Details for: CDX2

Gene ID: 1045

Symbol: CDX2

Ensembl ID: ENSG00000165556

Description: caudal type homeobox 2

Associated with

  • Developmental biology
    (R-HSA-1266738)
  • Incretin synthesis, secretion, and inactivation
    (R-HSA-400508)
  • Metabolism of proteins
    (R-HSA-392499)
  • Peptide hormone metabolism
    (R-HSA-2980736)
  • Pou5f1 (oct4), sox2, nanog repress genes related to differentiation
    (R-HSA-2892245)
  • Synthesis, secretion, and inactivation of glucagon-like peptide-1 (glp-1)
    (R-HSA-381771)
  • Transcriptional regulation of pluripotent stem cells
    (R-HSA-452723)
  • Anterior/posterior axis specification
    (GO:0009948)
  • Blood vessel development
    (GO:0001568)
  • Cell differentiation
    (GO:0030154)
  • Chromatin
    (GO:0000785)
  • Condensed nuclear chromosome
    (GO:0000794)
  • Digestive tract development
    (GO:0048565)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • Embryonic pattern specification
    (GO:0009880)
  • Endosome to lysosome transport
    (GO:0008333)
  • Establishment or maintenance of epithelial cell apical/basal polarity
    (GO:0045197)
  • Intestinal epithelial cell differentiation
    (GO:0060575)
  • Labyrinthine layer development
    (GO:0060711)
  • Methyl-cpg binding
    (GO:0008327)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Positive regulation of cell differentiation
    (GO:0045597)
  • Positive regulation of cell population proliferation
    (GO:0008284)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Regulation of somitogenesis
    (GO:0014807)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Somatic stem cell population maintenance
    (GO:0035019)
  • Stem cell differentiation
    (GO:0048863)
  • Transcription repressor complex
    (GO:0017053)
  • Trophectodermal cell differentiation
    (GO:0001829)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 61.6220
    Cell Significance Index: -15.6300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 29.9692
    Cell Significance Index: -20.1100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.6944
    Cell Significance Index: -25.9700
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 7.9421
    Cell Significance Index: 60.2300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 7.4407
    Cell Significance Index: 337.2600
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 4.2504
    Cell Significance Index: 70.0400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 3.7880
    Cell Significance Index: 56.7600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 3.6464
    Cell Significance Index: 105.0600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 3.6123
    Cell Significance Index: 78.2600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.6644
    Cell Significance Index: 270.6900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.3459
    Cell Significance Index: 80.8000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.2436
    Cell Significance Index: 123.0200
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 1.2436
    Cell Significance Index: 12.5500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.9626
    Cell Significance Index: 20.5000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.8735
    Cell Significance Index: 95.0200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.6953
    Cell Significance Index: 22.2700
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.6062
    Cell Significance Index: 6.5700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.5308
    Cell Significance Index: 5.5000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.5135
    Cell Significance Index: 18.0500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.4743
    Cell Significance Index: 55.2800
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.4604
    Cell Significance Index: 3.2400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3927
    Cell Significance Index: 354.5900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1924
    Cell Significance Index: 13.3100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1409
    Cell Significance Index: 26.8100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0641
    Cell Significance Index: 3.3300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0537
    Cell Significance Index: 33.5200
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.0055
    Cell Significance Index: 0.0400
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.0048
    Cell Significance Index: 0.0300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0004
    Cell Significance Index: 0.0200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0019
    Cell Significance Index: -0.3200
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0025
    Cell Significance Index: -0.0300
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0060
    Cell Significance Index: -0.1000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0076
    Cell Significance Index: -0.1900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0081
    Cell Significance Index: -15.3000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0092
    Cell Significance Index: -6.7800
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.0106
    Cell Significance Index: -0.1000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0130
    Cell Significance Index: -1.4900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0149
    Cell Significance Index: -6.7800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0163
    Cell Significance Index: -9.2000
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0260
    Cell Significance Index: -0.3700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0280
    Cell Significance Index: -15.2800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0376
    Cell Significance Index: -7.9300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0796
    Cell Significance Index: -15.9600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0810
    Cell Significance Index: -16.0700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1125
    Cell Significance Index: -15.4500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1185
    Cell Significance Index: -13.5300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1186
    Cell Significance Index: -2.4600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1253
    Cell Significance Index: -14.7800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1305
    Cell Significance Index: -6.0800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.1395
    Cell Significance Index: -25.1500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1688
    Cell Significance Index: -17.2500
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.1821
    Cell Significance Index: -2.9500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.2065
    Cell Significance Index: -25.4000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2594
    Cell Significance Index: -7.0600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2747
    Cell Significance Index: -4.1400
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.2928
    Cell Significance Index: -3.1900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3092
    Cell Significance Index: -17.3500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3128
    Cell Significance Index: -19.1800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3183
    Cell Significance Index: -14.9600
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.3470
    Cell Significance Index: -3.6600
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -0.3472
    Cell Significance Index: -3.1400
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: -0.3679
    Cell Significance Index: -2.1600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.4072
    Cell Significance Index: -26.2700
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.4575
    Cell Significance Index: -7.9100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5119
    Cell Significance Index: -16.3000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5134
    Cell Significance Index: -16.8100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.5166
    Cell Significance Index: -14.8100
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.5290
    Cell Significance Index: -5.6200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.5603
    Cell Significance Index: -14.9600
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.5667
    Cell Significance Index: -8.1500
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.5752
    Cell Significance Index: -11.4700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.6076
    Cell Significance Index: -15.4800
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.6279
    Cell Significance Index: -15.3200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.6303
    Cell Significance Index: -16.8900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.6518
    Cell Significance Index: -16.2600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.6562
    Cell Significance Index: -17.2600
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.6643
    Cell Significance Index: -6.8900
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.7015
    Cell Significance Index: -11.2800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.7109
    Cell Significance Index: -10.1800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.7110
    Cell Significance Index: -11.9000
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.7216
    Cell Significance Index: -10.9600
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.7251
    Cell Significance Index: -7.9600
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.7323
    Cell Significance Index: -8.0100
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: -0.7406
    Cell Significance Index: -7.0900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.7524
    Cell Significance Index: -15.9700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.7674
    Cell Significance Index: -16.5800
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.7890
    Cell Significance Index: -11.5000
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.7948
    Cell Significance Index: -8.2300
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.8073
    Cell Significance Index: -13.8000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.8079
    Cell Significance Index: -15.9800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.8124
    Cell Significance Index: -16.3100
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.8429
    Cell Significance Index: -9.9100
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: -0.8562
    Cell Significance Index: -9.1700
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.8623
    Cell Significance Index: -12.5200
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.8772
    Cell Significance Index: -17.2700
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.8920
    Cell Significance Index: -12.2500
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.8997
    Cell Significance Index: -12.6100
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.9336
    Cell Significance Index: -11.1100
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.9496
    Cell Significance Index: -12.8100
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.9627
    Cell Significance Index: -11.7200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transcription Factor**: CDX2 is a transcription factor that regulates gene expression by binding to specific DNA sequences. 2. **Homeobox Domain**: CDX2 contains a homeobox domain, which is a characteristic feature of homeobox proteins involved in developmental processes. 3. **Cell-Specific Expression**: CDX2 is expressed in specific cell types, including microglial cells, megakaryocytes, hematopoietic stem cells, and intestinal epithelial cells. 4. **Regulatory Function**: CDX2 regulates the expression of genes involved in immune regulation, epithelial development, and stem cell maintenance. **Pathways and Functions:** 1. **Immune Regulation**: CDX2 regulates the expression of genes involved in immune responses, including the synthesis and secretion of glucagon-like peptide-1 (GLP-1) and the maintenance of somatic stem cell populations. 2. **Epithelial Development**: CDX2 is involved in the development and differentiation of epithelial cells, including intestinal epithelial cells and goblet cells. 3. **Stem Cell Maintenance**: CDX2 regulates the expression of genes involved in stem cell maintenance, including the repression of genes related to differentiation. 4. **Cell Differentiation**: CDX2 promotes cell differentiation by regulating the expression of genes involved in cell fate decisions. 5. **Transcriptional Regulation**: CDX2 regulates transcription by binding to specific DNA sequences and interacting with other transcription factors. **Clinical Significance:** 1. **Immune-Related Disorders**: CDX2 has been implicated in various immune-related disorders, including inflammatory bowel disease (IBD) and autoimmune diseases. 2. **Cancer**: CDX2 has been shown to play a role in cancer development and progression, particularly in colon cancer. 3. **Stem Cell Transplantation**: CDX2 may be involved in the regulation of stem cell populations in the context of hematopoietic stem cell transplantation. 4. **Therapeutic Applications**: CDX2 may serve as a potential therapeutic target for the treatment of immune-related disorders and cancer. In conclusion, CDX2 is a transcription factor that plays a crucial role in immune regulation, epithelial development, and stem cell maintenance. Its dysregulation has been implicated in various diseases, including immune-related disorders and cancer. Further research is needed to fully understand the mechanisms by which CDX2 regulates gene expression and to explore its therapeutic potential.

Genular Protein ID: 2702020272

Symbol: CDX2_HUMAN

Name: Homeobox protein CDX-2

UniProtKB Accession Codes:

Q99626 O00503 Q5VTU7 Q969L8 Q9UD92

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 Ensembl 1 GO 29 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIR 1 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9459001

Title: Cloning and chromosome assignment of the human CDX2 gene.

PubMed ID: 9459001

DOI: 10.1046/j.1469-1809.1997.6150393.x

PubMed ID: 9036867

Title: Molecular cloning, sequencing and expression of the mRNA encoding human Cdx1 and Cdx2 homeobox. Down-regulation of Cdx1 and Cdx2 mRNA expression during colorectal carcinogenesis.

PubMed ID: 9036867

DOI: 10.1002/(sici)1097-0215(19970220)74:1<35::aid-ijc7>3.0.co;2-1

PubMed ID: 11161380

Title: The homeobox gene CDX2 in colorectal carcinoma: a genetic analysis.

PubMed ID: 11161380

DOI: 10.1054/bjoc.2000.1544

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8105782

Title: Identification of homeobox genes expressed in human T-lymphocytes.

PubMed ID: 8105782

DOI: 10.1006/bbrc.1993.2235

PubMed ID: 9933478

Title: The caudal-related homeodomain protein Cdx-2 regulates vitamin D receptor gene expression in the small intestine.

PubMed ID: 9933478

DOI: 10.1359/jbmr.1999.14.2.240

PubMed ID: 28473536

Title: Impact of cytosine methylation on DNA binding specificities of human transcription factors.

PubMed ID: 28473536

DOI: 10.1126/science.aaj2239

Sequence Information:

  • Length: 313
  • Mass: 33520
  • Checksum: B5724F1F7CA569AF
  • Sequence:
    • MYVSYLLDKD VSMYPSSVRH SGGLNLAPQN FVSPPQYPDY GGYHVAAAAA AAANLDSAQS 
PGPSWPAAYG APLREDWNGY APGGAAAAAN AVAHGLNGGS PAAAMGYSSP ADYHPHHHPH 
HHPHHPAAAP SCASGLLQTL NPGPPGPAAT AAAEQLSPGG QRRNLCEWMR KPAQQSLGSQ 
VKTRTKDKYR VVYTDHQRLE LEKEFHYSRY ITIRRKAELA ATLGLSERQV KIWFQNRRAK 
ERKINKKKLQ QQQQQQPPQP PPPPPQPPQP QPGPLRSVPE PLSPVSSLQA SVPGSVPGVL 
GPTGGVLNPT VTQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.