Details for: TMEM147

Gene ID: 10430

Symbol: TMEM147

Ensembl ID: ENSG00000105677

Description: transmembrane protein 147

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 2.49
    Marker Score: 19,438
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 2.47
    Marker Score: 2,978
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 2.36
    Marker Score: 2,464
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.33
    Marker Score: 20,055
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.26
    Marker Score: 9,744
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 2.24
    Marker Score: 6,177
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.1
    Marker Score: 3,376
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 2.09
    Marker Score: 3,469
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.05
    Marker Score: 4,281
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 2.03
    Marker Score: 1,726
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.01
    Marker Score: 2,256
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.99
    Marker Score: 50,996
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.99
    Marker Score: 7,660
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.98
    Marker Score: 7,784
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.97
    Marker Score: 2,898
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.94
    Marker Score: 1,298
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.94
    Marker Score: 4,418
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.93
    Marker Score: 684
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.92
    Marker Score: 4,690
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.92
    Marker Score: 1,055
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.9
    Marker Score: 1,498
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.88
    Marker Score: 12,264
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.87
    Marker Score: 64,874
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.87
    Marker Score: 4,722
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.87
    Marker Score: 1,977
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.86
    Marker Score: 2,958
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.84
    Marker Score: 7,514
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.81
    Marker Score: 4,864
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.81
    Marker Score: 9,537
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.81
    Marker Score: 20,392
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.81
    Marker Score: 1,807
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.79
    Marker Score: 4,057
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.78
    Marker Score: 3,023
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.77
    Marker Score: 1,800
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.77
    Marker Score: 4,194
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.76
    Marker Score: 592
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 1.75
    Marker Score: 2,412
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.74
    Marker Score: 493
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.74
    Marker Score: 867
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.73
    Marker Score: 4,519
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.72
    Marker Score: 2,479
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 1.72
    Marker Score: 1,530
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.72
    Marker Score: 3,426
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.7
    Marker Score: 1,813
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.69
    Marker Score: 709
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.67
    Marker Score: 1,777
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.67
    Marker Score: 16,830
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.67
    Marker Score: 391
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.66
    Marker Score: 10,828
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.66
    Marker Score: 1,047
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.65
    Marker Score: 1,778
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 1.64
    Marker Score: 655
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.63
    Marker Score: 3,848
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.63
    Marker Score: 3,318
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.63
    Marker Score: 2,304
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.62
    Marker Score: 4,413
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.61
    Marker Score: 1,514
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.61
    Marker Score: 3,019
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.6
    Marker Score: 2,834
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.58
    Marker Score: 904
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.58
    Marker Score: 2,101
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 1.57
    Marker Score: 543
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.57
    Marker Score: 1,315
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.57
    Marker Score: 1,794
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 1.56
    Marker Score: 351
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.56
    Marker Score: 449
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.54
    Marker Score: 794
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.54
    Marker Score: 1,635
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.54
    Marker Score: 20,248
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.53
    Marker Score: 7,535
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.53
    Marker Score: 1,915
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.52
    Marker Score: 2,782
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.52
    Marker Score: 1,429
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 1.52
    Marker Score: 1,015
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 1.51
    Marker Score: 480
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.5
    Marker Score: 1,757
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.5
    Marker Score: 566
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.5
    Marker Score: 1,089
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.5
    Marker Score: 606
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.5
    Marker Score: 9,128
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.5
    Marker Score: 358
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.5
    Marker Score: 711
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.49
    Marker Score: 1,549
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 1.49
    Marker Score: 609
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.48
    Marker Score: 7,123
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.48
    Marker Score: 931
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.48
    Marker Score: 11,015
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.47
    Marker Score: 687
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.47
    Marker Score: 362
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.46
    Marker Score: 2,853
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 1.46
    Marker Score: 638
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 1.45
    Marker Score: 368
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.44
    Marker Score: 165,610
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.44
    Marker Score: 978
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.42
    Marker Score: 1,835
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.42
    Marker Score: 455
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 1.41
    Marker Score: 751
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 1.4
    Marker Score: 275
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.4
    Marker Score: 2,960
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 1.4
    Marker Score: 1,687

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transmembrane Structure:** TMEM147 is a transmembrane protein, consisting of a single transmembrane domain, which allows it to interact with both the extracellular and intracellular environments. 2. **Multi-pass Transmembrane Protein:** TMEM147 is a multi-pass transmembrane protein, meaning it spans the cell membrane multiple times, facilitating its interaction with various cellular components. 3. **Expression Patterns:** TMEM147 is highly expressed in stratified epithelial cells, myeloid leukocytes, and erythroid progenitor cells, indicating its involvement in tissue homeostasis and immune function. 4. **Cellular Localization:** TMEM147 is localized to the plasma membrane, endoplasmic reticulum membrane, and nuclear membrane, highlighting its involvement in various cellular processes. **Pathways and Functions:** TMEM147 is involved in several cellular pathways, including: 1. **Protein Localization:** TMEM147 plays a crucial role in regulating protein localization to the nuclear inner membrane, which is essential for maintaining nuclear homeostasis. 2. **Multi-pass Transmembrane Protein Insertion into ER Membrane:** TMEM147 is involved in the insertion of multi-pass transmembrane proteins into the endoplasmic reticulum membrane, which is essential for protein folding and secretion. 3. **Protein Binding:** TMEM147 interacts with various proteins, including ribosomes, which are essential for protein synthesis and translation. 4. **Cellular Signaling:** TMEM147 is involved in cellular signaling pathways, including the regulation of cell growth, differentiation, and survival. **Clinical Significance:** TMEM147 has been implicated in various diseases and disorders, including: 1. **Immunodeficiency Disorders:** TMEM147 is involved in the regulation of immune function, and dysregulation of this gene has been linked to immunodeficiency disorders, such as autoimmune diseases and cancer. 2. **Cancer:** TMEM147 is overexpressed in various types of cancer, including breast, lung, and colon cancer, suggesting its potential role in tumorigenesis. 3. **Neurological Disorders:** TMEM147 has been implicated in neurological disorders, including Alzheimer's disease and Parkinson's disease, highlighting its potential role in maintaining neuronal homeostasis. 4. **Infectious Diseases:** TMEM147 is involved in the regulation of immune function, and dysregulation of this gene has been linked to infectious diseases, such as HIV and tuberculosis. In conclusion, TMEM147 is a complex transmembrane protein that plays a crucial role in maintaining cellular homeostasis and immune function. Its involvement in various cellular pathways and diseases highlights its potential as a therapeutic target for the treatment of various disorders. Further research is necessary to fully elucidate the functions and clinical significance of TMEM147.

Genular Protein ID: 4235059915

Symbol: TM147_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9BVK8 A8MWW0 O75790

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 8 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 2 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 20538592

Title: Transmembrane protein 147 (TMEM147) is a novel component of the Nicalin-NOMO protein complex.

PubMed ID: 20538592

DOI: 10.1074/jbc.m110.132548

PubMed ID: 21056967

Title: Regulation of M(3) muscarinic receptor expression and function by transmembrane protein 147.

PubMed ID: 21056967

DOI: 10.1124/mol.110.067363

PubMed ID: 32820719

Title: An ER translocon for multi-pass membrane protein biogenesis.

PubMed ID: 32820719

DOI: 10.7554/elife.56889

PubMed ID: 32694168

Title: TMEM147 interacts with lamin B receptor, regulates its localization and levels, and affects cholesterol homeostasis.

PubMed ID: 32694168

DOI: 10.1242/jcs.245357

PubMed ID: 36261522

Title: Substrate-driven assembly of a translocon for multipass membrane proteins.

PubMed ID: 36261522

DOI: 10.1038/s41586-022-05330-8

PubMed ID: 36044892

Title: Bi-allelic loss-of-function variants in TMEM147 cause moderate to profound intellectual disability with facial dysmorphism and pseudo-Pelger-Huet anomaly.

PubMed ID: 36044892

DOI: 10.1016/j.ajhg.2022.08.008

Sequence Information:

  • Length: 224
  • Mass: 25261
  • Checksum: 90122F32C34F16AE
  • Sequence:
    • MTLFHFGNCF ALAYFPYFIT YKCSGLSEYN AFWKCVQAGV TYLFVQLCKM LFLATFFPTW 
EGGIYDFIGE FMKASVDVAD LIGLNLVMSR NAGKGEYKIM VAALGWATAE LIMSRCIPLW 
VGARGIEFDW KYIQMSIDSN ISLVHYIVAS AQVWMITRYD LYHTFRPAVL LLMFLSVYKA 
FVMETFVHLC SLGSWAALLA RAVVTGLLAL STLALYVAVV NVHS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.