Details for: SEMA4F

Gene ID: 10505

Symbol: SEMA4F

Ensembl ID: ENSG00000135622

Description: ssemaphorin 4F

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.6
    Marker Score: 2,796
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.25
    Marker Score: 845
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.2
    Marker Score: 1,854
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.18
    Marker Score: 72,283
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4,806
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.13
    Marker Score: 10,709
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.13
    Marker Score: 819
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.07
    Marker Score: 10,028
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.04
    Marker Score: 1,492
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.03
    Marker Score: 2,088
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1
    Marker Score: 15,623
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,817
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,042
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.99
    Marker Score: 4,015
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,407
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.97
    Marker Score: 1,841
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 499
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 452
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,412
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.93
    Marker Score: 7,996
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5,245
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,735
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.91
    Marker Score: 364
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.91
    Marker Score: 13,559
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 317
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,282
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.86
    Marker Score: 3,341
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.81
    Marker Score: 30,799
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.79
    Marker Score: 6,070
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1,255
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 702
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.76
    Marker Score: 582
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.76
    Marker Score: 15,088
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 387
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.69
    Marker Score: 25,426
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 172
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.63
    Marker Score: 381
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.62
    Marker Score: 1,782
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.61
    Marker Score: 6,258
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.58
    Marker Score: 2,409
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.57
    Marker Score: 1,344
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.56
    Marker Score: 161
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.54
    Marker Score: 2,237
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.53
    Marker Score: 338
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.53
    Marker Score: 251
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.52
    Marker Score: 162
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.52
    Marker Score: 302
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.51
    Marker Score: 864
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.48
    Marker Score: 183
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.47
    Marker Score: 807
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.46
    Marker Score: 155
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.42
    Marker Score: 382
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.4
    Marker Score: 129
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.4
    Marker Score: 448
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.39
    Marker Score: 485
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.36
    Marker Score: 165
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.36
    Marker Score: 12,150
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.34
    Marker Score: 1,572
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.34
    Marker Score: 271
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.33
    Marker Score: 136
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.33
    Marker Score: 136
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.31
    Marker Score: 80
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.3
    Marker Score: 135
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.3
    Marker Score: 96
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.28
    Marker Score: 574
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.26
    Marker Score: 68
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.25
    Marker Score: 252
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.25
    Marker Score: 157
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.25
    Marker Score: 163
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.24
    Marker Score: 933
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.24
    Marker Score: 1,428
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.23
    Marker Score: 81
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 0.23
    Marker Score: 135
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.23
    Marker Score: 4,876
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 62
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.21
    Marker Score: 53
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.21
    Marker Score: 71
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 0.21
    Marker Score: 476
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 0.2
    Marker Score: 1,061
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 0.19
    Marker Score: 93
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 0.19
    Marker Score: 269
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.19
    Marker Score: 207
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.19
    Marker Score: 106
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.19
    Marker Score: 79
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.19
    Marker Score: 1,881
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.18
    Marker Score: 97
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.18
    Marker Score: 87
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.18
    Marker Score: 156
  • Cell Name: granule cell (CL0000120)
    Fold Change: 0.18
    Marker Score: 1,349
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 0.18
    Marker Score: 590
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.17
    Marker Score: 1,030
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.17
    Marker Score: 68
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 41
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 0.17
    Marker Score: 866
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.16
    Marker Score: 92
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.16
    Marker Score: 65
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.15
    Marker Score: 433
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 0.15
    Marker Score: 91
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.15
    Marker Score: 162

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** Sema4F is a transmembrane protein that belongs to the semaphorin family, characterized by its four extracellular sema domains and a single intracellular cytoplasmic domain. Its expression is widespread across various cell types, including germ cells, intestinal crypt stem cells, and glutamatergic neurons. SEMA4F's unique properties, such as its ability to bind to plexin receptors, make it an essential component in axon guidance, chemotaxis, and immune regulation. **Pathways and Functions:** Sema4F's involvement in axon guidance is mediated through its interaction with plexin receptors, which triggers signaling pathways that regulate axon extension and guidance. SEMA4F also exhibits chemorepellent activity, repelling axons and guiding them away from certain regions. In addition to its role in axon guidance, SEMA4F is involved in immune regulation, particularly in the development and function of immune cells, such as innate lymphoid cells and germ cells. Its expression in intestinal crypt stem cells suggests a role in maintaining intestinal homeostasis. **Clinical Significance:** Sema4F's dysregulation has been implicated in various neurological and immunological disorders, including: 1. **Neurodegenerative diseases:** SEMA4F's involvement in axon guidance and immune regulation suggests its potential role in neurodegenerative diseases, such as Alzheimer's and Parkinson's. 2. **Immune disorders:** SEMA4F's expression in immune cells and its role in immune regulation make it a potential target for the treatment of autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 3. **Cancer:** SEMA4F's expression in colon goblet cells and its role in immune regulation suggest its potential role in cancer development and progression. In conclusion, SEMA4F is a complex protein with multiple functions in axon guidance, immune regulation, and nervous system development. Its dysregulation has been implicated in various neurological and immunological disorders, making it a potential target for the treatment of these diseases. **References:** * [Insert references to studies that have investigated the role of SEMA4F in axon guidance, immune regulation, and neurological disorders] **Future Directions:** 1. **Investigating the role of SEMA4F in neurodegenerative diseases:** Further studies are needed to elucidate the mechanisms by which SEMA4F contributes to neurodegenerative diseases. 2. **Exploring the therapeutic potential of SEMA4F:** Targeting SEMA4F or its signaling pathways may provide new therapeutic strategies for the treatment of immune disorders and neurodegenerative diseases. 3. **Understanding the expression and function of SEMA4F in different cell types:** Further studies are needed to elucidate the expression and function of SEMA4F in various cell types and its role in different physiological and pathological processes.

Genular Protein ID: 1424281342

Symbol: SEM4F_HUMAN

Name: Semaphorin-4F

UniProtKB Accession Codes:

O95754 Q542Y7 Q9NS35

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 7 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 18 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 3 SAM 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10051670

Title: Cloning, expression, and genetic mapping of Sema W, a member of the semaphorin family.

PubMed ID: 10051670

DOI: 10.1073/pnas.96.5.2491

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 16303743

Title: Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.

PubMed ID: 16303743

DOI: 10.1093/dnares/12.2.117

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 770
  • Mass: 83511
  • Checksum: CFBB74B41DF0E9C8
  • Sequence:
    • MPASAARPRP GPGQPTASPF PLLLLAVLSG PVSGRVPRSV PRTSLPISEA DSCLTRFAVP 
HTYNYSVLLV DPASHTLYVG ARDTIFALSL PFSGERPRRI DWMVPEAHRQ NCRKKGKKED 
ECHNFVQILA IANASHLLTC GTFAFDPKCG VIDVSRFQQV ERLESGRGKC PFEPAQRSAA 
VMAGGVLYAA TVKNYLGTEP IITRAVGRAE DWIRTDTLPS WLNAPAFVAA VALSPAEWGD 
EDGDDEIYFF FTETSRAFDS YERIKVPRVA RVCAGDLGGR KTLQQRWTTF LKADLLCPGP 
EHGRASSVLQ DVAVLRPELG AGTPIFYGIF SSQWEGATIS AVCAFRPQDI RTVLNGPFRE 
LKHDCNRGLP VVDNDVPQPR PGECITNNMK LRHFGSSLSL PDRVLTFIRD HPLMDRPVFP 
ADGHPLLVTT DTAYLRVVAH RVTSLSGKEY DVLYLGTEDG HLHRAVRIGA QLSVLEDLAL 
FPEPQPVENM KLYHSWLLVG SRTEVTQVNT TNCGRLQSCS ECILAQDPVC AWSFRLDECV 
AHAGEHRGLV QDIESADVSS LCPKEPGERP VVFEVPVATA AHVVLPCSPS SAWASCVWHQ 
PSGVTALTPR RDGLEVVVTP GAMGAYACEC QEGGAAHVVA AYSLVWGSQR DAPSRAHTVG 
AGLAGFFLGI LAASLTLILI GRRQQRRRQR ELLARDKVGL DLGAPPSGTT SYSQDPPSPS 
PEDERLPLAL AKRGSGFGGF SPPFLLDPCP SPAHIRLTGA PLATCDETSI

Genular Protein ID: 520128071

Symbol: A0A087WYZ7_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A087WYZ7

Database IDs:

ARBA 6 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 1 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 4 Gene3D 2 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 8 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PROSITE-ProRule 1 PeptideAtlas 2 Pfam 3 Proteomes 2 RefSeq 1 SAM 3 SMART 2 SMR 1 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

Sequence Information:

  • Length: 737
  • Mass: 79980
  • Checksum: A069B3C7DA64EE2E
  • Sequence:
    • MPASAARPRP GPGQPTASPF PLLLLAVLSG PVSGRVPRSV PRTSLPISEA DSCLTRFAVP 
HTYNYSVLLV DPASHTLYVG ARDTIFALSL PFSGERPRRI DWMVPEAHRQ NCRKKGKKED 
VSRFQQVERL ESGRGKCPFE PAQRSAAVMA GGVLYAATVK NYLGTEPIIT RAVGRAEDWI 
RTDTLPSWLN APAFVAAVAL SPAEWGDEDG DDEIYFFFTE TSRAFDSYER IKVPRVARVC 
AGDLGGRKTL QQRWTTFLKA DLLCPGPEHG RASSVLQDVA VLRPELGAGT PIFYGIFSSQ 
WEGATISAVC AFRPQDIRTV LNGPFRELKH DCNRGLPVVD NDVPQPRPGE CITNNMKLRH 
FGSSLSLPDR VLTFIRDHPL MDRPVFPADG HPLLVTTDTA YLRVVAHRVT SLSGKEYDVL 
YLGTEDGHLH RAVRIGAQLS VLEDLALFPE PQPVENMKLY HSWLLVGSRT EVTQVNTTNC 
GRLQSCSECI LAQDPVCAWS FRLDECVAHA GEHRGLVQDI ESADVSSLCP KEPGERPVVF 
EVPVATAAHV VLPCSPSSAW ASCVWHQPSG VTALTPRRDG LEVVVTPGAM GAYACECQEG 
GAAHVVAAYS LVWGSQRDAP SRAHTVGAGL AGFFLGILAA SLTLILIGRR QQRRRQRELL 
ARDKVGLDLG APPSGTTSYS QDPPSPSPED ERLPLALAKR GSGFGGFSPP FLLDPCPSPA 
HIRLTGAPLA TCDETSI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.