: -5.8800
  • Cell Name: mature T cell (CL0002419)
    Fold Change: -0.6796
    Cell Significance Index: -4.8900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.7137
    Cell Significance Index: -15.2000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.7221
    Cell Significance Index: -31.9400
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.7253
    Cell Significance Index: -14.1800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.7499
    Cell Significance Index: -26.3500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transmembrane glycoprotein**: CD52 is a transmembrane protein, consisting of a large extracellular domain, a transmembrane domain, and a small intracellular domain. 2. **Restricted expression**: CD52 is predominantly expressed on mature T cells, natural regulatory T cells, and certain subsets of B cells, including germinal center B cells and IgG-negative class-switched memory B cells. 3. **Calcium signaling**: CD52 is involved in the regulation of cytosolic calcium ion concentration, which is essential for T cell activation and function. 4. **Protein synthesis**: CD52 is required for the synthesis of GPI-anchored proteins, which are involved in various cellular processes, including cell adhesion and signaling. **Pathways and Functions:** 1. **Extracellular calcium signaling**: CD52 regulates the influx of extracellular calcium ions into T cells, which is crucial for T cell activation and function. 2. **Protein synthesis**: CD52 is involved in the synthesis of GPI-anchored proteins, which are essential for various cellular processes, including cell adhesion and signaling. 3. **Cell activation**: CD52 plays a role in the activation of T cells, particularly in the context of calcium signaling. 4. **Regulation of T cell subsets**: CD52 is involved in the regulation of T cell subsets, including the maintenance of natural regulatory T cells and the suppression of effector T cells. **Clinical Significance:** 1. **Autoimmune diseases**: CD52 has been implicated in various autoimmune diseases, including multiple sclerosis, rheumatoid arthritis, and lupus. 2. **Therapeutic targeting**: The dysregulation of CD52 has made it an attractive target for therapeutic interventions, including monoclonal antibodies, such as alemtuzumab (Campath-1H), which has been approved for the treatment of chronic lymphocytic leukemia and multiple sclerosis. 3. **Immunotherapy**: CD52 is a potential target for immunotherapeutic interventions, including checkpoint inhibitors and cancer vaccines. 4. **Cancer immunotherapy**: CD52 has been implicated in the development of cancer immunotherapies, including adoptive T cell therapy and cancer vaccines. In conclusion, CD52 is a critical regulator of immune cell function, particularly in the context of T cell biology. Its dysregulation has been implicated in various autoimmune diseases, making it an attractive target for therapeutic interventions. Further research is needed to fully elucidate the role of CD52 in immune cell function and its potential as a therapeutic target.

Genular Protein ID: 1688975640

Symbol: CD52_HUMAN

Name: CAMPATH-1 antigen

UniProtKB Accession Codes:

P31358 Q5T138 Q9BW46

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EMBL 4 Ensembl 1 ExpressionAtlas 1 GO 7 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 1711975

Title: Characterization of the CAMPATH-1 (CDw52) antigen: biochemical analysis and cDNA cloning reveal an unusually small peptide backbone.

PubMed ID: 1711975

DOI: 10.1002/eji.1830210714

PubMed ID: 8418821

Title: A major mRNA of the human epididymal principal cells, HE5, encodes the leucocyte differentiation CDw52 antigen peptide backbone.

PubMed ID: 8418821

DOI: 10.1002/mrd.1080340103

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7688956

Title: Structure of the CAMPATH-1 antigen, a glycosylphosphatidylinositol-anchored glycoprotein which is an exceptionally good target for complement lysis.

PubMed ID: 7688956

DOI: 10.1042/bj2930633

Sequence Information:

  • Length: 61
  • Mass: 6614
  • Checksum: 4AE2A056682BEEA6
  • Sequence:
    • MKRFLFLLLT ISLLVMVQIQ TGLSGQNDTS QTSSPSASSN ISGGIFLFFV ANAIIHLFCF 
S

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.