Details for: MAD2L2

Gene ID: 10459

Symbol: MAD2L2

Ensembl ID: ENSG00000116670

Description: mitotic arrest deficient 2 like 2

Associated with

  • Dna damage bypass
    (R-HSA-73893)
  • Dna repair
    (R-HSA-73894)
  • Translesion synthesis by poli
    (R-HSA-5656121)
  • Translesion synthesis by polk
    (R-HSA-5655862)
  • Translesion synthesis by rev1
    (R-HSA-110312)
  • Translesion synthesis by y family dna polymerases bypasses lesions on dna template
    (R-HSA-110313)
  • Actin filament organization
    (GO:0007015)
  • Anaphase-promoting complex
    (GO:0005680)
  • Cell division
    (GO:0051301)
  • Chromatin
    (GO:0000785)
  • Chromosome
    (GO:0005694)
  • Cytoplasm
    (GO:0005737)
  • Dna damage response, signal transduction resulting in transcription
    (GO:0042772)
  • Double-strand break repair
    (GO:0006302)
  • Error-prone translesion synthesis
    (GO:0042276)
  • Jun kinase binding
    (GO:0008432)
  • Mitotic spindle assembly checkpoint signaling
    (GO:0007094)
  • Negative regulation of canonical wnt signaling pathway
    (GO:0090090)
  • Negative regulation of cell-cell adhesion mediated by cadherin
    (GO:2000048)
  • Negative regulation of dna-binding transcription factor activity
    (GO:0043433)
  • Negative regulation of double-strand break repair via homologous recombination
    (GO:2000042)
  • Negative regulation of epithelial to mesenchymal transition
    (GO:0010719)
  • Negative regulation of protein catabolic process
    (GO:0042177)
  • Negative regulation of transcription by competitive promoter binding
    (GO:0010944)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Negative regulation of transcription regulatory region dna binding
    (GO:2000678)
  • Negative regulation of ubiquitin protein ligase activity
    (GO:1904667)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of double-strand break repair via nonhomologous end joining
    (GO:2001034)
  • Positive regulation of epithelial to mesenchymal transition
    (GO:0010718)
  • Positive regulation of extracellular matrix assembly
    (GO:1901203)
  • Positive regulation of isotype switching
    (GO:0045830)
  • Positive regulation of peptidyl-serine phosphorylation
    (GO:0033138)
  • Protein binding
    (GO:0005515)
  • Regulation of cell growth
    (GO:0001558)
  • Rna polymerase ii-specific dna-binding transcription factor binding
    (GO:0061629)
  • Site of double-strand break
    (GO:0035861)
  • Somatic diversification of immunoglobulins involved in immune response
    (GO:0002208)
  • Spindle
    (GO:0005819)
  • Telomere maintenance in response to dna damage
    (GO:0043247)
  • Zeta dna polymerase complex
    (GO:0016035)

Other Information

Genular Protein ID: 3583182231

Symbol: MD2L2_HUMAN

Name: Mitotic spindle assembly checkpoint protein MAD2B

UniProtKB Accession Codes:

Q9UI95 B3KNE3 Q5TGW7 Q9UNA7 Q9Y6I6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 2 DNASU 1 DisGeNET 1 EMBL 10 EMDB 1 EPD 1 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 35 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 28 PDBsum 24 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 3 SASBDB 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10527948

Title: Evidence for an interaction of the metalloprotease-disintegrin tumour necrosis factor alpha convertase (TACE) with mitotic arrest deficient 2 (MAD2), and of the metalloprotease-disintegrin MDC9 with a novel MAD2-related protein, MAD2-beta.

PubMed ID: 10527948

DOI: 10.1042/bj3430673

PubMed ID: 10366450

Title: Characterization of MAD2B and other mitotic spindle checkpoint genes.

PubMed ID: 10366450

DOI: 10.1006/geno.1999.5831

PubMed ID: 10660610

Title: A human REV7 homolog that interacts with the polymerase zeta catalytic subunit hREV3 and the spindle assembly checkpoint protein hMAD2.

PubMed ID: 10660610

DOI: 10.1074/jbc.275.6.4391

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11459825

Title: Inhibition of Cdh1-APC by the MAD2-related protein MAD2L2: a novel mechanism for regulating Cdh1.

PubMed ID: 11459825

DOI: 10.1101/gad.897901

PubMed ID: 11459826

Title: MAD2B is an inhibitor of the anaphase-promoting complex.

PubMed ID: 11459826

DOI: 10.1101/gad.898701

PubMed ID: 11485998

Title: Interactions in the error-prone postreplication repair proteins hREV1, hREV3, and hREV7.

PubMed ID: 11485998

DOI: 10.1074/jbc.m102051200

PubMed ID: 11717438

Title: Impairment of MAD2B-PRCC interaction in mitotic checkpoint defective t(X;1)-positive renal cell carcinomas.

PubMed ID: 11717438

DOI: 10.1073/pnas.241304198

PubMed ID: 17719540

Title: A bacterial effector targets Mad2L2, an APC inhibitor, to modulate host cell cycling.

PubMed ID: 17719540

DOI: 10.1016/j.cell.2007.06.043

PubMed ID: 17541814

Title: Hepatocellular carcinoma-associated gene 2 interacts with MAD2L2.

PubMed ID: 17541814

DOI: 10.1007/s11010-007-9512-8

PubMed ID: 17296730

Title: Rev7/MAD2B links c-Jun N-terminal protein kinase pathway signaling to activation of the transcription factor Elk-1.

PubMed ID: 17296730

DOI: 10.1128/mcb.02276-06

PubMed ID: 19443654

Title: MAD2B, a novel TCF4-binding protein, modulates TCF4-mediated epithelial-mesenchymal transdifferentiation.

PubMed ID: 19443654

DOI: 10.1074/jbc.m109.005017

PubMed ID: 19753112

Title: The mitotic arrest deficient protein MAD2B interacts with the small GTPase RAN throughout the cell cycle.

PubMed ID: 19753112

DOI: 10.1371/journal.pone.0007020

PubMed ID: 20850016

Title: Quantitative interaction proteomics and genome-wide profiling of epigenetic histone marks and their readers.

PubMed ID: 20850016

DOI: 10.1016/j.cell.2010.08.020

PubMed ID: 21063390

Title: CAMP (C13orf8, ZNF828) is a novel regulator of kinetochore-microtubule attachment.

PubMed ID: 21063390

DOI: 10.1038/emboj.2010.276

PubMed ID: 24449906

Title: Human Pol zeta purified with accessory subunits is active in translesion DNA synthesis and complements Pol eta in cisplatin bypass.

PubMed ID: 24449906

DOI: 10.1073/pnas.1324001111

PubMed ID: 27500492

Title: Biallelic inactivation of REV7 is associated with Fanconi anemia.

PubMed ID: 27500492

DOI: 10.1172/jci88010

PubMed ID: 29656893

Title: DNA repair network analysis reveals shieldin as a key regulator of NHEJ and PARP inhibitor sensitivity.

PubMed ID: 29656893

DOI: 10.1016/j.cell.2018.03.050

PubMed ID: 29789392

Title: FAM35A associates with REV7 and modulates DNA damage responses of normal and BRCA1-defective cells.

PubMed ID: 29789392

DOI: 10.15252/embj.201899543

PubMed ID: 20164194

Title: Crystal structure of human REV7 in complex with a human REV3 fragment and structural implication of the interaction between DNA polymerase zeta and REV1.

PubMed ID: 20164194

DOI: 10.1074/jbc.m109.092403

Sequence Information:

  • Length: 211
  • Mass: 24334
  • Checksum: 1DE6353EF7D650B9
  • Sequence:
    • MTTLTRQDLN FGQVVADVLC EFLEVAVHLI LYVREVYPVG IFQKRKKYNV PVQMSCHPEL 
NQYIQDTLHC VKPLLEKNDV EKVVVVILDK EHRPVEKFVF EITQPPLLSI SSDSLLSHVE 
QLLRAFILKI SVCDAVLDHN PPGCTFTVLV HTREAATRNM EKIQVIKDFP WILADEQDVH 
MHDPRLIPLK TMTSDILKMQ LYVEERAHKG S

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.