Details for: CDX4

Gene ID: 1046

Symbol: CDX4

Ensembl ID: ENSG00000131264

Description: caudal type homeobox 4

Associated with

  • Animal organ morphogenesis
    (GO:0009887)
  • Anterior/posterior axis specification
    (GO:0009948)
  • Blood vessel development
    (GO:0001568)
  • Cell differentiation
    (GO:0030154)
  • Chromatin
    (GO:0000785)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Embryo development
    (GO:0009790)
  • Labyrinthine layer development
    (GO:0060711)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nucleus
    (GO:0005634)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 6.62
    Marker Score: 8193
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 3.71
    Marker Score: 6759
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 3.14
    Marker Score: 3164
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 2.13
    Marker Score: 552
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.72
    Marker Score: 554
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.71
    Marker Score: 492.5
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.58
    Marker Score: 495.5
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 1.56
    Marker Score: 493.5
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.36
    Marker Score: 495.5
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.35
    Marker Score: 498.5
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 1.2
    Marker Score: 549
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.19
    Marker Score: 496.5
  • Cell Name: Unknown (CL0000003)
    Fold Change: 1.19
    Marker Score: 3663
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7690
  • Cell Name: pericyte (CL0000669)
    Fold Change: 1.01
    Marker Score: 588
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 0.99
    Marker Score: 71406
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47631
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30390
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.96
    Marker Score: 1552.5
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.95
    Marker Score: 420.5
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5336
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.92
    Marker Score: 486.5
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.92
    Marker Score: 496.5
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.9
    Marker Score: 472.5
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.88
    Marker Score: 497.5
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5291
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.87
    Marker Score: 480.5
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.82
    Marker Score: 393.5
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.81
    Marker Score: 471.5
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.81
    Marker Score: 735
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.79
    Marker Score: 493.5
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.78
    Marker Score: 406
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.73
    Marker Score: 485.5
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.73
    Marker Score: 479.5
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.69
    Marker Score: 1316
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.69
    Marker Score: 551
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.68
    Marker Score: 714
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.63
    Marker Score: 483.5
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.62
    Marker Score: 479
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.59
    Marker Score: 495.5
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.58
    Marker Score: 554
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.57
    Marker Score: 496.5
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.57
    Marker Score: 3666
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.56
    Marker Score: 1136
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.52
    Marker Score: 467
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.49
    Marker Score: 296
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.48
    Marker Score: 286
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.46
    Marker Score: 443
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.46
    Marker Score: 463.5
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.4
    Marker Score: 421
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.39
    Marker Score: 439
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.38
    Marker Score: 493.5
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.37
    Marker Score: 434
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.36
    Marker Score: 3664
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.35
    Marker Score: 494.5
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.34
    Marker Score: 706
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.33
    Marker Score: 5236
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.32
    Marker Score: 552
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.31
    Marker Score: 545
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.29
    Marker Score: 495.5
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.28
    Marker Score: 1677
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.22
    Marker Score: 299.5
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.21
    Marker Score: 494.5
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.19
    Marker Score: 454
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.14
    Marker Score: 299
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.14
    Marker Score: 500
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.14
    Marker Score: 554
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.13
    Marker Score: 361.5
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.07
    Marker Score: 130
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.06
    Marker Score: 97
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.01
    Marker Score: 499.5
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.01
    Marker Score: 488.5
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.01
    Marker Score: 485.5

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Other Information

**Key characteristics:** * The CDX4 gene is a member of the homeobox family of transcription factors. * The homeodomain of CDX4 is a DNA-binding protein that is responsible for the regulation of gene expression. * CDX4 is a key regulator of the development of the central nervous system. * Mutations in the CDX4 gene have been linked to a number of neurological disorders, including autism and schizophrenia. **Pathways and functions:** * CDX4 is a key regulator of the development of the central nervous system. * The gene is expressed in oligodendrocytes, which are a type of neuron that is responsible for the development of the brain and spinal cord. * CDX4 binds to DNA sequences that are involved in the regulation of oligodendrocyte development. * This binding leads to the activation of transcription factors that promote the expression of genes that are involved in oligodendrocyte differentiation and survival. * CDX4 also binds to DNA sequences that are involved in the regulation of glial cells. * This binding leads to the activation of transcription factors that promote the expression of genes that are involved in glial cell differentiation and survival. **Clinical significance:** * Mutations in the CDX4 gene have been linked to a number of neurological disorders, including autism and schizophrenia. * These disorders are characterized by a number of symptoms, including intellectual disability, social awkwardness, and difficulty with communication. * CDX4 is a potential target for therapy in these disorders. * By understanding the role of CDX4 in brain development, it may be possible to develop new treatments for these disorders.

Genular Protein ID: 1172628620

Symbol: CDX4_HUMAN

Name: Homeobox protein CDX-4

UniProtKB Accession Codes:

O14627 A1A513 Q5JS20

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 1 GO 16 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 284
  • Mass: 30480
  • Checksum: 96D365D9F5F6D6D7
  • Sequence:
    • MYGSCLLEKE AGMYPGTLMS PGGDGTAGTG GTGGGGSPMP ASNFAAAPAF SHYMGYPHMP 
SMDPHWPSLG VWGSPYSPPR EDWSVYPGPS STMGTVPVND VTSSPAAFCS TDYSNLGPVG 
GGTSGSSLPG QAGGSLVPTD AGAAKASSPS RSRHSPYAWM RKTVQVTGKT RTKEKYRVVY 
TDHQRLELEK EFHCNRYITI QRKSELAVNL GLSERQVKIW FQNRRAKERK MIKKKISQFE 
NSGGSVQSDS DSISPGELPN TFFTTPSAVR GFQPIEIQQV IVSE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.