Details for: CEBPD

Gene ID: 1052

Symbol: CEBPD

Ensembl ID: ENSG00000221869

Description: CCAAT enhancer binding protein delta

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 527.1136
    Cell Significance Index: -81.9900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 324.0573
    Cell Significance Index: -82.2000
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 190.2305
    Cell Significance Index: -78.3700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 176.1200
    Cell Significance Index: -71.5500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 172.0104
    Cell Significance Index: -81.2100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 154.6312
    Cell Significance Index: -79.5400
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 121.0690
    Cell Significance Index: -81.2400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 74.9835
    Cell Significance Index: -71.5900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 66.5068
    Cell Significance Index: -82.0000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 27.1197
    Cell Significance Index: -72.6500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 21.5435
    Cell Significance Index: -66.1700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 20.6865
    Cell Significance Index: -81.6300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 14.0519
    Cell Significance Index: 248.3200
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 12.1629
    Cell Significance Index: 82.4100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 12.1037
    Cell Significance Index: -26.4900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 11.2141
    Cell Significance Index: 321.4600
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 10.9210
    Cell Significance Index: 67.2100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 6.4870
    Cell Significance Index: 176.5700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 6.2945
    Cell Significance Index: 469.1200
  • Cell Name: peg cell (CL4033014)
    Fold Change: 5.6351
    Cell Significance Index: 130.1900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 5.3190
    Cell Significance Index: 687.1700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 5.2833
    Cell Significance Index: 246.3300
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 4.6797
    Cell Significance Index: 41.5400
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 4.5287
    Cell Significance Index: 20.9100
  • Cell Name: theca cell (CL0000503)
    Fold Change: 4.3064
    Cell Significance Index: 25.3000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 4.2072
    Cell Significance Index: 197.7400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 4.0603
    Cell Significance Index: 557.5900
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 3.9593
    Cell Significance Index: 28.4400
  • Cell Name: salivary gland glandular cell (CL1001596)
    Fold Change: 3.8339
    Cell Significance Index: 21.3400
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 3.7796
    Cell Significance Index: 10.1300
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 3.7481
    Cell Significance Index: 78.1700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 3.7157
    Cell Significance Index: 262.7900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.6356
    Cell Significance Index: 67.2000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 2.2112
    Cell Significance Index: 977.6300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.8362
    Cell Significance Index: 225.7800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.6124
    Cell Significance Index: 290.6700
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.5393
    Cell Significance Index: 15.9300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.5202
    Cell Significance Index: 17.2700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.5147
    Cell Significance Index: 827.2300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.3898
    Cell Significance Index: 178.1600
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.2165
    Cell Significance Index: 12.7000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.1554
    Cell Significance Index: 30.3800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7890
    Cell Significance Index: 85.8200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.7247
    Cell Significance Index: 15.7000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7060
    Cell Significance Index: 36.6800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.6700
    Cell Significance Index: 17.8900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.6270
    Cell Significance Index: 474.5600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.4316
    Cell Significance Index: 7.2700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4226
    Cell Significance Index: 84.7800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3971
    Cell Significance Index: 27.4600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3890
    Cell Significance Index: 23.3600
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.3596
    Cell Significance Index: 4.6100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3382
    Cell Significance Index: 25.9600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.3191
    Cell Significance Index: 6.6800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2477
    Cell Significance Index: 42.3000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2433
    Cell Significance Index: 48.2800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.2216
    Cell Significance Index: 162.4700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2004
    Cell Significance Index: 5.0100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1394
    Cell Significance Index: 4.0200
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 0.0923
    Cell Significance Index: 1.4900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0834
    Cell Significance Index: 75.3000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0592
    Cell Significance Index: 111.5000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0467
    Cell Significance Index: 29.6400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0344
    Cell Significance Index: 1.2100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0264
    Cell Significance Index: 2.7000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0011
    Cell Significance Index: -0.1100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.0106
    Cell Significance Index: -2.0200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0113
    Cell Significance Index: -20.8700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0226
    Cell Significance Index: -34.7600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0561
    Cell Significance Index: -76.3400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0571
    Cell Significance Index: -42.2800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0581
    Cell Significance Index: -36.2800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0588
    Cell Significance Index: -2.9700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0859
    Cell Significance Index: -39.0100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0860
    Cell Significance Index: -2.3000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0888
    Cell Significance Index: -50.1000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1426
    Cell Significance Index: -41.0400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1623
    Cell Significance Index: -18.5900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.1815
    Cell Significance Index: -65.1000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2498
    Cell Significance Index: -52.6100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2905
    Cell Significance Index: -42.2300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3000
    Cell Significance Index: -5.0200
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.3053
    Cell Significance Index: -7.4500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.3443
    Cell Significance Index: -14.1100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3496
    Cell Significance Index: -9.7700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.3779
    Cell Significance Index: -3.4800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3842
    Cell Significance Index: -44.7700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4024
    Cell Significance Index: -31.8700
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.4411
    Cell Significance Index: -2.6700
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.4532
    Cell Significance Index: -6.5100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4639
    Cell Significance Index: -52.9500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.5164
    Cell Significance Index: -26.9000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.6066
    Cell Significance Index: -40.7900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.6503
    Cell Significance Index: -76.6900
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.6741
    Cell Significance Index: -9.9500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.7377
    Cell Significance Index: -76.8200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.7419
    Cell Significance Index: -14.4800
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.7631
    Cell Significance Index: -6.4100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.9272
    Cell Significance Index: -12.6500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.9476
    Cell Significance Index: -42.9500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transcriptional Regulation:** CEBPD is a transcriptional regulator that binds to specific DNA sequences, thereby modulating the activity of transcription factors and regulating gene expression. 2. **Immune Response:** CEBPD is significantly expressed in inflammatory cells and is involved in the regulation of immune responses, particularly in the context of viral infections and cytokine signaling. 3. **Cellular Differentiation:** CEBPD is required for the differentiation of various cell types, including hematopoietic progenitor cells, adipocytes, and osteoblasts. 4. **Cellular Localization:** CEBPD is primarily localized to the nucleus, where it regulates transcriptional activity. **Pathways and Functions:** 1. **Chromatin Remodeling:** CEBPD regulates chromatin remodeling by interacting with chromatin-modifying enzymes, thereby influencing gene expression. 2. **Cytokine Signaling:** CEBPD modulates cytokine signaling by interacting with transcription factors, such as NF-κB and IRF3, which are key regulators of immune responses. 3. **Developmental Biology:** CEBPD is involved in the regulation of developmental processes, including inner ear development and hematopoietic progenitor cell differentiation. 4. **Disease Pathways:** CEBPD has been implicated in various disease pathways, including infectious diseases, autoimmune diseases, and cancer. **Clinical Significance:** 1. **Infectious Diseases:** CEBPD plays a critical role in the regulation of immune responses, particularly in the context of viral infections, such as HCMV. 2. **Autoimmune Diseases:** CEBPD has been implicated in autoimmune diseases, such as rheumatoid arthritis and lupus, where it regulates the activity of immune cells and cytokine signaling. 3. **Cancer:** CEBPD has been shown to be involved in cancer development and progression, particularly in the context of immune evasion and tumor microenvironment remodeling. 4. **Therapeutic Targeting:** CEBPD has emerged as a potential therapeutic target for the treatment of various diseases, including autoimmune diseases and cancer, where its regulation of immune responses and cellular differentiation can be exploited to modulate disease progression. In conclusion, CEBPD is a critical regulator of immune response and cellular differentiation, with implications for various biological processes, including development, disease, and cancer. Further research is needed to fully elucidate the mechanisms by which CEBPD regulates gene expression and to explore its therapeutic potential.

Genular Protein ID: 714343694

Symbol: CEBPD_HUMAN

Name: CCAAT/enhancer-binding protein delta

UniProtKB Accession Codes:

P49716 Q14937 Q2M2X9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 ComplexPortal 4 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 4 Ensembl 1 GO 18 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1741402

Title: A member of the C/EBP family, NF-IL6 beta, forms a heterodimer and transcriptionally synergizes with NF-IL6.

PubMed ID: 1741402

DOI: 10.1073/pnas.89.4.1473

PubMed ID: 8314590

Title: The human C/EBP delta (CRP3/CELF) gene: structure and chromosomal localization.

PubMed ID: 8314590

DOI: 10.1006/geno.1993.1220

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16397300

Title: Functional role of NF-IL6beta and its sumoylation and acetylation modifications in promoter activation of cyclooxygenase 2 gene.

PubMed ID: 16397300

DOI: 10.1093/nar/gkj422

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

Sequence Information:

  • Length: 269
  • Mass: 28467
  • Checksum: AFDE9E2244BDF84A
  • Sequence:
    • MSAALFSLDG PARGAPWPAE PAPFYEPGRA GKPGRGAEPG ALGEPGAAAP AMYDDESAID 
FSAYIDSMAA VPTLELCHDE LFADLFNSNH KAGGAGPLEL LPGGPARPLG PGPAAPRLLK 
REPDWGDGDA PGSLLPAQVA ACAQTVVSLA AAGQPTPPTS PEPPRSSPRQ TPAPGPAREK 
SAGKRGPDRG SPEYRQRRER NNIAVRKSRD KAKRRNQEMQ QKLVELSAEN EKLHQRVEQL 
TRDLAGLRQF FKQLPSPPFL PAAGTADCR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.