CREB3 | ENSG00000107175 | NCBI 10488

Details for: CREB3

Gene ID: 10488

Symbol: CREB3

Ensembl ID: ENSG00000107175

Description: cAMP responsive element binding protein 3

Associated with

Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Creb3 factors activate genes
(R-HSA-8874211)
Unfolded protein response (upr)
(R-HSA-381119)
Chemotaxis
(GO:0006935)
Chromatin
(GO:0000785)
Cytosol
(GO:0005829)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Endoplasmic reticulum
(GO:0005783)
Endoplasmic reticulum membrane
(GO:0005789)
Endoplasmic reticulum unfolded protein response
(GO:0030968)
Golgi membrane
(GO:0000139)
Identical protein binding
(GO:0042802)
Integrated stress response signaling
(GO:0140467)
Negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
(GO:1902236)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of monocyte chemotaxis
(GO:0090026)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Rna polymerase ii transcription regulator complex
(GO:0090575)
Sequence-specific double-stranded dna binding
(GO:1990837)
Transcription coregulator binding
(GO:0001221)

Other Information

Proteins

Cyclic AMP-responsive element-binding protein 3

Genular Protein ID: 2112521442

Symbol: CREB3_HUMAN

Name: Cyclic AMP-responsive element-binding protein 3

UniProtKB Accession Codes:

O43889 D0PTW6 O14671 O14919 Q5TCV1 Q96GK8 Q9H2W3 Q9UE77

Database IDs:

Citations:

PubMed ID: 9271389

Title: Luman, a new member of the CREB/ATF family, binds to herpes simplex virus VP16-associated host cellular factor.

PubMed ID: 9271389

DOI: 10.1128/mcb.17.9.5117

PubMed ID: 9389645

Title: Viral mimicry: common mode of association with HCF by VP16 and the cellular protein LZIP.

PubMed ID: 9389645

DOI: 10.1101/gad.11.23.3122

PubMed ID: 10675342

Title: Hepatitis C virus core protein-induced loss of LZIP function correlates with cellular transformation.

PubMed ID: 10675342

DOI: 10.1093/emboj/19.4.729

PubMed ID: 19779205

Title: A novel isoform of human LZIP negatively regulates the transactivation of the glucocorticoid receptor.

PubMed ID: 19779205

DOI: 10.1210/me.2009-0009

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10623756

Title: Potential role for luman, the cellular homologue of herpes simplex virus VP16 (alpha gene trans-inducing factor), in herpesvirus latency.

PubMed ID: 10623756

DOI: 10.1128/jvi.74.2.934-943.2000

PubMed ID: 10629049

Title: Mutations in host cell factor 1 separate its role in cell proliferation from recruitment of VP16 and LZIP.

PubMed ID: 10629049

DOI: 10.1128/mcb.20.3.919-928.2000

PubMed ID: 10984507

Title: N-terminal transcriptional activation domain of LZIP comprises two LxxLL motifs and the host cell factor-1 binding motif.

PubMed ID: 10984507

DOI: 10.1073/pnas.190062797

PubMed ID: 12138176

Title: Luman, the cellular counterpart of herpes simplex virus VP16, is processed by regulated intramembrane proteolysis.

PubMed ID: 12138176

DOI: 10.1128/mcb.22.16.5639-5649.2002

PubMed ID: 15001559

Title: Human LZIP binds to CCR1 and differentially affects the chemotactic activities of CCR1-dependent chemokines.

PubMed ID: 15001559

DOI: 10.1096/fj.03-0867fje

PubMed ID: 15845366

Title: Luman is capable of binding and activating transcription from the unfolded protein response element.

PubMed ID: 15845366

DOI: 10.1016/j.bbrc.2005.03.141

PubMed ID: 15705566

Title: Zhangfei is a potent and specific inhibitor of the host cell factor-binding transcription factor Luman.

PubMed ID: 15705566

DOI: 10.1074/jbc.m500728200

PubMed ID: 17054986

Title: Luman, a new partner of HIV-1 TMgp41, interferes with Tat-mediated transcription of the HIV-1 LTR.

PubMed ID: 17054986

DOI: 10.1016/j.jmb.2006.09.080

PubMed ID: 16940180

Title: Luman/CREB3 induces transcription of the endoplasmic reticulum (ER) stress response protein Herp through an ER stress response element.

PubMed ID: 16940180

DOI: 10.1128/mcb.01046-06

PubMed ID: 17296613

Title: Regulation of human LZIP expression by NF-kappaB and its involvement in monocyte cell migration induced by Lkn-1.

PubMed ID: 17296613

DOI: 10.1074/jbc.m607962200

PubMed ID: 18587271

Title: Human LZIP induces monocyte CC chemokine receptor 2 expression leading to enhancement of monocyte chemoattractant protein 1/CCL2-induced cell migration.

PubMed ID: 18587271

DOI: 10.3858/emm.2008.40.3.332

PubMed ID: 18391022

Title: A novel protein, Luman/CREB3 recruitment factor, inhibits Luman activation of the unfolded protein response.

PubMed ID: 18391022

DOI: 10.1128/mcb.01439-07

PubMed ID: 20546900

Title: DC-STAMP interacts with ER-resident transcription factor LUMAN which becomes activated during DC maturation.

PubMed ID: 20546900

DOI: 10.1016/j.molimm.2010.04.019

Sequence Information:

Length: 371
Mass: 41379
Checksum: 82152E496B924EEC
Sequence:

MELELDAGDQ DLLAFLLEES GDLGTAPDEA VRAPLDWALP LSEVPSDWEV DDLLCSLLSP 
PASLNILSSS NPCLVHHDHT YSLPRETVSM DLESESCRKE GTQMTPQHME ELAEQEIARL 
VLTDEEKSLL EKEGLILPET LPLTKTEEQI LKRVRRKIRN KRSAQESRRK KKVYVGGLES 
RVLKYTAQNM ELQNKVQLLE EQNLSLLDQL RKLQAMVIEI SNKTSSSSTC ILVLLVSFCL 
LLVPAMYSSD TRGSLPAEHG VLSRQLRALP SEDPYQLELP ALQSEVPKDS THQWLDGSDC 
VLQAPGNTSC LLHYMPQAPS AEPPLEWPFP DLFSEPLCRG PILPLQANLT RKGGWLPTGS 
PSVILQDRYS G

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CREB3

Associated with

Other Information

Luman, a new member of the CREB/ATF family, binds to herpes simplex virus VP16-associated host cellular factor. PubMed ID: 9271389

Viral mimicry: common mode of association with HCF by VP16 and the cellular protein LZIP. PubMed ID: 9389645

Hepatitis C virus core protein-induced loss of LZIP function correlates with cellular transformation. PubMed ID: 10675342

A novel isoform of human LZIP negatively regulates the transactivation of the glucocorticoid receptor. PubMed ID: 19779205

DNA sequence and analysis of human chromosome 9. PubMed ID: 15164053

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Potential role for luman, the cellular homologue of herpes simplex virus VP16 (alpha gene trans-inducing factor), in herpesvirus latency. PubMed ID: 10623756

Mutations in host cell factor 1 separate its role in cell proliferation from recruitment of VP16 and LZIP. PubMed ID: 10629049

N-terminal transcriptional activation domain of LZIP comprises two LxxLL motifs and the host cell factor-1 binding motif. PubMed ID: 10984507

Luman, the cellular counterpart of herpes simplex virus VP16, is processed by regulated intramembrane proteolysis. PubMed ID: 12138176

Human LZIP binds to CCR1 and differentially affects the chemotactic activities of CCR1-dependent chemokines. PubMed ID: 15001559

Luman is capable of binding and activating transcription from the unfolded protein response element. PubMed ID: 15845366

Zhangfei is a potent and specific inhibitor of the host cell factor-binding transcription factor Luman. PubMed ID: 15705566

Luman, a new partner of HIV-1 TMgp41, interferes with Tat-mediated transcription of the HIV-1 LTR. PubMed ID: 17054986

Luman/CREB3 induces transcription of the endoplasmic reticulum (ER) stress response protein Herp through an ER stress response element. PubMed ID: 16940180

Regulation of human LZIP expression by NF-kappaB and its involvement in monocyte cell migration induced by Lkn-1. PubMed ID: 17296613

Human LZIP induces monocyte CC chemokine receptor 2 expression leading to enhancement of monocyte chemoattractant protein 1/CCL2-induced cell migration. PubMed ID: 18587271

A novel protein, Luman/CREB3 recruitment factor, inhibits Luman activation of the unfolded protein response. PubMed ID: 18391022

DC-STAMP interacts with ER-resident transcription factor LUMAN which becomes activated during DC maturation. PubMed ID: 20546900