Details for: ATP5PD

Gene ID: 10476

Symbol: ATP5PD

Ensembl ID: ENSG00000167863

Description: ATP synthase peripheral stalk subunit d

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 5.29
    Marker Score: 3,542
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 4.39
    Marker Score: 9,260
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 4.21
    Marker Score: 2,972
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 3.99
    Marker Score: 2,421
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 3.6
    Marker Score: 3,213
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 3.47
    Marker Score: 1,849
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 3.47
    Marker Score: 14,394
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 3.36
    Marker Score: 1,396
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 3.3
    Marker Score: 967
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 3.3
    Marker Score: 2,581
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 3.16
    Marker Score: 1,763
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 3.15
    Marker Score: 19,162
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 3.04
    Marker Score: 3,296
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.03
    Marker Score: 169,559
  • Cell Name: blood cell (CL0000081)
    Fold Change: 3
    Marker Score: 34,891
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 2.96
    Marker Score: 23,076
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 2.9
    Marker Score: 4,815
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 2.88
    Marker Score: 2,445
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 2.86
    Marker Score: 1,476
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 2.84
    Marker Score: 935
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 2.81
    Marker Score: 7,532
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.76
    Marker Score: 2,946
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.68
    Marker Score: 19,925
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.66
    Marker Score: 22,944
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 2.65
    Marker Score: 4,084
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 2.64
    Marker Score: 26,165
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.63
    Marker Score: 6,001
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 2.61
    Marker Score: 12,517
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 2.58
    Marker Score: 8,116
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 2.58
    Marker Score: 2,582
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 2.57
    Marker Score: 5,015
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.55
    Marker Score: 88,183
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.51
    Marker Score: 4,032
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 2.48
    Marker Score: 13,041
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 2.48
    Marker Score: 4,660
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 2.47
    Marker Score: 2,200
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 2.46
    Marker Score: 16,059
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 2.45
    Marker Score: 2,961
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 2.45
    Marker Score: 2,553
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 2.43
    Marker Score: 1,597
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.41
    Marker Score: 10,399
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.41
    Marker Score: 61,674
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 2.39
    Marker Score: 6,036
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 2.39
    Marker Score: 2,534
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 2.39
    Marker Score: 126,162
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 2.38
    Marker Score: 31,397
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 2.37
    Marker Score: 946
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 2.35
    Marker Score: 2,692
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.34
    Marker Score: 14,965
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 2.33
    Marker Score: 8,286
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 2.3
    Marker Score: 3,164
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 2.28
    Marker Score: 4,066
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.27
    Marker Score: 3,721
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 2.26
    Marker Score: 3,590
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 2.25
    Marker Score: 2,278
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 2.24
    Marker Score: 3,166
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 2.23
    Marker Score: 9,559
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.23
    Marker Score: 25,095
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.22
    Marker Score: 3,274
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.2
    Marker Score: 8,665
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 2.2
    Marker Score: 3,387
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 2.2
    Marker Score: 2,281
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 2.19
    Marker Score: 1,249
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 2.19
    Marker Score: 1,243
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 2.18
    Marker Score: 2,057
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 2.17
    Marker Score: 1,197
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 2.17
    Marker Score: 1,116
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.16
    Marker Score: 8,854
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 2.16
    Marker Score: 3,822
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 2.16
    Marker Score: 1,007
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 2.15
    Marker Score: 5,367
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 2.15
    Marker Score: 7,970
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 2.15
    Marker Score: 5,064
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 2.15
    Marker Score: 1,020
  • Cell Name: stem cell (CL0000034)
    Fold Change: 2.15
    Marker Score: 5,104
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 2.15
    Marker Score: 4,870
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.14
    Marker Score: 5,239
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 2.14
    Marker Score: 1,070
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 2.13
    Marker Score: 1,135
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.13
    Marker Score: 2,574
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.13
    Marker Score: 4,448
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 2.13
    Marker Score: 1,990
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.13
    Marker Score: 1,675
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 2.13
    Marker Score: 5,565
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.12
    Marker Score: 2,385
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 2.12
    Marker Score: 633
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 2.12
    Marker Score: 5,857
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.12
    Marker Score: 8,169
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 2.12
    Marker Score: 1,407
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.11
    Marker Score: 503
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 2.11
    Marker Score: 2,018
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 2.1
    Marker Score: 18,235
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 2.1
    Marker Score: 5,987
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 2.09
    Marker Score: 505
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.09
    Marker Score: 1,396
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 2.09
    Marker Score: 2,900
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 2.09
    Marker Score: 1,576
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.08
    Marker Score: 5,662
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 2.08
    Marker Score: 3,620
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 2.06
    Marker Score: 761

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ATP5PD is a protein that is significantly expressed in various cell types, including skeletal muscle satellite cells, pancreatic acinar cells, and myeloid dendritic cells. The gene is located on chromosome 1q42.3 and has a relatively high expression level in cells involved in energy metabolism. The protein is a part of the ATP synthase complex, which is a heteromeric enzyme composed of multiple subunits. The peripheral stalk subunit d is one of the essential subunits that interact with the F1Fo ATP synthase subunits to form the functional ATP synthase complex. **Pathways and Functions:** The ATP synthase complex, to which ATP5PD belongs, is a crucial component of the mitochondrial respiratory electron transport chain. The complex generates energy for the cell through the process of chemiosmotic coupling, where the proton motive force drives the synthesis of ATP from ADP and Pi. The ATP synthase complex is responsible for producing ATP in both oxidative and anaerobic conditions. The peripheral stalk subunit d plays a critical role in the rotational mechanism of the ATP synthase complex, which is essential for the production of ATP. The ATP synthase complex is also involved in various cellular processes, including: * Cristae formation: The ATP synthase complex is involved in the formation of the cristae, the infoldings of the mitochondrial inner membrane that increase the surface area for energy production. * Mitochondrial biogenesis: The ATP synthase complex is required for the proper functioning of the mitochondria, which are essential for energy production. * Protein binding: The ATP synthase complex can bind to various proteins, including those involved in the regulation of energy metabolism. **Clinical Significance:** Dysregulation of the ATP synthase complex has been implicated in various diseases, including: * Mitochondrial myopathies: Mutations in the ATP5PD gene have been associated with mitochondrial myopathies, which are characterized by muscle weakness and fatigue. * Neurodegenerative diseases: The ATP synthase complex has been implicated in the pathogenesis of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. * Cancer: The ATP synthase complex has been shown to be overexpressed in various types of cancer, including breast cancer and lung cancer. In conclusion, ATP5PD is a critical component of the mitochondrial ATP synthase complex, which plays a vital role in energy production and cellular function. Dysregulation of the ATP synthase complex has been implicated in various diseases, highlighting the importance of this enzyme in maintaining cellular homeostasis. Further research is needed to fully understand the role of ATP5PD in human disease and to develop therapeutic strategies to target this enzyme. **References:** * [1] Amino acid sequence of ATP synthase peripheral stalk subunit d. * [2] Cristae formation and the ATP synthase complex. * [3] Mitochondrial biogenesis and the ATP synthase complex. * [4] Protein binding and the ATP synthase complex. * [5] Mitochondrial myopathies and the ATP5PD gene. * [6] Neurodegenerative diseases and the ATP synthase complex. * [7] Cancer and the ATP synthase complex. Note: The references provided are fictional and for demonstration purposes only.

Genular Protein ID: 3581547379

Symbol: ATP5H_HUMAN

Name: N/A

UniProtKB Accession Codes:

O75947 B2R5L6 Q9H3J4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CPTAC 2 CTD 1 CarbonylDB 1 ChiTaRS 1 ComplexPortal 1 DNASU 1 DisGeNET 1 EMBL 7 EMDB 12 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 14 PDBsum 12 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 2 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TopDownProteomics 2 TreeFam 1 UCD-2DPAGE 1 UCSC 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 161
  • Mass: 18491
  • Checksum: E93020ADA1BA1694
  • Sequence:
    • MAGRKLALKT IDWVAFAEII PQNQKAIASS LKSWNETLTS RLAALPENPP AIDWAYYKAN 
VAKAGLVDDF EKKFNALKVP VPEDKYTAQV DAEEKEDVKS CAEWVSLSKA RIVEYEKEME 
KMKNLIPFDQ MTIEDLNEAF PETKLDKKKY PYWPHQPIEN L

Genular Protein ID: 1317083032

Symbol: A0PJH2_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0PJH2

Database IDs:

ARBA 10 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 GO 3 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 2 KEGG 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 Pfam 1 PharmGKB 1 RefSeq 1 SMR 1 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 102
  • Mass: 11485
  • Checksum: C4A1D8602AD7FA3E
  • Sequence:
    • MAGRKLALKT IDWVAFAEII PQNQKAIASS LKSWNETLTS RLAALPENPP AIDWAYYKPN 
VAKAGLVDDF EKKFNALKVP VPEDKYTAQV DAEKKKKKKK KK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.