Details for: MERTK

Gene ID: 10461

Symbol: MERTK

Ensembl ID: ENSG00000153208

Description: MER proto-oncogene, tyrosine kinase

Associated with

Other Information

Genular Protein ID: 432685175

Symbol: MERTK_HUMAN

Name: Tyrosine-protein kinase Mer

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8086340

Title: Cloning and mRNA expression analysis of a novel human protooncogene, c-mer.

PubMed ID: 8086340

PubMed ID: 11062461

Title: Mutations in MERTK, the human orthologue of the RCS rat retinal dystrophy gene, cause retinitis pigmentosa.

PubMed ID: 11062461

DOI: 10.1038/81555

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 8702477

Title: Identification of the major autophosphorylation sites of Nyk/Mer, an NCAM-related receptor tyrosine kinase.

PubMed ID: 8702477

DOI: 10.1074/jbc.271.31.18355

PubMed ID: 9160883

Title: Identification of Gas6 as a ligand for Mer, a neural cell adhesion molecule related receptor tyrosine kinase implicated in cellular transformation.

PubMed ID: 9160883

DOI: 10.1038/sj.onc.1201039

PubMed ID: 12920122

Title: An SH2 domain-dependent, phosphotyrosine-independent interaction between Vav1 and the Mer receptor tyrosine kinase: a mechanism for localizing guanine nucleotide-exchange factor action.

PubMed ID: 12920122

DOI: 10.1074/jbc.m305817200

PubMed ID: 16288044

Title: Activated tyrosine kinase Ack1 promotes prostate tumorigenesis: role of Ack1 in polyubiquitination of tumor suppressor Wwox.

PubMed ID: 16288044

DOI: 10.1158/0008-5472.can-05-1127

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 16737840

Title: Signalling and functional diversity within the Axl subfamily of receptor tyrosine kinases.

PubMed ID: 16737840

DOI: 10.1016/j.cytogfr.2006.04.004

PubMed ID: 17005688

Title: Tyro3 family-mediated cell entry of Ebola and Marburg viruses.

PubMed ID: 17005688

DOI: 10.1128/jvi.01157-06

PubMed ID: 18421305

Title: Immunobiology of the TAM receptors.

PubMed ID: 18421305

DOI: 10.1038/nri2303

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 21792939

Title: Galectin-3 is a new MerTK-specific eat-me signal.

PubMed ID: 21792939

DOI: 10.1002/jcp.22955

PubMed ID: 32640697

Title: Mertk Interacts with Tim-4 to Enhance Tim-4-Mediated Efferocytosis.

PubMed ID: 32640697

DOI: 10.3390/cells9071625

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

PubMed ID: 21602930

Title: Detection of variants in 15 genes in 87 unrelated Chinese patients with Leber congenital amaurosis.

PubMed ID: 21602930

DOI: 10.1371/journal.pone.0019458

Sequence Information:

  • Length: 999
  • Mass: 110249
  • Checksum: 05BC339F05DFD355
  • Sequence:
  • MGPAPLPLLL GLFLPALWRR AITEAREEAK PYPLFPGPFP GSLQTDHTPL LSLPHASGYQ 
    PALMFSPTQP GRPHTGNVAI PQVTSVESKP LPPLAFKHTV GHIILSEHKG VKFNCSISVP 
    NIYQDTTISW WKDGKELLGA HHAITQFYPD DEVTAIIASF SITSVQRSDN GSYICKMKIN 
    NEEIVSDPIY IEVQGLPHFT KQPESMNVTR NTAFNLTCQA VGPPEPVNIF WVQNSSRVNE 
    QPEKSPSVLT VPGLTEMAVF SCEAHNDKGL TVSKGVQINI KAIPSPPTEV SIRNSTAHSI 
    LISWVPGFDG YSPFRNCSIQ VKEADPLSNG SVMIFNTSAL PHLYQIKQLQ ALANYSIGVS 
    CMNEIGWSAV SPWILASTTE GAPSVAPLNV TVFLNESSDN VDIRWMKPPT KQQDGELVGY 
    RISHVWQSAG ISKELLEEVG QNGSRARISV QVHNATCTVR IAAVTRGGVG PFSDPVKIFI 
    PAHGWVDYAP SSTPAPGNAD PVLIIFGCFC GFILIGLILY ISLAIRKRVQ ETKFGNAFTE 
    EDSELVVNYI AKKSFCRRAI ELTLHSLGVS EELQNKLEDV VIDRNLLILG KILGEGEFGS 
    VMEGNLKQED GTSLKVAVKT MKLDNSSQRE IEEFLSEAAC MKDFSHPNVI RLLGVCIEMS 
    SQGIPKPMVI LPFMKYGDLH TYLLYSRLET GPKHIPLQTL LKFMVDIALG MEYLSNRNFL 
    HRDLAARNCM LRDDMTVCVA DFGLSKKIYS GDYYRQGRIA KMPVKWIAIE SLADRVYTSK 
    SDVWAFGVTM WEIATRGMTP YPGVQNHEMY DYLLHGHRLK QPEDCLDELY EIMYSCWRTD 
    PLDRPTFSVL RLQLEKLLES LPDVRNQADV IYVNTQLLES SEGLAQGSTL APLDLNIDPD 
    SIIASCTPRA AISVVTAEVH DSKPHEGRYI LNGGSEEWED LTSAPSAAVT AEKNSVLPGE 
    RLVRNGVSWS HSSMLPLGSS LPDELLFADD SSEGSEVLM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.