Details for: ADARB2

Gene ID: 105

Symbol: ADARB2

Ensembl ID: ENSG00000185736

Description: adenosine deaminase RNA specific B2 (inactive)

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 164.3843
    Cell Significance Index: -41.7000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 10.3730
    Cell Significance Index: 3720.6300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 8.3707
    Cell Significance Index: -18.3200
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 7.9493
    Cell Significance Index: 103.0900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 7.5819
    Cell Significance Index: 466.0200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 6.9980
    Cell Significance Index: 167.8300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 4.7462
    Cell Significance Index: 266.3300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.8857
    Cell Significance Index: 52.7000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.7895
    Cell Significance Index: 57.3200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.9066
    Cell Significance Index: 627.0600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.7550
    Cell Significance Index: 143.6900
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 0.6929
    Cell Significance Index: 6.9800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.4464
    Cell Significance Index: 6.0900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3269
    Cell Significance Index: 295.1900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3196
    Cell Significance Index: 64.1100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2426
    Cell Significance Index: 24.0000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1996
    Cell Significance Index: 4.9900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.1524
    Cell Significance Index: 3.0600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1112
    Cell Significance Index: 18.0900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1102
    Cell Significance Index: 5.1400
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.0420
    Cell Significance Index: 0.5300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0405
    Cell Significance Index: 25.7300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0111
    Cell Significance Index: 0.3200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0049
    Cell Significance Index: -0.3000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0055
    Cell Significance Index: -0.6000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0074
    Cell Significance Index: -0.2600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0126
    Cell Significance Index: -23.7500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0145
    Cell Significance Index: -26.8000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0178
    Cell Significance Index: -27.4300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0279
    Cell Significance Index: -20.7000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0312
    Cell Significance Index: -42.3700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0422
    Cell Significance Index: -30.9300
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0454
    Cell Significance Index: -0.5500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0607
    Cell Significance Index: -34.2400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0679
    Cell Significance Index: -30.0100
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0686
    Cell Significance Index: -0.8200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0696
    Cell Significance Index: -31.5800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0808
    Cell Significance Index: -44.1300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1052
    Cell Significance Index: -4.7700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1100
    Cell Significance Index: -31.6600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1102
    Cell Significance Index: -2.3800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.1467
    Cell Significance Index: -26.4400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1689
    Cell Significance Index: -33.5200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1734
    Cell Significance Index: -25.2100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1984
    Cell Significance Index: -41.7800
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.2051
    Cell Significance Index: -4.0900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.2155
    Cell Significance Index: -5.2200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.2159
    Cell Significance Index: -12.9600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.2218
    Cell Significance Index: -28.4300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.2243
    Cell Significance Index: -4.8600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.2313
    Cell Significance Index: -39.5000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.2373
    Cell Significance Index: -29.1800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.2463
    Cell Significance Index: -17.0400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2636
    Cell Significance Index: -30.2000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2845
    Cell Significance Index: -21.8300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2888
    Cell Significance Index: -37.3100
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.3160
    Cell Significance Index: -6.2200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.3252
    Cell Significance Index: -44.6600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.3686
    Cell Significance Index: -43.4800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.3695
    Cell Significance Index: -37.7400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.3697
    Cell Significance Index: -7.6700
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.3716
    Cell Significance Index: -4.3400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3845
    Cell Significance Index: -44.8100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3910
    Cell Significance Index: -30.9700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.4081
    Cell Significance Index: -6.1500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4187
    Cell Significance Index: -43.6000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4302
    Cell Significance Index: -28.9300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.5035
    Cell Significance Index: -7.2100
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.5241
    Cell Significance Index: -6.5000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.5366
    Cell Significance Index: -34.6200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.5468
    Cell Significance Index: -40.7500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.5825
    Cell Significance Index: -25.3300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.5829
    Cell Significance Index: -9.9900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.6299
    Cell Significance Index: -32.8100
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.6314
    Cell Significance Index: -6.7700
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.7184
    Cell Significance Index: -6.8100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.7466
    Cell Significance Index: -35.0900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.7636
    Cell Significance Index: -48.1300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.8104
    Cell Significance Index: -42.5500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.8173
    Cell Significance Index: -26.7600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.8287
    Cell Significance Index: -29.0300
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.8793
    Cell Significance Index: -18.8000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.9112
    Cell Significance Index: -29.0200
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.9294
    Cell Significance Index: -13.2300
  • Cell Name: interneuron (CL0000099)
    Fold Change: -0.9486
    Cell Significance Index: -11.0800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.9500
    Cell Significance Index: -42.0200
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: -0.9805
    Cell Significance Index: -11.1400
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.9884
    Cell Significance Index: -12.9000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.0216
    Cell Significance Index: -26.2600
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -1.0358
    Cell Significance Index: -17.9100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -1.0930
    Cell Significance Index: -41.3900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -1.0996
    Cell Significance Index: -57.1200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -1.1028
    Cell Significance Index: -31.4700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -1.1079
    Cell Significance Index: -24.2600
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -1.1552
    Cell Significance Index: -24.1100
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -1.1745
    Cell Significance Index: -17.3400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.1874
    Cell Significance Index: -43.5900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.1937
    Cell Significance Index: -35.1600
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -1.2099
    Cell Significance Index: -30.1800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -1.2302
    Cell Significance Index: -26.2000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ADARB2 is a gene that codes for a protein involved in RNA editing, specifically in the editing of double-stranded RNA. The gene is characterized by its expression in specific cell types, including stellate neurons, GABAergic interneurons, and oligodendrocyte precursor cells. The protein product of ADARB2, RED2_HUMAN, is a double-stranded RNA-specific editase B2, which suggests its role in editing double-stranded RNA. **Pathways and Functions:** ADARB2 is involved in several pathways, including: 1. **Adenosine deaminase activity**: ADARB2 is involved in the deamination of adenosine to inosine, a process that is crucial for RNA editing. 2. **Adenosine to inosine editing**: ADARB2 plays a key role in editing adenosine to inosine in double-stranded RNA, which is essential for maintaining genome stability and regulating gene expression. 3. **Cytoplasmic localization**: ADARB2 is primarily localized to the cytoplasm, where it can interact with double-stranded RNA and regulate its editing. 4. **Double-stranded RNA binding**: ADARB2 binds to double-stranded RNA, which allows it to edit its nucleotides and regulate gene expression. 5. **Metal ion binding**: ADARB2 binds to metal ions, such as zinc and magnesium, which are essential for its enzymatic activity. **Clinical Significance:** ADARB2 has been implicated in various neurological disorders, including: 1. **Neurodevelopmental disorders**: ADARB2 has been linked to neurodevelopmental disorders, such as autism spectrum disorder and intellectual disability, which are characterized by impaired RNA editing and gene regulation. 2. **Neurodegenerative diseases**: ADARB2 has been implicated in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, which are characterized by impaired RNA editing and gene regulation. 3. **Cancer**: ADARB2 has been linked to cancer, particularly in the context of RNA editing and gene regulation. In conclusion, ADARB2 is a gene that plays a critical role in RNA editing and has been implicated in various neurological and immunological disorders. Further research is needed to fully understand the mechanisms of ADARB2 and its role in human disease. **Recommendations:** 1. **Further research**: Conduct further research to elucidate the mechanisms of ADARB2 and its role in human disease. 2. **Investigate ADARB2 in neurological disorders**: Investigate ADARB2 in neurological disorders, such as autism spectrum disorder and Alzheimer's disease, to better understand its role in these conditions. 3. **Develop therapeutic strategies**: Develop therapeutic strategies to target ADARB2 in the context of neurological and immunological disorders. By shedding light on the mysteries of ADARB2, we can gain a deeper understanding of the complex mechanisms of RNA editing and its role in human disease.

Genular Protein ID: 2427913924

Symbol: RED2_HUMAN

Name: Double-stranded RNA-specific editase B2

UniProtKB Accession Codes:

Q9NS39 B2RPJ5 Q5VUT6 Q5VW42

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChEBI 3 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 9 Ensembl 2 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10836796

Title: A third member of the RNA-specific adenosine deaminase gene family, ADAR3, contains both single- and double-stranded RNA binding domains.

PubMed ID: 10836796

DOI: 10.1017/s1355838200000170

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18178553

Title: Down-regulation of RNA editing in pediatric astrocytomas: ADAR2 editing activity inhibits cell migration and proliferation.

PubMed ID: 18178553

DOI: 10.1074/jbc.m708316200

PubMed ID: 22113393

Title: Activity regulation of adenosine deaminases acting on RNA (ADARs).

PubMed ID: 22113393

DOI: 10.1007/s12035-011-8220-2

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 739
  • Mass: 80621
  • Checksum: A158A81D35894F79
  • Sequence:
    • MASVLGSGRG SGGLSSQLKC KSKRRRRRRS KRKDKVSILS TFLAPFKHLS PGITNTEDDD 
TLSTSSAEVK ENRNVGNLAA RPPPSGDRAR GGAPGAKRKR PLEEGNGGHL CKLQLVWKKL 
SWSVAPKNAL VQLHELRPGL QYRTVSQTGP VHAPVFAVAV EVNGLTFEGT GPTKKKAKMR 
AAELALRSFV QFPNACQAHL AMGGGPGPGT DFTSDQADFP DTLFQEFEPP APRPGLAGGR 
PGDAALLSAA YGRRRLLCRA LDLVGPTPAT PAAPGERNPV VLLNRLRAGL RYVCLAEPAE 
RRARSFVMAV SVDGRTFEGS GRSKKLARGQ AAQAALQELF DIQMPGHAPG RARRTPMPQE 
FADSISQLVT QKFREVTTDL TPMHARHKAL AGIVMTKGLD ARQAQVVALS SGTKCISGEH 
LSDQGLVVND CHAEVVARRA FLHFLYTQLE LHLSKRREDS ERSIFVRLKE GGYRLRENIL 
FHLYVSTSPC GDARLHSPYE ITTDLHSSKH LVRKFRGHLR TKIESGEGTV PVRGPSAVQT 
WDGVLLGEQL ITMSCTDKIA RWNVLGLQGA LLSHFVEPVY LQSIVVGSLH HTGHLARVMS 
HRMEGVGQLP ASYRHNRPLL SGVSDAEARQ PGKSPPFSMN WVVGSADLEI INATTGRRSC 
GGPSRLCKHV LSARWARLYG RLSTRTPSPG DTPSMYCEAK LGAHTYQSVK QQLFKAFQKA 
GLGTWVRKPP EQQQFLLTL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.