PPIE | ENSG00000084072 | NCBI 10450

Details for: PPIE

Gene ID: 10450

Symbol: PPIE

Ensembl ID: ENSG00000084072

Description: peptidylprolyl isomerase E

Associated with

Dna repair
(R-HSA-73894)
Dual incision in tc-ner
(R-HSA-6782135)
Formation of tc-ner pre-incision complex
(R-HSA-6781823)
Gap-filling dna repair synthesis and ligation in tc-ner
(R-HSA-6782210)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Metabolism of rna
(R-HSA-8953854)
Mrna splicing
(R-HSA-72172)
Mrna splicing - major pathway
(R-HSA-72163)
Neutrophil degranulation
(R-HSA-6798695)
Nucleotide excision repair
(R-HSA-5696398)
Processing of capped intron-containing pre-mrna
(R-HSA-72203)
Transcription-coupled nucleotide excision repair (tc-ner)
(R-HSA-6781827)
Catalytic step 2 spliceosome
(GO:0071013)
Cyclosporin a binding
(GO:0016018)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Extracellular region
(GO:0005576)
Ficolin-1-rich granule lumen
(GO:1904813)
Intracellular membrane-bounded organelle
(GO:0043231)
Mrna binding
(GO:0003729)
Mrna splicing, via spliceosome
(GO:0000398)
Nuclear speck
(GO:0016607)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Peptidyl-prolyl cis-trans isomerase activity
(GO:0003755)
Poly(a) binding
(GO:0008143)
Positive regulation of viral genome replication
(GO:0045070)
Protein binding
(GO:0005515)
Protein folding
(GO:0006457)
Protein peptidyl-prolyl isomerization
(GO:0000413)
Regulation of dna-templated transcription
(GO:0006355)
Rna binding
(GO:0003723)
Secretory granule lumen
(GO:0034774)
U2-type catalytic step 2 spliceosome
(GO:0071007)

Other Information

Proteins

Peptidyl-prolyl cis-trans isomerase E

Genular Protein ID: 272230624

Symbol: PPIE_HUMAN

Name: Peptidyl-prolyl cis-trans isomerase E

UniProtKB Accession Codes:

Q9UNP9 B2R971 O43634 O43635 Q32Q72 Q3S611 Q5TGA0 Q5TGA2 Q5TGA3 Q9UIZ5

Database IDs:

Citations:

PubMed ID: 9747881

Title: Co-amplification of a novel cyclophilin-like gene (PPIE) with L-myc in small cell lung cancer cell lines.

PubMed ID: 9747881

DOI: 10.1038/sj.onc.1202006

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8977107

Title: A nuclear RNA-binding cyclophilin in human T cells.

PubMed ID: 8977107

DOI: 10.1016/s0014-5793(96)01248-3

PubMed ID: 11991638

Title: Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis.

PubMed ID: 11991638

DOI: 10.1017/s1355838202021088

PubMed ID: 18258190

Title: Human CyP33 binds specifically to mRNA and binding stimulates PPIase activity of hCyP33.

PubMed ID: 18258190

DOI: 10.1016/j.febslet.2008.01.055

PubMed ID: 17981804

Title: Isolation of XAB2 complex involved in pre-mRNA splicing, transcription, and transcription-coupled repair.

PubMed ID: 17981804

DOI: 10.1074/jbc.m706647200

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25599396

Title: The RNA helicase Aquarius exhibits structural adaptations mediating its recruitment to spliceosomes.

PubMed ID: 25599396

DOI: 10.1038/nsmb.2951

PubMed ID: 15963461

Title: 1.88 A crystal structure of the C domain of hCyP33: a novel domain of peptidyl-prolyl cis-trans isomerase.

PubMed ID: 15963461

DOI: 10.1016/j.bbrc.2005.06.006

PubMed ID: 20677832

Title: The PHD3 domain of MLL acts as a CYP33-regulated switch between MLL-mediated activation and repression.

PubMed ID: 20677832

DOI: 10.1021/bi1009387

PubMed ID: 20541251

Title: Pro isomerization in MLL1 PHD3-bromo cassette connects H3K4me readout to CyP33 and HDAC-mediated repression.

PubMed ID: 20541251

DOI: 10.1016/j.cell.2010.05.016

PubMed ID: 20460131

Title: Molecular mechanism of MLL PHD3 and RNA recognition by the Cyp33 RRM domain.

PubMed ID: 20460131

DOI: 10.1016/j.jmb.2010.04.067

PubMed ID: 28076346

Title: Cryo-EM structure of a human spliceosome activated for step 2 of splicing.

PubMed ID: 28076346

DOI: 10.1038/nature21079

Sequence Information:

Length: 301
Mass: 33431
Checksum: F3226149A790BA42
Sequence:

MATTKRVLYV GGLAEEVDDK VLHAAFIPFG DITDIQIPLD YETEKHRGFA FVEFELAEDA 
AAAIDNMNES ELFGRTIRVN LAKPMRIKEG SSRPVWSDDD WLKKFSGKTL EENKEEEGSE 
PPKAETQEGE PIAKKARSNP QVYMDIKIGN KPAGRIQMLL RSDVVPMTAE NFRCLCTHEK 
GFGFKGSSFH RIIPQFMCQG GDFTNHNGTG GKSIYGKKFD DENFILKHTG PGLLSMANSG 
PNTNGSQFFL TCDKTDWLDG KHVVFGEVTE GLDVLRQIEA QGSKDGKPKQ KVIIADCGEY 
V

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: PPIE

Associated with

Other Information

Co-amplification of a novel cyclophilin-like gene (PPIE) with L-myc in small cell lung cancer cell lines. PubMed ID: 9747881

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

A nuclear RNA-binding cyclophilin in human T cells. PubMed ID: 8977107

Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. PubMed ID: 11991638

Human CyP33 binds specifically to mRNA and binding stimulates PPIase activity of hCyP33. PubMed ID: 18258190

Isolation of XAB2 complex involved in pre-mRNA splicing, transcription, and transcription-coupled repair. PubMed ID: 17981804

Initial characterization of the human central proteome. PubMed ID: 21269460

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

The RNA helicase Aquarius exhibits structural adaptations mediating its recruitment to spliceosomes. PubMed ID: 25599396

1.88 A crystal structure of the C domain of hCyP33: a novel domain of peptidyl-prolyl cis-trans isomerase. PubMed ID: 15963461

The PHD3 domain of MLL acts as a CYP33-regulated switch between MLL-mediated activation and repression. PubMed ID: 20677832

Pro isomerization in MLL1 PHD3-bromo cassette connects H3K4me readout to CyP33 and HDAC-mediated repression. PubMed ID: 20541251

Molecular mechanism of MLL PHD3 and RNA recognition by the Cyp33 RRM domain. PubMed ID: 20460131

Cryo-EM structure of a human spliceosome activated for step 2 of splicing. PubMed ID: 28076346