CEBPA | ENSG00000245848 | NCBI 1050

Details for: CEBPA

Gene ID: 1050

Symbol: CEBPA

Ensembl ID: ENSG00000245848

Description: CCAAT enhancer binding protein alpha

Associated with

Developmental biology
(R-HSA-1266738)
Transcriptional regulation of granulopoiesis
(R-HSA-9616222)
Transcriptional regulation of white adipocyte differentiation
(R-HSA-381340)
Brown fat cell differentiation
(GO:0050873)
C/ebp complex
(GO:1990647)
Cellular response to lithium ion
(GO:0071285)
Cellular response to organic cyclic compound
(GO:0071407)
Cellular response to tumor necrosis factor
(GO:0071356)
Cholesterol metabolic process
(GO:0008203)
Chop-c/ebp complex
(GO:0036488)
Chromatin
(GO:0000785)
Chromatin dna binding
(GO:0031490)
Cytokine-mediated signaling pathway
(GO:0019221)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna-templated transcription
(GO:0006351)
Dna binding
(GO:0003677)
Embryonic placenta development
(GO:0001892)
Epithelial cell maturation
(GO:0002070)
Fat cell differentiation
(GO:0045444)
Generation of precursor metabolites and energy
(GO:0006091)
Glucose homeostasis
(GO:0042593)
Granulocyte differentiation
(GO:0030851)
Hematopoietic stem cell proliferation
(GO:0071425)
Identical protein binding
(GO:0042802)
Inner ear development
(GO:0048839)
Integrated stress response signaling
(GO:0140467)
Interleukin-6-mediated signaling pathway
(GO:0070102)
Intracellular membrane-bounded organelle
(GO:0043231)
Kinase binding
(GO:0019900)
Lipid homeostasis
(GO:0055088)
Liver development
(GO:0001889)
Lung development
(GO:0030324)
Macrophage differentiation
(GO:0030225)
Mitochondrion organization
(GO:0007005)
Myeloid cell differentiation
(GO:0030099)
Negative regulation of cell cycle
(GO:0045786)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of hematopoietic stem cell proliferation
(GO:1902034)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Notch signaling pathway
(GO:0007219)
Nucleolus
(GO:0005730)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of fat cell differentiation
(GO:0045600)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of inflammatory response
(GO:0050729)
Positive regulation of macrophage activation
(GO:0043032)
Positive regulation of osteoblast differentiation
(GO:0045669)
Positive regulation of proteasomal ubiquitin-dependent protein catabolic process
(GO:0032436)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Regulation of cell cycle
(GO:0051726)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Rna polymerase ii-specific dna-binding transcription factor binding
(GO:0061629)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Rna polymerase ii transcription regulator complex
(GO:0090575)
Stat family protein binding
(GO:0097677)
Transcription cis-regulatory region binding
(GO:0000976)
Transcription regulator complex
(GO:0005667)
Urea cycle
(GO:0000050)
White fat cell differentiation
(GO:0050872)

Other Information

Proteins

CEBPA_HUMAN

Genular Protein ID: 2856205059

Symbol: CEBPA_HUMAN

Name: N/A

UniProtKB Accession Codes:

P49715 A7LNP2 P78319 Q05CA4

Database IDs:

Citations:

PubMed ID: 7575576

Title: Molecular cloning, sequence, and expression patterns of the human gene encoding CCAAT/enhancer binding protein alpha (C/EBP alpha).

PubMed ID: 7575576

DOI: 10.1006/bbrc.1995.2439

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9915821

Title: Interaction of hepatitis B viral X protein and CCAAT/enhancer-binding protein alpha synergistically activates the hepatitis B viral enhancer II/pregenomic promoter.

PubMed ID: 9915821

DOI: 10.1074/jbc.274.5.2858

PubMed ID: 10725330

Title: Ubinuclein, a novel nuclear protein interacting with cellular and viral transcription factors.

PubMed ID: 10725330

DOI: 10.1083/jcb.148.6.1165

PubMed ID: 12661007

Title: Mutations of CEBPA in acute myeloid leukemia FAB types M1 and M2.

PubMed ID: 12661007

DOI: 10.1002/gcc.10185

PubMed ID: 15107404

Title: Liver tumors escape negative control of proliferation via PI3K/Akt-mediated block of C/EBP alpha growth inhibitory activity.

PubMed ID: 15107404

DOI: 10.1101/gad.1183304

PubMed ID: 15078966

Title: CCAAT/enhancer binding protein alpha binds to the Epstein-Barr virus (EBV) ZTA protein through oligomeric interactions and contributes to cooperative transcriptional activation of the ZTA promoter through direct binding to the ZII and ZIIIB motifs during induction of the EBV lytic cycle.

PubMed ID: 15078966

DOI: 10.1128/jvi.78.9.4847-4865.2004

PubMed ID: 14660596

Title: The CCAAT enhancer-binding protein alpha (C/EBPalpha) requires a SWI/SNF complex for proliferation arrest.

PubMed ID: 14660596

DOI: 10.1074/jbc.m312709200

PubMed ID: 15575056

Title: Mutation of CEBPA in familial acute myeloid leukemia.

PubMed ID: 15575056

DOI: 10.1056/nejmoa041331

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20410507

Title: Differential ability of Tribbles family members to promote degradation of C/EBPalpha and induce acute myelogenous leukemia.

PubMed ID: 20410507

DOI: 10.1182/blood-2009-07-229450

PubMed ID: 20075868

Title: Nucleolar retention of a translational C/EBPalpha isoform stimulates rDNA transcription and cell size.

PubMed ID: 20075868

DOI: 10.1038/emboj.2009.404

PubMed ID: 20176812

Title: Repression of transcriptional activity of C/EBPalpha by E2F-dimerization partner complexes.

PubMed ID: 20176812

DOI: 10.1128/mcb.01619-09

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 26455797

Title: Molecular mechanism of CCAAT-enhancer binding protein recruitment by the TRIB1 pseudokinase.

PubMed ID: 26455797

DOI: 10.1016/j.str.2015.08.017

PubMed ID: 27923061

Title: Comparative Transcriptomic and Epigenomic Analyses Reveal New Regulators of Murine Brown Adipogenesis.

PubMed ID: 27923061

DOI: 10.1371/journal.pgen.1006474

PubMed ID: 27041596

Title: Structural basis for substrate selectivity of the E3 ligase COP1.

PubMed ID: 27041596

DOI: 10.1016/j.str.2016.03.002

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 11242107

Title: Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-alpha (C/EBPalpha), in acute myeloid leukemia.

PubMed ID: 11242107

DOI: 10.1038/85820

Sequence Information:

Length: 358
Mass: 37561
Checksum: 574C0A049E25BCAC
Sequence:

MESADFYEAE PRPPMSSHLQ SPPHAPSSAA FGFPRGAGPA QPPAPPAAPE PLGGICEHET 
SIDISAYIDP AAFNDEFLAD LFQHSRQQEK AKAAVGPTGG GGGGDFDYPG APAGPGGAVM 
PGGAHGPPPG YGCAAAGYLD GRLEPLYERV GAPALRPLVI KQEPREEDEA KQLALAGLFP 
YQPPPPPPPS HPHPHPPPAH LAAPHLQFQI AHCGQTTMHL QPGHPTPPPT PVPSPHPAPA 
LGAAGLPGPG SALKGLGAAH PDLRASGGSG AGKAKKSVDK NSNEYRVRRE RNNIAVRKSR 
DKAKQRNVET QQKVLELTSD NDRLRKRVEQ LSRELDTLRG IFRQLPESSL VKAMGNCA

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CEBPA

Associated with

Other Information

Molecular cloning, sequence, and expression patterns of the human gene encoding CCAAT/enhancer binding protein alpha (C/EBP alpha). PubMed ID: 7575576

The DNA sequence and biology of human chromosome 19. PubMed ID: 15057824

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Interaction of hepatitis B viral X protein and CCAAT/enhancer-binding protein alpha synergistically activates the hepatitis B viral enhancer II/pregenomic promoter. PubMed ID: 9915821

Ubinuclein, a novel nuclear protein interacting with cellular and viral transcription factors. PubMed ID: 10725330

Mutations of CEBPA in acute myeloid leukemia FAB types M1 and M2. PubMed ID: 12661007

Liver tumors escape negative control of proliferation via PI3K/Akt-mediated block of C/EBP alpha growth inhibitory activity. PubMed ID: 15107404

The CCAAT enhancer-binding protein alpha (C/EBPalpha) requires a SWI/SNF complex for proliferation arrest. PubMed ID: 14660596

Mutation of CEBPA in familial acute myeloid leukemia. PubMed ID: 15575056

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Differential ability of Tribbles family members to promote degradation of C/EBPalpha and induce acute myelogenous leukemia. PubMed ID: 20410507

Nucleolar retention of a translational C/EBPalpha isoform stimulates rDNA transcription and cell size. PubMed ID: 20075868

Repression of transcriptional activity of C/EBPalpha by E2F-dimerization partner complexes. PubMed ID: 20176812

Uncovering global SUMOylation signaling networks in a site-specific manner. PubMed ID: 25218447

Molecular mechanism of CCAAT-enhancer binding protein recruitment by the TRIB1 pseudokinase. PubMed ID: 26455797

Comparative Transcriptomic and Epigenomic Analyses Reveal New Regulators of Murine Brown Adipogenesis. PubMed ID: 27923061

Structural basis for substrate selectivity of the E3 ligase COP1. PubMed ID: 27041596

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733

Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-alpha (C/EBPalpha), in acute myeloid leukemia. PubMed ID: 11242107