Details for: VAV3

Gene ID: 10451

Symbol: VAV3

Ensembl ID: ENSG00000134215

Description: vav guanine nucleotide exchange factor 3

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 4.5
    Marker Score: 3,695
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 3.67
    Marker Score: 4,154
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 3.51
    Marker Score: 4,722
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 3.37
    Marker Score: 4,081
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 2.9
    Marker Score: 919
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 2.66
    Marker Score: 2,355
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 2.47
    Marker Score: 2,725
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 2.46
    Marker Score: 2,492
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 2.29
    Marker Score: 77,315
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 2.27
    Marker Score: 1,746
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 2.27
    Marker Score: 2,403
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 2.17
    Marker Score: 1,143
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 2.14
    Marker Score: 727
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.12
    Marker Score: 8,886
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.11
    Marker Score: 45,080
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 2.11
    Marker Score: 5,648
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.07
    Marker Score: 1,211
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.95
    Marker Score: 2,089
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.86
    Marker Score: 545
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.84
    Marker Score: 795
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.83
    Marker Score: 4,627
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.72
    Marker Score: 17,756
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.72
    Marker Score: 3,495
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.69
    Marker Score: 6,645
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.66
    Marker Score: 389
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 1.64
    Marker Score: 715
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.59
    Marker Score: 1,048
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.51
    Marker Score: 485
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.49
    Marker Score: 1,284
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.48
    Marker Score: 3,485
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167,668
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.45
    Marker Score: 1,560
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.44
    Marker Score: 2,550
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.41
    Marker Score: 443
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.4
    Marker Score: 1,985
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.39
    Marker Score: 948
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.36
    Marker Score: 1,427
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 1.35
    Marker Score: 704
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.35
    Marker Score: 809
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.26
    Marker Score: 1,091
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.25
    Marker Score: 4,431
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 1.2
    Marker Score: 243
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.2
    Marker Score: 1,991
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.2
    Marker Score: 698
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.2
    Marker Score: 460
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.17
    Marker Score: 43,229
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.17
    Marker Score: 10,086
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.15
    Marker Score: 3,623
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.15
    Marker Score: 1,129
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.14
    Marker Score: 1,469
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.13
    Marker Score: 9,927
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.13
    Marker Score: 11,449
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.1
    Marker Score: 762
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.09
    Marker Score: 1,086
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.09
    Marker Score: 725
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 1.05
    Marker Score: 376
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.02
    Marker Score: 3,943
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.02
    Marker Score: 1,061
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,727
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,951
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.99
    Marker Score: 831
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,397
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.97
    Marker Score: 491
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 488
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,405
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.94
    Marker Score: 14,774
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 0.94
    Marker Score: 309
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.94
    Marker Score: 5,638
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 443
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.94
    Marker Score: 297
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.93
    Marker Score: 1,796
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.93
    Marker Score: 3,792
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 0.93
    Marker Score: 539
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,717
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.9
    Marker Score: 360
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.87
    Marker Score: 314
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,275
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.86
    Marker Score: 491
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.86
    Marker Score: 538
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.86
    Marker Score: 4,909
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 0.85
    Marker Score: 257
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.84
    Marker Score: 3,245
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.83
    Marker Score: 1,274
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.82
    Marker Score: 260
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.82
    Marker Score: 670
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.8
    Marker Score: 611
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.79
    Marker Score: 854
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.78
    Marker Score: 1,014
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,268
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 0.78
    Marker Score: 1,627
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.77
    Marker Score: 780
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.77
    Marker Score: 311
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.76
    Marker Score: 3,203
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.76
    Marker Score: 480
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.75
    Marker Score: 369
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.75
    Marker Score: 711
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.73
    Marker Score: 380
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.73
    Marker Score: 2,042
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 458
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.71
    Marker Score: 3,307

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** VAV3 is a small GEF that belongs to the Vav family, which includes Vav1, Vav2, and Vav3. It is characterized by its ability to exchange GDP for GTP, activating downstream effectors of the small GTPase family, particularly Rho GTPases. VAV3 is highly expressed in various tissues and cell types, including the nervous system, immune cells, and epithelial cells. Its expression is also specific to certain cell types, such as syncytiotrophoblast cells and Purkinje cells. **Pathways and Functions** VAV3 has been implicated in multiple signaling pathways, including: 1. **Rho GTPase cycle**: VAV3 activates Rho GTPases, which play critical roles in regulating cell migration, adhesion, and cytoskeleton dynamics. 2. **B cell receptor signaling pathway**: VAV3 regulates B cell receptor signaling, leading to the activation of downstream effectors, including phospholipase C and protein kinase B. 3. **Angiogenesis**: VAV3 has been shown to promote angiogenesis by regulating the expression of pro-angiogenic factors, such as vascular endothelial growth factor (VEGF). 4. **Immune responses**: VAV3 is involved in regulating immune responses, including the activation of immune cells, such as neutrophils and macrophages. 5. **Cytoskeleton dynamics**: VAV3 regulates actin dynamics, which is essential for cell migration, adhesion, and phagocytosis. **Clinical Significance** Dysregulation of VAV3 has been linked to various diseases, including: 1. **Cancer**: VAV3 is overexpressed in various types of cancer, including breast, lung, and colon cancer, and is associated with poor prognosis. 2. **Autoimmune disorders**: VAV3 is implicated in autoimmune diseases, such as rheumatoid arthritis and lupus, where it regulates immune cell activation and proliferation. 3. **Infectious diseases**: VAV3 is involved in regulating immune responses to infections, including Leishmania and HIV. 4. **Neurological disorders**: VAV3 is implicated in neurological disorders, such as Parkinson's disease and Alzheimer's disease, where it regulates neuronal survival and migration. In conclusion, VAV3 is a multifunctional GEF that plays critical roles in regulating various cellular processes, including cell signaling, migration, and survival. Its dysregulation has been linked to various diseases, highlighting the importance of VAV3 as a therapeutic target in cancer, autoimmune disorders, and infectious diseases.

Genular Protein ID: 763359068

Symbol: VAV3_HUMAN

Name: Guanine nucleotide exchange factor VAV3

UniProtKB Accession Codes:

Q9UKW4 B1AMM0 B1APV5 B4E232 B7ZLR1 E9PQ97 O60498 O95230 Q9Y5X8

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 7 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 13 EPD 1 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 27 Gene3D 6 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 18 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PRINTS 3 PRO 1 PROSITE 8 PROSITE-ProRule 6 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 6 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 17 RefSeq 3 SIGNOR 1 SMART 6 SMR 1 STRING 1 SUPFAM 5 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9705494

Title: Non-stoichiometric reduced complexity probes for cDNA arrays.

PubMed ID: 9705494

DOI: 10.1093/nar/26.17.3883

PubMed ID: 10523675

Title: Biological and regulatory properties of Vav-3, a new member of the Vav family of oncoproteins.

PubMed ID: 10523675

DOI: 10.1128/mcb.19.11.7870

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11094073

Title: Vav3 mediates receptor protein tyrosine kinase signaling, regulates GTPase activity, modulates cell morphology, and induces cell transformation.

PubMed ID: 11094073

DOI: 10.1128/mcb.20.24.9212-9224.2000

PubMed ID: 12400014

Title: Adaptor protein APS binds the NH2-terminal autoinhibitory domain of guanine nucleotide exchange factor Vav3 and augments its activity.

PubMed ID: 12400014

DOI: 10.1038/sj.onc.1205927

PubMed ID: 16782872

Title: Essential role of Vav family guanine nucleotide exchange factors in EphA receptor-mediated angiogenesis.

PubMed ID: 16782872

DOI: 10.1128/mcb.02215-05

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

Sequence Information:

  • Length: 847
  • Mass: 97776
  • Checksum: C1E29F0B094CB721
  • Sequence:
    • MEPWKQCAQW LIHCKVLPTN HRVTWDSAQV FDLAQTLRDG VLLCQLLNNL RAHSINLKEI 
NLRPQMSQFL CLKNIRTFLT ACCETFGMRK SELFEAFDLF DVRDFGKVIE TLSRLSRTPI 
ALATGIRPFP TEESINDEDI YKGLPDLIDE TLVEDEEDLY DCVYGEDEGG EVYEDLMKAE 
EAHQPKCPEN DIRSCCLAEI KQTEEKYTET LESIEKYFMA PLKRFLTAAE FDSVFINIPE 
LVKLHRNLMQ EIHDSIVNKN DQNLYQVFIN YKERLVIYGQ YCSGVESAIS SLDYISKTKE 
DVKLKLEECS KRANNGKFTL RDLLVVPMQR VLKYHLLLQE LVKHTTDPTE KANLKLALDA 
MKDLAQYVNE VKRDNETLRE IKQFQLSIEN LNQPVLLFGR PQGDGEIRIT TLDKHTKQER 
HIFLFDLAVI VCKRKGDNYE MKEIIDLQQY KIANNPTTDK ENKKWSYGFY LIHTQGQNGL 
EFYCKTKDLK KKWLEQFEMA LSNIRPDYAD SNFHDFKMHT FTRVTSCKVC QMLLRGTFYQ 
GYLCFKCGAR AHKECLGRVD NCGRVNSGEQ GTLKLPEKRT NGLRRTPKQV DPGLPKMQVI 
RNYSGTPPPA LHEGPPLQLQ AGDTVELLKG DAHSLFWQGR NLASGEVGFF PSDAVKPCPC 
VPKPVDYSCQ PWYAGAMERL QAETELINRV NSTYLVRHRT KESGEYAISI KYNNEAKHIK 
ILTRDGFFHI AENRKFKSLM ELVEYYKHHS LKEGFRTLDT TLQFPYKEPE HSAGQRGNRA 
GNSLLSPKVL GIAIARYDFC ARDMRELSLL KGDVVKIYTK MSANGWWRGE VNGRVGWFPS 
TYVEEDE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.