Details for: CEACAM5

Gene ID: 1048

Symbol: CEACAM5

Ensembl ID: ENSG00000105388

Description: CEA cell adhesion molecule 5

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 3.08
    Marker Score: 2097
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 3.07
    Marker Score: 9630
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 2.33
    Marker Score: 2234
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 2.04
    Marker Score: 1365
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.95
    Marker Score: 561
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.49
    Marker Score: 736
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.48
    Marker Score: 1479
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.19
    Marker Score: 7618
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 1.18
    Marker Score: 15804
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.17
    Marker Score: 336
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.15
    Marker Score: 7614
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.12
    Marker Score: 2661
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.03
    Marker Score: 387
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71818
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48043
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1
    Marker Score: 4782
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 509
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 462
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5355
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.93
    Marker Score: 8021
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 327
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5292
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.87
    Marker Score: 4555
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.83
    Marker Score: 1355
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.83
    Marker Score: 333.5
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.83
    Marker Score: 386.5
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.81
    Marker Score: 793
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.8
    Marker Score: 582.5
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.79
    Marker Score: 210
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 397
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.76
    Marker Score: 694
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.76
    Marker Score: 3171
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.73
    Marker Score: 5668
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.71
    Marker Score: 1136
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.7
    Marker Score: 429
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.69
    Marker Score: 481
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.63
    Marker Score: 667
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.59
    Marker Score: 380
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 443
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.54
    Marker Score: 988
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.5
    Marker Score: 418
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 0.5
    Marker Score: 135.5
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.48
    Marker Score: 382
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 278.5
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.45
    Marker Score: 856
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.45
    Marker Score: 206
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.45
    Marker Score: 129
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.43
    Marker Score: 180
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.43
    Marker Score: 867
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.42
    Marker Score: 184
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.42
    Marker Score: 126
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.41
    Marker Score: 274.5
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.4
    Marker Score: 618
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.39
    Marker Score: 389
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.38
    Marker Score: 95
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.37
    Marker Score: 96
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 0.36
    Marker Score: 114
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.35
    Marker Score: 730.5
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.34
    Marker Score: 378
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.33
    Marker Score: 5208
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 0.32
    Marker Score: 391
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.31
    Marker Score: 886.5
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.31
    Marker Score: 93
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.3
    Marker Score: 136
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.27
    Marker Score: 390
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.26
    Marker Score: 90
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.26
    Marker Score: 154
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.25
    Marker Score: 300.5
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.24
    Marker Score: 228
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 0.24
    Marker Score: 65
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.22
    Marker Score: 200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.22
    Marker Score: 218
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.22
    Marker Score: 1299
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.2
    Marker Score: 353
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.2
    Marker Score: 63
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.2
    Marker Score: 103
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.19
    Marker Score: 1430
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.19
    Marker Score: 203.5
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.19
    Marker Score: 67
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.17
    Marker Score: 292
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.17
    Marker Score: 43
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.16
    Marker Score: 92
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 0.16
    Marker Score: 38
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.15
    Marker Score: 180
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.15
    Marker Score: 52
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.15
    Marker Score: 243
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.15
    Marker Score: 91
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.15
    Marker Score: 163
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.14
    Marker Score: 493.5
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.14
    Marker Score: 96
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.13
    Marker Score: 139
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 0.13
    Marker Score: 41
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.13
    Marker Score: 77
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.13
    Marker Score: 34
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.13
    Marker Score: 114
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.13
    Marker Score: 31

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Other Information

## Summary CEACAM5 is a cell adhesion molecule that plays a crucial role in various cellular processes. It is expressed in a wide range of cell types, including epithelial cells, immune cells, and cancer cells. ## Key characteristics * CEACAM5 is a transmembrane protein with a molecular weight of approximately 130 kDa. * It is a member of the cadherin superfamily of cell adhesion molecules. * It is expressed in high levels on the cell surface of epithelial cells, where it is involved in cell-cell adhesion and signaling. * It is also expressed on immune cells, where it plays a role in cell-cell adhesion and immune surveillance. * It is a key regulator of cell survival, proliferation, migration, and differentiation. ## Pathways and functions * CEACAM5 is involved in a variety of cellular processes, including: * Cell-cell adhesion: CEACAM5 is a key molecule for cell-cell adhesion in epithelial cells and immune cells. * Apoptosis: It is involved in the regulation of apoptosis, the process by which cells die on their own. * Cell migration: CEACAM5 is involved in cell migration by facilitating cell-cell adhesion and signaling. * Immune surveillance: CEACAM5 is expressed on immune cells and plays a role in cell-cell adhesion and immune surveillance. * Cancer: CEACAM5 is frequently overexpressed in cancer cells, where it promotes cell survival, migration, and invasion. ## Clinical significance * Mutations in CEACAM5 have been linked to a number of human cancers, including colorectal cancer, breast cancer, and lung cancer. * Targeting CEACAM5 has been investigated as a therapeutic strategy for cancer, but it has not been successful so far. * Further research is needed to understand the role of CEACAM5 in cancer and to develop new therapeutic strategies.

Genular Protein ID: 1817482593

Symbol: CEAM5_HUMAN

Name: Carcinoembryonic antigen-related cell adhesion molecule 5

UniProtKB Accession Codes:

P06731 H9KVA7

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 3 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EMBL 16 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 18 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 4 PIR 1 PRIDE 1 PRO 1 PROSITE 1 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 2 RefSeq 4 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3670312

Title: Isolation and characterization of full-length functional cDNA clones for human carcinoembryonic antigen.

PubMed ID: 3670312

DOI: 10.1128/mcb.7.9.3221-3230.1987

PubMed ID: 3220478

Title: Carcinoembryonic antigen family: characterization of cDNAs coding for NCA and CEA and suggestion of nonrandom sequence variation in their conserved loop-domains.

PubMed ID: 3220478

DOI: 10.1016/0888-7543(88)90160-7

PubMed ID: 2342461

Title: Cloning of the complete gene for carcinoembryonic antigen: analysis of its promoter indicates a region conveying cell type-specific expression.

PubMed ID: 2342461

DOI: 10.1128/mcb.10.6.2738-2748.1990

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 3814146

Title: Primary structure of human carcinoembryonic antigen (CEA) deduced from cDNA sequence.

PubMed ID: 3814146

DOI: 10.1016/0006-291x(87)90304-4

PubMed ID: 3033671

Title: Isolation and characterization of cDNA clones encoding the human carcinoembryonic antigen reveal a highly conserved repeating structure.

PubMed ID: 3033671

DOI: 10.1073/pnas.84.9.2960

PubMed ID: 2803308

Title: Cell adhesion activity of non-specific cross-reacting antigen (NCA) and carcinoembryonic antigen (CEA) expressed on CHO cell surface: homophilic and heterophilic adhesion.

PubMed ID: 2803308

DOI: 10.1016/0006-291x(89)91679-3

PubMed ID: 2317824

Title: Expression of complementary DNA and genomic clones for carcinoembryonic antigen and nonspecific cross-reacting antigen in Chinese hamster ovary and mouse fibroblast cells and characterization of the membrane-expressed products.

PubMed ID: 2317824

PubMed ID: 10436421

Title: Four carcinoembryonic antigen subfamily members, CEA, NCA, BGP and CGM2, selectively expressed in the normal human colonic epithelium, are integral components of the fuzzy coat.

PubMed ID: 10436421

DOI: 10.1159/000030075

PubMed ID: 10910050

Title: Human carcinoembryonic antigen functions as a general inhibitor of anoikis.

PubMed ID: 10910050

PubMed ID: 10864933

Title: Self recognition in the Ig superfamily. Identification of precise subdomains in carcinoembryonic antigen required for intercellular adhesion.

PubMed ID: 10864933

DOI: 10.1074/jbc.m909242199

PubMed ID: 16740002

Title: Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry.

PubMed ID: 16740002

DOI: 10.1021/pr050492k

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 26483485

Title: Diverse oligomeric states of CEACAM IgV domains.

PubMed ID: 26483485

DOI: 10.1073/pnas.1509511112

PubMed ID: 10854848

Title: Structural models for carcinoembryonic antigen and its complex with the single-chain Fv antibody molecule MFE23.

PubMed ID: 10854848

DOI: 10.1016/s0014-5793(00)01612-4

PubMed ID: 18086185

Title: Binding of Dr adhesins of Escherichia coli to carcinoembryonic antigen triggers receptor dissociation.

PubMed ID: 18086185

DOI: 10.1111/j.1365-2958.2007.06054.x

Sequence Information:

  • Length: 702
  • Mass: 76796
  • Checksum: 6299AE26CDDBDB5C
  • Sequence:
    • MESPSAPPHR WCIPWQRLLL TASLLTFWNP PTTAKLTIES TPFNVAEGKE VLLLVHNLPQ 
HLFGYSWYKG ERVDGNRQII GYVIGTQQAT PGPAYSGREI IYPNASLLIQ NIIQNDTGFY 
TLHVIKSDLV NEEATGQFRV YPELPKPSIS SNNSKPVEDK DAVAFTCEPE TQDATYLWWV 
NNQSLPVSPR LQLSNGNRTL TLFNVTRNDT ASYKCETQNP VSARRSDSVI LNVLYGPDAP 
TISPLNTSYR SGENLNLSCH AASNPPAQYS WFVNGTFQQS TQELFIPNIT VNNSGSYTCQ 
AHNSDTGLNR TTVTTITVYA EPPKPFITSN NSNPVEDEDA VALTCEPEIQ NTTYLWWVNN 
QSLPVSPRLQ LSNDNRTLTL LSVTRNDVGP YECGIQNELS VDHSDPVILN VLYGPDDPTI 
SPSYTYYRPG VNLSLSCHAA SNPPAQYSWL IDGNIQQHTQ ELFISNITEK NSGLYTCQAN 
NSASGHSRTT VKTITVSAEL PKPSISSNNS KPVEDKDAVA FTCEPEAQNT TYLWWVNGQS 
LPVSPRLQLS NGNRTLTLFN VTRNDARAYV CGIQNSVSAN RSDPVTLDVL YGPDTPIISP 
PDSSYLSGAN LNLSCHSASN PSPQYSWRIN GIPQQHTQVL FIAKITPNNN GTYACFVSNL 
ATGRNNSIVK SITVSASGTS PGLSAGATVG IMIGVLVGVA LI

Genular Protein ID: 1008400546

Symbol: Q53G30_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q53G30

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 3 CTD 1 DNASU 1 EMBL 2 Gene3D 1 GenomeRNAi 1 InterPro 6 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 3 RefSeq 2 SAM 1 SMART 2 SUPFAM 1

Citations:

PubMed ID: 8125298

Title: Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.

PubMed ID: 8125298

DOI: 10.1016/0378-1119(94)90802-8

PubMed ID: 9373149

Title: Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.

PubMed ID: 9373149

DOI: 10.1016/S0378-1119(97)00411-3

Sequence Information:

  • Length: 702
  • Mass: 76868
  • Checksum: 62992426CDDABB5C
  • Sequence:
    • MESPSAPPHR WCIPWQRLLL TASLLTFWNP PTTAKLTIES TPFNVAEGKE VLLLVHNLPQ 
HLFGYSWYKG ERVDGNRQII GYVIGTQQAT PGPAYSGREI IYPNASLLIQ NIIQNDTGFY 
TLHVIKSDLV NEEATGQFRV YPELPKPSIS SNNSKPVEDK DAVAFTCEPE TQDATYLWWV 
NNQSLPVSPR LQLSNGNRTL TLFNVTRNDT ASYKCETQNP VSARRSDSVI LNVLYGPDAP 
TISPLNTSYR SGENLNLSCH AASNPPAQYS WFVNGTFQQS TQELFIPNIT VNNSGSYTCQ 
AHNSDTGLNR TTVTTITVYA EPPKPFITSN NSNPVEDEDA VALTCEPEIQ NTTYLWWVNN 
QSLPVSPRLQ LSNDNRTLTL LSVTRNDVGP YECGIQNELS VDHSDPVILN VLYGPDDPTI 
SPSYTYYRPG VNLSLSCHAA SNPPAQYSWL IDENIQQHTQ ELFISNITEK NSGLYTCQAN 
NSASGHSRTT VKTITVSAEL PKPSISSNNS KPVEDKDAVA FTCEPEAQNT TYLWWVNGQS 
LPVSPRLQLS NGNRTLTLFN VTRNDARAYV CGIQNSVSAN RSDPVTLDVL YGPDTPIISP 
PDSSYLSGAN LNLSCHSASN PSPQYSWRIN GIPQQHTQVL FIAKITPNNN GTYACFVSNL 
ATGRNNSIVK SITVSASGTS PGLSAGATVG IMIGVLVGVA LI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.