CEBPA | ENSG00000245848 | NCBI 1050

Details for: CEBPA

Gene ID: 1050

Symbol: CEBPA

Ensembl ID: ENSG00000245848

Description: CCAAT enhancer binding protein alpha

Associated with

Adipogenesis
(R-HSA-9843745)
Developmental biology
(R-HSA-1266738)
Epigenetic regulation by wdr5-containing histone modifying complexes
(R-HSA-9917777)
Epigenetic regulation of adipogenesis genes by mll3 and mll4 complexes
(R-HSA-9851695)
Epigenetic regulation of gene expression
(R-HSA-212165)
Epigenetic regulation of gene expression by mll3 and mll4 complexes
(R-HSA-9818564)
Gene expression (transcription)
(R-HSA-74160)
Mll4 and mll3 complexes regulate expression of pparg target genes in adipogenesis and hepatic steatosis
(R-HSA-9841922)
Transcriptional regulation of granulopoiesis
(R-HSA-9616222)
Transcriptional regulation of white adipocyte differentiation
(R-HSA-381340)
Brown fat cell differentiation
(GO:0050873)
C/ebp complex
(GO:1990647)
Cellular response to lithium ion
(GO:0071285)
Cellular response to organic cyclic compound
(GO:0071407)
Cellular response to tumor necrosis factor
(GO:0071356)
Cholesterol metabolic process
(GO:0008203)
Chop-c/ebp complex
(GO:0036488)
Chromatin
(GO:0000785)
Chromatin dna binding
(GO:0031490)
Cytokine-mediated signaling pathway
(GO:0019221)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna-templated transcription
(GO:0006351)
Dna binding
(GO:0003677)
Embryonic placenta development
(GO:0001892)
Energy homeostasis
(GO:0097009)
Epithelial cell maturation
(GO:0002070)
Fat cell differentiation
(GO:0045444)
Generation of precursor metabolites and energy
(GO:0006091)
Glucose homeostasis
(GO:0042593)
Granulocyte differentiation
(GO:0030851)
Hematopoietic stem cell proliferation
(GO:0071425)
Identical protein binding
(GO:0042802)
Inner ear development
(GO:0048839)
Integrated stress response signaling
(GO:0140467)
Interleukin-6-mediated signaling pathway
(GO:0070102)
Intracellular membrane-bounded organelle
(GO:0043231)
Kinase binding
(GO:0019900)
Lipid homeostasis
(GO:0055088)
Liver development
(GO:0001889)
Lung development
(GO:0030324)
Macrophage differentiation
(GO:0030225)
Mitochondrion organization
(GO:0007005)
Myeloid cell differentiation
(GO:0030099)
Negative regulation of cell cycle
(GO:0045786)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of hematopoietic stem cell proliferation
(GO:1902034)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Notch signaling pathway
(GO:0007219)
Nucleolus
(GO:0005730)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of dna-templated transcription initiation
(GO:2000144)
Positive regulation of fat cell differentiation
(GO:0045600)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of inflammatory response
(GO:0050729)
Positive regulation of macrophage activation
(GO:0043032)
Positive regulation of osteoblast differentiation
(GO:0045669)
Positive regulation of proteasomal ubiquitin-dependent protein catabolic process
(GO:0032436)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Regulation of cell cycle
(GO:0051726)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Rna polymerase ii-specific dna-binding transcription factor binding
(GO:0061629)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Rna polymerase ii transcription regulator complex
(GO:0090575)
Rna polymerase i transcription regulatory region sequence-specific dna binding
(GO:0001163)
Stat family protein binding
(GO:0097677)
Transcription by rna polymerase i
(GO:0006360)
Transcription cis-regulatory region binding
(GO:0000976)
Transcription regulator complex
(GO:0005667)
Urea cycle
(GO:0000050)
White fat cell differentiation
(GO:0050872)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 85.6343
Cell Significance Index: -13.3200
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 42.6583
Cell Significance Index: -10.8200
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 28.1112
Cell Significance Index: -14.4600
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 20.6178
Cell Significance Index: -13.8400
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 10.7628
Cell Significance Index: -13.2700
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 5.6554
Cell Significance Index: -15.1500
Cell Name: hepatoblast (CL0005026)
Fold Change: 4.7444
Cell Significance Index: 79.8000
Cell Name: sebaceous gland cell (CL2000021)
Fold Change: 3.7331
Cell Significance Index: 4.8300
Cell Name: epidermal cell (CL0000362)
Fold Change: 3.5884
Cell Significance Index: 8.0900
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 3.3134
Cell Significance Index: -13.0800
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 2.8169
Cell Significance Index: 75.3500
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 2.7185
Cell Significance Index: 123.2200
Cell Name: early promyelocyte (CL0002154)
Fold Change: 2.2699
Cell Significance Index: 14.4900
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 1.9797
Cell Significance Index: 140.0100
Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.9026
Cell Significance Index: 188.2100
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 1.8080
Cell Significance Index: 48.4500
Cell Name: granular cell of epidermis (CL0002189)
Fold Change: 1.7373
Cell Significance Index: 2.0000
Cell Name: paneth cell of colon (CL0009009)
Fold Change: 1.6251
Cell Significance Index: 24.3500
Cell Name: late promyelocyte (CL0002151)
Fold Change: 1.2699
Cell Significance Index: 8.4300
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.2654
Cell Significance Index: 36.4600
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.2519
Cell Significance Index: 17.0800
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 1.2406
Cell Significance Index: 74.4800
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 1.2093
Cell Significance Index: 131.5400
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.1976
Cell Significance Index: 62.2100
Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.0645
Cell Significance Index: 211.2500
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 1.0463
Cell Significance Index: 170.1700
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 0.9870
Cell Significance Index: 15.2700
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.9539
Cell Significance Index: 421.7500
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.9260
Cell Significance Index: 59.7400
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 0.9247
Cell Significance Index: 8.5200
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.8507
Cell Significance Index: 18.4300
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.6721
Cell Significance Index: 46.4800
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.6063
Cell Significance Index: 16.1900
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.5770
Cell Significance Index: 521.0200
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.5013
Cell Significance Index: 90.3700
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.4588
Cell Significance Index: 87.3100
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.4381
Cell Significance Index: 11.9300
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.3935
Cell Significance Index: 8.3800
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.3928
Cell Significance Index: 48.3000
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.3078
Cell Significance Index: 10.8200
Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 0.2961
Cell Significance Index: 1.8400
Cell Name: subcutaneous adipocyte (CL0002521)
Fold Change: 0.2320
Cell Significance Index: 1.0100
Cell Name: Hofbauer cell (CL3000001)
Fold Change: 0.1901
Cell Significance Index: 1.5500
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.1320
Cell Significance Index: 3.3000
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 0.0872
Cell Significance Index: 25.1000
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.0464
Cell Significance Index: 9.3000
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.0398
Cell Significance Index: 30.1100
Cell Name: basal cell of epidermis (CL0002187)
Fold Change: 0.0089
Cell Significance Index: 0.1400
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.0032
Cell Significance Index: -0.0900
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0057
Cell Significance Index: -10.6700
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0079
Cell Significance Index: -1.3500
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.0130
Cell Significance Index: -0.1400
Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0162
Cell Significance Index: -8.8500
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0165
Cell Significance Index: -12.1100
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0208
Cell Significance Index: -13.2400
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0216
Cell Significance Index: -16.0100
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0231
Cell Significance Index: -14.4300
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0258
Cell Significance Index: -14.5700
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0296
Cell Significance Index: -10.6300
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0327
Cell Significance Index: -14.8400
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0426
Cell Significance Index: -4.3500
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.0426
Cell Significance Index: -1.2200
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.0601
Cell Significance Index: -1.1100
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0609
Cell Significance Index: -7.1000
Cell Name: odontoblast (CL0000060)
Fold Change: -0.0622
Cell Significance Index: -7.9700
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0764
Cell Significance Index: -3.8600
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0806
Cell Significance Index: -16.9800
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0824
Cell Significance Index: -11.3100
Cell Name: lactocyte (CL0002325)
Fold Change: -0.0830
Cell Significance Index: -10.7200
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0896
Cell Significance Index: -4.2100
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0937
Cell Significance Index: -13.6200
Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: -0.0979
Cell Significance Index: -0.8100
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.1076
Cell Significance Index: -3.4500
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1175
Cell Significance Index: -13.4600
Cell Name: syncytiotrophoblast cell (CL0000525)
Fold Change: -0.1221
Cell Significance Index: -1.1600
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.1241
Cell Significance Index: -14.6400
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1269
Cell Significance Index: -13.2100
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1535
Cell Significance Index: -11.4400
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.1545
Cell Significance Index: -10.3900
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.1619
Cell Significance Index: -2.4400
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.1631
Cell Significance Index: -12.9200
Cell Name: myeloid leukocyte (CL0000766)
Fold Change: -0.1704
Cell Significance Index: -1.3800
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.1857
Cell Significance Index: -14.2500
Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
Fold Change: -0.1917
Cell Significance Index: -2.6900
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.1980
Cell Significance Index: -9.2300
Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.2058
Cell Significance Index: -8.9500
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.2220
Cell Significance Index: -13.6100
Cell Name: keratinocyte (CL0000312)
Fold Change: -0.2328
Cell Significance Index: -5.8200
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.2466
Cell Significance Index: -12.9500
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.2518
Cell Significance Index: -14.1300
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.2665
Cell Significance Index: -11.7900
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.2829
Cell Significance Index: -9.9100
Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.2887
Cell Significance Index: -11.8300
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.2942
Cell Significance Index: -18.0800
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.2962
Cell Significance Index: -10.8800
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.3009
Cell Significance Index: -9.8500
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.3058
Cell Significance Index: -11.5800
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.3098
Cell Significance Index: -8.8400
Cell Name: stem cell (CL0000034)
Fold Change: -0.3137
Cell Significance Index: -2.2800
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.3196
Cell Significance Index: -6.6900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** CEBPA is a transcription factor that belongs to the CCAAT-binding protein family. It consists of three main domains: the C-terminal domain, the central domain, and the N-terminal domain. The central domain is responsible for DNA binding, while the N-terminal domain is involved in protein-protein interactions. CEBPA is highly expressed in hematopoietic cells, particularly in granulocytes and macrophages, where it regulates the expression of genes involved in cell differentiation, proliferation, and survival. **Pathways and Functions** CEBPA is involved in various cellular pathways, including: 1. **Cellular response to tumor necrosis factor (TNF)**: CEBPA regulates the expression of genes involved in the TNF signaling pathway, which is crucial for the regulation of immune responses. 2. **Cholesterol metabolic process**: CEBPA is involved in regulating the expression of genes involved in cholesterol metabolism, which is essential for the regulation of lipid homeostasis. 3. **Cytokine-mediated signaling pathway**: CEBPA regulates the expression of genes involved in cytokine signaling, which is crucial for the regulation of immune responses. 4. **Dna-binding transcription activator activity**: CEBPA is involved in regulating the expression of genes by binding to specific DNA sequences and interacting with other transcription factors. 5. **Hematopoietic stem cell proliferation**: CEBPA regulates the expression of genes involved in hematopoietic stem cell proliferation, which is essential for the development of blood cells. **Clinical Significance** CEBPA is significantly expressed in various cancers, including acute myeloid leukemia (AML) and chronic lymphocytic leukemia (CLL). Mutations in the CEBPA gene have been associated with AML, which is characterized by the overexpression of CEBPA. The overexpression of CEBPA is thought to contribute to the development of AML by regulating the expression of genes involved in cell proliferation and differentiation. CEBPA is also involved in the regulation of inflammatory responses, and its expression is elevated in conditions characterized by chronic inflammation, such as rheumatoid arthritis. Additionally, CEBPA has been implicated in the regulation of immune responses in autoimmune diseases, such as lupus and multiple sclerosis. In conclusion, CEBPA is a transcription factor that plays a crucial role in various cellular processes, including differentiation, development, and immune responses. Its expression is significantly elevated in hematopoietic cells, particularly in granulocytes and macrophages, where it regulates the expression of genes involved in cell differentiation, proliferation, and survival. CEBPA's involvement in various cellular pathways and its clinical significance make it an important target for the treatment of various diseases, including cancer and autoimmune diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

CEBPA_HUMAN

Genular Protein ID: 2856205059

Symbol: CEBPA_HUMAN

Name: N/A

UniProtKB Accession Codes:

P49715 A7LNP2 P78319 Q05CA4

Database IDs:

Citations:

PubMed ID: 7575576

Title: Molecular cloning, sequence, and expression patterns of the human gene encoding CCAAT/enhancer binding protein alpha (C/EBP alpha).

PubMed ID: 7575576

DOI: 10.1006/bbrc.1995.2439

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9915821

Title: Interaction of hepatitis B viral X protein and CCAAT/enhancer-binding protein alpha synergistically activates the hepatitis B viral enhancer II/pregenomic promoter.

PubMed ID: 9915821

DOI: 10.1074/jbc.274.5.2858

PubMed ID: 10725330

Title: Ubinuclein, a novel nuclear protein interacting with cellular and viral transcription factors.

PubMed ID: 10725330

DOI: 10.1083/jcb.148.6.1165

PubMed ID: 12661007

Title: Mutations of CEBPA in acute myeloid leukemia FAB types M1 and M2.

PubMed ID: 12661007

DOI: 10.1002/gcc.10185

PubMed ID: 15107404

Title: Liver tumors escape negative control of proliferation via PI3K/Akt-mediated block of C/EBP alpha growth inhibitory activity.

PubMed ID: 15107404

DOI: 10.1101/gad.1183304

PubMed ID: 15078966

Title: CCAAT/enhancer binding protein alpha binds to the Epstein-Barr virus (EBV) ZTA protein through oligomeric interactions and contributes to cooperative transcriptional activation of the ZTA promoter through direct binding to the ZII and ZIIIB motifs during induction of the EBV lytic cycle.

PubMed ID: 15078966

DOI: 10.1128/jvi.78.9.4847-4865.2004

PubMed ID: 14660596

Title: The CCAAT enhancer-binding protein alpha (C/EBPalpha) requires a SWI/SNF complex for proliferation arrest.

PubMed ID: 14660596

DOI: 10.1074/jbc.m312709200

PubMed ID: 15575056

Title: Mutation of CEBPA in familial acute myeloid leukemia.

PubMed ID: 15575056

DOI: 10.1056/nejmoa041331

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20410507

Title: Differential ability of Tribbles family members to promote degradation of C/EBPalpha and induce acute myelogenous leukemia.

PubMed ID: 20410507

DOI: 10.1182/blood-2009-07-229450

PubMed ID: 20075868

Title: Nucleolar retention of a translational C/EBPalpha isoform stimulates rDNA transcription and cell size.

PubMed ID: 20075868

DOI: 10.1038/emboj.2009.404

PubMed ID: 20176812

Title: Repression of transcriptional activity of C/EBPalpha by E2F-dimerization partner complexes.

PubMed ID: 20176812

DOI: 10.1128/mcb.01619-09

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 26455797

Title: Molecular mechanism of CCAAT-enhancer binding protein recruitment by the TRIB1 pseudokinase.

PubMed ID: 26455797

DOI: 10.1016/j.str.2015.08.017

PubMed ID: 27923061

Title: Comparative Transcriptomic and Epigenomic Analyses Reveal New Regulators of Murine Brown Adipogenesis.

PubMed ID: 27923061

DOI: 10.1371/journal.pgen.1006474

PubMed ID: 27041596

Title: Structural basis for substrate selectivity of the E3 ligase COP1.

PubMed ID: 27041596

DOI: 10.1016/j.str.2016.03.002

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 11242107

Title: Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-alpha (C/EBPalpha), in acute myeloid leukemia.

PubMed ID: 11242107

DOI: 10.1038/85820

Sequence Information:

Length: 358
Mass: 37561
Checksum: 574C0A049E25BCAC
Sequence:

MESADFYEAE PRPPMSSHLQ SPPHAPSSAA FGFPRGAGPA QPPAPPAAPE PLGGICEHET 
SIDISAYIDP AAFNDEFLAD LFQHSRQQEK AKAAVGPTGG GGGGDFDYPG APAGPGGAVM 
PGGAHGPPPG YGCAAAGYLD GRLEPLYERV GAPALRPLVI KQEPREEDEA KQLALAGLFP 
YQPPPPPPPS HPHPHPPPAH LAAPHLQFQI AHCGQTTMHL QPGHPTPPPT PVPSPHPAPA 
LGAAGLPGPG SALKGLGAAH PDLRASGGSG AGKAKKSVDK NSNEYRVRRE RNNIAVRKSR 
DKAKQRNVET QQKVLELTSD NDRLRKRVEQ LSRELDTLRG IFRQLPESSL VKAMGNCA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CEBPA

Associated with

Cells (max top 100)

Other Information

Molecular cloning, sequence, and expression patterns of the human gene encoding CCAAT/enhancer binding protein alpha (C/EBP alpha). PubMed ID: 7575576

The DNA sequence and biology of human chromosome 19. PubMed ID: 15057824

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Interaction of hepatitis B viral X protein and CCAAT/enhancer-binding protein alpha synergistically activates the hepatitis B viral enhancer II/pregenomic promoter. PubMed ID: 9915821

Ubinuclein, a novel nuclear protein interacting with cellular and viral transcription factors. PubMed ID: 10725330

Mutations of CEBPA in acute myeloid leukemia FAB types M1 and M2. PubMed ID: 12661007

Liver tumors escape negative control of proliferation via PI3K/Akt-mediated block of C/EBP alpha growth inhibitory activity. PubMed ID: 15107404

The CCAAT enhancer-binding protein alpha (C/EBPalpha) requires a SWI/SNF complex for proliferation arrest. PubMed ID: 14660596

Mutation of CEBPA in familial acute myeloid leukemia. PubMed ID: 15575056

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Differential ability of Tribbles family members to promote degradation of C/EBPalpha and induce acute myelogenous leukemia. PubMed ID: 20410507

Nucleolar retention of a translational C/EBPalpha isoform stimulates rDNA transcription and cell size. PubMed ID: 20075868

Repression of transcriptional activity of C/EBPalpha by E2F-dimerization partner complexes. PubMed ID: 20176812

Uncovering global SUMOylation signaling networks in a site-specific manner. PubMed ID: 25218447

Molecular mechanism of CCAAT-enhancer binding protein recruitment by the TRIB1 pseudokinase. PubMed ID: 26455797

Comparative Transcriptomic and Epigenomic Analyses Reveal New Regulators of Murine Brown Adipogenesis. PubMed ID: 27923061

Structural basis for substrate selectivity of the E3 ligase COP1. PubMed ID: 27041596

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733

Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-alpha (C/EBPalpha), in acute myeloid leukemia. PubMed ID: 11242107