SEC23A | ENSG00000100934 | NCBI 10484

Details for: SEC23A

Gene ID: 10484

Symbol: SEC23A

Ensembl ID: ENSG00000100934

Description: SEC23 homolog A, COPII coat complex component

Associated with

Adaptive immune system
(R-HSA-1280218)
Antigen presentation: folding, assembly and peptide loading of class i mhc
(R-HSA-983170)
Asparagine n-linked glycosylation
(R-HSA-446203)
Cargo concentration in the er
(R-HSA-5694530)
Class i mhc mediated antigen processing & presentation
(R-HSA-983169)
Copii-mediated vesicle transport
(R-HSA-204005)
Disease
(R-HSA-1643685)
Er to golgi anterograde transport
(R-HSA-199977)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Membrane trafficking
(R-HSA-199991)
Metabolism
(R-HSA-1430728)
Metabolism of lipids
(R-HSA-556833)
Metabolism of proteins
(R-HSA-392499)
Metabolism of steroids
(R-HSA-8957322)
Mhc class ii antigen presentation
(R-HSA-2132295)
Post-translational protein modification
(R-HSA-597592)
Regulation of cholesterol biosynthesis by srebp (srebf)
(R-HSA-1655829)
Sars-cov-2 activates/modulates innate and adaptive immune responses
(R-HSA-9705671)
Sars-cov-2 infection
(R-HSA-9694516)
Sars-cov-2-host interactions
(R-HSA-9705683)
Sars-cov infections
(R-HSA-9679506)
Transport to the golgi and subsequent modification
(R-HSA-948021)
Vesicle-mediated transport
(R-HSA-5653656)
Viral infection pathways
(R-HSA-9824446)
Copii-coated vesicle cargo loading
(GO:0090110)
Copii vesicle coat
(GO:0030127)
Cytosol
(GO:0005829)
Endoplasmic reticulum exit site
(GO:0070971)
Endoplasmic reticulum membrane
(GO:0005789)
Er to golgi transport vesicle membrane
(GO:0012507)
Golgi membrane
(GO:0000139)
Gtpase activator activity
(GO:0005096)
Intracellular protein transport
(GO:0006886)
Perinuclear region of cytoplasm
(GO:0048471)
Protein binding
(GO:0005515)
Protein localization to plasma membrane
(GO:0072659)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

SEC23-related protein A

Genular Protein ID: 2512519883

Symbol: SC23A_HUMAN

Name: SEC23-related protein A

UniProtKB Accession Codes:

Q15436 B2R5P4 B3KXI2 Q8NE16

Database IDs:

Citations:

PubMed ID: 8898360

Title: Cloning and functional characterization of mammalian homologues of the COPII component Sec23.

PubMed ID: 8898360

DOI: 10.1091/mbc.7.10.1535

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17192411

Title: Two mammalian Sec16 homologues have nonredundant functions in endoplasmic reticulum (ER) export and transitional ER organization.

PubMed ID: 17192411

DOI: 10.1091/mbc.e06-08-0707

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28442536

Title: TANGO1 recruits Sec16 to coordinately organize ER exit sites for efficient secretion.

PubMed ID: 28442536

DOI: 10.1083/jcb.201703084

PubMed ID: 31806350

Title: The ER-Localized Transmembrane Protein TMEM39A/SUSR2 Regulates Autophagy by Controlling the Trafficking of the PtdIns(4)P Phosphatase SAC1.

PubMed ID: 31806350

DOI: 10.1016/j.molcel.2019.10.035

PubMed ID: 34349020

Title: Proteolytic processing of secretory pathway kinase Fam20C by site-1 protease promotes biomineralization.

PubMed ID: 34349020

DOI: 10.1073/pnas.2100133118

PubMed ID: 17499046

Title: The transport signal on Sec22 for packaging into COPII-coated vesicles is a conformational epitope.

PubMed ID: 17499046

DOI: 10.1016/j.molcel.2007.03.017

PubMed ID: 18843296

Title: Structural basis of cargo membrane protein discrimination by the human COPII coat machinery.

PubMed ID: 18843296

DOI: 10.1038/emboj.2008.208

PubMed ID: 27551091

Title: TANGO1/cTAGE5 receptor as a polyvalent template for assembly of large COPII coats.

PubMed ID: 27551091

DOI: 10.1073/pnas.1605916113

PubMed ID: 16980979

Title: Cranio-lenticulo-sutural dysplasia is caused by a SEC23A mutation leading to abnormal endoplasmic-reticulum-to-Golgi trafficking.

PubMed ID: 16980979

DOI: 10.1038/ng1876

Sequence Information:

Length: 765
Mass: 86161
Checksum: 128DF9964B253313
Sequence:

MTTYLEFIQQ NEERDGVRFS WNVWPSSRLE ATRMVVPVAA LFTPLKERPD LPPIQYEPVL 
CSRTTCRAVL NPLCQVDYRA KLWACNFCYQ RNQFPPSYAG ISELNQPAEL LPQFSSIEYV 
VLRGPQMPLI FLYVVDTCME DEDLQALKES MQMSLSLLPP TALVGLITFG RMVQVHELGC 
EGISKSYVFR GTKDLSAKQL QEMLGLSKVP LTQATRGPQV QQPPPSNRFL QPVQKIDMNL 
TDLLGELQRD PWPVPQGKRP LRSSGVALSI AVGLLECTFP NTGARIMMFI GGPATQGPGM 
VVGDELKTPI RSWHDIDKDN AKYVKKGTKH FEALANRAAT TGHVIDIYAC ALDQTGLLEM 
KCCPNLTGGY MVMGDSFNTS LFKQTFQRVF TKDMHGQFKM GFGGTLEIKT SREIKISGAI 
GPCVSLNSKG PCVSENEIGT GGTCQWKICG LSPTTTLAIY FEVVNQHNAP IPQGGRGAIQ 
FVTQYQHSSG QRRIRVTTIA RNWADAQTQI QNIAASFDQE AAAILMARLA IYRAETEEGP 
DVLRWLDRQL IRLCQKFGEY HKDDPSSFRF SETFSLYPQF MFHLRRSSFL QVFNNSPDES 
SYYRHHFMRQ DLTQSLIMIQ PILYAYSFSG PPEPVLLDSS SILADRILLM DTFFQILIYH 
GETIAQWRKS GYQDMPEYEN FRHLLQAPVD DAQEILHSRF PMPRYIDTEH GGSQARFLLS 
KVNPSQTHNN MYAWGQESGA PILTDDVSLQ VFMDHLKKLA VSSAA

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: SEC23A

Associated with

Other Information

Cloning and functional characterization of mammalian homologues of the COPII component Sec23. PubMed ID: 8898360

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and analysis of human chromosome 14. PubMed ID: 12508121

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Two mammalian Sec16 homologues have nonredundant functions in endoplasmic reticulum (ER) export and transitional ER organization. PubMed ID: 17192411

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Initial characterization of the human central proteome. PubMed ID: 21269460

Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features. PubMed ID: 22223895

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

TANGO1 recruits Sec16 to coordinately organize ER exit sites for efficient secretion. PubMed ID: 28442536

The ER-Localized Transmembrane Protein TMEM39A/SUSR2 Regulates Autophagy by Controlling the Trafficking of the PtdIns(4)P Phosphatase SAC1. PubMed ID: 31806350

Proteolytic processing of secretory pathway kinase Fam20C by site-1 protease promotes biomineralization. PubMed ID: 34349020

The transport signal on Sec22 for packaging into COPII-coated vesicles is a conformational epitope. PubMed ID: 17499046

Structural basis of cargo membrane protein discrimination by the human COPII coat machinery. PubMed ID: 18843296

TANGO1/cTAGE5 receptor as a polyvalent template for assembly of large COPII coats. PubMed ID: 27551091

Cranio-lenticulo-sutural dysplasia is caused by a SEC23A mutation leading to abnormal endoplasmic-reticulum-to-Golgi trafficking. PubMed ID: 16980979