Details for: LRRC41

Gene ID: 10489

Symbol: LRRC41

Ensembl ID: ENSG00000132128

Description: leucine rich repeat containing 41

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.5
    Marker Score: 2,158
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.5
    Marker Score: 5,886
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.41
    Marker Score: 1,501
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.36
    Marker Score: 2,843
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.36
    Marker Score: 5,866
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.35
    Marker Score: 8,802
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.35
    Marker Score: 12,657
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.34
    Marker Score: 82,672
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.3
    Marker Score: 48,076
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.3
    Marker Score: 12,381
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.28
    Marker Score: 4,733
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.27
    Marker Score: 10,872
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.26
    Marker Score: 842
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.25
    Marker Score: 1,349
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.24
    Marker Score: 5,054
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.23
    Marker Score: 3,360
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.23
    Marker Score: 1,303
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.23
    Marker Score: 1,809
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.22
    Marker Score: 46,254
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.21
    Marker Score: 2,062
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.18
    Marker Score: 40,945
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.18
    Marker Score: 1,820
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.15
    Marker Score: 671
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.15
    Marker Score: 631
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.14
    Marker Score: 4,426
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.14
    Marker Score: 4,766
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.14
    Marker Score: 11,455
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.14
    Marker Score: 22,642
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.13
    Marker Score: 4,695
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.12
    Marker Score: 12,643
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.12
    Marker Score: 16,745
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.11
    Marker Score: 315
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.1
    Marker Score: 11,358
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.08
    Marker Score: 8,290
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.06
    Marker Score: 4,075
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 1.05
    Marker Score: 1,032
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.05
    Marker Score: 1,058
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.05
    Marker Score: 16,400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.05
    Marker Score: 18,555
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.04
    Marker Score: 1,080
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.02
    Marker Score: 6,025
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.02
    Marker Score: 848
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1.01
    Marker Score: 352
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,651
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47,876
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,382
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.98
    Marker Score: 2,298
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.96
    Marker Score: 246
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.96
    Marker Score: 1,014
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.96
    Marker Score: 1,573
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.95
    Marker Score: 1,019
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.95
    Marker Score: 32,284
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.95
    Marker Score: 277
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.94
    Marker Score: 8,112
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,389
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.94
    Marker Score: 1,052
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.93
    Marker Score: 700
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.93
    Marker Score: 1,429
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 477
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.92
    Marker Score: 19,624
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 434
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.91
    Marker Score: 214
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,722
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.9
    Marker Score: 1,168
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.9
    Marker Score: 11,877
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.89
    Marker Score: 555
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.89
    Marker Score: 1,021
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.88
    Marker Score: 1,067
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.88
    Marker Score: 5,026
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.88
    Marker Score: 357
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.87
    Marker Score: 3,578
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.87
    Marker Score: 424
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,292
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.87
    Marker Score: 171
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.87
    Marker Score: 614
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.87
    Marker Score: 1,091
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.87
    Marker Score: 938
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.87
    Marker Score: 1,540
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.86
    Marker Score: 1,012
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 307
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.85
    Marker Score: 210
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.85
    Marker Score: 580
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.85
    Marker Score: 272
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.85
    Marker Score: 1,929
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.85
    Marker Score: 1,374
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.85
    Marker Score: 341
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.83
    Marker Score: 786
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.83
    Marker Score: 3,455
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.83
    Marker Score: 6,167
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.82
    Marker Score: 880
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.81
    Marker Score: 398
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.81
    Marker Score: 325
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.81
    Marker Score: 998
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.81
    Marker Score: 811
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.8
    Marker Score: 507
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.8
    Marker Score: 694
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.8
    Marker Score: 737
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.8
    Marker Score: 1,955
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.8
    Marker Score: 231
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.8
    Marker Score: 323

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** LRRC41 is a protein encoded by the ENSG00000132128 gene, which is significantly expressed in various cell types, including oogonial cells, placental villous trophoblasts, epithelial cells of the nephron, decidual cells, and interstitial cells of the ovary. Its primary characteristic is the presence of leucine-rich repeat domains, which are known to be involved in protein-protein interactions and recognition. LRRC41's expression pattern and protein structure suggest its involvement in a wide range of cellular functions, including antigen processing, protein ubiquitination, and signal transduction. **Pathways and Functions:** LRRC41's involvement in various cellular pathways is a testament to its multifaceted role in immune regulation and cellular function. Some of the key pathways and functions associated with LRRC41 include: 1. **Adaptive Immune System:** LRRC41 is involved in the adaptive immune response, particularly in the processing and presentation of antigens through Class I MHC molecules. 2. **Antigen Processing: Ubiquitination & Proteasome Degradation:** LRRC41 plays a crucial role in the ubiquitination and proteasome degradation of proteins, which is essential for the proper functioning of the immune system. 3. **Class I MHC Mediated Antigen Processing & Presentation:** LRRC41 is involved in the processing and presentation of antigens through Class I MHC molecules, which is critical for the recognition of infected cells and the activation of immune responses. 4. **Signal Transduction:** LRRC41 is also involved in signal transduction pathways, including those mediated by Rho GTPases, Miro GTPases, and Rhobtb3, which are essential for cellular signaling and response. 5. **Protein Binding and Ubiquitination:** LRRC41's leucine-rich repeat domains enable it to interact with other proteins, including those involved in protein ubiquitination and degradation. **Clinical Significance:** The clinical significance of LRRC41 lies in its potential role in various diseases, including: 1. **Autoimmune Disorders:** Alterations in LRRC41 expression or function may contribute to the development of autoimmune disorders, such as multiple sclerosis or type 1 diabetes. 2. **Cancer:** LRRC41's involvement in antigen processing and presentation may also play a role in cancer development and progression. 3. **Neurological Disorders:** LRRC41's expression in neurons and its involvement in signal transduction pathways may also contribute to the development of neurological disorders, such as Alzheimer's disease or Parkinson's disease. In conclusion, LRRC41 is a complex gene with significant implications in the adaptive immune system, protein metabolism, and cellular signaling pathways. Further research is needed to fully elucidate the clinical significance of LRRC41 and its potential role in various diseases.

Genular Protein ID: 2319059934

Symbol: LRC41_HUMAN

Name: Leucine-rich repeat-containing protein 41

UniProtKB Accession Codes:

Q15345 A8K5G8 Q3MJ96 Q5TDF5 Q71RA8 Q9BSM0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 12 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 3 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15498874

Title: Large-scale cDNA transfection screening for genes related to cancer development and progression.

PubMed ID: 15498874

DOI: 10.1073/pnas.0404089101

PubMed ID: 11384984

Title: Muf1, a novel elongin BC-interacting leucine-rich repeat protein that can assemble with Cul5 and Rbx1 to reconstitute a ubiquitin ligase.

PubMed ID: 11384984

DOI: 10.1074/jbc.m103093200

PubMed ID: 15601820

Title: VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases.

PubMed ID: 15601820

DOI: 10.1101/gad.1252404

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 812
  • Mass: 88650
  • Checksum: 9356F26D014B436A
  • Sequence:
    • MAAPEAWRAR SCWFCEVAAA TTMEATSREA APAKSSASGP NAPPALFELC GRAVSAHMGV 
LESGVWALPG PILQSILPLL NIYYLERIEE TALKKGLSTQ AIWRRLWDEL MKTRPSSLES 
VTCWRAKFME AFFSHVLRGT IDVSSDRRLC DQRFSPLLHS SRHVRQLTIC NMLQGATELV 
AEPNRRVLET LASSLHTLKF RHLLFSDVAA QQSLRQLLHQ LIHHGAVSQV SLYSWPVPES 
ALFILILTMS AGFWQPGPGG PPCRLCGEAS RGRAPSRDEG SLLLGSRRPR RDAAERCAAA 
LMASRRKSEA KQMPRAAPAT RVTRRSTQES LTAGGTDLKR ELHPPATSHE APGTKRSPSA 
PAATSSASSS TSSYKRAPAS SAPQPKPLKR FKRAAGKKGA RTRQGPGAES EDLYDFVFIV 
AGEKEDGEEM EIGEVACGAL DGSDPSCLGL PALEASQRFR SISTLELFTV PLSTEAALTL 
CHLLSSWVSL ESLTLSYNGL GSNIFRLLDS LRALSGQAGC RLRALHLSDL FSPLPILELT 
RAIVRALPLL RVLSIRVDHP SQRDNPGVPG NAGPPSHIIG DEEIPENCLE QLEMGFPRGA 
QPAPLLCSVL KASGSLQQLS LDSATFASPQ DFGLVLQTLK EYNLALKRLS FHDMNLADCQ 
SEVLFLLQNL TLQEITFSFC RLFEKRPAQF LPEMVAAMKG NSTLKGLRLP GNRLGNAGLL 
ALADVFSEDS SSSLCQLDIS SNCIKPDGLL EFAKRLERWG RGAFGHLRLF QNWLDQDAVT 
AREAIRRLRA TCHVVSDSWD SSQAFADYVS TM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.