Details for: EIF3M

Gene ID: 10480

Symbol: EIF3M

Ensembl ID: ENSG00000149100

Description: eukaryotic translation initiation factor 3 subunit M

Associated with

  • Activation of the mrna upon binding of the cap-binding complex and eifs, and subsequent binding to 43s
    (R-HSA-72662)
  • Cap-dependent translation initiation
    (R-HSA-72737)
  • Eukaryotic translation initiation
    (R-HSA-72613)
  • Formation of a pool of free 40s subunits
    (R-HSA-72689)
  • Formation of the ternary complex, and subsequently, the 43s complex
    (R-HSA-72695)
  • Gtp hydrolysis and joining of the 60s ribosomal subunit
    (R-HSA-72706)
  • L13a-mediated translational silencing of ceruloplasmin expression
    (R-HSA-156827)
  • Metabolism of proteins
    (R-HSA-392499)
  • Ribosomal scanning and start codon recognition
    (R-HSA-72702)
  • Translation
    (R-HSA-72766)
  • Translation initiation complex formation
    (R-HSA-72649)
  • Cytoplasmic translational initiation
    (GO:0002183)
  • Cytosol
    (GO:0005829)
  • Eukaryotic 43s preinitiation complex
    (GO:0016282)
  • Eukaryotic 48s preinitiation complex
    (GO:0033290)
  • Eukaryotic translation initiation factor 3 complex
    (GO:0005852)
  • Eukaryotic translation initiation factor 3 complex, eif3m
    (GO:0071541)
  • Formation of cytoplasmic translation initiation complex
    (GO:0001732)
  • Protein binding
    (GO:0005515)
  • Translational initiation
    (GO:0006413)
  • Translation initiation factor activity
    (GO:0003743)
  • Translation initiation factor binding
    (GO:0031369)

Other Information

Genular Protein ID: 4004050920

Symbol: EIF3M_HUMAN

Name: Fetal lung protein B5

UniProtKB Accession Codes:

Q7L2H7 A8K7X4 B4E2Q4 O60735 Q2F836 Q53HL6 Q9BXW1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 13 EMDB 9 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 10 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HAMAP 1 HAMAP-Rule 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 12 PDBsum 11 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 6 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15919898

Title: A new class of receptor for herpes simplex virus has heptad repeat motifs that are common to membrane fusion proteins.

PubMed ID: 15919898

DOI: 10.1128/jvi.79.12.7419-7430.2005

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17719568

Title: Subtractive hybridisation screen identifies genes regulated by glucose deprivation in human neuroblastoma cells.

PubMed ID: 17719568

DOI: 10.1016/j.brainres.2007.07.042

PubMed ID: 15601822

Title: Release of initiation factors from 48S complexes during ribosomal subunit joining and the link between establishment of codon-anticodon base-pairing and hydrolysis of eIF2-bound GTP.

PubMed ID: 15601822

DOI: 10.1101/gad.1255704

PubMed ID: 15904532

Title: PCI proteins eIF3e and eIF3m define distinct translation initiation factor 3 complexes.

PubMed ID: 15904532

DOI: 10.1186/1741-7007-3-14

PubMed ID: 15919899

Title: The C-terminus of the B5 receptor for herpes simplex virus contains a functional region important for infection.

PubMed ID: 15919899

DOI: 10.1128/jvi.79.12.7431-7437.2005

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 15703437

Title: Binding of eukaryotic initiation factor 3 to ribosomal 40S subunits and its role in ribosomal dissociation and anti-association.

PubMed ID: 15703437

DOI: 10.1261/rna.7215305

PubMed ID: 16766523

Title: Translation initiation factor eIF4G-1 binds to eIF3 through the eIF3e subunit.

PubMed ID: 16766523

DOI: 10.1074/jbc.m605418200

PubMed ID: 17403899

Title: CIF-1, a shared subunit of the COP9/signalosome and eukaryotic initiation factor 3 complexes, regulates MEL-26 levels in the Caenorhabditis elegans embryo.

PubMed ID: 17403899

DOI: 10.1128/mcb.01724-06

PubMed ID: 17322308

Title: Structural characterization of the human eukaryotic initiation factor 3 protein complex by mass spectrometry.

PubMed ID: 17322308

DOI: 10.1074/mcp.m600399-mcp200

PubMed ID: 18599441

Title: Mass spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3.

PubMed ID: 18599441

DOI: 10.1073/pnas.0801313105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25849773

Title: eIF3 targets cell-proliferation messenger RNAs for translational activation or repression.

PubMed ID: 25849773

DOI: 10.1038/nature14267

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27462815

Title: eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation.

PubMed ID: 27462815

DOI: 10.1038/nature18954

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 374
  • Mass: 42503
  • Checksum: 63736CA2B093D794
  • Sequence:
    • MSVPAFIDIS EEDQAAELRA YLKSKGAEIS EENSEGGLHV DLAQIIEACD VCLKEDDKDV 
ESVMNSVVSL LLILEPDKQE ALIESLCEKL VKFREGERPS LRLQLLSNLF HGMDKNTPVR 
YTVYCSLIKV AASCGAIQYI PTELDQVRKW ISDWNLTTEK KHTLLRLLYE ALVDCKKSDA 
ASKVMVELLG SYTEDNASQA RVDAHRCIVR ALKDPNAFLF DHLLTLKPVK FLEGELIHDL 
LTIFVSAKLA SYVKFYQNNK DFIDSLGLLH EQNMAKMRLL TFMGMAVENK EISFDTMQQE 
LQIGADDVEA FVIDAVRTKM VYCKIDQTQR KVVVSHSTHR TFGKQQWQQL YDTLNAWKQN 
LNKVKNSLLS LSDT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.