Details for: CLGN

Gene ID: 1047

Symbol: CLGN

Ensembl ID: ENSG00000153132

Description: calmegin

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.95
    Marker Score: 2689
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 1.78
    Marker Score: 2467
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.48
    Marker Score: 169387
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 1.31
    Marker Score: 979
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 850
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.23
    Marker Score: 715
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.21
    Marker Score: 876
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.17
    Marker Score: 26196
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4806
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71817
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48042
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 505
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 458
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5331
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.93
    Marker Score: 386
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 370
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2736
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 322
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5284
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.84
    Marker Score: 190
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.82
    Marker Score: 628
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.82
    Marker Score: 12775
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1259
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 705
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.76
    Marker Score: 306
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 392
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 458
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.71
    Marker Score: 7357
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 175
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.66
    Marker Score: 2330
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.65
    Marker Score: 2530
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.6
    Marker Score: 1044
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.58
    Marker Score: 35686
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.58
    Marker Score: 5034
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.57
    Marker Score: 2371
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.57
    Marker Score: 1174
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.56
    Marker Score: 804
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 441
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.55
    Marker Score: 161
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.55
    Marker Score: 361
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.54
    Marker Score: 1867
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 171
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.53
    Marker Score: 361
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.52
    Marker Score: 443
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.51
    Marker Score: 244
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.49
    Marker Score: 480
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.48
    Marker Score: 447
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.47
    Marker Score: 4056
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.45
    Marker Score: 203
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.44
    Marker Score: 1795
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.43
    Marker Score: 189
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.43
    Marker Score: 736
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.42
    Marker Score: 681
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.42
    Marker Score: 156
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.41
    Marker Score: 774.5
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 0.4
    Marker Score: 564
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.38
    Marker Score: 137
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.38
    Marker Score: 1475
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.38
    Marker Score: 375
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.37
    Marker Score: 394
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.37
    Marker Score: 3492
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.36
    Marker Score: 13794
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.36
    Marker Score: 757
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.36
    Marker Score: 12544
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.36
    Marker Score: 403
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.36
    Marker Score: 358
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 0.36
    Marker Score: 117
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.35
    Marker Score: 112
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.35
    Marker Score: 222
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.35
    Marker Score: 101
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.35
    Marker Score: 2678
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 0.34
    Marker Score: 203
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.34
    Marker Score: 282
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.34
    Marker Score: 1378
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.33
    Marker Score: 178
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.33
    Marker Score: 156
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.33
    Marker Score: 302
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.33
    Marker Score: 661
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.32
    Marker Score: 85
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.31
    Marker Score: 160
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.3
    Marker Score: 286
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.3
    Marker Score: 2829
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.3
    Marker Score: 112
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 0.29
    Marker Score: 978
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.29
    Marker Score: 352
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.29
    Marker Score: 3873
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.28
    Marker Score: 303
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.27
    Marker Score: 602
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.27
    Marker Score: 1142
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.27
    Marker Score: 140
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.27
    Marker Score: 766
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.27
    Marker Score: 507
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.26
    Marker Score: 89
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.26
    Marker Score: 165
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.26
    Marker Score: 122
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.26
    Marker Score: 733
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.25
    Marker Score: 113
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.25
    Marker Score: 482

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Other Information

**Key characteristics:** * The CLGN gene is located on chromosome 15q21.1. * It is a large gene, encoding a protein of 1,283 amino acids. * The protein is a calcium-binding protein that is expressed in high levels in cells that are involved in spermatogenesis and fertilization. * CLGN is also expressed in a number of other cell types, including immune cells, neurons, and epithelial cells. * The protein is involved in a variety of cellular processes, including cell migration, adhesion, and differentiation. * CLGN is a key regulator of sperm binding to the zona pellucida, a glycoprotein that is found on the surface of the egg. * The protein is also involved in the regulation of calcium signaling, which is a process that is essential for a variety of cellular processes, including fertilization and cell division. **Pathways and functions:** * CLGN is involved in the binding of sperm to the zona pellucida. * The protein is also involved in the regulation of calcium signaling, which is a process that is essential for a variety of cellular processes, including fertilization and cell division. * CLGN is also involved in the assembly of protein complexes, which are large assemblies of proteins that are essential for a variety of cellular processes. * The protein is also involved in the folding of proteins, which is the process by which proteins are assembled into functional molecules. * CLGN is a key regulator of sperm binding to the zona pellucida, a glycoprotein that is found on the surface of the egg. * The protein is also involved in the regulation of calcium signaling, which is a process that is essential for a variety of cellular processes, including fertilization and cell division. **Clinical significance:** Mutations in the CLGN gene have been linked to a number of human diseases, including infertility, erectile dysfunction, and heart disease. These diseases are caused by mutations that disrupt the function of the CLGN protein, which can lead to problems with sperm binding, calcium signaling, and protein folding.

Genular Protein ID: 2904819561

Symbol: CLGN_HUMAN

Name: Calmegin

UniProtKB Accession Codes:

O14967 B3KS90 B4DXV8 D3DNY8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 7 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 10 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 2 SAM 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9434179

Title: Cloning and characterization of the human Calmegin gene encoding putative testis-specific chaperone.

PubMed ID: 9434179

DOI: 10.1016/s0378-1119(97)00537-4

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 17507649

Title: A developmentally regulated chaperone complex for the endoplasmic reticulum of male haploid germ cells.

PubMed ID: 17507649

DOI: 10.1091/mbc.e07-02-0147

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 610
  • Mass: 70039
  • Checksum: F024FC4010D42D7E
  • Sequence:
    • MHFQAFWLCL GLLFISINAE FMDDDVETED FEENSEEIDV NESELSSEIK YKTPQPIGEV 
YFAETFDSGR LAGWVLSKAK KDDMDEEISI YDGRWEIEEL KENQVPGDRG LVLKSRAKHH 
AISAVLAKPF IFADKPLIVQ YEVNFQDGID CGGAYIKLLA DTDDLILENF YDKTSYIIMF 
GPDKCGEDYK LHFIFRHKHP KTGVFEEKHA KPPDVDLKKF FTDRKTHLYT LVMNPDDTFE 
VLVDQTVVNK GSLLEDVVPP IKPPKEIEDP NDKKPEEWDE RAKIPDPSAV KPEDWDESEP 
AQIEDSSVVK PAGWLDDEPK FIPDPNAEKP DDWNEDTDGE WEAPQILNPA CRIGCGEWKP 
PMIDNPKYKG VWRPPLVDNP NYQGIWSPRK IPNPDYFEDD HPFLLTSFSA LGLELWSMTS 
DIYFDNFIIC SEKEVADHWA ADGWRWKIMI ANANKPGVLK QLMAAAEGHP WLWLIYLVTA 
GVPIALITSF CWPRKVKKKH KDTEYKKTDI CIPQTKGVLE QEEKEEKAAL EKPMDLEEEK 
KQNDGEMLEK EEESEPEEKS EEEIEIIEGQ EESNQSNKSG SEDEMKEADE STGSGDGPIK 
SVRKRRVRKD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.