TAB1 | ENSG00000100324 | NCBI 10454

Details for: TAB1

Gene ID: 10454

Symbol: TAB1

Ensembl ID: ENSG00000100324

Description: TGF-beta activated kinase 1 (MAP3K7) binding protein 1

Associated with

Activated tak1 mediates p38 mapk activation
(R-HSA-450302)
Alpha-protein kinase 1 signaling pathway
(R-HSA-9645460)
C-type lectin receptors (clrs)
(R-HSA-5621481)
Clec7a (dectin-1) signaling
(R-HSA-5607764)
Cytokine signaling in immune system
(R-HSA-1280215)
Death receptor signaling
(R-HSA-73887)
Deubiquitination
(R-HSA-5688426)
Disease
(R-HSA-1643685)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated nf-kb activation
(R-HSA-2871837)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Interleukin-1 family signaling
(R-HSA-446652)
Interleukin-1 signaling
(R-HSA-9020702)
Interleukin-17 signaling
(R-HSA-448424)
Irak2 mediated activation of tak1 complex
(R-HSA-937042)
Irak2 mediated activation of tak1 complex upon tlr7/8 or 9 stimulation
(R-HSA-975163)
Jnk (c-jun kinases) phosphorylation and activation mediated by activated human tak1
(R-HSA-450321)
Map kinase activation
(R-HSA-450294)
Metabolism of proteins
(R-HSA-392499)
Myd88 cascade initiated on plasma membrane
(R-HSA-975871)
Myd88 dependent cascade initiated on endosome
(R-HSA-975155)
Myd88-independent tlr4 cascade
(R-HSA-166166)
Myd88:mal(tirap) cascade initiated on plasma membrane
(R-HSA-166058)
Nod1/2 signaling pathway
(R-HSA-168638)
Nucleotide-binding domain, leucine rich repeat containing receptor (nlr) signaling pathways
(R-HSA-168643)
Post-translational protein modification
(R-HSA-597592)
Sars-cov-2 activates/modulates innate and adaptive immune responses
(R-HSA-9705671)
Sars-cov-2 infection
(R-HSA-9694516)
Sars-cov-2-host interactions
(R-HSA-9705683)
Sars-cov infections
(R-HSA-9679506)
Signaling by interleukins
(R-HSA-449147)
Signal transduction
(R-HSA-162582)
Tak1-dependent ikk and nf-kappa-b activation
(R-HSA-445989)
Ticam1,traf6-dependent induction of tak1 complex
(R-HSA-9014325)
Tnfr1-induced nf-kappa-b signaling pathway
(R-HSA-5357956)
Tnf signaling
(R-HSA-75893)
Toll-like receptor cascades
(R-HSA-168898)
Toll like receptor 2 (tlr2) cascade
(R-HSA-181438)
Toll like receptor 3 (tlr3) cascade
(R-HSA-168164)
Toll like receptor 4 (tlr4) cascade
(R-HSA-166016)
Toll like receptor 5 (tlr5) cascade
(R-HSA-168176)
Toll like receptor 7/8 (tlr7/8) cascade
(R-HSA-168181)
Toll like receptor 9 (tlr9) cascade
(R-HSA-168138)
Toll like receptor 10 (tlr10) cascade
(R-HSA-168142)
Toll like receptor tlr1:tlr2 cascade
(R-HSA-168179)
Toll like receptor tlr6:tlr2 cascade
(R-HSA-168188)
Traf6 mediated induction of nfkb and map kinases upon tlr7/8 or 9 activation
(R-HSA-975138)
Traf6-mediated induction of tak1 complex within tlr4 complex
(R-HSA-937072)
Trif(ticam1)-mediated tlr4 signaling
(R-HSA-937061)
Ub-specific processing proteases
(R-HSA-5689880)
Viral infection pathways
(R-HSA-9824446)
Aorta development
(GO:0035904)
Cardiac septum development
(GO:0003279)
Coronary vasculature development
(GO:0060976)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Endoplasmic reticulum
(GO:0005783)
Endosome membrane
(GO:0010008)
Enzyme activator activity
(GO:0008047)
Heart morphogenesis
(GO:0003007)
In utero embryonic development
(GO:0001701)
Lung development
(GO:0030324)
Mitogen-activated protein kinase p38 binding
(GO:0048273)
Molecular adaptor activity
(GO:0060090)
Non-canonical nf-kappab signal transduction
(GO:0038061)
Nuclear speck
(GO:0016607)
Positive regulation of mapk cascade
(GO:0043410)
Positive regulation of protein serine/threonine kinase activity
(GO:0071902)
Protein-containing complex
(GO:0032991)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein dephosphorylation
(GO:0006470)
Protein serine/threonine kinase activator activity
(GO:0043539)
Protein serine/threonine phosphatase activity
(GO:0004722)
Transforming growth factor beta receptor signaling pathway
(GO:0007179)

Other Information

Proteins

TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

Genular Protein ID: 2490430961

Symbol: TAB1_HUMAN

Name: TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

UniProtKB Accession Codes:

Q15750 Q2PP09 Q8IZW2

Database IDs:

Citations:

PubMed ID: 8638164

Title: TAB1: an activator of the TAK1 MAPKKK in TGF-beta signal transduction.

PubMed ID: 8638164

DOI: 10.1126/science.272.5265.1179

PubMed ID: 12429732

Title: TAB1beta (transforming growth factor-beta-activated protein kinase 1-binding protein 1beta), a novel splicing variant of TAB1 that interacts with p38alpha but not TAK1.

PubMed ID: 12429732

DOI: 10.1074/jbc.m210918200

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10094049

Title: The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway.

PubMed ID: 10094049

DOI: 10.1038/18465

PubMed ID: 10838074

Title: Phosphorylation-dependent activation of TAK1 mitogen-activated protein kinase kinase kinase by TAB1.

PubMed ID: 10838074

DOI: 10.1016/s0014-5793(00)01588-x

PubMed ID: 11323434

Title: An evolutionarily conserved motif in the TAB1 C-terminal region is necessary for interaction with and activation of TAK1 MAPKKK.

PubMed ID: 11323434

DOI: 10.1074/jbc.m102631200

PubMed ID: 11460167

Title: TAK1 is a ubiquitin-dependent kinase of MKK and IKK.

PubMed ID: 11460167

DOI: 10.1038/35085597

PubMed ID: 11865055

Title: IAP suppression of apoptosis involves distinct mechanisms: the TAK1/JNK1 signaling cascade and caspase inhibition.

PubMed ID: 11865055

DOI: 10.1128/mcb.22.6.1754-1766.2002

PubMed ID: 11847341

Title: MAPKK-independent activation of p38alpha mediated by TAB1-dependent autophosphorylation of p38alpha.

PubMed ID: 11847341

DOI: 10.1126/science.1067289

PubMed ID: 14592977

Title: Feedback control of the protein kinase TAK1 by SAPK2a/p38alpha.

PubMed ID: 14592977

DOI: 10.1093/emboj/cdg552

PubMed ID: 16845370

Title: The Yersinia enterocolitica effector YopP inhibits host cell signalling by inactivating the protein kinase TAK1 in the IL-1 signalling pathway.

PubMed ID: 16845370

DOI: 10.1038/sj.embor.7400754

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18021073

Title: Roles for TAB1 in regulating the IL-1-dependent phosphorylation of the TAB3 regulatory subunit and activity of the TAK1 complex.

PubMed ID: 18021073

DOI: 10.1042/bj20071149

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22307082

Title: O-GlcNAcylation of TAB1 modulates TAK1-mediated cytokine release.

PubMed ID: 22307082

DOI: 10.1038/emboj.2012.8

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24403530

Title: Dual-specificity phosphatase 14 (DUSP14/MKP6) negatively regulates TCR signaling by inhibiting TAB1 activation.

PubMed ID: 24403530

DOI: 10.4049/jimmunol.1300989

PubMed ID: 25260751

Title: The MEKK1 PHD ubiquitinates TAB1 to activate MAPKs in response to cytokines.

PubMed ID: 25260751

DOI: 10.15252/embj.201488351

PubMed ID: 25714464

Title: The E3 ubiquitin ligase Itch inhibits p38alpha signaling and skin inflammation through the ubiquitylation of Tab1.

PubMed ID: 25714464

DOI: 10.1126/scisignal.2005903

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 16879102

Title: TAK1-binding protein 1 is a pseudophosphatase.

PubMed ID: 16879102

DOI: 10.1042/bj20061077

PubMed ID: 17560374

Title: XIAP induces NF-kappaB activation via the BIR1/TAB1 interaction and BIR1 dimerization.

PubMed ID: 17560374

DOI: 10.1016/j.molcel.2007.05.006

PubMed ID: 29229647

Title: TAB1-Induced Autoactivation of p38alpha Mitogen-Activated Protein Kinase Is Crucially Dependent on Threonine 185.

PubMed ID: 29229647

DOI: 10.1128/mcb.00409-17

Sequence Information:

Length: 504
Mass: 54644
Checksum: A45743288718983A
Sequence:

MAAQRRSLLQ SEQQPSWTDD LPLCHLSGVG SASNRSYSAD GKGTESHPPE DSWLKFRSEN 
NCFLYGVFNG YDGNRVTNFV AQRLSAELLL GQLNAEHAEA DVRRVLLQAF DVVERSFLES 
IDDALAEKAS LQSQLPEGVP QHQLPPQYQK ILERLKTLER EISGGAMAVV AVLLNNKLYV 
ANVGTNRALL CKSTVDGLQV TQLNVDHTTE NEDELFRLSQ LGLDAGKIKQ VGIICGQEST 
RRIGDYKVKY GYTDIDLLSA AKSKPIIAEP EIHGAQPLDG VTGFLVLMSE GLYKALEAAH 
GPGQANQEIA AMIDTEFAKQ TSLDAVAQAV VDRVKRIHSD TFASGGERAR FCPRHEDMTL 
LVRNFGYPLG EMSQPTPSPA PAAGGRVYPV SVPYSSAQST SKTSVTLSLV MPSQGQMVNG 
AHSASTLDEA TPTLTNQSPT LTLQSTNTHT QSSSSSSDGG LFRSRPAHSL PPGEDGRVEP 
YVDFAEFYRL WSVDHGEQSV VTAP

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: TAB1

Associated with

Other Information

TAB1: an activator of the TAK1 MAPKKK in TGF-beta signal transduction. PubMed ID: 8638164

TAB1beta (transforming growth factor-beta-activated protein kinase 1-binding protein 1beta), a novel splicing variant of TAB1 that interacts with p38alpha but not TAK1. PubMed ID: 12429732

The DNA sequence of human chromosome 22. PubMed ID: 10591208

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway. PubMed ID: 10094049

Phosphorylation-dependent activation of TAK1 mitogen-activated protein kinase kinase kinase by TAB1. PubMed ID: 10838074

An evolutionarily conserved motif in the TAB1 C-terminal region is necessary for interaction with and activation of TAK1 MAPKKK. PubMed ID: 11323434

TAK1 is a ubiquitin-dependent kinase of MKK and IKK. PubMed ID: 11460167

IAP suppression of apoptosis involves distinct mechanisms: the TAK1/JNK1 signaling cascade and caspase inhibition. PubMed ID: 11865055

MAPKK-independent activation of p38alpha mediated by TAB1-dependent autophosphorylation of p38alpha. PubMed ID: 11847341

Feedback control of the protein kinase TAK1 by SAPK2a/p38alpha. PubMed ID: 14592977

The Yersinia enterocolitica effector YopP inhibits host cell signalling by inactivating the protein kinase TAK1 in the IL-1 signalling pathway. PubMed ID: 16845370

Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. PubMed ID: 18220336

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Roles for TAB1 in regulating the IL-1-dependent phosphorylation of the TAB3 regulatory subunit and activity of the TAK1 complex. PubMed ID: 18021073

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

O-GlcNAcylation of TAB1 modulates TAK1-mediated cytokine release. PubMed ID: 22307082

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Dual-specificity phosphatase 14 (DUSP14/MKP6) negatively regulates TCR signaling by inhibiting TAB1 activation. PubMed ID: 24403530

The MEKK1 PHD ubiquitinates TAB1 to activate MAPKs in response to cytokines. PubMed ID: 25260751

The E3 ubiquitin ligase Itch inhibits p38alpha signaling and skin inflammation through the ubiquitylation of Tab1. PubMed ID: 25714464

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

TAK1-binding protein 1 is a pseudophosphatase. PubMed ID: 16879102

XIAP induces NF-kappaB activation via the BIR1/TAB1 interaction and BIR1 dimerization. PubMed ID: 17560374

TAB1-Induced Autoactivation of p38alpha Mitogen-Activated Protein Kinase Is Crucially Dependent on Threonine 185. PubMed ID: 29229647