Details for: CDX2

Gene ID: 1045

Symbol: CDX2

Ensembl ID: ENSG00000165556

Description: caudal type homeobox 2

Associated with

  • Developmental biology
    (R-HSA-1266738)
  • Incretin synthesis, secretion, and inactivation
    (R-HSA-400508)
  • Metabolism of proteins
    (R-HSA-392499)
  • Peptide hormone metabolism
    (R-HSA-2980736)
  • Pou5f1 (oct4), sox2, nanog repress genes related to differentiation
    (R-HSA-2892245)
  • Synthesis, secretion, and inactivation of glucagon-like peptide-1 (glp-1)
    (R-HSA-381771)
  • Transcriptional regulation of pluripotent stem cells
    (R-HSA-452723)
  • Animal organ morphogenesis
    (GO:0009887)
  • Anterior/posterior axis specification
    (GO:0009948)
  • Blood vessel development
    (GO:0001568)
  • Cell differentiation
    (GO:0030154)
  • Chromatin
    (GO:0000785)
  • Condensed nuclear chromosome
    (GO:0000794)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • Embryo development
    (GO:0009790)
  • Endosome to lysosome transport
    (GO:0008333)
  • Establishment or maintenance of epithelial cell apical/basal polarity
    (GO:0045197)
  • Intestinal epithelial cell differentiation
    (GO:0060575)
  • Labyrinthine layer development
    (GO:0060711)
  • Methyl-cpg binding
    (GO:0008327)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Positive regulation of cell differentiation
    (GO:0045597)
  • Positive regulation of cell population proliferation
    (GO:0008284)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Regulation of somitogenesis
    (GO:0014807)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Somatic stem cell population maintenance
    (GO:0035019)
  • Stem cell differentiation
    (GO:0048863)
  • Transcription repressor complex
    (GO:0017053)
  • Trophectodermal cell differentiation
    (GO:0001829)

Other Information

Genular Protein ID: 2702020272

Symbol: CDX2_HUMAN

Name: Homeobox protein CDX-2

UniProtKB Accession Codes:

Q99626 O00503 Q5VTU7 Q969L8 Q9UD92

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 Ensembl 1 GO 29 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 4 PIR 1 PRINTS 2 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9459001

Title: Cloning and chromosome assignment of the human CDX2 gene.

PubMed ID: 9459001

DOI: 10.1046/j.1469-1809.1997.6150393.x

PubMed ID: 9036867

Title: Molecular cloning, sequencing and expression of the mRNA encoding human Cdx1 and Cdx2 homeobox. Down-regulation of Cdx1 and Cdx2 mRNA expression during colorectal carcinogenesis.

PubMed ID: 9036867

DOI: 10.1002/(sici)1097-0215(19970220)74:1<35::aid-ijc7>3.0.co;2-1

PubMed ID: 11161380

Title: The homeobox gene CDX2 in colorectal carcinoma: a genetic analysis.

PubMed ID: 11161380

DOI: 10.1054/bjoc.2000.1544

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8105782

Title: Identification of homeobox genes expressed in human T-lymphocytes.

PubMed ID: 8105782

DOI: 10.1006/bbrc.1993.2235

PubMed ID: 9933478

Title: The caudal-related homeodomain protein Cdx-2 regulates vitamin D receptor gene expression in the small intestine.

PubMed ID: 9933478

DOI: 10.1359/jbmr.1999.14.2.240

PubMed ID: 28473536

Title: Impact of cytosine methylation on DNA binding specificities of human transcription factors.

PubMed ID: 28473536

DOI: 10.1126/science.aaj2239

Sequence Information:

  • Length: 313
  • Mass: 33520
  • Checksum: B5724F1F7CA569AF
  • Sequence:
    • MYVSYLLDKD VSMYPSSVRH SGGLNLAPQN FVSPPQYPDY GGYHVAAAAA AAANLDSAQS 
PGPSWPAAYG APLREDWNGY APGGAAAAAN AVAHGLNGGS PAAAMGYSSP ADYHPHHHPH 
HHPHHPAAAP SCASGLLQTL NPGPPGPAAT AAAEQLSPGG QRRNLCEWMR KPAQQSLGSQ 
VKTRTKDKYR VVYTDHQRLE LEKEFHYSRY ITIRRKAELA ATLGLSERQV KIWFQNRRAK 
ERKINKKKLQ QQQQQQPPQP PPPPPQPPQP QPGPLRSVPE PLSPVSSLQA SVPGSVPGVL 
GPTGGVLNPT VTQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.