Details for: FBXW10

Gene ID: 10517

Symbol: FBXW10

Ensembl ID: ENSG00000171931

Description: F-box and WD repeat domain containing 10

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: amacrine cell (CL0000561)
    Fold Change: 9.49
    Marker Score: 30,398
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 6.39
    Marker Score: 18,635
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 5.68
    Marker Score: 16,849
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 3.8
    Marker Score: 32,177
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 3.47
    Marker Score: 3,324
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 3.46
    Marker Score: 9,922
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 2.93
    Marker Score: 8,367
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.15
    Marker Score: 2,168
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.48
    Marker Score: 170,058
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,817
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,041
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,408
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5,331
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2,741
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,285
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,261
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 706
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 394
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.57
    Marker Score: 453
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.56
    Marker Score: 1,917
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.44
    Marker Score: 904
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.38
    Marker Score: 1,071
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.35
    Marker Score: 2,332
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.33
    Marker Score: 105
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.23
    Marker Score: 2,003
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.23
    Marker Score: 196
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.22
    Marker Score: 422
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.21
    Marker Score: 86
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.21
    Marker Score: 62
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.21
    Marker Score: 2,768
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.2
    Marker Score: 122
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2
    Marker Score: 3,110
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.2
    Marker Score: 217
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.19
    Marker Score: 1,665
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.18
    Marker Score: 372
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.17
    Marker Score: 35
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.17
    Marker Score: 101
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.16
    Marker Score: 307
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.16
    Marker Score: 58
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.16
    Marker Score: 206
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.16
    Marker Score: 70
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.15
    Marker Score: 49
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.15
    Marker Score: 236
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.15
    Marker Score: 33
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.15
    Marker Score: 100
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.14
    Marker Score: 84
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.14
    Marker Score: 588
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.14
    Marker Score: 235
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.13
    Marker Score: 33
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.13
    Marker Score: 1,234
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.12
    Marker Score: 1,055
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.12
    Marker Score: 35
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.12
    Marker Score: 35
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.12
    Marker Score: 72
  • Cell Name: starburst amacrine cell (CL0004232)
    Fold Change: 0.12
    Marker Score: 34
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.12
    Marker Score: 35
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.12
    Marker Score: 363
  • Cell Name: lung neuroendocrine cell (CL1000223)
    Fold Change: 0.12
    Marker Score: 33
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.12
    Marker Score: 55
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.12
    Marker Score: 692
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.11
    Marker Score: 48
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.11
    Marker Score: 29
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.11
    Marker Score: 66
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.11
    Marker Score: 139
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.11
    Marker Score: 149
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.11
    Marker Score: 99
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.11
    Marker Score: 51
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 0.11
    Marker Score: 29
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.11
    Marker Score: 35
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.11
    Marker Score: 28
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: 0.11
    Marker Score: 35
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.11
    Marker Score: 128
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.11
    Marker Score: 6,494
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.1
    Marker Score: 35
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.1
    Marker Score: 27
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.1
    Marker Score: 98
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.1
    Marker Score: 27
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.1
    Marker Score: 32
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.1
    Marker Score: 49
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.1
    Marker Score: 30
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.1
    Marker Score: 233
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.1
    Marker Score: 31
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.1
    Marker Score: 917
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.1
    Marker Score: 33
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.09
    Marker Score: 64
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.09
    Marker Score: 148
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.09
    Marker Score: 42
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.09
    Marker Score: 34
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.09
    Marker Score: 99
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.09
    Marker Score: 3,194
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.09
    Marker Score: 33
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.08
    Marker Score: 33
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.08
    Marker Score: 33
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.08
    Marker Score: 35
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.08
    Marker Score: 211
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.08
    Marker Score: 49
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.08
    Marker Score: 30
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.08
    Marker Score: 35
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.08
    Marker Score: 80

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **F-box and WD repeat domain structure:** FBXW10's F-box domain is essential for its function as an E3 ubiquitin ligase, targeting specific proteins for degradation. The WD repeat domain, on the other hand, mediates protein-protein interactions, facilitating the recruitment of substrates to the F-box domain. 2. **Ubiquitination and proteasome degradation:** FBXW10's E3 ubiquitin ligase activity regulates the degradation of target proteins, including those involved in immune response and protein folding. 3. **Widespread expression:** FBXW10 is expressed in various cell types, including amacrine cells, retinal bipolar neurons, and immune cells, highlighting its role in maintaining tissue-specific homeostasis. 4. **Regulation of immune responses:** FBXW10 modulates immune responses through its involvement in antigen processing, presentation, and the regulation of immune-related proteins. **Pathways and Functions:** 1. **Adaptive immune system:** FBXW10 regulates the degradation of immune-related proteins, such as those involved in the adaptive immune response. 2. **Antigen processing and ubiquitination:** FBXW10's E3 ubiquitin ligase activity targets antigens for degradation, influencing the processing and presentation of antigens to the immune system. 3. **Association with tric/cct:** FBXW10 interacts with tric/cct, a protein complex involved in biosynthesis, facilitating the regulation of protein expression. 4. **Chaperonin-mediated protein folding:** FBXW10 influences protein folding through its interaction with chaperonins, ensuring proper protein conformation and function. 5. **Neddylation and post-translational modification:** FBXW10's involvement in neddylation and post-translational protein modification processes underscores its role in regulating protein function and degradation. **Clinical Significance:** 1. **Immune-related disorders:** Alterations in FBXW10 expression or function may contribute to immune-related disorders, such as autoimmune diseases or immunodeficiencies. 2. **Cancer:** FBXW10's role in regulating protein degradation and ubiquitination may impact cancer progression, as dysregulation of these processes can contribute to tumorigenesis. 3. **Neurological disorders:** FBXW10's expression in the brain and its involvement in chaperonin-mediated protein folding suggest its potential role in neurological disorders, such as neurodegenerative diseases. 4. **Retinal diseases:** FBXW10's expression in retinal cells and its involvement in protein folding and degradation processes highlight its potential role in retinal diseases, such as retinitis pigmentosa. In conclusion, FBXW10's multifaceted role in regulating immune responses, protein folding, and cellular homeostasis underscores its importance as a key player in maintaining tissue-specific balance. Further investigation into FBXW10's function and clinical significance will provide valuable insights into the molecular mechanisms underlying various diseases, ultimately informing the development of novel therapeutic strategies.

Genular Protein ID: 631226116

Symbol: FBW10_HUMAN

Name: F-box/WD repeat-containing protein 10

UniProtKB Accession Codes:

Q5XX13 C9JRY8 C9JZD7 Q8TC00 Q9H0F0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 2 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 EPD 1 Ensembl 3 ExpressionAtlas 1 GO 1 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 3 RefSeq 2 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 15520277

Title: Systematic analysis and nomenclature of mammalian F-box proteins.

PubMed ID: 15520277

DOI: 10.1101/gad.1255304

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 20498703

Title: Lamin A rod domain mutants target heterochromatin protein 1alpha and beta for proteasomal degradation by activation of F-box protein, FBXW10.

PubMed ID: 20498703

DOI: 10.1371/journal.pone.0010620

Sequence Information:

  • Length: 1052
  • Mass: 119846
  • Checksum: C5FDFC2824E918F4
  • Sequence:
    • MENLESRLKN APYFRCEKGT DSIPLCRKCE TCVLAWKIFS TKEWFCRIND ISQRRFLVGI 
LKQLNSLYLL HYFQNILQTT QGKDFIYNRS RINLSKKEGK VVKSSLNQML DKTVEQKMKE 
ILYWFANSTQ WTKANYTLLL LQMCNPKLLL TAANVIRVLF LREENNISGL NQDITDVCFS 
PEKDHSSKSA TSQVYWTAKT QHTSLPLSKA PENEHLLGAA SNPEEPWRNS LRCISEMNRL 
FSGKGDITKP GYDPCNLLVD LDDIRDLSSG FSKYRDFIRY LPIHLSKYIL RMLDRHTLNK 
CASVSQHWAA MAQQVKMDLS AHGFIQNQIT FLQGSYTRGI DPNYANKVSI PVPKMVDDGK 
SMRVKHPKWK LRTKNEYNLW TAYQNEETQQ VLIEERNVFC GTYNVRILSD TWDQNRVIHY 
SGGDLIAVSS NRKIHLLDII QVKAIPVEFR GHAGSVRALF LCEEENFLLS GSYDLSIRYW 
DLKSGVCTRI FGGHQGTITC MDLCKNRLVS GGRDCQVKVW DVDTGKCLKT FRHKDPILAT 
RINDTYIVSS CERGLVKVWH IAMAQLVKTL SGHEGAVKCL FFDQWHLLSG STDGLVMAWS 
MVGKYERCLM AFKHPKEVLD VSLLFLRVIS ACADGKIRIY NFLNGNCMKV LKANGRGDPV 
LSFFIQGNRM VVNTESNVLM FQFEHIKWQY AVEKTKQKKN KEKEEEKEEN SLMEILSKCN 
IQVHSPRESV SSKQTVIQEL LPGKPPKSRV LLKPAKFSSA VLIEELQSQG KSKSPRRDAD 
DVEKAQKQGQ LETPGKLPSH PKKKSWKIPM SPDQFLLTVS ALQHAHNSGE FAYPCRPQTE 
ITDVWGPSIS YPRKVLNFKG KSIQRAVDRL RLSNPPIDVK RTSIPLEIQK LQPNLKISLH 
SPRVQSTIPQ PMIIRSRFSG SLKGGDQVTS SIERAVCSTG PLTSMQVIKP NRMLAPQVGT 
ATLSLKKERP RIYTALDPFR VNTEFVLLTV KEEKEHQEAK MKEYQAREST GVVDPGKVSK 
AAWIRKIKGL PIDNFTKQGK TAAPELGQNV FI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.