Details for: HOXB13

Gene ID: 10481

Symbol: HOXB13

Ensembl ID: ENSG00000159184

Description: homeobox B13

Associated with

  • Angiogenesis
    (GO:0001525)
  • Chromatin
    (GO:0000785)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • Epidermis development
    (GO:0008544)
  • Epithelial cell maturation involved in prostate gland development
    (GO:0060743)
  • Methyl-cpg binding
    (GO:0008327)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nucleoplasm
    (GO:0005654)
  • Prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
    (GO:0060527)
  • Protein binding
    (GO:0005515)
  • Regulation of growth
    (GO:0040008)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Response to testosterone
    (GO:0033574)
  • Response to wounding
    (GO:0009611)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sequence-specific dna binding
    (GO:0043565)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Transcription regulator complex
    (GO:0005667)

Other Information

Genular Protein ID: 2180662215

Symbol: HXB13_HUMAN

Name: Homeobox protein Hox-B13

UniProtKB Accession Codes:

Q92826 B2R878 Q96QM4 Q99810

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 1 EvolutionaryTrace 1 GO 18 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 15 PDBsum 8 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8756292

Title: Hoxb-13: a new Hox gene in a distant region of the HOXB cluster maintains colinearity.

PubMed ID: 8756292

DOI: 10.1242/dev.122.8.2475

PubMed ID: 9665387

Title: Modulation of the human homeobox genes PRX-2 and HOXB13 in scarless fetal wounds.

PubMed ID: 9665387

DOI: 10.1046/j.1523-1747.1998.00238.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 28473536

Title: Impact of cytosine methylation on DNA binding specificities of human transcription factors.

PubMed ID: 28473536

DOI: 10.1126/science.aaj2239

PubMed ID: 11857506

Title: Complete mutation analysis panel of the 39 human HOX genes.

PubMed ID: 11857506

DOI: 10.1002/tera.10009

PubMed ID: 22714738

Title: Confirmation of the HOXB13 G84E germline mutation in familial prostate cancer.

PubMed ID: 22714738

DOI: 10.1158/1055-9965.epi-12-0495

PubMed ID: 22236224

Title: Germline mutations in HOXB13 and prostate-cancer risk.

PubMed ID: 22236224

DOI: 10.1056/nejmoa1110000

PubMed ID: 23292082

Title: HOXB13 G84E mutation in Finland: population-based analysis of prostate, breast, and colorectal cancer risk.

PubMed ID: 23292082

DOI: 10.1158/1055-9965.epi-12-1000-t

PubMed ID: 23064873

Title: HOXB13 is a susceptibility gene for prostate cancer: results from the international consortium for prostate cancer genetics (ICPCG).

PubMed ID: 23064873

DOI: 10.1007/s00439-012-1229-4

PubMed ID: 25629170

Title: Imputation of the Rare HOXB13 G84E Mutation and Cancer Risk in a Large Population-Based Cohort.

PubMed ID: 25629170

DOI: 10.1371/journal.pgen.1004930

PubMed ID: 27424772

Title: Recurrent HOXB13 mutations in the Dutch population do not associate with increased breast cancer risk.

PubMed ID: 27424772

DOI: 10.1038/srep30026

Sequence Information:

  • Length: 284
  • Mass: 30676
  • Checksum: 3EE5898449C33CFE
  • Sequence:
    • MEPGNYATLD GAKDIEGLLG AGGGRNLVAH SPLTSHPAAP TLMPAVNYAP LDLPGSAEPP 
KQCHPCPGVP QGTSPAPVPY GYFGGGYYSC RVSRSSLKPC AQAATLAAYP AETPTAGEEY 
PSRPTEFAFY PGYPGTYQPM ASYLDVSVVQ TLGAPGEPRH DSLLPVDSYQ SWALAGGWNS 
QMCCQGEQNP PGPFWKAAFA DSSGQHPPDA CAFRRGRKKR IPYSKGQLRE LEREYAANKF 
ITKDKRRKIS AATSLSERQI TIWFQNRRVK EKKVLAKVKN SATP

Genular Protein ID: 1668046764

Symbol: Q4KR72_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q4KR72

Database IDs:

ARBA 5 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 GO 3 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 4 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 RefSeq 1 RuleBase 1 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 284
  • Mass: 30664
  • Checksum: 2F159865B9C33CE3
  • Sequence:
    • MEPGNYATLD GAKDIEGLLG AGGGRNLVAH SPLTSHPAAP TLMPAVNYAP LDLPGSAEPP 
KQCHPCPGVP QGTSPAPVPY GYFGGGYYSC RVSRSSLKPC AQAATLAAYP AETPTAGEEY 
PSRPTEFAFY PGYPGTYQPM ASYLDVSVVQ TLGAPGEPRH DSLLPVDSYQ SWALAGGWNS 
QMCCQGEQNP PGPFWKAAFA DSSGQHPPDA CAFRRGRKKR TPYSKGQLRE LEREYAANKF 
ITKDKRRKIS AATSLSERQI TIWFQNRRVK EKKVLAKVKN SATP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.