Details for: CDX4

Gene ID: 1046

Symbol: CDX4

Ensembl ID: ENSG00000131264

Description: caudal type homeobox 4

Associated with

  • Anterior/posterior axis specification
    (GO:0009948)
  • Blood vessel development
    (GO:0001568)
  • Cell differentiation
    (GO:0030154)
  • Chromatin
    (GO:0000785)
  • Digestive tract development
    (GO:0048565)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Embryonic pattern specification
    (GO:0009880)
  • Labyrinthine layer development
    (GO:0060711)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nucleus
    (GO:0005634)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.0632
    Cell Significance Index: 1.0800
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.0524
    Cell Significance Index: 0.6900
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.0467
    Cell Significance Index: 0.6100
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.0441
    Cell Significance Index: 0.4500
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.0419
    Cell Significance Index: 0.5300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0187
    Cell Significance Index: 0.5000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0182
    Cell Significance Index: 0.2600
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.0182
    Cell Significance Index: 0.1800
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.0165
    Cell Significance Index: 0.4200
  • Cell Name: adipocyte (CL0000136)
    Fold Change: 0.0150
    Cell Significance Index: 0.2000
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: 0.0090
    Cell Significance Index: 0.1800
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.0090
    Cell Significance Index: 0.1300
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.0028
    Cell Significance Index: 0.0700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0022
    Cell Significance Index: 0.0600
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.0010
    Cell Significance Index: 0.0100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0003
    Cell Significance Index: 0.0200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: 0.0002
    Cell Significance Index: 0.0100
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0008
    Cell Significance Index: -0.4100
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0017
    Cell Significance Index: -0.0200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0023
    Cell Significance Index: -0.4100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0025
    Cell Significance Index: -0.5000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0040
    Cell Significance Index: -0.4900
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0046
    Cell Significance Index: -0.0600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0051
    Cell Significance Index: -0.5800
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0051
    Cell Significance Index: -0.0500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0074
    Cell Significance Index: -0.5000
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.0082
    Cell Significance Index: -0.0700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0082
    Cell Significance Index: -0.1200
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0085
    Cell Significance Index: -0.1100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0110
    Cell Significance Index: -0.2400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0132
    Cell Significance Index: -0.4600
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0138
    Cell Significance Index: -0.2100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0142
    Cell Significance Index: -0.3500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0145
    Cell Significance Index: -0.5500
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.0149
    Cell Significance Index: -0.2400
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0154
    Cell Significance Index: -0.2500
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0156
    Cell Significance Index: -0.3100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0163
    Cell Significance Index: -0.4800
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.0170
    Cell Significance Index: -0.2100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0172
    Cell Significance Index: -0.4900
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0172
    Cell Significance Index: -0.2500
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0175
    Cell Significance Index: -0.2400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0177
    Cell Significance Index: -0.5700
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0182
    Cell Significance Index: -0.2500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0183
    Cell Significance Index: -0.6000
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0192
    Cell Significance Index: -0.2300
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: -0.0192
    Cell Significance Index: -0.1800
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0200
    Cell Significance Index: -0.2300
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0203
    Cell Significance Index: -0.2700
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0210
    Cell Significance Index: -0.2500
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0222
    Cell Significance Index: -0.2300
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0225
    Cell Significance Index: -0.3200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0229
    Cell Significance Index: -0.5700
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: -0.0236
    Cell Significance Index: -0.1800
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0242
    Cell Significance Index: -0.3100
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.0243
    Cell Significance Index: -0.3400
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0245
    Cell Significance Index: -0.3300
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0246
    Cell Significance Index: -0.2600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0259
    Cell Significance Index: -0.5200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0259
    Cell Significance Index: -0.9100
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.0260
    Cell Significance Index: -0.3000
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0262
    Cell Significance Index: -0.3100
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0265
    Cell Significance Index: -0.3400
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0266
    Cell Significance Index: -0.2500
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0268
    Cell Significance Index: -0.5300
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0273
    Cell Significance Index: -0.2800
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.0279
    Cell Significance Index: -0.3400
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0284
    Cell Significance Index: -0.3300
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0287
    Cell Significance Index: -0.3300
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.0288
    Cell Significance Index: -0.3500
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0288
    Cell Significance Index: -0.3400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0292
    Cell Significance Index: -0.6200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0293
    Cell Significance Index: -0.4900
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0304
    Cell Significance Index: -0.5300
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0308
    Cell Significance Index: -0.3300
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0308
    Cell Significance Index: -0.2600
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.0308
    Cell Significance Index: -0.1900
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0313
    Cell Significance Index: -0.3700
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0313
    Cell Significance Index: -0.3300
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0316
    Cell Significance Index: -0.3500
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0321
    Cell Significance Index: -0.3500
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0322
    Cell Significance Index: -0.3600
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0337
    Cell Significance Index: -0.4000
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0337
    Cell Significance Index: -0.3400
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: -0.0339
    Cell Significance Index: -0.3800
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0343
    Cell Significance Index: -0.3000
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0348
    Cell Significance Index: -0.3300
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0351
    Cell Significance Index: -0.4600
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0353
    Cell Significance Index: -0.4600
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0368
    Cell Significance Index: -0.4900
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.0370
    Cell Significance Index: -0.4300
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0383
    Cell Significance Index: -0.4800
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0392
    Cell Significance Index: -0.4000
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0399
    Cell Significance Index: -0.4900
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.0414
    Cell Significance Index: -0.4400
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0419
    Cell Significance Index: -0.4800
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0436
    Cell Significance Index: -0.5500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0436
    Cell Significance Index: -0.5200
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -0.0438
    Cell Significance Index: -0.5000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CDX4 is a member of the caudal family of homeobox transcription factors, which are essential regulators of embryonic development and tissue differentiation. CDX4 is specifically expressed in various cell types, including oligodendrocyte precursor cells, microglial cells, blood vessel endothelial cells, and connective tissue cells. Its expression is also observed in male germ cells, kidney capillary endothelial cells, renal beta-intercalated cells, parietal epithelial cells, and podocytes. **Pathways and Functions:** CDX4 is involved in multiple signaling pathways, including: 1. **Animal organ morphogenesis:** CDX4 regulates the development and patterning of various organs, including the nervous system, kidney, and pancreas. 2. **Anterior/posterior axis specification:** CDX4 is essential for the establishment of the anterior/posterior axis in embryonic development. 3. **Blood vessel development:** CDX4 regulates the formation and maintenance of blood vessels, particularly in the kidney and pancreas. 4. **Cell differentiation:** CDX4 promotes the differentiation of various cell types, including immune cells. 5. **Chromatin and DNA-binding transcription activator activity:** CDX4 interacts with chromatin and regulates the transcription of target genes. **Clinical Significance:** CDX4 has been implicated in several immunological disorders, including: 1. **Multiple sclerosis:** CDX4 has been shown to be overexpressed in the brains of patients with multiple sclerosis, a chronic autoimmune disease characterized by demyelination and axonal damage. 2. **Rheumatoid arthritis:** CDX4 has been implicated in the pathogenesis of rheumatoid arthritis, a chronic autoimmune disease characterized by inflammation and joint damage. 3. **Kidney disease:** CDX4 has been shown to be involved in the development of kidney disease, particularly in the context of diabetic nephropathy. In conclusion, CDX4 is a transcription factor with a wide range of functions in immunology and beyond. Its dysregulation has been implicated in several immunological disorders, highlighting the importance of further investigation into the role of CDX4 in human disease. **Future Directions:** 1. **Immunomodulatory effects:** The immunomodulatory effects of CDX4 on immune cells, particularly in the context of autoimmune diseases, warrant further investigation. 2. **Targeted therapies:** The development of targeted therapies that modulate CDX4 activity may provide new therapeutic options for immunological disorders. 3. **Gene therapy:** Gene therapy approaches that aim to restore CDX4 expression in diseased tissues may offer new avenues for treatment. In summary, CDX4 is a multifunctional transcription factor that plays a crucial role in various cellular processes, including cell differentiation, development, and immune responses. Further investigation into the role of CDX4 in immunology and disease is essential for the development of new therapeutic strategies.

Genular Protein ID: 1172628620

Symbol: CDX4_HUMAN

Name: Homeobox protein CDX-4

UniProtKB Accession Codes:

O14627 A1A513 Q5JS20

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 1 GO 16 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 284
  • Mass: 30480
  • Checksum: 96D365D9F5F6D6D7
  • Sequence:
    • MYGSCLLEKE AGMYPGTLMS PGGDGTAGTG GTGGGGSPMP ASNFAAAPAF SHYMGYPHMP 
SMDPHWPSLG VWGSPYSPPR EDWSVYPGPS STMGTVPVND VTSSPAAFCS TDYSNLGPVG 
GGTSGSSLPG QAGGSLVPTD AGAAKASSPS RSRHSPYAWM RKTVQVTGKT RTKEKYRVVY 
TDHQRLELEK EFHCNRYITI QRKSELAVNL GLSERQVKIW FQNRRAKERK MIKKKISQFE 
NSGGSVQSDS DSISPGELPN TFFTTPSAVR GFQPIEIQQV IVSE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.