Details for: COG5

Gene ID: 10466

Symbol: COG5

Ensembl ID: ENSG00000164597

Description: component of oligomeric golgi complex 5

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 4.14
    Marker Score: 5,824
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 3.57
    Marker Score: 79,741
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 2.58
    Marker Score: 1,501
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.57
    Marker Score: 54,778
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 2.55
    Marker Score: 3,085
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 2.55
    Marker Score: 1,768
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 2.53
    Marker Score: 5,552
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 2.52
    Marker Score: 3,384
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.5
    Marker Score: 2,833
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.47
    Marker Score: 49,192
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 2.45
    Marker Score: 4,712
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 2.45
    Marker Score: 11,316
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.42
    Marker Score: 10,142
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 2.36
    Marker Score: 1,243
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.35
    Marker Score: 35,080
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 2.31
    Marker Score: 762
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.31
    Marker Score: 85,045
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.29
    Marker Score: 17,538
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.27
    Marker Score: 2,613
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 2.24
    Marker Score: 1,936
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 2.24
    Marker Score: 645
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.21
    Marker Score: 83,962
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 2.2
    Marker Score: 644
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 2.15
    Marker Score: 7,630
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.14
    Marker Score: 1,251
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 2.13
    Marker Score: 2,356
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 2.12
    Marker Score: 1,630
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 2.1
    Marker Score: 1,864
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 2.1
    Marker Score: 1,042
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 2.07
    Marker Score: 8,638
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.06
    Marker Score: 8,527
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.03
    Marker Score: 36,013
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2
    Marker Score: 7,743
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.98
    Marker Score: 121,485
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.95
    Marker Score: 18,360
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.9
    Marker Score: 3,320
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.9
    Marker Score: 1,132
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.88
    Marker Score: 2,344
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.86
    Marker Score: 674
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.85
    Marker Score: 916
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.81
    Marker Score: 3,034
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 1.81
    Marker Score: 1,359
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.77
    Marker Score: 18,322
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.77
    Marker Score: 16,789
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 1.76
    Marker Score: 980
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.76
    Marker Score: 737
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 1.75
    Marker Score: 1,441
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.75
    Marker Score: 15,025
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.75
    Marker Score: 4,373
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.71
    Marker Score: 541
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.69
    Marker Score: 4,827
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 1.68
    Marker Score: 912
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.65
    Marker Score: 924
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.65
    Marker Score: 1,779
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.65
    Marker Score: 26,417
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.63
    Marker Score: 3,908
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 1.63
    Marker Score: 517
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.63
    Marker Score: 6,626
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 1.62
    Marker Score: 717
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.58
    Marker Score: 2,445
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.54
    Marker Score: 1,016
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 1.5
    Marker Score: 549
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.5
    Marker Score: 839
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.48
    Marker Score: 378
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.46
    Marker Score: 1,389
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.45
    Marker Score: 1,256
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 1.44
    Marker Score: 456
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 1.44
    Marker Score: 945
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.42
    Marker Score: 1,750
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 1.41
    Marker Score: 365
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.38
    Marker Score: 1,666
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.38
    Marker Score: 377
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 1.38
    Marker Score: 7,218
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.35
    Marker Score: 498
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.31
    Marker Score: 477
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 1.3
    Marker Score: 4,274
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.28
    Marker Score: 1,815
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.26
    Marker Score: 1,838
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 1.25
    Marker Score: 884
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.23
    Marker Score: 597
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.22
    Marker Score: 1,305
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.18
    Marker Score: 442
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 1.18
    Marker Score: 310
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.14
    Marker Score: 390
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.14
    Marker Score: 4,037
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 1.12
    Marker Score: 582
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.12
    Marker Score: 424
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.12
    Marker Score: 37,865
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 1.11
    Marker Score: 225
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.1
    Marker Score: 2,591
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.09
    Marker Score: 7,024
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.06
    Marker Score: 1,122
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.05
    Marker Score: 1,101
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.04
    Marker Score: 4,476
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 1.02
    Marker Score: 323
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,676
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1
    Marker Score: 598
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47,902
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 0.98
    Marker Score: 5,270
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,388

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern:** COG5 is highly expressed in various cell types, including chromaffin cells, cardiac myocytes, corneal endothelial cells, and astrocytes of the cerebral cortex. 2. **Subcellular Localization:** The COG5 protein is predominantly localized to the Golgi apparatus, where it interacts with other proteins to form the oligomeric Golgi complex. 3. **Function:** COG5 is involved in the assembly and function of the oligomeric Golgi complex, which is essential for protein glycosylation, transport, and retrograde trafficking. 4. **Disease Association:** Mutations in the COG5 gene have been associated with autosomal recessive polycystic kidney disease (ARPKD), a rare genetic disorder characterized by the development of cysts in the kidneys. **Pathways and Functions:** 1. **Asparagine N-Linked Glycosylation:** COG5 is involved in the assembly of the oligomeric Golgi complex, which is necessary for the efficient glycosylation of proteins. 2. **CopI-mediated Anterograde Transport:** COG5 interacts with CopI, a protein complex involved in the transport of proteins from the endoplasmic reticulum to the Golgi apparatus. 3. **Glycosylation:** COG5 is necessary for the proper glycosylation of proteins, which is essential for their function and stability. 4. **Retrograde Transport:** COG5 is involved in the retrograde transport of proteins from the Golgi apparatus to the endoplasmic reticulum, which is essential for protein degradation and recycling. **Clinical Significance:** 1. **Autosomal Recessive Polycystic Kidney Disease (ARPKD):** Mutations in the COG5 gene have been associated with ARPKD, a rare genetic disorder characterized by the development of cysts in the kidneys. 2. **Protein Glycosylation Defects:** COG5 mutations can lead to defects in protein glycosylation, which can result in various diseases, including cancer and metabolic disorders. 3. **Golgi Apparatus Dysfunction:** COG5 mutations can also lead to dysfunction of the Golgi apparatus, which can result in various cellular processes, including protein secretion and cell signaling. 4. **Therapeutic Opportunities:** Understanding the function of COG5 and its role in human disease can lead to the development of new therapeutic strategies, including gene therapy and small molecule inhibitors of COG5. In conclusion, the COG5 gene is a critical component of the oligomeric Golgi complex, and its dysfunction can lead to various diseases, including ARPKD and protein glycosylation defects. Further research is necessary to fully understand the function of COG5 and its role in human disease, which can lead to the development of new therapeutic strategies.

Genular Protein ID: 1706403850

Symbol: COG5_HUMAN

Name: 13S Golgi transport complex 90 kDa subunit

UniProtKB Accession Codes:

Q9UP83 A4D0R6 A4D0R7 O14555 O95008 Q6NUL5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 EPD 1 Ensembl 3 ExpressionAtlas 1 GO 13 GeneCards 1 GeneReviews 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 3 RefSeq 3 SAM 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9792665

Title: Purification and characterization of a novel 13 S hetero-oligomeric protein complex that stimulates in vitro Golgi transport.

PubMed ID: 9792665

DOI: 10.1074/jbc.273.45.29565

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19690088

Title: Deficiency in COG5 causes a moderate form of congenital disorders of glycosylation.

PubMed ID: 19690088

DOI: 10.1093/hmg/ddp389

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 860
  • Mass: 94901
  • Checksum: CE98BD7F82CB7D82
  • Sequence:
    • MGWVGGRRRD SASPPGRSRS AADDINPAPA NMEGGGGSVA VAGLGARGSG AAAATVRELL 
QDGCYSDFLN EDFDVKTYTS QSIHQAVIAE QLAKLAQGIS QLDRELHLQV VARHEDLLAQ 
ATGIESLEGV LQMMQTRIGA LQGAVDRIKA KIVEPYNKIV ARTAQLARLQ VACDLLRRII 
RILNLSKRLQ GQLQGGSREI TKAAQSLNEL DYLSQGIDLS GIEVIENDLL FIARARLEVE 
NQAKRLLEQG LETQNPTQVG TALQVFYNLG TLKDTITSVV DGYCATLEEN INSALDIKVL 
TQPSQSAVRG GPGRSTMPTP GNTAALRASF WTNMEKLMDH IYAVCGQVQH LQKVLAKKRD 
PVSHICFIEE IVKDGQPEIF YTFWNSVTQA LSSQFHMATN SSMFLKQAFE GEYPKLLRLY 
NDLWKRLQQY SQHIQGNFNA SGTTDLYVDL QHMEDDAQDI FIPKKPDYDP EKALKDSLQP 
YEAAYLSKSL SRLFDPINLV FPPGGRNPPS SDELDGIIKT IASELNVAAV DTNLTLAVSK 
NVAKTIQLYS VKSEQLLSTQ GDASQVIGPL TEGQRRNVAV VNSLYKLHQS VTKVVSSQSS 
FPLAAEQTII SALKAIHALM ENAVQPLLTS VGDAIEAIII TMHQEDFSGS LSSSGKPDVP 
CSLYMKELQG FIARVMSDYF KHFECLDFVF DNTEAIAQRA VELFIRHASL IRPLGEGGKM 
RLAADFAQME LAVGPFCRRV SDLGKSYRML RSFRPLLFQA SEHVASSPAL GDVIPFSIII 
QFLFTRAPAE LKSPFQRAEW SHTRFSQWLD DHPSEKDRLL LIRGALEAYV QSVRSREGKE 
FAPVYPIMVQ LLQKAMSALQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.