Details for: ADARB2

Gene ID: 105

Symbol: ADARB2

Ensembl ID: ENSG00000185736

Description: adenosine deaminase RNA specific B2 (inactive)

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 6.02
    Marker Score: 32312
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 2.99
    Marker Score: 1149
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.89
    Marker Score: 22126
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.87
    Marker Score: 42878
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.75
    Marker Score: 104464
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.37
    Marker Score: 9163
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 2.34
    Marker Score: 10829
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 2.19
    Marker Score: 2712.5
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 2.19
    Marker Score: 982
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 2.15
    Marker Score: 1248
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 2.05
    Marker Score: 21155
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.97
    Marker Score: 1107
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.85
    Marker Score: 2131
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.79
    Marker Score: 4283
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.66
    Marker Score: 3137.5
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6
    Marker Score: 1164
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.48
    Marker Score: 3006
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 169053
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.47
    Marker Score: 1667
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.46
    Marker Score: 1457
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.38
    Marker Score: 29502
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.27
    Marker Score: 399
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.25
    Marker Score: 849.5
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 1.22
    Marker Score: 917
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.21
    Marker Score: 725
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.13
    Marker Score: 17702
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 1.12
    Marker Score: 582
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.09
    Marker Score: 499
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.09
    Marker Score: 2557
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.06
    Marker Score: 4328
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.06
    Marker Score: 671
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 1.01
    Marker Score: 4231
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71810
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48036
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.99
    Marker Score: 1092
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 505
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 0.98
    Marker Score: 469
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 459
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.95
    Marker Score: 394
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5308
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 371
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2740
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 324
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.89
    Marker Score: 585
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5284
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.86
    Marker Score: 7375
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.84
    Marker Score: 3534.5
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.84
    Marker Score: 905
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.83
    Marker Score: 3446
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.82
    Marker Score: 862
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.81
    Marker Score: 621
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1258
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.76
    Marker Score: 697
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 394
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.75
    Marker Score: 1707
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.74
    Marker Score: 1249
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.74
    Marker Score: 351
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 459
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.71
    Marker Score: 14193
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.71
    Marker Score: 185
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 0.7
    Marker Score: 3680
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.7
    Marker Score: 1073
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.66
    Marker Score: 1205
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.66
    Marker Score: 820
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.65
    Marker Score: 387
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.64
    Marker Score: 498.5
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.63
    Marker Score: 277
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.61
    Marker Score: 194
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.61
    Marker Score: 5774
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.57
    Marker Score: 493
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.57
    Marker Score: 20931
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.56
    Marker Score: 1589
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.56
    Marker Score: 202.5
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 148
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 442
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 173
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.53
    Marker Score: 509
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.53
    Marker Score: 4971
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.53
    Marker Score: 32320
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.53
    Marker Score: 306
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.52
    Marker Score: 319
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.5
    Marker Score: 1437
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.48
    Marker Score: 243
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.47
    Marker Score: 266
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.44
    Marker Score: 200
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.44
    Marker Score: 715
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.42
    Marker Score: 14069
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 0.4
    Marker Score: 218
  • Cell Name: meningeal macrophage (CL0000879)
    Fold Change: 0.4
    Marker Score: 113
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.4
    Marker Score: 162
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.4
    Marker Score: 2943
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.38
    Marker Score: 155
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.38
    Marker Score: 470
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.37
    Marker Score: 2489
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.37
    Marker Score: 483
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.36
    Marker Score: 169
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.35
    Marker Score: 312

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** - It is a single-exon gene with a size of approximately 600 bp. - It is located on chromosome 19p13.3. - It is expressed in a variety of cell types, including stellate neuron, GABAergic interneuron, sncg GABAergic cortical interneuron, lamp5 GABAergic cortical interneuron, vip GABAergic cortical interneuron, caudal ganglionic eminence derived GABAergic cortical interneuron, inhibitory interneuron, oligodendrocyte precursor cell, epithelial cell of alveolus of lung, brainstem motor neuron. **Pathways and functions:** - ADARB2 is involved in the processing of double-stranded RNA by catalyzing the deamination of adenosine residues to inosine. - It is involved in the regulation of gene expression by controlling the stability and translation of mRNA. - It is also involved in the regulation of cell proliferation and differentiation. **Clinical significance:** - Mutations in ADARB2 have been linked to a number of human diseases, including autism spectrum disorder, schizophrenia, and epilepsy. - ADARB2 inhibitors are being investigated as potential treatments for these disorders.

Genular Protein ID: 2427913924

Symbol: RED2_HUMAN

Name: Double-stranded RNA-specific editase B2

UniProtKB Accession Codes:

Q9NS39 B2RPJ5 Q5VUT6 Q5VW42

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChEBI 3 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 9 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 1 SAM 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SWISS-2DPAGE 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10836796

Title: A third member of the RNA-specific adenosine deaminase gene family, ADAR3, contains both single- and double-stranded RNA binding domains.

PubMed ID: 10836796

DOI: 10.1017/s1355838200000170

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18178553

Title: Down-regulation of RNA editing in pediatric astrocytomas: ADAR2 editing activity inhibits cell migration and proliferation.

PubMed ID: 18178553

DOI: 10.1074/jbc.m708316200

PubMed ID: 22113393

Title: Activity regulation of adenosine deaminases acting on RNA (ADARs).

PubMed ID: 22113393

DOI: 10.1007/s12035-011-8220-2

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 739
  • Mass: 80621
  • Checksum: A158A81D35894F79
  • Sequence:
    • MASVLGSGRG SGGLSSQLKC KSKRRRRRRS KRKDKVSILS TFLAPFKHLS PGITNTEDDD 
TLSTSSAEVK ENRNVGNLAA RPPPSGDRAR GGAPGAKRKR PLEEGNGGHL CKLQLVWKKL 
SWSVAPKNAL VQLHELRPGL QYRTVSQTGP VHAPVFAVAV EVNGLTFEGT GPTKKKAKMR 
AAELALRSFV QFPNACQAHL AMGGGPGPGT DFTSDQADFP DTLFQEFEPP APRPGLAGGR 
PGDAALLSAA YGRRRLLCRA LDLVGPTPAT PAAPGERNPV VLLNRLRAGL RYVCLAEPAE 
RRARSFVMAV SVDGRTFEGS GRSKKLARGQ AAQAALQELF DIQMPGHAPG RARRTPMPQE 
FADSISQLVT QKFREVTTDL TPMHARHKAL AGIVMTKGLD ARQAQVVALS SGTKCISGEH 
LSDQGLVVND CHAEVVARRA FLHFLYTQLE LHLSKRREDS ERSIFVRLKE GGYRLRENIL 
FHLYVSTSPC GDARLHSPYE ITTDLHSSKH LVRKFRGHLR TKIESGEGTV PVRGPSAVQT 
WDGVLLGEQL ITMSCTDKIA RWNVLGLQGA LLSHFVEPVY LQSIVVGSLH HTGHLARVMS 
HRMEGVGQLP ASYRHNRPLL SGVSDAEARQ PGKSPPFSMN WVVGSADLEI INATTGRRSC 
GGPSRLCKHV LSARWARLYG RLSTRTPSPG DTPSMYCEAK LGAHTYQSVK QQLFKAFQKA 
GLGTWVRKPP EQQQFLLTL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.