SEMA4D | ENSG00000187764 | NCBI 10507

Details for: SEMA4D

Gene ID: 10507

Symbol: SEMA4D

Ensembl ID: ENSG00000187764

Description: semaphorin 4D

Associated with

Developmental biology
(R-HSA-1266738)
Nervous system development
(R-HSA-9675108)
Other semaphorin interactions
(R-HSA-416700)
Sema4d induced cell migration and growth-cone collapse
(R-HSA-416572)
Sema4d in semaphorin signaling
(R-HSA-400685)
Sema4d mediated inhibition of cell attachment and migration
(R-HSA-416550)
Semaphorin interactions
(R-HSA-373755)
Axon guidance
(GO:0007411)
Bone trabecula morphogenesis
(GO:0061430)
Cell adhesion
(GO:0007155)
Chemorepellent activity
(GO:0045499)
Extracellular space
(GO:0005615)
Immune response
(GO:0006955)
Leukocyte aggregation
(GO:0070486)
Negative chemotaxis
(GO:0050919)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of axon extension involved in axon guidance
(GO:0048843)
Negative regulation of cell adhesion
(GO:0007162)
Negative regulation of osteoblast differentiation
(GO:0045668)
Negative regulation of peptidyl-tyrosine phosphorylation
(GO:0050732)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Neural crest cell migration
(GO:0001755)
Ossification involved in bone maturation
(GO:0043931)
Plasma membrane
(GO:0005886)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of collateral sprouting
(GO:0048672)
Positive regulation of gtpase activity
(GO:0043547)
Positive regulation of inhibitory synapse assembly
(GO:1905704)
Positive regulation of peptidyl-tyrosine phosphorylation
(GO:0050731)
Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0051897)
Positive regulation of protein phosphorylation
(GO:0001934)
Positive regulation of rho protein signal transduction
(GO:0035025)
Protein binding
(GO:0005515)
Receptor ligand activity
(GO:0048018)
Regulation of cell projection organization
(GO:0031344)
Regulation of cell shape
(GO:0008360)
Regulation of dendrite morphogenesis
(GO:0048814)
Semaphorin-plexin signaling pathway
(GO:0071526)
Semaphorin receptor binding
(GO:0030215)
Semaphorin receptor complex
(GO:0002116)
Signaling receptor activity
(GO:0038023)
Signaling receptor binding
(GO:0005102)
Transmembrane signaling receptor activity
(GO:0004888)

Other Information

Proteins

Semaphorin-4D

Genular Protein ID: 3759105766

Symbol: SEM4D_HUMAN

Name: Semaphorin-4D

UniProtKB Accession Codes:

Q92854 B2RPM6 Q7Z5S4 Q8N8B0

Database IDs:

Citations:

PubMed ID: 8876214

Title: Human CD100, a novel leukocyte semaphorin that promotes B-cell aggregation and differentiation.

PubMed ID: 8876214

DOI: 10.1073/pnas.93.21.11780

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10520995

Title: Plexins are a large family of receptors for transmembrane, secreted and GPI-anchored semaphorins in vertebrates.

PubMed ID: 10520995

DOI: 10.1016/s0092-8674(00)80063-x

PubMed ID: 16055703

Title: Semaphorin 4D/plexin-B1 induces endothelial cell migration through the activation of PYK2, Src, and the phosphatidylinositol 3-kinase-Akt pathway.

PubMed ID: 16055703

DOI: 10.1128/mcb.25.16.6889-6898.2005

PubMed ID: 16263699

Title: Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach.

PubMed ID: 16263699

DOI: 10.1074/mcp.m500324-mcp200

PubMed ID: 19788569

Title: The semaphorin 4D-plexin-B signalling complex regulates dendritic and axonal complexity in developing neurons via diverse pathways.

PubMed ID: 19788569

DOI: 10.1111/j.1460-9568.2009.06934.x

PubMed ID: 19349973

Title: Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.

PubMed ID: 19349973

DOI: 10.1038/nbt.1532

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 12958590

Title: The ligand-binding face of the semaphorins revealed by the high-resolution crystal structure of SEMA4D.

PubMed ID: 12958590

DOI: 10.1038/nsb977

PubMed ID: 20877282

Title: Structural basis of semaphorin-plexin signalling.

PubMed ID: 20877282

DOI: 10.1038/nature09468

Sequence Information:

Length: 862
Mass: 96150
Checksum: 7B18EFEA98789371
Sequence:

MRMCTPIRGL LMALAVMFGT AMAFAPIPRI TWEHREVHLV QFHEPDIYNY SALLLSEDKD 
TLYIGAREAV FAVNALNISE KQHEVYWKVS EDKKAKCAEK GKSKQTECLN YIRVLQPLSA 
TSLYVCGTNA FQPACDHLNL TSFKFLGKNE DGKGRCPFDP AHSYTSVMVD GELYSGTSYN 
FLGSEPIISR NSSHSPLRTE YAIPWLNEPS FVFADVIRKS PDSPDGEDDR VYFFFTEVSV 
EYEFVFRVLI PRIARVCKGD QGGLRTLQKK WTSFLKARLI CSRPDSGLVF NVLRDVFVLR 
SPGLKVPVFY ALFTPQLNNV GLSAVCAYNL STAEEVFSHG KYMQSTTVEQ SHTKWVRYNG 
PVPKPRPGAC IDSEARAANY TSSLNLPDKT LQFVKDHPLM DDSVTPIDNR PRLIKKDVNY 
TQIVVDRTQA LDGTVYDVMF VSTDRGALHK AISLEHAVHI IEETQLFQDF EPVQTLLLSS 
KKGNRFVYAG SNSGVVQAPL AFCGKHGTCE DCVLARDPYC AWSPPTATCV ALHQTESPSR 
GLIQEMSGDA SVCPDKSKGS YRQHFFKHGG TAELKCSQKS NLARVFWKFQ NGVLKAESPK 
YGLMGRKNLL IFNLSEGDSG VYQCLSEERV KNKTVFQVVA KHVLEVKVVP KPVVAPTLSV 
VQTEGSRIAT KVLVASTQGS SPPTPAVQAT SSGAITLPPK PAPTGTSCEP KIVINTVPQL 
HSEKTMYLKS SDNRLLMSLF LFFFVLFLCL FFYNCYKGYL PRQCLKFRSA LLIGKKKPKS 
DFCDREQSLK ETLVEPGSFS QQNGEHPKPA LDTGYETEQD TITSKVPTDR EDSQRIDDLS 
ARDKPFDVKC ELKFADSDAD GD

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: SEMA4D

Associated with

Other Information

Human CD100, a novel leukocyte semaphorin that promotes B-cell aggregation and differentiation. PubMed ID: 8876214

DNA sequence and analysis of human chromosome 9. PubMed ID: 15164053

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Plexins are a large family of receptors for transmembrane, secreted and GPI-anchored semaphorins in vertebrates. PubMed ID: 10520995

Semaphorin 4D/plexin-B1 induces endothelial cell migration through the activation of PYK2, Src, and the phosphatidylinositol 3-kinase-Akt pathway. PubMed ID: 16055703

Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach. PubMed ID: 16263699

The semaphorin 4D-plexin-B signalling complex regulates dendritic and axonal complexity in developing neurons via diverse pathways. PubMed ID: 19788569

Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins. PubMed ID: 19349973

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

The ligand-binding face of the semaphorins revealed by the high-resolution crystal structure of SEMA4D. PubMed ID: 12958590

Structural basis of semaphorin-plexin signalling. PubMed ID: 20877282