Details for: KAT5
Associated with
Other Information
Genular Protein ID: 1233245509
Symbol: KAT5_HUMAN
Name: Histone acetyltransferase HTATIP
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8607265
Title: Identification of a cellular protein that specifically interacts with the essential cysteine region of the HIV-1 Tat transactivator.
PubMed ID: 8607265
PubMed ID: 11416127
Title: PLIP, a novel splice variant of Tip60, interacts with group IV cytosolic phospholipase A(2), induces apoptosis, and potentiates prostaglandin production.
PubMed ID: 11416127
PubMed ID: 12801643
Title: Identification of a larger form of the histone acetyl transferase Tip60.
PubMed ID: 12801643
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16554811
Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.
PubMed ID: 16554811
DOI: 10.1038/nature04632
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 12963728
Title: Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex.
PubMed ID: 12963728
PubMed ID: 10096020
Title: Tip60 acetylates six lysines of a specific class in core histones in vitro.
PubMed ID: 10096020
PubMed ID: 10966108
Title: Involvement of the TIP60 histone acetylase complex in DNA repair and apoptosis.
PubMed ID: 10966108
PubMed ID: 11262386
Title: Tip60 and HDAC7 interact with the endothelin receptor a and may be involved in downstream signaling.
PubMed ID: 11262386
PubMed ID: 11927554
Title: Tip60 is targeted to proteasome-mediated degradation by Mdm2 and accumulates after UV irradiation.
PubMed ID: 11927554
PubMed ID: 12776177
Title: MYC recruits the TIP60 histone acetyltransferase complex to chromatin.
PubMed ID: 12776177
PubMed ID: 12468530
Title: Tip60 acetyltransferase activity is controlled by phosphorylation.
PubMed ID: 12468530
PubMed ID: 12551922
PubMed ID: 15196461
Title: The highly conserved and multifunctional NuA4 HAT complex.
PubMed ID: 15196461
PubMed ID: 15310756
Title: Role of the histone acetyl transferase Tip60 in the p53 pathway.
PubMed ID: 15310756
PubMed ID: 15502158
Title: von Hippel-Lindau partner Jade-1 is a transcriptional co-activator associated with histone acetyltransferase activity.
PubMed ID: 15502158
PubMed ID: 14966270
Title: Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans.
PubMed ID: 14966270
PubMed ID: 15121871
Title: E2F-dependent histone acetylation and recruitment of the Tip60 acetyltransferase complex to chromatin in late G1.
PubMed ID: 15121871
PubMed ID: 15042092
Title: A large-scale RNAi screen in human cells identifies new components of the p53 pathway.
PubMed ID: 15042092
DOI: 10.1038/nature02371
PubMed ID: 16001085
Title: HIV-1 Tat targets Tip60 to impair the apoptotic cell response to genotoxic stresses.
PubMed ID: 16001085
PubMed ID: 16141325
Title: A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM.
PubMed ID: 16141325
PubMed ID: 16835243
Title: The histidine triad protein Hint1 triggers apoptosis independent of its enzymatic activity.
PubMed ID: 16835243
PubMed ID: 16387653
Title: ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation.
PubMed ID: 16387653
PubMed ID: 17709392
Title: DNA damage-dependent acetylation and ubiquitination of H2AX enhances chromatin dynamics.
PubMed ID: 17709392
DOI: 10.1128/mcb.00579-07
PubMed ID: 17360565
Title: FOXP3 interactions with histone acetyltransferase and class II histone deacetylases are required for repression.
PubMed ID: 17360565
PubMed ID: 17996965
Title: The orphan nuclear receptor Rev-erbbeta recruits Tip60 and HDAC1 to regulate apolipoprotein CIII promoter.
PubMed ID: 17996965
PubMed ID: 18451177
Title: TRIM68 regulates ligand-dependent transcription of androgen receptor in prostate cancer cells.
PubMed ID: 18451177
PubMed ID: 18397884
Title: Regulation of TIP60 by ATF2 modulates ATM activation.
PubMed ID: 18397884
PubMed ID: 17704809
Title: Functional characterization of TIP60 sumoylation in UV-irradiated DNA damage response.
PubMed ID: 17704809
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19909775
Title: TRIM24 mediates ligand-dependent activation of androgen receptor and is repressed by a bromodomain-containing protein, BRD7, in prostate cancer cells.
PubMed ID: 19909775
PubMed ID: 19783983
Title: Histone H3 methylation links DNA damage detection to activation of the tumour suppressor Tip60.
PubMed ID: 19783983
DOI: 10.1038/ncb1982
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 20100829
Title: SIRT1 regulates autoacetylation and histone acetyltransferase activity of TIP60.
PubMed ID: 20100829
PubMed ID: 21858214
Title: GPR50 interacts with TIP60 to modulate glucocorticoid receptor signalling.
PubMed ID: 21858214
PubMed ID: 22539723
Title: GSK3-TIP60-ULK1 signaling pathway links growth factor deprivation to autophagy.
PubMed ID: 22539723
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24835996
Title: Dynamic interactions between TIP60 and p300 regulate FOXP3 function through a structural switch defined by a single lysine on TIP60.
PubMed ID: 24835996
PubMed ID: 25301942
Title: Regulation of histone acetyltransferase TIP60 function by histone deacetylase 3.
PubMed ID: 25301942
PubMed ID: 25245946
Title: Two ZNF509 (ZBTB49) isoforms induce cell-cycle arrest by activating transcription of p21/CDKN1A and RB upon exposure to genotoxic stress.
PubMed ID: 25245946
DOI: 10.1093/nar/gku857
PubMed ID: 24463511
Title: ANP32E is a histone chaperone that removes H2A.Z from chromatin.
PubMed ID: 24463511
DOI: 10.1038/nature12922
PubMed ID: 25560918
Title: The chromodomain-containing histone acetyltransferase TIP60 acts as a code reader, recognizing the epigenetic codes for initiating transcription.
PubMed ID: 25560918
PubMed ID: 26291311
Title: KAT5-mediated SOX4 acetylation orchestrates chromatin remodeling during myoblast differentiation.
PubMed ID: 26291311
PubMed ID: 26438602
Title: Acetylation of histone H2AX at Lys 5 by the TIP60 histone acetyltransferase complex is essential for the dynamic binding of NBS1 to damaged chromatin.
PubMed ID: 26438602
DOI: 10.1128/mcb.00757-15
PubMed ID: 25865756
Title: The stress-responsive gene ATF3 regulates the histone acetyltransferase Tip60.
PubMed ID: 25865756
DOI: 10.1038/ncomms7752
PubMed ID: 27153538
Title: The TIP60 complex regulates bivalent chromatin recognition by 53BP1 through direct H4K20me binding and H2AK15 acetylation.
PubMed ID: 27153538
PubMed ID: 26829474
Title: Acetylation of Aurora B by TIP60 ensures accurate chromosomal segregation.
PubMed ID: 26829474
PubMed ID: 29192674
Title: Landscape of the regulatory elements for lysine 2-hydroxyisobutyrylation pathway.
PubMed ID: 29192674
DOI: 10.1038/cr.2017.149
PubMed ID: 29335245
Title: CDK9-mediated phosphorylation controls the interaction of TIP60 with the transcriptional machinery.
PubMed ID: 29335245
PubMed ID: 29174981
Title: Acetylation of TIP60 at K104 is essential for metabolic stress-induced apoptosis in cells of hepatocellular cancer.
PubMed ID: 29174981
PubMed ID: 29040603
Title: Mitosis-specific acetylation tunes Ran effector binding for chromosome segregation.
PubMed ID: 29040603
DOI: 10.1093/jmcb/mjx045
PubMed ID: 29765047
Title: Tip60-mediated lipin 1 acetylation and ER translocation determine triacylglycerol synthesis rate.
PubMed ID: 29765047
PubMed ID: 30409912
Title: Dynamic acetylation of the kinetochore-associated protein HEC1 ensures accurate microtubule-kinetochore attachment.
PubMed ID: 30409912
PubMed ID: 30704899
Title: Pacer is a mediator of mTORC1 and GSK3-TIP60 signaling in regulation of autophagosome maturation and lipid metabolism.
PubMed ID: 30704899
PubMed ID: 33076429
Title: VRK1 phosphorylates Tip60/KAT5 and is required for H4K16 acetylation in response to DNA Damage.
PubMed ID: 33076429
PubMed ID: 32034146
Title: Acetylation of XPF by TIP60 facilitates XPF-ERCC1 complex assembly and activation.
PubMed ID: 32034146
PubMed ID: 32817552
Title: KAT5 acetylates cGAS to promote innate immune response to DNA virus.
PubMed ID: 32817552
PubMed ID: 32832608
Title: TIP60 K430 SUMOylation attenuates its interaction with DNA-PKcs in S-phase cells: Facilitating homologous recombination and emerging target for cancer therapy.
PubMed ID: 32832608
PubMed ID: 33938178
Title: Lysine acetyltransferase Tip60 acetylates the APP adaptor Fe65 to increase its transcriptional activity.
PubMed ID: 33938178
PubMed ID: 34077757
Title: Choline kinase alpha 2 acts as a protein kinase to promote lipolysis of lipid droplets.
PubMed ID: 34077757
PubMed ID: 34608293
Title: Dynamic crotonylation of EB1 by TIP60 ensures accurate spindle positioning in mitosis.
PubMed ID: 34608293
PubMed ID: 32822602
Title: De Novo KAT5 Variants Cause a Syndrome with Recognizable Facial Dysmorphisms, Cerebellar Atrophy, Sleep Disturbance, and Epilepsy.
PubMed ID: 32822602
PubMed ID: 29494751
Title: Structural and histone binding studies of the chromo barrel domain of TIP60.
PubMed ID: 29494751
Sequence Information:
- Length: 513
- Mass: 58582
- Checksum: 63724F5E10B957D5
- Sequence:
MAEVGEIIEG CRLPVLRRNQ DNEDEWPLAE ILSVKDISGR KLFYVHYIDF NKRLDEWVTH ERLDLKKIQF PKKEAKTPTK NGLPGSRPGS PEREVPASAQ ASGKTLPIPV QITLRFNLPK EREAIPGGEP DQPLSSSSCL QPNHRSTKRK VEVVSPATPV PSETAPASVF PQNGAARRAV AAQPGRKRKS NCLGTDEDSQ DSSDGIPSAP RMTGSLVSDR SHDDIVTRMK NIECIELGRH RLKPWYFSPY PQELTTLPVL YLCEFCLKYG RSLKCLQRHL TKCDLRHPPG NEIYRKGTIS FFEIDGRKNK SYSQNLCLLA KCFLDHKTLY YDTDPFLFYV MTEYDCKGFH IVGYFSKEKE STEDYNVACI LTLPPYQRRG YGKLLIEFSY ELSKVEGKTG TPEKPLSDLG LLSYRSYWSQ TILEILMGLK SESGERPQIT INEISEITSI KKEDVISTLQ YLNLINYYKG QYILTLSEDI VDGHERAMLK RLLRIDSKCL HFTPKDWSKR GKW
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.