Details for: PPIE

Gene ID: 10450

Symbol: PPIE

Ensembl ID: ENSG00000084072

Description: peptidylprolyl isomerase E

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 1.75
    Marker Score: 1,828
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.43
    Marker Score: 2,982
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.39
    Marker Score: 943
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.34
    Marker Score: 1,419
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.33
    Marker Score: 1,912
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.33
    Marker Score: 5,213
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.26
    Marker Score: 4,660
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.25
    Marker Score: 2,123
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.21
    Marker Score: 4,696
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.21
    Marker Score: 350
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.21
    Marker Score: 806
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.16
    Marker Score: 3,209
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.14
    Marker Score: 39,612
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.14
    Marker Score: 4,671
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.13
    Marker Score: 320
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.11
    Marker Score: 1,635
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 1.1
    Marker Score: 329
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.09
    Marker Score: 4,690
  • Cell Name: neural cell (CL0002319)
    Fold Change: 1.09
    Marker Score: 524
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.08
    Marker Score: 1,439
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.08
    Marker Score: 539
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.08
    Marker Score: 568
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.07
    Marker Score: 251
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.07
    Marker Score: 2,511
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.06
    Marker Score: 1,069
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 1.05
    Marker Score: 789
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.05
    Marker Score: 579
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.05
    Marker Score: 577
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.04
    Marker Score: 2,840
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.04
    Marker Score: 2,203
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.03
    Marker Score: 1,297
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.03
    Marker Score: 13,562
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.01
    Marker Score: 8,732
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1
    Marker Score: 7,698
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1
    Marker Score: 475
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 1
    Marker Score: 368
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1
    Marker Score: 11,590
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,618
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.99
    Marker Score: 725
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47,841
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.99
    Marker Score: 14,790
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.99
    Marker Score: 928
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.98
    Marker Score: 400
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,377
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.97
    Marker Score: 2,868
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.97
    Marker Score: 1,712
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.96
    Marker Score: 1,598
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.96
    Marker Score: 9,689
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.96
    Marker Score: 8,253
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.96
    Marker Score: 8,336
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.96
    Marker Score: 2,178
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.96
    Marker Score: 1,021
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.95
    Marker Score: 2,263
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.94
    Marker Score: 590
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,382
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.93
    Marker Score: 182
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.93
    Marker Score: 2,527
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.92
    Marker Score: 5,903
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.92
    Marker Score: 1,608
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.92
    Marker Score: 475
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.92
    Marker Score: 220
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.92
    Marker Score: 14,323
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.91
    Marker Score: 431
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.91
    Marker Score: 1,445
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.9
    Marker Score: 290
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.9
    Marker Score: 222
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.9
    Marker Score: 55,260
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.9
    Marker Score: 5,124
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.9
    Marker Score: 314
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.9
    Marker Score: 6,674
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.89
    Marker Score: 1,465
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.89
    Marker Score: 2,673
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.89
    Marker Score: 17,649
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.89
    Marker Score: 405
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 0.88
    Marker Score: 233
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.87
    Marker Score: 176
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.87
    Marker Score: 1,335
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.87
    Marker Score: 302
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.86
    Marker Score: 547
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.86
    Marker Score: 419
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.86
    Marker Score: 5,196
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 308
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.85
    Marker Score: 32,467
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.85
    Marker Score: 761
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.85
    Marker Score: 885
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.85
    Marker Score: 2,916
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.85
    Marker Score: 5,510
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.85
    Marker Score: 1,305
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.84
    Marker Score: 2,130
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.84
    Marker Score: 1,601
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.84
    Marker Score: 1,707
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.84
    Marker Score: 7,978
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.84
    Marker Score: 1,644
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.84
    Marker Score: 890
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.84
    Marker Score: 847
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.83
    Marker Score: 8,265
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.83
    Marker Score: 17,801
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.83
    Marker Score: 206
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.83
    Marker Score: 219
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.83
    Marker Score: 182

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Catalytic activity**: PPIE exhibits peptidylprolyl cis-trans isomerase activity, which involves the catalytic conversion of cis-prolyl peptide bonds to trans-prolyl peptide bonds. 2. **Spliceosome-mediated mRNA splicing**: PPIE is involved in the U2-type catalytic step 2 spliceosome, a complex that mediates the splicing of pre-mRNA to form mature mRNA. 3. **Protein folding**: PPIE plays a role in protein folding by facilitating the correct conformation of proteins, which is essential for their proper function. 4. **DNA repair**: PPIE is involved in DNA repair processes, including nucleotide excision repair and transcription-coupled nucleotide excision repair (TC-NER). **Pathways and Functions** 1. **Catalytic step 2 spliceosome**: PPIE is a component of the U2-type catalytic step 2 spliceosome, which is responsible for the removal of introns from pre-mRNA. 2. **RNA binding**: PPIE binds to RNA, facilitating its splicing and processing. 3. **Protein binding**: PPIE interacts with various proteins, including those involved in transcription and DNA repair. 4. **Peptidyl-prolyl cis-trans isomerase activity**: PPIE catalyzes the conversion of cis-prolyl peptide bonds to trans-prolyl peptide bonds, which is essential for protein folding and stability. 5. **Regulation of DNA-templated transcription**: PPIE plays a role in regulating DNA-templated transcription by facilitating the assembly of transcriptional machinery. **Clinical Significance** 1. **Disease association**: PPIE has been associated with various diseases, including cancer, where its dysregulation can lead to genomic instability and tumorigenesis. 2. **Cancer therapy**: PPIE has been identified as a potential target for cancer therapy, as its inhibition can disrupt DNA repair processes and promote cancer cell death. 3. **Neurological disorders**: PPIE has been implicated in various neurological disorders, including Alzheimer's disease and Parkinson's disease, where its dysregulation can contribute to disease progression. 4. **Immunological disorders**: PPIE has been associated with immunological disorders, including autoimmune diseases, where its dysregulation can contribute to immune system dysfunction. In conclusion, PPIE is a multifunctional enzyme that plays a critical role in various cellular processes, including protein folding, transcription, and DNA repair. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding its mechanisms of action and its potential as a therapeutic target.

Genular Protein ID: 272230624

Symbol: PPIE_HUMAN

Name: Peptidyl-prolyl cis-trans isomerase E

UniProtKB Accession Codes:

Q9UNP9 B2R971 O43634 O43635 Q32Q72 Q3S611 Q5TGA0 Q5TGA2 Q5TGA3 Q9UIZ5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 2 CORUM 1 CTD 1 ChEBI 2 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 13 EMDB 13 EPD 1 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 21 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 42 PDBsum 28 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 3 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 6 RefSeq 4 Rhea 3 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TopDownProteomics 2 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9747881

Title: Co-amplification of a novel cyclophilin-like gene (PPIE) with L-myc in small cell lung cancer cell lines.

PubMed ID: 9747881

DOI: 10.1038/sj.onc.1202006

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8977107

Title: A nuclear RNA-binding cyclophilin in human T cells.

PubMed ID: 8977107

DOI: 10.1016/s0014-5793(96)01248-3

PubMed ID: 11991638

Title: Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis.

PubMed ID: 11991638

DOI: 10.1017/s1355838202021088

PubMed ID: 18258190

Title: Human CyP33 binds specifically to mRNA and binding stimulates PPIase activity of hCyP33.

PubMed ID: 18258190

DOI: 10.1016/j.febslet.2008.01.055

PubMed ID: 17981804

Title: Isolation of XAB2 complex involved in pre-mRNA splicing, transcription, and transcription-coupled repair.

PubMed ID: 17981804

DOI: 10.1074/jbc.m706647200

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25599396

Title: The RNA helicase Aquarius exhibits structural adaptations mediating its recruitment to spliceosomes.

PubMed ID: 25599396

DOI: 10.1038/nsmb.2951

PubMed ID: 15963461

Title: 1.88 A crystal structure of the C domain of hCyP33: a novel domain of peptidyl-prolyl cis-trans isomerase.

PubMed ID: 15963461

DOI: 10.1016/j.bbrc.2005.06.006

PubMed ID: 20677832

Title: The PHD3 domain of MLL acts as a CYP33-regulated switch between MLL-mediated activation and repression.

PubMed ID: 20677832

DOI: 10.1021/bi1009387

PubMed ID: 20541251

Title: Pro isomerization in MLL1 PHD3-bromo cassette connects H3K4me readout to CyP33 and HDAC-mediated repression.

PubMed ID: 20541251

DOI: 10.1016/j.cell.2010.05.016

PubMed ID: 20460131

Title: Molecular mechanism of MLL PHD3 and RNA recognition by the Cyp33 RRM domain.

PubMed ID: 20460131

DOI: 10.1016/j.jmb.2010.04.067

PubMed ID: 28076346

Title: Cryo-EM structure of a human spliceosome activated for step 2 of splicing.

PubMed ID: 28076346

DOI: 10.1038/nature21079

Sequence Information:

  • Length: 301
  • Mass: 33431
  • Checksum: F3226149A790BA42
  • Sequence:
    • MATTKRVLYV GGLAEEVDDK VLHAAFIPFG DITDIQIPLD YETEKHRGFA FVEFELAEDA 
AAAIDNMNES ELFGRTIRVN LAKPMRIKEG SSRPVWSDDD WLKKFSGKTL EENKEEEGSE 
PPKAETQEGE PIAKKARSNP QVYMDIKIGN KPAGRIQMLL RSDVVPMTAE NFRCLCTHEK 
GFGFKGSSFH RIIPQFMCQG GDFTNHNGTG GKSIYGKKFD DENFILKHTG PGLLSMANSG 
PNTNGSQFFL TCDKTDWLDG KHVVFGEVTE GLDVLRQIEA QGSKDGKPKQ KVIIADCGEY 
V

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.