VAV3 | ENSG00000134215 | NCBI 10451

Details for: VAV3

Gene ID: 10451

Symbol: VAV3

Ensembl ID: ENSG00000134215

Description: vav guanine nucleotide exchange factor 3

Associated with

Axon guidance
(R-HSA-422475)
Azathioprine adme
(R-HSA-9748787)
Cdc42 gtpase cycle
(R-HSA-9013148)
Cell death signalling via nrage, nrif and nade
(R-HSA-204998)
Dap12 interactions
(R-HSA-2172127)
Dap12 signaling
(R-HSA-2424491)
Death receptor signaling
(R-HSA-73887)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Drug adme
(R-HSA-9748784)
Eph-ephrin mediated repulsion of cells
(R-HSA-3928665)
Eph-ephrin signaling
(R-HSA-2682334)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated ca+2 mobilization
(R-HSA-2871809)
Fceri mediated mapk activation
(R-HSA-2871796)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-HSA-2029480)
Fcgr3a-mediated phagocytosis
(R-HSA-9664422)
G alpha (12/13) signalling events
(R-HSA-416482)
Gpcr downstream signalling
(R-HSA-388396)
Gpvi-mediated activation cascade
(R-HSA-114604)
Hemostasis
(R-HSA-109582)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Leishmania infection
(R-HSA-9658195)
Leishmania phagocytosis
(R-HSA-9664417)
Nervous system development
(R-HSA-9675108)
Nrage signals death through jnk
(R-HSA-193648)
P75 ntr receptor-mediated signalling
(R-HSA-193704)
Parasite infection
(R-HSA-9664407)
Parasitic infection pathways
(R-HSA-9824443)
Platelet activation, signaling and aggregation
(R-HSA-76002)
Rac1 gtpase cycle
(R-HSA-9013149)
Rac2 gtpase cycle
(R-HSA-9013404)
Regulation of actin dynamics for phagocytic cup formation
(R-HSA-2029482)
Rhoa gtpase cycle
(R-HSA-8980692)
Rhog gtpase cycle
(R-HSA-9013408)
Rho gtpase cycle
(R-HSA-9012999)
Signaling by gpcr
(R-HSA-372790)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signaling by vegf
(R-HSA-194138)
Signal transduction
(R-HSA-162582)
Vegfa-vegfr2 pathway
(R-HSA-4420097)
Vegfr2 mediated vascular permeability
(R-HSA-5218920)
Angiogenesis
(GO:0001525)
B cell receptor signaling pathway
(GO:0050853)
Cell migration
(GO:0016477)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Dna damage response
(GO:0006974)
Epidermal growth factor receptor binding
(GO:0005154)
Fc-epsilon receptor signaling pathway
(GO:0038095)
Fc-gamma receptor signaling pathway involved in phagocytosis
(GO:0038096)
Gtpase activator activity
(GO:0005096)
Guanyl-nucleotide exchange factor activity
(GO:0005085)
Immunological synapse
(GO:0001772)
Integrin-mediated signaling pathway
(GO:0007229)
Lamellipodium assembly
(GO:0030032)
Metal ion binding
(GO:0046872)
Neutrophil chemotaxis
(GO:0030593)
Plasma membrane
(GO:0005886)
Platelet activation
(GO:0030168)
Positive regulation of b cell proliferation
(GO:0030890)
Positive regulation of cell adhesion
(GO:0045785)
Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0051897)
Protein binding
(GO:0005515)
Regulation of cell size
(GO:0008361)
Regulation of gtpase activity
(GO:0043087)
Regulation of small gtpase mediated signal transduction
(GO:0051056)
Response to xenobiotic stimulus
(GO:0009410)
Small gtpase-mediated signal transduction
(GO:0007264)
Vesicle fusion
(GO:0006906)

Other Information

Proteins

Guanine nucleotide exchange factor VAV3

Genular Protein ID: 763359068

Symbol: VAV3_HUMAN

Name: Guanine nucleotide exchange factor VAV3

UniProtKB Accession Codes:

Q9UKW4 B1AMM0 B1APV5 B4E232 B7ZLR1 E9PQ97 O60498 O95230 Q9Y5X8

Database IDs:

Citations:

PubMed ID: 9705494

Title: Non-stoichiometric reduced complexity probes for cDNA arrays.

PubMed ID: 9705494

DOI: 10.1093/nar/26.17.3883

PubMed ID: 10523675

Title: Biological and regulatory properties of Vav-3, a new member of the Vav family of oncoproteins.

PubMed ID: 10523675

DOI: 10.1128/mcb.19.11.7870

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11094073

Title: Vav3 mediates receptor protein tyrosine kinase signaling, regulates GTPase activity, modulates cell morphology, and induces cell transformation.

PubMed ID: 11094073

DOI: 10.1128/mcb.20.24.9212-9224.2000

PubMed ID: 12400014

Title: Adaptor protein APS binds the NH2-terminal autoinhibitory domain of guanine nucleotide exchange factor Vav3 and augments its activity.

PubMed ID: 12400014

DOI: 10.1038/sj.onc.1205927

PubMed ID: 16782872

Title: Essential role of Vav family guanine nucleotide exchange factors in EphA receptor-mediated angiogenesis.

PubMed ID: 16782872

DOI: 10.1128/mcb.02215-05

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

Sequence Information:

Length: 847
Mass: 97776
Checksum: C1E29F0B094CB721
Sequence:

MEPWKQCAQW LIHCKVLPTN HRVTWDSAQV FDLAQTLRDG VLLCQLLNNL RAHSINLKEI 
NLRPQMSQFL CLKNIRTFLT ACCETFGMRK SELFEAFDLF DVRDFGKVIE TLSRLSRTPI 
ALATGIRPFP TEESINDEDI YKGLPDLIDE TLVEDEEDLY DCVYGEDEGG EVYEDLMKAE 
EAHQPKCPEN DIRSCCLAEI KQTEEKYTET LESIEKYFMA PLKRFLTAAE FDSVFINIPE 
LVKLHRNLMQ EIHDSIVNKN DQNLYQVFIN YKERLVIYGQ YCSGVESAIS SLDYISKTKE 
DVKLKLEECS KRANNGKFTL RDLLVVPMQR VLKYHLLLQE LVKHTTDPTE KANLKLALDA 
MKDLAQYVNE VKRDNETLRE IKQFQLSIEN LNQPVLLFGR PQGDGEIRIT TLDKHTKQER 
HIFLFDLAVI VCKRKGDNYE MKEIIDLQQY KIANNPTTDK ENKKWSYGFY LIHTQGQNGL 
EFYCKTKDLK KKWLEQFEMA LSNIRPDYAD SNFHDFKMHT FTRVTSCKVC QMLLRGTFYQ 
GYLCFKCGAR AHKECLGRVD NCGRVNSGEQ GTLKLPEKRT NGLRRTPKQV DPGLPKMQVI 
RNYSGTPPPA LHEGPPLQLQ AGDTVELLKG DAHSLFWQGR NLASGEVGFF PSDAVKPCPC 
VPKPVDYSCQ PWYAGAMERL QAETELINRV NSTYLVRHRT KESGEYAISI KYNNEAKHIK 
ILTRDGFFHI AENRKFKSLM ELVEYYKHHS LKEGFRTLDT TLQFPYKEPE HSAGQRGNRA 
GNSLLSPKVL GIAIARYDFC ARDMRELSLL KGDVVKIYTK MSANGWWRGE VNGRVGWFPS 
TYVEEDE

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: VAV3

Associated with

Other Information

Non-stoichiometric reduced complexity probes for cDNA arrays. PubMed ID: 9705494

Biological and regulatory properties of Vav-3, a new member of the Vav family of oncoproteins. PubMed ID: 10523675

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Vav3 mediates receptor protein tyrosine kinase signaling, regulates GTPase activity, modulates cell morphology, and induces cell transformation. PubMed ID: 11094073

Adaptor protein APS binds the NH2-terminal autoinhibitory domain of guanine nucleotide exchange factor Vav3 and augments its activity. PubMed ID: 12400014

Essential role of Vav family guanine nucleotide exchange factors in EphA receptor-mediated angiogenesis. PubMed ID: 16782872

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332