Details for: HOXB13

Gene ID: 10481

Symbol: HOXB13

Ensembl ID: ENSG00000159184

Description: homeobox B13

Associated with

  • Angiogenesis
    (GO:0001525)
  • Chromatin
    (GO:0000785)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • Epidermis development
    (GO:0008544)
  • Epithelial cell maturation involved in prostate gland development
    (GO:0060743)
  • Methyl-cpg binding
    (GO:0008327)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nucleoplasm
    (GO:0005654)
  • Prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
    (GO:0060527)
  • Protein binding
    (GO:0005515)
  • Regulation of growth
    (GO:0040008)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Response to testosterone
    (GO:0033574)
  • Response to wounding
    (GO:0009611)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sequence-specific dna binding
    (GO:0043565)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Transcription regulator complex
    (GO:0005667)

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 4.2
    Marker Score: 5,188
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 2.26
    Marker Score: 4,116
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.07
    Marker Score: 2,085
  • Cell Name: T cell (CL0000084)
    Fold Change: 1.64
    Marker Score: 2,833
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.53
    Marker Score: 1,714
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.41
    Marker Score: 821
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4,799
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.11
    Marker Score: 7,384
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.05
    Marker Score: 710
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.02
    Marker Score: 741
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,800
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,028
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1
    Marker Score: 513
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.99
    Marker Score: 467
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,407
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,411
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.94
    Marker Score: 942
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.94
    Marker Score: 378
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5,254
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.92
    Marker Score: 330
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,739
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.88
    Marker Score: 456
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,283
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.85
    Marker Score: 493
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,263
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 707
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 401
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.77
    Marker Score: 321
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.73
    Marker Score: 1,167
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.64
    Marker Score: 611
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.62
    Marker Score: 1,472
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.6
    Marker Score: 571
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.57
    Marker Score: 1,082
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.57
    Marker Score: 164
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.52
    Marker Score: 900
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.51
    Marker Score: 497
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.51
    Marker Score: 161
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5
    Marker Score: 317
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.48
    Marker Score: 973
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 282
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.46
    Marker Score: 1,442
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.45
    Marker Score: 209
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.43
    Marker Score: 1,042
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.42
    Marker Score: 127
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.41
    Marker Score: 239
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.41
    Marker Score: 430
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.39
    Marker Score: 97
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.39
    Marker Score: 560
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.35
    Marker Score: 576
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.35
    Marker Score: 1,696
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.35
    Marker Score: 1,087
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.34
    Marker Score: 694
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.32
    Marker Score: 290
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.28
    Marker Score: 196
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.28
    Marker Score: 410
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.27
    Marker Score: 4,295
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.27
    Marker Score: 317
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.27
    Marker Score: 140
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.25
    Marker Score: 151
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.25
    Marker Score: 78
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 67
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.23
    Marker Score: 50
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 75
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.21
    Marker Score: 190
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.21
    Marker Score: 101
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.21
    Marker Score: 333
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.21
    Marker Score: 60
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.19
    Marker Score: 298
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.19
    Marker Score: 295
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.19
    Marker Score: 147
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.19
    Marker Score: 49
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.18
    Marker Score: 45
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.18
    Marker Score: 45
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.18
    Marker Score: 45
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.18
    Marker Score: 93
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.17
    Marker Score: 201
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.17
    Marker Score: 111
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.16
    Marker Score: 429
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.16
    Marker Score: 57
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.15
    Marker Score: 68
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.15
    Marker Score: 39
  • Cell Name: type D enteroendocrine cell (CL0000502)
    Fold Change: 0.15
    Marker Score: 46
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 0.15
    Marker Score: 40
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.15
    Marker Score: 35
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.15
    Marker Score: 124
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.14
    Marker Score: 46
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.13
    Marker Score: 50
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.13
    Marker Score: 33
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.13
    Marker Score: 44
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.12
    Marker Score: 49
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.12
    Marker Score: 49
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.11
    Marker Score: 44
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.11
    Marker Score: 50
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.11
    Marker Score: 29
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.11
    Marker Score: 34
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.11
    Marker Score: 74
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 0.11
    Marker Score: 47
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.11
    Marker Score: 41
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.11
    Marker Score: 81

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** HOXB13 is a transcription factor that belongs to the homeobox family, which regulates gene expression during embryonic development. It is highly expressed in various cell types, including oligodendrocyte precursor cells, microglial cells, blood vessel endothelial cells, T cells, plasma cells, and prostate epithelial cells. HOXB13's expression is tightly regulated by various signaling pathways, including the Wnt/β-catenin pathway, which is crucial for its development and function. **Pathways and Functions:** HOXB13's primary function is to regulate gene expression by binding to specific DNA sequences, thereby modulating the transcription of target genes. Its involvement in immune-related pathways includes: 1. **Angiogenesis:** HOXB13 regulates the expression of angiogenic factors, such as VEGF, which is essential for the formation of new blood vessels. 2. **Epidermis development:** HOXB13 plays a crucial role in the development of the epidermis, which is the outermost layer of the skin. 3. **Epithelial cell maturation:** HOXB13 regulates the maturation of epithelial cells in the prostate gland, which is essential for the development of the prostate glandular acinus. 4. **Negative regulation of transcription:** HOXB13 acts as a negative regulator of transcription by binding to specific DNA sequences, thereby inhibiting the expression of target genes. 5. **Response to testosterone:** HOXB13 is responsive to testosterone, which is essential for the development and maintenance of the prostate gland. **Clinical Significance:** HOXB13's involvement in immune-related diseases has significant clinical implications. Dysregulation of HOXB13 expression has been linked to various diseases, including: 1. **Prostate cancer:** HOXB13's role in prostate gland development and maturation makes it a potential therapeutic target for prostate cancer treatment. 2. **Autoimmune diseases:** HOXB13's involvement in immune regulation and response to wounding makes it a potential therapeutic target for autoimmune diseases. 3. **Inflammatory disorders:** HOXB13's role in angiogenesis and epithelial cell maturation makes it a potential therapeutic target for inflammatory disorders. **Proteins and Signaling Pathways:** HOXB13 interacts with various proteins, including transcriptional co-factors and signaling molecules, to regulate gene expression. Some of the key proteins and signaling pathways involved in HOXB13's function include: 1. **RNA polymerase II:** HOXB13 regulates the expression of target genes by binding to specific DNA sequences, thereby modulating the activity of RNA polymerase II. 2. **Wnt/β-catenin pathway:** HOXB13's expression is regulated by the Wnt/β-catenin pathway, which is crucial for its development and function. 3. **Transcriptional co-factors:** HOXB13 interacts with various transcriptional co-factors, including TFIID and TFIIB, to regulate gene expression. In conclusion, HOXB13 plays a crucial role in immune regulation and disease, and its dysregulation has significant clinical implications. Further research is needed to fully understand the molecular mechanisms underlying HOXB13's involvement in immune-related diseases and to explore its therapeutic potential.

Genular Protein ID: 2180662215

Symbol: HXB13_HUMAN

Name: Homeobox protein Hox-B13

UniProtKB Accession Codes:

Q92826 B2R878 Q96QM4 Q99810

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 1 EvolutionaryTrace 1 GO 18 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 15 PDBsum 8 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8756292

Title: Hoxb-13: a new Hox gene in a distant region of the HOXB cluster maintains colinearity.

PubMed ID: 8756292

DOI: 10.1242/dev.122.8.2475

PubMed ID: 9665387

Title: Modulation of the human homeobox genes PRX-2 and HOXB13 in scarless fetal wounds.

PubMed ID: 9665387

DOI: 10.1046/j.1523-1747.1998.00238.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 28473536

Title: Impact of cytosine methylation on DNA binding specificities of human transcription factors.

PubMed ID: 28473536

DOI: 10.1126/science.aaj2239

PubMed ID: 11857506

Title: Complete mutation analysis panel of the 39 human HOX genes.

PubMed ID: 11857506

DOI: 10.1002/tera.10009

PubMed ID: 22714738

Title: Confirmation of the HOXB13 G84E germline mutation in familial prostate cancer.

PubMed ID: 22714738

DOI: 10.1158/1055-9965.epi-12-0495

PubMed ID: 22236224

Title: Germline mutations in HOXB13 and prostate-cancer risk.

PubMed ID: 22236224

DOI: 10.1056/nejmoa1110000

PubMed ID: 23292082

Title: HOXB13 G84E mutation in Finland: population-based analysis of prostate, breast, and colorectal cancer risk.

PubMed ID: 23292082

DOI: 10.1158/1055-9965.epi-12-1000-t

PubMed ID: 23064873

Title: HOXB13 is a susceptibility gene for prostate cancer: results from the international consortium for prostate cancer genetics (ICPCG).

PubMed ID: 23064873

DOI: 10.1007/s00439-012-1229-4

PubMed ID: 25629170

Title: Imputation of the Rare HOXB13 G84E Mutation and Cancer Risk in a Large Population-Based Cohort.

PubMed ID: 25629170

DOI: 10.1371/journal.pgen.1004930

PubMed ID: 27424772

Title: Recurrent HOXB13 mutations in the Dutch population do not associate with increased breast cancer risk.

PubMed ID: 27424772

DOI: 10.1038/srep30026

Sequence Information:

  • Length: 284
  • Mass: 30676
  • Checksum: 3EE5898449C33CFE
  • Sequence:
    • MEPGNYATLD GAKDIEGLLG AGGGRNLVAH SPLTSHPAAP TLMPAVNYAP LDLPGSAEPP 
KQCHPCPGVP QGTSPAPVPY GYFGGGYYSC RVSRSSLKPC AQAATLAAYP AETPTAGEEY 
PSRPTEFAFY PGYPGTYQPM ASYLDVSVVQ TLGAPGEPRH DSLLPVDSYQ SWALAGGWNS 
QMCCQGEQNP PGPFWKAAFA DSSGQHPPDA CAFRRGRKKR IPYSKGQLRE LEREYAANKF 
ITKDKRRKIS AATSLSERQI TIWFQNRRVK EKKVLAKVKN SATP

Genular Protein ID: 1668046764

Symbol: Q4KR72_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q4KR72

Database IDs:

ARBA 5 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 GO 3 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 4 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 RefSeq 1 RuleBase 1 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 284
  • Mass: 30664
  • Checksum: 2F159865B9C33CE3
  • Sequence:
    • MEPGNYATLD GAKDIEGLLG AGGGRNLVAH SPLTSHPAAP TLMPAVNYAP LDLPGSAEPP 
KQCHPCPGVP QGTSPAPVPY GYFGGGYYSC RVSRSSLKPC AQAATLAAYP AETPTAGEEY 
PSRPTEFAFY PGYPGTYQPM ASYLDVSVVQ TLGAPGEPRH DSLLPVDSYQ SWALAGGWNS 
QMCCQGEQNP PGPFWKAAFA DSSGQHPPDA CAFRRGRKKR TPYSKGQLRE LEREYAANKF 
ITKDKRRKIS AATSLSERQI TIWFQNRRVK EKKVLAKVKN SATP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.