Details for: CEBPE

Gene ID: 1053

Symbol: CEBPE

Ensembl ID: ENSG00000092067

Description: CCAAT enhancer binding protein epsilon

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 8.6149
    Cell Significance Index: -1.3400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 4.9282
    Cell Significance Index: -1.2500
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 1.4065
    Cell Significance Index: 20.5000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 1.0868
    Cell Significance Index: -1.3400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.4797
    Cell Significance Index: 6.8700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.2206
    Cell Significance Index: 5.9000
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.1858
    Cell Significance Index: 3.7800
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 0.1765
    Cell Significance Index: 2.2600
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.1760
    Cell Significance Index: 2.2300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.0330
    Cell Significance Index: 0.6100
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.0204
    Cell Significance Index: 0.1700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0146
    Cell Significance Index: 0.9400
  • Cell Name: basophil mast progenitor cell (CL0002028)
    Fold Change: 0.0142
    Cell Significance Index: 0.1200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.0100
    Cell Significance Index: 0.2600
  • Cell Name: Langerhans cell (CL0000453)
    Fold Change: 0.0073
    Cell Significance Index: 0.0700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0053
    Cell Significance Index: 0.2500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0036
    Cell Significance Index: 0.0900
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.0028
    Cell Significance Index: 0.0300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0028
    Cell Significance Index: 4.2500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: 0.0009
    Cell Significance Index: 0.0400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0000
    Cell Significance Index: -0.0800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0003
    Cell Significance Index: -0.4200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0003
    Cell Significance Index: -0.0200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0005
    Cell Significance Index: -0.9800
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0008
    Cell Significance Index: -0.0200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0012
    Cell Significance Index: -0.1700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0017
    Cell Significance Index: -1.0700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0018
    Cell Significance Index: -1.3900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0019
    Cell Significance Index: -1.3900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0019
    Cell Significance Index: -1.0300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0019
    Cell Significance Index: -1.2100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0021
    Cell Significance Index: -0.1300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0024
    Cell Significance Index: -1.3600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0028
    Cell Significance Index: -1.2500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0029
    Cell Significance Index: -1.0300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0038
    Cell Significance Index: -0.6800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0041
    Cell Significance Index: -1.1900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0048
    Cell Significance Index: -0.4900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0049
    Cell Significance Index: -0.9800
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0049
    Cell Significance Index: -0.0400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0054
    Cell Significance Index: -0.7500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0057
    Cell Significance Index: -1.2100
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0062
    Cell Significance Index: -0.0900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0066
    Cell Significance Index: -0.8100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0074
    Cell Significance Index: -1.4700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0077
    Cell Significance Index: -1.3200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0093
    Cell Significance Index: -0.4000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0095
    Cell Significance Index: -1.1200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0100
    Cell Significance Index: -1.1600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0113
    Cell Significance Index: -1.3000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0116
    Cell Significance Index: -0.5400
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: -0.0125
    Cell Significance Index: -0.0800
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0164
    Cell Significance Index: -0.2300
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0177
    Cell Significance Index: -0.3100
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0181
    Cell Significance Index: -0.4500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0194
    Cell Significance Index: -0.6800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0206
    Cell Significance Index: -0.6800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0208
    Cell Significance Index: -1.0800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0213
    Cell Significance Index: -1.1200
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.0221
    Cell Significance Index: -0.2600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0230
    Cell Significance Index: -1.2900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0234
    Cell Significance Index: -1.0600
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0244
    Cell Significance Index: -0.3500
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.0251
    Cell Significance Index: -0.3100
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0260
    Cell Significance Index: -0.3500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0269
    Cell Significance Index: -0.9900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0286
    Cell Significance Index: -0.9100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0288
    Cell Significance Index: -0.8300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0301
    Cell Significance Index: -0.7300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0301
    Cell Significance Index: -1.3300
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.0302
    Cell Significance Index: -0.3200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0302
    Cell Significance Index: -1.0600
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0322
    Cell Significance Index: -0.6300
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.0335
    Cell Significance Index: -0.3600
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0351
    Cell Significance Index: -0.5100
  • Cell Name: immature neutrophil (CL0000776)
    Fold Change: -0.0354
    Cell Significance Index: -0.2700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0365
    Cell Significance Index: -1.0500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0371
    Cell Significance Index: -0.9900
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0381
    Cell Significance Index: -0.5900
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0398
    Cell Significance Index: -0.8300
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0402
    Cell Significance Index: -0.5200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0405
    Cell Significance Index: -1.1900
  • Cell Name: melanocyte (CL0000148)
    Fold Change: -0.0406
    Cell Significance Index: -0.3800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0407
    Cell Significance Index: -0.8800
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0408
    Cell Significance Index: -1.2900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0415
    Cell Significance Index: -0.8800
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.0419
    Cell Significance Index: -0.4200
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0422
    Cell Significance Index: -0.8300
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.0423
    Cell Significance Index: -0.5100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0425
    Cell Significance Index: -1.0600
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0435
    Cell Significance Index: -0.5500
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0440
    Cell Significance Index: -1.1200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0445
    Cell Significance Index: -1.3100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0448
    Cell Significance Index: -1.2200
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0449
    Cell Significance Index: -0.7200
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0451
    Cell Significance Index: -0.5800
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0471
    Cell Significance Index: -0.8000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0475
    Cell Significance Index: -1.2500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0480
    Cell Significance Index: -1.0500
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0482
    Cell Significance Index: -0.6300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CEBPE is a member of the CCAAT/enhancer-binding protein (C/EBP) family, which is characterized by its ability to bind to specific DNA sequences and regulate gene expression. CEBPE is primarily expressed in hematopoietic cells, including macrophages and granulocytes, as well as in certain epithelial tissues, such as intestinal crypt stem cells and kidney proximal convoluted tubule epithelial cells. The protein exhibits a unique structure, consisting of a basic domain and a leucine zipper motif, which enables it to interact with other transcription factors and regulate gene expression. **Pathways and Functions:** CEBPE is involved in several key pathways, including: 1. **Cellular Response to Lipopolysaccharide (LPS):** CEBPE regulates the expression of genes involved in the immune response to LPS, a component of bacterial cell walls. By binding to specific DNA sequences, CEBPE modulates the transcription of genes that encode pro-inflammatory cytokines and chemokines. 2. **Granulocyte Differentiation:** CEBPE plays a crucial role in the differentiation of granulocytes, including neutrophils and monocytes, by regulating the expression of genes involved in their development and maturation. 3. **Macrophage Differentiation:** CEBPE also regulates the differentiation of macrophages, a type of immune cell that plays a key role in the defense against pathogens and foreign substances. 4. **Transcriptional Regulation:** CEBPE acts as a transcriptional regulator by binding to specific DNA sequences and modulating the expression of target genes. It interacts with other transcription factors, such as NF-κB and AP-1, to regulate gene expression. **Clinical Significance:** Dysregulation of CEBPE has been implicated in various diseases, including: 1. **Autoimmune Disorders:** Alterations in CEBPE expression have been linked to autoimmune diseases, such as rheumatoid arthritis and lupus, where the immune system mistakenly attacks healthy tissues. 2. **Cancer:** CEBPE has been shown to play a role in the development and progression of certain types of cancer, including leukemia and lymphoma. 3. **Inflammatory Disorders:** CEBPE regulates the expression of genes involved in inflammation, making it a potential therapeutic target for treating inflammatory disorders, such as asthma and Crohn's disease. In conclusion, CEBPE is a crucial transcription factor that plays a significant role in regulating immune response, cellular differentiation, and development. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the mechanisms of CEBPE regulation and its potential therapeutic applications. **References:** [Insert relevant references to support the discussion] **Note:** This article is a summary of the key characteristics, pathways, and functions of the CEBPE gene, and its clinical significance. As an expert immunologist, I have provided a detailed review of the current knowledge on CEBPE, highlighting its importance in the context of immunology and disease.

Genular Protein ID: 2989185112

Symbol: CEBPE_HUMAN

Name: CCAAT/enhancer-binding protein epsilon

UniProtKB Accession Codes:

Q15744 Q15745 Q8IYI2 Q99803

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ComplexPortal 7 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 4 Ensembl 1 EvolutionaryTrace 1 GO 22 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIRSF 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8661101

Title: A novel human CCAAT/enhancer binding protein gene, C/EBPepsilon, is expressed in cells of lymphoid and myeloid lineages and is localized on chromosome 14q11.2 close to the T-cell receptor alpha/delta locus.

PubMed ID: 8661101

DOI: 10.1006/geno.1996.0319

PubMed ID: 9032264

Title: Cloning of the novel human myeloid-cell-specific C/EBP-epsilon transcription factor.

PubMed ID: 9032264

DOI: 10.1128/mcb.17.3.1375

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10359588

Title: Neutrophil-specific granule deficiency results from a novel mutation with loss of function of the transcription factor CCAAT/enhancer binding protein epsilon.

PubMed ID: 10359588

DOI: 10.1084/jem.189.11.1847

PubMed ID: 11313242

Title: Neutrophil-specific granule deficiency: homozygous recessive inheritance of a frameshift mutation in the gene encoding transcription factor CCAAT/enhancer binding protein--epsilon.

PubMed ID: 11313242

DOI: 10.1182/blood.v97.9.2561

PubMed ID: 26019275

Title: A novel in-frame deletion in the leucine zipper domain of C/EBPepsilon leads to neutrophil-specific granule deficiency.

PubMed ID: 26019275

DOI: 10.4049/jimmunol.1402222

PubMed ID: 28369036

Title: Chromatin-remodeling factor SMARCD2 regulates transcriptional networks controlling differentiation of neutrophil granulocytes.

PubMed ID: 28369036

DOI: 10.1038/ng.3833

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 31201888

Title: Gain-of-function CEBPE mutation causes noncanonical autoinflammatory inflammasomopathy.

PubMed ID: 31201888

DOI: 10.1016/j.jaci.2019.06.003

PubMed ID: 17244686

Title: Growth factor independence-1 (Gfi-1) plays a role in mediating specific granule deficiency (SGD) in a patient lacking a gene-inactivating mutation in the C/EBPepsilon gene.

PubMed ID: 17244686

DOI: 10.1182/blood-2005-05-022004

PubMed ID: 29651288

Title: CEBPE-mutant specific granule deficiency correlates with aberrant granule organization and substantial proteome alterations in neutrophils.

PubMed ID: 29651288

DOI: 10.3389/fimmu.2018.00588

PubMed ID: 32391290

Title: Brain Abscess as Severe Presentation of Specific Granule Deficiency.

PubMed ID: 32391290

DOI: 10.3389/fped.2020.00117

Sequence Information:

  • Length: 281
  • Mass: 30603
  • Checksum: B0A1DFA88C04C3D0
  • Sequence:
    • MSHGTYYECE PRGGQQPLEF SGGRAGPGEL GDMCEHEASI DLSAYIESGE EQLLSDLFAV 
KPAPEARGLK GPGTPAFPHY LPPDPRPFAY PPHTFGPDRK ALGPGIYSSP GSYDPRAVAV 
KEEPRGPEGS RAASRGSYNP LQYQVAHCGQ TAMHLPPTLA APGQPLRVLK APLATAAPPC 
SPLLKAPSPA GPLHKGKKAV NKDSLEYRLR RERNNIAVRK SRDKAKRRIL ETQQKVLEYM 
AENERLRSRV EQLTQELDTL RNLFRQIPEA ANLIKGVGGC S

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.