CEBPB | ENSG00000172216 | NCBI 1051

Details for: CEBPB

Gene ID: 1051

Symbol: CEBPB

Ensembl ID: ENSG00000172216

Description: CCAAT enhancer binding protein beta

Associated with

Atf4 activates genes in response to endoplasmic reticulum stress
(R-HSA-380994)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to starvation
(R-HSA-9711097)
Cellular senescence
(R-HSA-2559583)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Nuclear events stimulated by alk signaling in cancer
(R-HSA-9725371)
Perk regulates gene expression
(R-HSA-381042)
Response of eif2ak1 (hri) to heme deficiency
(R-HSA-9648895)
Response of eif2ak4 (gcn2) to amino acid deficiency
(R-HSA-9633012)
Rna polymerase ii transcription
(R-HSA-73857)
Senescence-associated secretory phenotype (sasp)
(R-HSA-2559582)
Signaling by alk fusions and activated point mutants
(R-HSA-9725370)
Signaling by alk in cancer
(R-HSA-9700206)
Transcriptional regulation by ventx
(R-HSA-8853884)
Transcriptional regulation of granulopoiesis
(R-HSA-9616222)
Transcriptional regulation of white adipocyte differentiation
(R-HSA-381340)
Unfolded protein response (upr)
(R-HSA-381119)
Acute-phase response
(GO:0006953)
Brown fat cell differentiation
(GO:0050873)
C/ebp complex
(GO:1990647)
Cellular response to amino acid stimulus
(GO:0071230)
Chop-c/ebp complex
(GO:0036488)
Chromatin
(GO:0000785)
Chromatin dna binding
(GO:0031490)
Condensed chromosome, centromeric region
(GO:0000779)
Cytoplasm
(GO:0005737)
Defense response to bacterium
(GO:0042742)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna-binding transcription repressor activity, rna polymerase ii-specific
(GO:0001227)
Dna binding
(GO:0003677)
Embryonic placenta development
(GO:0001892)
Hepatocyte proliferation
(GO:0072574)
Histone acetyltransferase binding
(GO:0035035)
Histone deacetylase binding
(GO:0042826)
Immune response
(GO:0006955)
Inflammatory response
(GO:0006954)
Integrated stress response signaling
(GO:0140467)
Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
(GO:0070059)
Kinase binding
(GO:0019900)
Liver regeneration
(GO:0097421)
Mammary gland epithelial cell differentiation
(GO:0060644)
Mammary gland epithelial cell proliferation
(GO:0033598)
Myeloid cell development
(GO:0061515)
Negative regulation of neuron apoptotic process
(GO:0043524)
Negative regulation of t cell proliferation
(GO:0042130)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Neuron differentiation
(GO:0030182)
Nuclear matrix
(GO:0016363)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Ovarian follicle development
(GO:0001541)
Positive regulation of biomineral tissue development
(GO:0070169)
Positive regulation of cold-induced thermogenesis
(GO:0120162)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of fat cell differentiation
(GO:0045600)
Positive regulation of inflammatory response
(GO:0050729)
Positive regulation of interleukin-4 production
(GO:0032753)
Positive regulation of osteoblast differentiation
(GO:0045669)
Positive regulation of sodium-dependent phosphate transport
(GO:2000120)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Regulation of cell differentiation
(GO:0045595)
Regulation of dendritic cell differentiation
(GO:2001198)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of interleukin-6 production
(GO:0032675)
Regulation of odontoblast differentiation
(GO:1901329)
Regulation of osteoclast differentiation
(GO:0045670)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Response to endoplasmic reticulum stress
(GO:0034976)
Response to lipopolysaccharide
(GO:0032496)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Rna polymerase ii core promoter sequence-specific dna binding
(GO:0000979)
Rna polymerase ii transcription regulator complex
(GO:0090575)
Rna polymerase ii transcription regulatory region sequence-specific dna binding
(GO:0000977)
Sequence-specific double-stranded dna binding
(GO:1990837)
Transcription by rna polymerase ii
(GO:0006366)
Transcription cis-regulatory region binding
(GO:0000976)
Ubiquitin-like protein ligase binding
(GO:0044389)

Other Information

Proteins

Liver activator protein

Genular Protein ID: 4163143888

Symbol: CEBPB_HUMAN

Name: Liver activator protein

UniProtKB Accession Codes:

P17676 A8K671 Q96IH2 Q9H4Z5

Database IDs:

Citations:

PubMed ID: 2112087

Title: A nuclear factor for IL-6 expression (NF-IL6) is a member of a C/EBP family.

PubMed ID: 2112087

DOI: 10.1002/j.1460-2075.1990.tb08316.x

PubMed ID: 15498874

Title: Large-scale cDNA transfection screening for genes related to cancer development and progression.

PubMed ID: 15498874

DOI: 10.1073/pnas.0404089101

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7635140

Title: Identification of a transcriptional regulatory factor for human aromatase cytochrome P450 gene expression as nuclear factor interleukin-6 (NF-IL6), a member of the CCAAT/enhancer-binding protein family.

PubMed ID: 7635140

DOI: 10.1111/j.1432-1033.1995.tb20699.x

PubMed ID: 1741402

Title: A member of the C/EBP family, NF-IL6 beta, forms a heterodimer and transcriptionally synergizes with NF-IL6.

PubMed ID: 1741402

DOI: 10.1073/pnas.89.4.1473

PubMed ID: 9374525

Title: Antioxidant-induced nuclear translocation of CCAAT/enhancer-binding protein beta. A critical role for protein kinase A-mediated phosphorylation of Ser299.

PubMed ID: 9374525

DOI: 10.1074/jbc.272.48.30356

PubMed ID: 11018027

Title: Crystal structure of the CCAAT box/enhancer-binding protein beta activating transcription factor-4 basic leucine zipper heterodimer in the absence of DNA.

PubMed ID: 11018027

DOI: 10.1074/jbc.m005594200

PubMed ID: 11684016

Title: C/EBPbeta phosphorylation by RSK creates a functional XEXD caspase inhibitory box critical for cell survival.

PubMed ID: 11684016

DOI: 10.1016/s1097-2765(01)00374-4

PubMed ID: 11741938

Title: Dynamic regulation of cyclooxygenase-2 promoter activity by isoforms of CCAAT/enhancer-binding proteins.

PubMed ID: 11741938

DOI: 10.1074/jbc.m108075200

PubMed ID: 12048245

Title: MEKK1 plays a critical role in activating the transcription factor C/EBP-beta-dependent gene expression in response to IFN-gamma.

PubMed ID: 12048245

DOI: 10.1073/pnas.122075799

PubMed ID: 12810706

Title: Modification of CCAAT/enhancer-binding protein-beta by the small ubiquitin-like modifier (SUMO) family members, SUMO-2 and SUMO-3.

PubMed ID: 12810706

DOI: 10.1074/jbc.m305680200

PubMed ID: 17467953

Title: Nine-amino-acid transactivation domain: establishment and prediction utilities.

PubMed ID: 17467953

DOI: 10.1016/j.ygeno.2007.02.003

PubMed ID: 18647749

Title: G9a-mediated lysine methylation alters the function of CCAAT/enhancer-binding protein-beta.

PubMed ID: 18647749

DOI: 10.1074/jbc.m802132200

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20111005

Title: Crosstalk between C/EBPbeta phosphorylation, arginine methylation, and SWI/SNF/Mediator implies an indexing transcription factor code.

PubMed ID: 20111005

DOI: 10.1038/emboj.2010.3

PubMed ID: 20829347

Title: Endoplasmic reticulum stress-activated C/EBP homologous protein enhances nuclear factor-kappaB signals via repression of peroxisome proliferator-activated receptor gamma.

PubMed ID: 20829347

DOI: 10.1074/jbc.m110.136259

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 25451943

Title: Transcriptional Regulation of Adipocyte Differentiation: A Central Role for CCAAT/Enhancer-binding Protein (C/EBP) beta.

PubMed ID: 25451943

DOI: 10.1074/jbc.r114.619957

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 27923061

Title: Comparative Transcriptomic and Epigenomic Analyses Reveal New Regulators of Murine Brown Adipogenesis.

PubMed ID: 27923061

DOI: 10.1371/journal.pgen.1006474

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 11257229

Title: Structural analyses of DNA recognition by the AML1/Runx-1 Runt domain and its allosteric control by CBFbeta.

PubMed ID: 11257229

DOI: 10.1016/s0092-8674(01)00271-9

PubMed ID: 11792321

Title: Mechanism of c-Myb-C/EBP beta cooperation from separated sites on a promoter.

PubMed ID: 11792321

DOI: 10.1016/s0092-8674(01)00636-5

Sequence Information:

Length: 345
Mass: 36106
Checksum: 9B725BD6CCAA771D
Sequence:

MQRLVAWDPA CLPLPPPPPA FKSMEVANFY YEADCLAAAY GGKAAPAAPP AARPGPRPPA 
GELGSIGDHE RAIDFSPYLE PLGAPQAPAP ATATDTFEAA PPAPAPAPAS SGQHHDFLSD 
LFSDDYGGKN CKKPAEYGYV SLGRLGAAKG ALHPGCFAPL HPPPPPPPPP AELKAEPGFE 
PADCKRKEEA GAPGGGAGMA AGFPYALRAY LGYQAVPSGS SGSLSTSSSS SPPGTPSPAD 
AKAPPTACYA GAAPAPSQVK SKAKKTVDKH SDEYKIRRER NNIAVRKSRD KAKMRNLETQ 
HKVLELTAEN ERLQKKVEQL SRELSTLRNL FKQLPEPLLA SSGHC

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CEBPB

Associated with

Other Information

A nuclear factor for IL-6 expression (NF-IL6) is a member of a C/EBP family. PubMed ID: 2112087

Large-scale cDNA transfection screening for genes related to cancer development and progression. PubMed ID: 15498874

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and comparative analysis of human chromosome 20. PubMed ID: 11780052

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Identification of a transcriptional regulatory factor for human aromatase cytochrome P450 gene expression as nuclear factor interleukin-6 (NF-IL6), a member of the CCAAT/enhancer-binding protein family. PubMed ID: 7635140

A member of the C/EBP family, NF-IL6 beta, forms a heterodimer and transcriptionally synergizes with NF-IL6. PubMed ID: 1741402

Antioxidant-induced nuclear translocation of CCAAT/enhancer-binding protein beta. A critical role for protein kinase A-mediated phosphorylation of Ser299. PubMed ID: 9374525

Crystal structure of the CCAAT box/enhancer-binding protein beta activating transcription factor-4 basic leucine zipper heterodimer in the absence of DNA. PubMed ID: 11018027

C/EBPbeta phosphorylation by RSK creates a functional XEXD caspase inhibitory box critical for cell survival. PubMed ID: 11684016

Dynamic regulation of cyclooxygenase-2 promoter activity by isoforms of CCAAT/enhancer-binding proteins. PubMed ID: 11741938

MEKK1 plays a critical role in activating the transcription factor C/EBP-beta-dependent gene expression in response to IFN-gamma. PubMed ID: 12048245

Modification of CCAAT/enhancer-binding protein-beta by the small ubiquitin-like modifier (SUMO) family members, SUMO-2 and SUMO-3. PubMed ID: 12810706

Nine-amino-acid transactivation domain: establishment and prediction utilities. PubMed ID: 17467953

G9a-mediated lysine methylation alters the function of CCAAT/enhancer-binding protein-beta. PubMed ID: 18647749

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Crosstalk between C/EBPbeta phosphorylation, arginine methylation, and SWI/SNF/Mediator implies an indexing transcription factor code. PubMed ID: 20111005

Endoplasmic reticulum stress-activated C/EBP homologous protein enhances nuclear factor-kappaB signals via repression of peroxisome proliferator-activated receptor gamma. PubMed ID: 20829347

Uncovering global SUMOylation signaling networks in a site-specific manner. PubMed ID: 25218447

SUMO-2 orchestrates chromatin modifiers in response to DNA damage. PubMed ID: 25772364

Transcriptional Regulation of Adipocyte Differentiation: A Central Role for CCAAT/Enhancer-binding Protein (C/EBP) beta. PubMed ID: 25451943

System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability. PubMed ID: 25755297

Comparative Transcriptomic and Epigenomic Analyses Reveal New Regulators of Murine Brown Adipogenesis. PubMed ID: 27923061

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733

Structural analyses of DNA recognition by the AML1/Runx-1 Runt domain and its allosteric control by CBFbeta. PubMed ID: 11257229

Mechanism of c-Myb-C/EBP beta cooperation from separated sites on a promoter. PubMed ID: 11792321