CEBPB | ENSG00000172216 | NCBI 1051

Details for: CEBPB

Gene ID: 1051

Symbol: CEBPB

Ensembl ID: ENSG00000172216

Description: CCAAT enhancer binding protein beta

Associated with

Adipogenesis
(R-HSA-9843745)
Atf4 activates genes in response to endoplasmic reticulum stress
(R-HSA-380994)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to starvation
(R-HSA-9711097)
Cellular senescence
(R-HSA-2559583)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Nuclear events stimulated by alk signaling in cancer
(R-HSA-9725371)
Perk regulates gene expression
(R-HSA-381042)
Response of eif2ak1 (hri) to heme deficiency
(R-HSA-9648895)
Response of eif2ak4 (gcn2) to amino acid deficiency
(R-HSA-9633012)
Rna polymerase ii transcription
(R-HSA-73857)
Senescence-associated secretory phenotype (sasp)
(R-HSA-2559582)
Signaling by alk fusions and activated point mutants
(R-HSA-9725370)
Signaling by alk in cancer
(R-HSA-9700206)
Transcriptional regulation by ventx
(R-HSA-8853884)
Transcriptional regulation of granulopoiesis
(R-HSA-9616222)
Transcriptional regulation of white adipocyte differentiation
(R-HSA-381340)
Unfolded protein response (upr)
(R-HSA-381119)
Acute-phase response
(GO:0006953)
Brown fat cell differentiation
(GO:0050873)
C/ebp complex
(GO:1990647)
Cellular response to amino acid stimulus
(GO:0071230)
Chop-c/ebp complex
(GO:0036488)
Chromatin
(GO:0000785)
Chromatin dna binding
(GO:0031490)
Condensed chromosome, centromeric region
(GO:0000779)
Cytoplasm
(GO:0005737)
Defense response to bacterium
(GO:0042742)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna-binding transcription repressor activity, rna polymerase ii-specific
(GO:0001227)
Dna binding
(GO:0003677)
Embryonic placenta development
(GO:0001892)
Granuloma formation
(GO:0002432)
Hepatocyte proliferation
(GO:0072574)
Histone acetyltransferase binding
(GO:0035035)
Histone deacetylase binding
(GO:0042826)
Immune response
(GO:0006955)
Inflammatory response
(GO:0006954)
Integrated stress response signaling
(GO:0140467)
Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
(GO:0070059)
Kinase binding
(GO:0019900)
Liver regeneration
(GO:0097421)
Mammary gland epithelial cell differentiation
(GO:0060644)
Mammary gland epithelial cell proliferation
(GO:0033598)
Myeloid cell development
(GO:0061515)
Negative regulation of neuron apoptotic process
(GO:0043524)
Negative regulation of t cell proliferation
(GO:0042130)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Neuron differentiation
(GO:0030182)
Nuclear matrix
(GO:0016363)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Ovarian follicle development
(GO:0001541)
Positive regulation of biomineral tissue development
(GO:0070169)
Positive regulation of cold-induced thermogenesis
(GO:0120162)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of fat cell differentiation
(GO:0045600)
Positive regulation of inflammatory response
(GO:0050729)
Positive regulation of interleukin-4 production
(GO:0032753)
Positive regulation of osteoblast differentiation
(GO:0045669)
Positive regulation of sodium-dependent phosphate transport
(GO:2000120)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Regulation of cell differentiation
(GO:0045595)
Regulation of dendritic cell differentiation
(GO:2001198)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of interleukin-6 production
(GO:0032675)
Regulation of odontoblast differentiation
(GO:1901329)
Regulation of osteoclast differentiation
(GO:0045670)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Response to endoplasmic reticulum stress
(GO:0034976)
Response to lipopolysaccharide
(GO:0032496)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Rna polymerase ii core promoter sequence-specific dna binding
(GO:0000979)
Rna polymerase ii transcription regulator complex
(GO:0090575)
Rna polymerase ii transcription regulatory region sequence-specific dna binding
(GO:0000977)
Sequence-specific double-stranded dna binding
(GO:1990837)
T-helper 1 cell activation
(GO:0035711)
Transcription by rna polymerase ii
(GO:0006366)
Transcription cis-regulatory region binding
(GO:0000976)
Ubiquitin-like protein ligase binding
(GO:0044389)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 421.8066
Cell Significance Index: -65.6100
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 247.5523
Cell Significance Index: -62.7900
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 144.4116
Cell Significance Index: -68.1800
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 128.9014
Cell Significance Index: -66.3100
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 102.1874
Cell Significance Index: -68.5700
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 54.2436
Cell Significance Index: -66.8800
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 21.0537
Cell Significance Index: -56.4000
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 16.8726
Cell Significance Index: -66.5800
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 16.3994
Cell Significance Index: -50.3700
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 15.5477
Cell Significance Index: 445.6900
Cell Name: stem cell of epidermis (CL1000428)
Fold Change: 12.0443
Cell Significance Index: 35.8200
Cell Name: type I muscle cell (CL0002211)
Fold Change: 5.1260
Cell Significance Index: 125.0700
Cell Name: type II muscle cell (CL0002212)
Fold Change: 4.7449
Cell Significance Index: 76.5600
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 4.2094
Cell Significance Index: 297.7100
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 4.0090
Cell Significance Index: 188.4200
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 3.8372
Cell Significance Index: 526.9500
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 3.7341
Cell Significance Index: 101.6400
Cell Name: perivascular cell (CL4033054)
Fold Change: 3.5454
Cell Significance Index: 16.3700
Cell Name: odontoblast (CL0000060)
Fold Change: 3.4170
Cell Significance Index: 438.0400
Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: 2.9500
Cell Significance Index: 18.1600
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 2.8378
Cell Significance Index: 52.4500
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 2.8072
Cell Significance Index: 1241.1300
Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 2.2677
Cell Significance Index: 14.0900
Cell Name: lactocyte (CL0002325)
Fold Change: 1.8491
Cell Significance Index: 238.8900
Cell Name: cell in vitro (CL0001034)
Fold Change: 1.7908
Cell Significance Index: 977.9800
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 1.7712
Cell Significance Index: 82.5800
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 1.4995
Cell Significance Index: 111.7600
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.4048
Cell Significance Index: 37.5100
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 1.1539
Cell Significance Index: 125.5100
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 1.1468
Cell Significance Index: 141.0100
Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 1.1040
Cell Significance Index: 7.4800
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.0439
Cell Significance Index: 54.2300
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 1.0421
Cell Significance Index: 62.5600
Cell Name: peg cell (CL4033014)
Fold Change: 0.9652
Cell Significance Index: 22.3000
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.9337
Cell Significance Index: 168.3200
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.5485
Cell Significance Index: 108.8600
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.4882
Cell Significance Index: 97.9400
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.3490
Cell Significance Index: 15.8200
Cell Name: oral mucosa squamous cell (CL1001576)
Fold Change: 0.2991
Cell Significance Index: 2.5700
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2483
Cell Significance Index: 47.2500
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.1668
Cell Significance Index: 28.4800
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.1195
Cell Significance Index: 90.4800
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.1124
Cell Significance Index: 11.1200
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0554
Cell Significance Index: 35.1900
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.0476
Cell Significance Index: 1.1900
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0170
Cell Significance Index: 31.9500
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0208
Cell Significance Index: -28.2500
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.0230
Cell Significance Index: -1.5900
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0249
Cell Significance Index: -38.3200
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0277
Cell Significance Index: -2.8300
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0301
Cell Significance Index: -10.8100
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0309
Cell Significance Index: -22.9200
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0322
Cell Significance Index: -59.4300
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0499
Cell Significance Index: -31.1500
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0676
Cell Significance Index: -49.5300
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0702
Cell Significance Index: -39.6100
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.0774
Cell Significance Index: -2.0700
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.1052
Cell Significance Index: -47.7500
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1253
Cell Significance Index: -36.0600
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.1831
Cell Significance Index: -5.2800
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.2174
Cell Significance Index: -45.8000
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.2176
Cell Significance Index: -25.3600
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.2369
Cell Significance Index: -27.1400
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.2470
Cell Significance Index: -28.1900
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.2516
Cell Significance Index: -4.2100
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.2599
Cell Significance Index: -37.7800
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: -0.2692
Cell Significance Index: -2.8100
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.2961
Cell Significance Index: -4.0400
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.3396
Cell Significance Index: -17.1600
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: -0.3704
Cell Significance Index: -6.5500
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.3800
Cell Significance Index: -19.9500
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.3902
Cell Significance Index: -29.9500
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.4579
Cell Significance Index: -54.0000
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.5404
Cell Significance Index: -3.2700
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.5442
Cell Significance Index: -11.7900
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.5564
Cell Significance Index: -11.8500
Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.5801
Cell Significance Index: -23.7700
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: -0.6153
Cell Significance Index: -9.5200
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.6164
Cell Significance Index: -64.1800
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.6249
Cell Significance Index: -42.0200
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.6263
Cell Significance Index: -10.5500
Cell Name: glomerular capillary endothelial cell (CL1001005)
Fold Change: -0.6359
Cell Significance Index: -2.3700
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.6485
Cell Significance Index: -20.7700
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.6571
Cell Significance Index: -42.4000
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.6928
Cell Significance Index: -18.5700
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.7168
Cell Significance Index: -56.7700
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.7421
Cell Significance Index: -20.7400
Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
Fold Change: -0.7424
Cell Significance Index: -8.2000
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.8489
Cell Significance Index: -29.8300
Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: -0.9107
Cell Significance Index: -9.9400
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.9355
Cell Significance Index: -8.6200
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: -0.9579
Cell Significance Index: -6.2500
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -1.0430
Cell Significance Index: -64.1100
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -1.0835
Cell Significance Index: -68.2900
Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -1.0874
Cell Significance Index: -16.0500
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -1.0978
Cell Significance Index: -67.3100
Cell Name: lung endothelial cell (CL1001567)
Fold Change: -1.0979
Cell Significance Index: -57.1900
Cell Name: syncytiotrophoblast cell (CL0000525)
Fold Change: -1.1507
Cell Significance Index: -10.9300
Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: -1.1703
Cell Significance Index: -9.8300
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -1.2204
Cell Significance Index: -31.3700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** CEBPB is a transcription factor that belongs to the C/EBP family, which consists of five members: C/EBPα, C/EBPβ, C/EBPγ, C/EBPδ, and C/EBPε. CEBPB is characterized by its ability to bind to specific DNA sequences, known as CCAAT boxes, and to interact with other transcription factors, such as NF-κB and AP-1. This interaction enables CEBPB to regulate the expression of target genes involved in various cellular processes. CEBPB has a homodimeric structure, consisting of two identical subunits, which are crucial for its DNA-binding activity and transcriptional regulation. The protein is also capable of forming heterodimers with other C/EBP family members, such as C/EBPα, to regulate gene expression. **Pathways and Functions** CEBPB is involved in several signaling pathways, including: 1. **Acute-phase response**: CEBPB plays a key role in the regulation of the acute-phase response, which is a complex process involving the coordinated expression of hundreds of genes in response to inflammatory stimuli. 2. **Inflammation**: CEBPB is a key regulator of the inflammatory response, and its expression is significantly elevated in response to inflammatory stimuli, such as cytokines and bacterial lipopolysaccharide. 3. **Cellular differentiation**: CEBPB is involved in the regulation of cellular differentiation, particularly in the development of adipocytes and macrophages. 4. **Integrated stress response**: CEBPB is a key regulator of the integrated stress response, which is a complex process involving the coordinated expression of genes in response to endoplasmic reticulum stress. **Clinical Significance** CEBPB has been implicated in various diseases, including: 1. **Inflammatory disorders**: CEBPB has been shown to play a key role in the regulation of the inflammatory response, making it a potential target for the treatment of inflammatory disorders, such as rheumatoid arthritis and inflammatory bowel disease. 2. **Cancer**: CEBPB has been implicated in the regulation of cellular differentiation and proliferation in various cancer types, including lung, breast, and colon cancer. 3. **Metabolic disorders**: CEBPB has been shown to play a key role in the regulation of glucose and lipid metabolism, making it a potential target for the treatment of metabolic disorders, such as type 2 diabetes and obesity. In conclusion, CEBPB is a transcription factor that plays a crucial role in regulating various cellular processes, including inflammation, immune response, and cellular differentiation. Its expression is significantly elevated in response to inflammatory stimuli, making it a key regulator of the acute-phase response. The clinical significance of CEBPB has been implicated in various diseases, including inflammatory disorders, cancer, and metabolic disorders. Further research is needed to fully understand the role of CEBPB in these diseases and to identify potential therapeutic targets.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Liver activator protein

Genular Protein ID: 4163143888

Symbol: CEBPB_HUMAN

Name: Liver activator protein

UniProtKB Accession Codes:

P17676 A8K671 Q96IH2 Q9H4Z5

Database IDs:

Citations:

PubMed ID: 2112087

Title: A nuclear factor for IL-6 expression (NF-IL6) is a member of a C/EBP family.

PubMed ID: 2112087

DOI: 10.1002/j.1460-2075.1990.tb08316.x

PubMed ID: 15498874

Title: Large-scale cDNA transfection screening for genes related to cancer development and progression.

PubMed ID: 15498874

DOI: 10.1073/pnas.0404089101

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7635140

Title: Identification of a transcriptional regulatory factor for human aromatase cytochrome P450 gene expression as nuclear factor interleukin-6 (NF-IL6), a member of the CCAAT/enhancer-binding protein family.

PubMed ID: 7635140

DOI: 10.1111/j.1432-1033.1995.tb20699.x

PubMed ID: 1741402

Title: A member of the C/EBP family, NF-IL6 beta, forms a heterodimer and transcriptionally synergizes with NF-IL6.

PubMed ID: 1741402

DOI: 10.1073/pnas.89.4.1473

PubMed ID: 9374525

Title: Antioxidant-induced nuclear translocation of CCAAT/enhancer-binding protein beta. A critical role for protein kinase A-mediated phosphorylation of Ser299.

PubMed ID: 9374525

DOI: 10.1074/jbc.272.48.30356

PubMed ID: 11018027

Title: Crystal structure of the CCAAT box/enhancer-binding protein beta activating transcription factor-4 basic leucine zipper heterodimer in the absence of DNA.

PubMed ID: 11018027

DOI: 10.1074/jbc.m005594200

PubMed ID: 11684016

Title: C/EBPbeta phosphorylation by RSK creates a functional XEXD caspase inhibitory box critical for cell survival.

PubMed ID: 11684016

DOI: 10.1016/s1097-2765(01)00374-4

PubMed ID: 11741938

Title: Dynamic regulation of cyclooxygenase-2 promoter activity by isoforms of CCAAT/enhancer-binding proteins.

PubMed ID: 11741938

DOI: 10.1074/jbc.m108075200

PubMed ID: 12048245

Title: MEKK1 plays a critical role in activating the transcription factor C/EBP-beta-dependent gene expression in response to IFN-gamma.

PubMed ID: 12048245

DOI: 10.1073/pnas.122075799

PubMed ID: 12810706

Title: Modification of CCAAT/enhancer-binding protein-beta by the small ubiquitin-like modifier (SUMO) family members, SUMO-2 and SUMO-3.

PubMed ID: 12810706

DOI: 10.1074/jbc.m305680200

PubMed ID: 17467953

Title: Nine-amino-acid transactivation domain: establishment and prediction utilities.

PubMed ID: 17467953

DOI: 10.1016/j.ygeno.2007.02.003

PubMed ID: 18647749

Title: G9a-mediated lysine methylation alters the function of CCAAT/enhancer-binding protein-beta.

PubMed ID: 18647749

DOI: 10.1074/jbc.m802132200

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20111005

Title: Crosstalk between C/EBPbeta phosphorylation, arginine methylation, and SWI/SNF/Mediator implies an indexing transcription factor code.

PubMed ID: 20111005

DOI: 10.1038/emboj.2010.3

PubMed ID: 20829347

Title: Endoplasmic reticulum stress-activated C/EBP homologous protein enhances nuclear factor-kappaB signals via repression of peroxisome proliferator-activated receptor gamma.

PubMed ID: 20829347

DOI: 10.1074/jbc.m110.136259

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 25451943

Title: Transcriptional Regulation of Adipocyte Differentiation: A Central Role for CCAAT/Enhancer-binding Protein (C/EBP) beta.

PubMed ID: 25451943

DOI: 10.1074/jbc.r114.619957

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 27923061

Title: Comparative Transcriptomic and Epigenomic Analyses Reveal New Regulators of Murine Brown Adipogenesis.

PubMed ID: 27923061

DOI: 10.1371/journal.pgen.1006474

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 11257229

Title: Structural analyses of DNA recognition by the AML1/Runx-1 Runt domain and its allosteric control by CBFbeta.

PubMed ID: 11257229

DOI: 10.1016/s0092-8674(01)00271-9

PubMed ID: 11792321

Title: Mechanism of c-Myb-C/EBP beta cooperation from separated sites on a promoter.

PubMed ID: 11792321

DOI: 10.1016/s0092-8674(01)00636-5

Sequence Information:

Length: 345
Mass: 36106
Checksum: 9B725BD6CCAA771D
Sequence:

MQRLVAWDPA CLPLPPPPPA FKSMEVANFY YEADCLAAAY GGKAAPAAPP AARPGPRPPA 
GELGSIGDHE RAIDFSPYLE PLGAPQAPAP ATATDTFEAA PPAPAPAPAS SGQHHDFLSD 
LFSDDYGGKN CKKPAEYGYV SLGRLGAAKG ALHPGCFAPL HPPPPPPPPP AELKAEPGFE 
PADCKRKEEA GAPGGGAGMA AGFPYALRAY LGYQAVPSGS SGSLSTSSSS SPPGTPSPAD 
AKAPPTACYA GAAPAPSQVK SKAKKTVDKH SDEYKIRRER NNIAVRKSRD KAKMRNLETQ 
HKVLELTAEN ERLQKKVEQL SRELSTLRNL FKQLPEPLLA SSGHC

Database document:

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Details for: CEBPB

Associated with

Cells (max top 100)

Other Information

A nuclear factor for IL-6 expression (NF-IL6) is a member of a C/EBP family. PubMed ID: 2112087

Large-scale cDNA transfection screening for genes related to cancer development and progression. PubMed ID: 15498874

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and comparative analysis of human chromosome 20. PubMed ID: 11780052

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Identification of a transcriptional regulatory factor for human aromatase cytochrome P450 gene expression as nuclear factor interleukin-6 (NF-IL6), a member of the CCAAT/enhancer-binding protein family. PubMed ID: 7635140

A member of the C/EBP family, NF-IL6 beta, forms a heterodimer and transcriptionally synergizes with NF-IL6. PubMed ID: 1741402

Antioxidant-induced nuclear translocation of CCAAT/enhancer-binding protein beta. A critical role for protein kinase A-mediated phosphorylation of Ser299. PubMed ID: 9374525

Crystal structure of the CCAAT box/enhancer-binding protein beta activating transcription factor-4 basic leucine zipper heterodimer in the absence of DNA. PubMed ID: 11018027

C/EBPbeta phosphorylation by RSK creates a functional XEXD caspase inhibitory box critical for cell survival. PubMed ID: 11684016

Dynamic regulation of cyclooxygenase-2 promoter activity by isoforms of CCAAT/enhancer-binding proteins. PubMed ID: 11741938

MEKK1 plays a critical role in activating the transcription factor C/EBP-beta-dependent gene expression in response to IFN-gamma. PubMed ID: 12048245

Modification of CCAAT/enhancer-binding protein-beta by the small ubiquitin-like modifier (SUMO) family members, SUMO-2 and SUMO-3. PubMed ID: 12810706

Nine-amino-acid transactivation domain: establishment and prediction utilities. PubMed ID: 17467953

G9a-mediated lysine methylation alters the function of CCAAT/enhancer-binding protein-beta. PubMed ID: 18647749

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Crosstalk between C/EBPbeta phosphorylation, arginine methylation, and SWI/SNF/Mediator implies an indexing transcription factor code. PubMed ID: 20111005

Endoplasmic reticulum stress-activated C/EBP homologous protein enhances nuclear factor-kappaB signals via repression of peroxisome proliferator-activated receptor gamma. PubMed ID: 20829347

Uncovering global SUMOylation signaling networks in a site-specific manner. PubMed ID: 25218447

SUMO-2 orchestrates chromatin modifiers in response to DNA damage. PubMed ID: 25772364

Transcriptional Regulation of Adipocyte Differentiation: A Central Role for CCAAT/Enhancer-binding Protein (C/EBP) beta. PubMed ID: 25451943

System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability. PubMed ID: 25755297

Comparative Transcriptomic and Epigenomic Analyses Reveal New Regulators of Murine Brown Adipogenesis. PubMed ID: 27923061

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733

Structural analyses of DNA recognition by the AML1/Runx-1 Runt domain and its allosteric control by CBFbeta. PubMed ID: 11257229

Mechanism of c-Myb-C/EBP beta cooperation from separated sites on a promoter. PubMed ID: 11792321