Details for: CLGN

Gene ID: 1047

Symbol: CLGN

Ensembl ID: ENSG00000153132

Description: calmegin

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 97.0136
    Cell Significance Index: -15.0900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 52.4753
    Cell Significance Index: -13.3100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 12.9930
    Cell Significance Index: -12.4100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 12.7823
    Cell Significance Index: -15.7600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 1.9160
    Cell Significance Index: 117.4700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.0512
    Cell Significance Index: 58.9900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6994
    Cell Significance Index: 133.1100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.5900
    Cell Significance Index: 8.8400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.5879
    Cell Significance Index: 45.1200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4781
    Cell Significance Index: 47.2900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.4160
    Cell Significance Index: 8.8600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.4003
    Cell Significance Index: 25.2300
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.3256
    Cell Significance Index: 3.3700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3169
    Cell Significance Index: 286.1700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3105
    Cell Significance Index: 111.3700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3004
    Cell Significance Index: 59.6200
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.2982
    Cell Significance Index: 6.8900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2661
    Cell Significance Index: 53.3700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2397
    Cell Significance Index: 165.7700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2386
    Cell Significance Index: 25.9500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2351
    Cell Significance Index: 38.2400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2112
    Cell Significance Index: 12.6800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2062
    Cell Significance Index: 112.6200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.2025
    Cell Significance Index: 2.9900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1892
    Cell Significance Index: 5.4500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1689
    Cell Significance Index: 5.8700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1619
    Cell Significance Index: 8.5000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1617
    Cell Significance Index: 7.3300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1017
    Cell Significance Index: 11.8500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0834
    Cell Significance Index: 5.7700
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0569
    Cell Significance Index: 0.8800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0296
    Cell Significance Index: 1.0400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0152
    Cell Significance Index: 0.2600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0098
    Cell Significance Index: 18.4500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0083
    Cell Significance Index: 0.1800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0071
    Cell Significance Index: 1.2200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0015
    Cell Significance Index: 1.1300
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0009
    Cell Significance Index: -0.0400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0017
    Cell Significance Index: -1.0400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0061
    Cell Significance Index: -0.7800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0080
    Cell Significance Index: -0.4900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0081
    Cell Significance Index: -5.1400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0110
    Cell Significance Index: -20.3700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0117
    Cell Significance Index: -18.0700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0120
    Cell Significance Index: -6.7700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0124
    Cell Significance Index: -5.6400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0145
    Cell Significance Index: -0.3700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0151
    Cell Significance Index: -20.5100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0152
    Cell Significance Index: -3.2000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0179
    Cell Significance Index: -0.5000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0192
    Cell Significance Index: -14.5600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0305
    Cell Significance Index: -2.0500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0404
    Cell Significance Index: -11.6200
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0442
    Cell Significance Index: -0.3400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0477
    Cell Significance Index: -6.9300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0521
    Cell Significance Index: -9.4000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0654
    Cell Significance Index: -0.7800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0716
    Cell Significance Index: -5.3400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0761
    Cell Significance Index: -7.7700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0805
    Cell Significance Index: -1.6700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0878
    Cell Significance Index: -10.7900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0935
    Cell Significance Index: -2.5000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0951
    Cell Significance Index: -11.2100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0990
    Cell Significance Index: -13.5900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1059
    Cell Significance Index: -12.1400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1061
    Cell Significance Index: -2.2200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1081
    Cell Significance Index: -12.3400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1194
    Cell Significance Index: -15.4300
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.1213
    Cell Significance Index: -0.7200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1240
    Cell Significance Index: -5.7800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1256
    Cell Significance Index: -3.1400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1296
    Cell Significance Index: -4.1500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1424
    Cell Significance Index: -14.8300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1650
    Cell Significance Index: -7.3000
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.2153
    Cell Significance Index: -1.8300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2213
    Cell Significance Index: -8.3800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2217
    Cell Significance Index: -11.5500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2295
    Cell Significance Index: -11.9200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2387
    Cell Significance Index: -15.4000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2470
    Cell Significance Index: -6.3500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2650
    Cell Significance Index: -3.0100
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.2698
    Cell Significance Index: -3.4600
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.2998
    Cell Significance Index: -4.1600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3013
    Cell Significance Index: -8.8800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3077
    Cell Significance Index: -8.0900
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.3095
    Cell Significance Index: -5.1000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3178
    Cell Significance Index: -14.9400
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.3352
    Cell Significance Index: -8.3600
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.3484
    Cell Significance Index: -4.9500
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -0.3521
    Cell Significance Index: -4.9500
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.3572
    Cell Significance Index: -2.4200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3616
    Cell Significance Index: -13.2800
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.3664
    Cell Significance Index: -5.2500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3678
    Cell Significance Index: -8.8200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.3763
    Cell Significance Index: -5.6700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3822
    Cell Significance Index: -10.2400
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.3851
    Cell Significance Index: -4.3600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4007
    Cell Significance Index: -13.1200
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.4104
    Cell Significance Index: -5.7600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4108
    Cell Significance Index: -14.3900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** Calmegin is a calcium-binding protein that interacts with calmodulin, a calcium-modulated protein that regulates numerous cellular processes. Calmegin is predominantly expressed in specific cell types, including double-negative thymocytes, Mueller cells, mural cells, primitive red blood cells, intestinal crypt stem cells, and GABAergic interneurons. Its expression pattern suggests a specialized role in maintaining tissue homeostasis and regulating cell signaling pathways. **Pathways and Functions:** Calmegin is involved in several cellular pathways, including: 1. **Fertilization**: Calmegin is expressed in sperm and plays a crucial role in the binding of sperm to the zona pellucida, a glycoprotein layer surrounding the egg. 2. **Calcium ion binding**: Calmegin binds to calcium ions, which triggers a cascade of signaling events that regulate various cellular processes. 3. **Endoplasmic reticulum (ER) function**: Calmegin is localized to the ER membrane and is involved in the assembly and folding of proteins. 4. **Protein-containing complex assembly**: Calmegin interacts with other proteins to form complexes that regulate cellular processes, such as cell signaling and protein folding. 5. **Unfolded protein binding**: Calmegin binds to unfolded proteins, which is essential for protein folding and quality control in the ER. **Clinical Significance:** Calmegin's involvement in fertilization and cell signaling pathways makes it a potential target for therapeutic interventions in reproductive disorders, such as infertility and miscarriage. Additionally, its role in maintaining tissue homeostasis and regulating cell signaling pathways suggests that Calmegin may be involved in various diseases, including cancer, neurodegenerative disorders, and autoimmune diseases. In conclusion, Calmegin is a multifunctional protein that plays a critical role in fertilization, cell signaling, and tissue homeostasis. Further research is necessary to fully elucidate its mechanisms of action and to explore its potential therapeutic applications. **Implications for Immunology:** Calmegin's involvement in cell signaling pathways and immune cell function (e.g., GABAergic interneurons) suggests that it may play a role in modulating immune responses. Further studies are needed to investigate the immunological implications of Calmegin and its potential as a biomarker or therapeutic target in immune-related disorders. **Future Directions:** 1. **Functional studies**: Investigate the specific mechanisms by which Calmegin regulates fertilization, cell signaling, and tissue homeostasis. 2. **Clinical studies**: Explore the potential therapeutic applications of Calmegin in reproductive disorders and other diseases. 3. **Immunological studies**: Investigate the role of Calmegin in immune cell function and its potential as a biomarker or therapeutic target in immune-related disorders.

Genular Protein ID: 2904819561

Symbol: CLGN_HUMAN

Name: Calmegin

UniProtKB Accession Codes:

O14967 B3KS90 B4DXV8 D3DNY8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 2 ExpressionAtlas 1 GO 10 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9434179

Title: Cloning and characterization of the human Calmegin gene encoding putative testis-specific chaperone.

PubMed ID: 9434179

DOI: 10.1016/s0378-1119(97)00537-4

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 17507649

Title: A developmentally regulated chaperone complex for the endoplasmic reticulum of male haploid germ cells.

PubMed ID: 17507649

DOI: 10.1091/mbc.e07-02-0147

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 610
  • Mass: 70039
  • Checksum: F024FC4010D42D7E
  • Sequence:
    • MHFQAFWLCL GLLFISINAE FMDDDVETED FEENSEEIDV NESELSSEIK YKTPQPIGEV 
YFAETFDSGR LAGWVLSKAK KDDMDEEISI YDGRWEIEEL KENQVPGDRG LVLKSRAKHH 
AISAVLAKPF IFADKPLIVQ YEVNFQDGID CGGAYIKLLA DTDDLILENF YDKTSYIIMF 
GPDKCGEDYK LHFIFRHKHP KTGVFEEKHA KPPDVDLKKF FTDRKTHLYT LVMNPDDTFE 
VLVDQTVVNK GSLLEDVVPP IKPPKEIEDP NDKKPEEWDE RAKIPDPSAV KPEDWDESEP 
AQIEDSSVVK PAGWLDDEPK FIPDPNAEKP DDWNEDTDGE WEAPQILNPA CRIGCGEWKP 
PMIDNPKYKG VWRPPLVDNP NYQGIWSPRK IPNPDYFEDD HPFLLTSFSA LGLELWSMTS 
DIYFDNFIIC SEKEVADHWA ADGWRWKIMI ANANKPGVLK QLMAAAEGHP WLWLIYLVTA 
GVPIALITSF CWPRKVKKKH KDTEYKKTDI CIPQTKGVLE QEEKEEKAAL EKPMDLEEEK 
KQNDGEMLEK EEESEPEEKS EEEIEIIEGQ EESNQSNKSG SEDEMKEADE STGSGDGPIK 
SVRKRRVRKD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.