Details for: ATG7
Associated with
Cells (max top 100)
(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: mature microglial cell (CL0002629)
Fold Change: 2.88
Marker Score: 1,041 - Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 2.87
Marker Score: 61,245 - Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 2.75
Marker Score: 2,437 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 2.68
Marker Score: 3,041 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 2.63
Marker Score: 6,594 - Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 2.54
Marker Score: 1,674 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 2.52
Marker Score: 50,093 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 2.41
Marker Score: 10,103 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 2.4
Marker Score: 35,883 - Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 2.36
Marker Score: 89,801 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 2.31
Marker Score: 85,209 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 2.27
Marker Score: 3,059 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 2.27
Marker Score: 662 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 2.22
Marker Score: 9,210 - Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: 2.15
Marker Score: 1,496 - Cell Name: mature astrocyte (CL0002627)
Fold Change: 2.15
Marker Score: 1,416 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 2.14
Marker Score: 20,147 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: 2.14
Marker Score: 675 - Cell Name: central nervous system macrophage (CL0000878)
Fold Change: 2.12
Marker Score: 1,053 - Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 2.09
Marker Score: 16,000 - Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 2.05
Marker Score: 3,950 - Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 2.05
Marker Score: 860 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 2.05
Marker Score: 4,506 - Cell Name: cardiac neuron (CL0010022)
Fold Change: 2.05
Marker Score: 2,553 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 2.04
Marker Score: 125,506 - Cell Name: taste receptor cell (CL0000209)
Fold Change: 2.04
Marker Score: 1,760 - Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 2.03
Marker Score: 2,243 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 2.01
Marker Score: 35,733 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 2
Marker Score: 2,424 - Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 1.97
Marker Score: 2,272 - Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.97
Marker Score: 7,603 - Cell Name: inhibitory interneuron (CL0000498)
Fold Change: 1.96
Marker Score: 9,085 - Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: 1.93
Marker Score: 5,499 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 1.88
Marker Score: 19,440 - Cell Name: pyramidal neuron (CL0000598)
Fold Change: 1.88
Marker Score: 3,155 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 1.87
Marker Score: 17,722 - Cell Name: germ cell (CL0000586)
Fold Change: 1.85
Marker Score: 3,224 - Cell Name: corneal endothelial cell (CL0000132)
Fold Change: 1.84
Marker Score: 1,073 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 1.8
Marker Score: 1,055 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 1.8
Marker Score: 15,469 - Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 1.79
Marker Score: 1,069 - Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 1.78
Marker Score: 940 - Cell Name: contractile cell (CL0000183)
Fold Change: 1.76
Marker Score: 954 - Cell Name: alveolar type 2 fibroblast cell (CL4028006)
Fold Change: 1.68
Marker Score: 935 - Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 1.68
Marker Score: 3,412 - Cell Name: syncytiotrophoblast cell (CL0000525)
Fold Change: 1.67
Marker Score: 1,374 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 1.66
Marker Score: 564 - Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 1.65
Marker Score: 517 - Cell Name: renal principal cell (CL0005009)
Fold Change: 1.64
Marker Score: 1,265 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 1.61
Marker Score: 2,479 - Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: 1.6
Marker Score: 2,322 - Cell Name: lactocyte (CL0002325)
Fold Change: 1.59
Marker Score: 25,558 - Cell Name: ON retinal ganglion cell (CL4023032)
Fold Change: 1.59
Marker Score: 434 - Cell Name: neuron (CL0000540)
Fold Change: 1.59
Marker Score: 6,464 - Cell Name: fat cell (CL0000136)
Fold Change: 1.58
Marker Score: 884 - Cell Name: oligodendrocyte (CL0000128)
Fold Change: 1.56
Marker Score: 3,733 - Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: 1.56
Marker Score: 34,837 - Cell Name: lung goblet cell (CL1000143)
Fold Change: 1.51
Marker Score: 435 - Cell Name: mural cell (CL0008034)
Fold Change: 1.46
Marker Score: 167,526 - Cell Name: photoreceptor cell (CL0000210)
Fold Change: 1.46
Marker Score: 1,096 - Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 1.45
Marker Score: 1,565 - Cell Name: epithelial cell of lower respiratory tract (CL0002632)
Fold Change: 1.43
Marker Score: 5,970 - Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: 1.42
Marker Score: 361 - Cell Name: astrocyte (CL0000127)
Fold Change: 1.41
Marker Score: 1,226 - Cell Name: subcutaneous fat cell (CL0002521)
Fold Change: 1.4
Marker Score: 511 - Cell Name: A2 amacrine cell (CL0004219)
Fold Change: 1.38
Marker Score: 437 - Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 1.37
Marker Score: 1,311 - Cell Name: skin fibroblast (CL0002620)
Fold Change: 1.32
Marker Score: 342 - Cell Name: mononuclear cell (CL0000842)
Fold Change: 1.29
Marker Score: 416 - Cell Name: Purkinje cell (CL0000121)
Fold Change: 1.27
Marker Score: 42,738 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.25
Marker Score: 19,610 - Cell Name: cerebellar granule cell precursor (CL0002362)
Fold Change: 1.25
Marker Score: 701 - Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 1.25
Marker Score: 2,935 - Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: 1.2
Marker Score: 4,272 - Cell Name: oocyte (CL0000023)
Fold Change: 1.2
Marker Score: 297 - Cell Name: mesangial cell (CL0000650)
Fold Change: 1.18
Marker Score: 1,429 - Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 1.17
Marker Score: 1,449 - Cell Name: parietal epithelial cell (CL1000452)
Fold Change: 1.16
Marker Score: 422 - Cell Name: basal cell of epidermis (CL0002187)
Fold Change: 1.15
Marker Score: 502 - Cell Name: podocyte (CL0000653)
Fold Change: 1.15
Marker Score: 425 - Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 1.15
Marker Score: 1,624 - Cell Name: hepatic stellate cell (CL0000632)
Fold Change: 1.14
Marker Score: 430 - Cell Name: chromaffin cell (CL0000166)
Fold Change: 1.1
Marker Score: 1,552 - Cell Name: Hofbauer cell (CL3000001)
Fold Change: 1.1
Marker Score: 605 - Cell Name: granule cell (CL0000120)
Fold Change: 1.09
Marker Score: 8,190 - Cell Name: endocrine cell (CL0000163)
Fold Change: 1.08
Marker Score: 557 - Cell Name: hepatoblast (CL0005026)
Fold Change: 1.04
Marker Score: 3,393 - Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: 1.03
Marker Score: 1,107 - Cell Name: macroglial cell (CL0000126)
Fold Change: 1.03
Marker Score: 2,375 - Cell Name: stellate neuron (CL0000122)
Fold Change: 1.03
Marker Score: 5,548 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 1.02
Marker Score: 6,565 - Cell Name: Kupffer cell (CL0000091)
Fold Change: 1.02
Marker Score: 1,020 - Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 1.02
Marker Score: 611 - Cell Name: cholangiocyte (CL1000488)
Fold Change: 1.02
Marker Score: 380 - Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
Fold Change: 1.01
Marker Score: 267 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 1.01
Marker Score: 6,051 - Cell Name: papillary tips cell (CL1000597)
Fold Change: 1.01
Marker Score: 203 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1
Marker Score: 1,052 - Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71,709 - Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 47,935
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 430809665
Symbol: ATG7_HUMAN
Name: Ubiquitin-like modifier-activating enzyme ATG7
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10233149
Title: Glucose-induced autophagy of peroxisomes in Pichia pastoris requires a unique E1-like protein.
PubMed ID: 10233149
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16641997
Title: The DNA sequence, annotation and analysis of human chromosome 3.
PubMed ID: 16641997
DOI: 10.1038/nature04728
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 17974005
Title: The full-ORF clone resource of the German cDNA consortium.
PubMed ID: 17974005
PubMed ID: 11096062
Title: The human homolog of Saccharomyces cerevisiae Apg7p is a Protein-activating enzyme for multiple substrates including human Apg12p, GATE-16, GABARAP, and MAP-LC3.
PubMed ID: 11096062
PubMed ID: 11890701
Title: Murine Apg12p has a substrate preference for murine Apg7p over three Apg8p homologs.
PubMed ID: 11890701
PubMed ID: 11825910
Title: Human Apg3p/Aut1p homologue is an authentic E2 enzyme for multiple substrates, GATE-16, GABARAP, and MAP-LC3, and facilitates the conjugation of hApg12p to hApg5p.
PubMed ID: 11825910
PubMed ID: 16303767
Title: Phosphatidylserine in addition to phosphatidylethanolamine is an in vitro target of the mammalian Atg8 modifiers, LC3, GABARAP, and GATE-16.
PubMed ID: 16303767
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19124466
Title: Regulation of autophagy by the p300 acetyltransferase.
PubMed ID: 19124466
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20543840
Title: Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity.
PubMed ID: 20543840
DOI: 10.1038/ncb2069
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 22170151
Title: The FAP motif within human ATG7, an autophagy-related E1-like enzyme, is essential for the E2-substrate reaction of LC3 lipidation.
PubMed ID: 22170151
PubMed ID: 22223895
Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.
PubMed ID: 22223895
PubMed ID: 23386620
Title: Heat shock factor 1 (HSF1) controls chemoresistance and autophagy through transcriptional regulation of autophagy-related protein 7 (ATG7).
PubMed ID: 23386620
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 34161705
Title: Developmental Consequences of Defective ATG7-Mediated Autophagy in Humans.
PubMed ID: 34161705
Sequence Information:
- Length: 703
- Mass: 77960
- Checksum: ABBD1A29A6C58356
- Sequence:
MAAATGDPGL SKLQFAPFSS ALDVGFWHEL TQKKLNEYRL DEAPKDIKGY YYNGDSAGLP ARLTLEFSAF DMSAPTPARC CPAIGTLYNT NTLESFKTAD KKLLLEQAAN EIWESIKSGT ALENPVLLNK FLLLTFADLK KYHFYYWFCY PALCLPESLP LIQGPVGLDQ RFSLKQIEAL ECAYDNLCQT EGVTALPYFL IKYDENMVLV SLLKHYSDFF QGQRTKITIG VYDPCNLAQY PGWPLRNFLV LAAHRWSSSF QSVEVVCFRD RTMQGARDVA HSIIFEVKLP EMAFSPDCPK AVGWEKNQKG GMGPRMVNLS ECMDPKRLAE SSVDLNLKLM CWRLVPTLDL DKVVSVKCLL LGAGTLGCNV ARTLMGWGVR HITFVDNAKI SYSNPVRQPL YEFEDCLGGG KPKALAAADR LQKIFPGVNA RGFNMSIPMP GHPVNFSSVT LEQARRDVEQ LEQLIESHDV VFLLMDTRES RWLPAVIAAS KRKLVINAAL GFDTFVVMRH GLKKPKQQGA GDLCPNHPVA SADLLGSSLF ANIPGYKLGC YFCNDVVAPG DSTRDRTLDQ QCTVSRPGLA VIAGALAVEL MVSVLQHPEG GYAIASSSDD RMNEPPTSLG LVPHQIRGFL SRFDNVLPVS LAFDKCTACS SKVLDQYERE GFNFLAKVFN SSHSFLEDLT GLTLLHQETQ AAEIWDMSDD ETI
Genular Protein ID: 3610867477
Symbol: B3KQM6_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 16303743
Title: Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.
PubMed ID: 16303743
Sequence Information:
- Length: 703
- Mass: 77946
- Checksum: ABB08A36A6C58349
- Sequence:
MAAATGDPGL SKLQFAPFSS ALDVGFWHEL TQKKLNEYRL DEAPKDIKGY YYNGDSAGLP ARLTLEFSAF DMSAPTPARC CPAIGTLYNT NTLESFKTAD KKLLLEQAAN EIWESIKSGT ALENPVLLNK FLLLTFADLK KYHFYYWFCY PALCLPESLP LIQGPVGLDQ RFSLKQIEAL ECAYDNLCQT EGVTALPYFL IKYDENMVLV SLLKHYSDFF QGQRTKITIG VYDPCNLAQY PGWPLRNFLV LAAHRWSSSF QSVEVVCFRD RTMQGARDVA HSIIFEVKLP EMAFSPDCPK AVGWEKNQKG GMGPRMVNLS ECMDPKRLAE SSVDLNLKLM CWRLVPTLDL DKVVSVKCLL LGAGTLGCNV ARTLMGWGVR HITFVDNAKI SYSNPVRQPL YEFEDCLGGG KPKALAAADR LQKIFPGVNA RGFNMSIPMP GHPVNFSSVT LEQARRDVEQ LEQLIESHDV VFLLMDTRES RWLPAVIAAS KRKLVINAAL GFDTFVVMRH GLKKPKQQGA GDLCPNHPVA SADLLGSSLF ANIPGYKLGC YFCNDVVAPG DSTRDRTLDQ QCTVSRPGLA VVAGALAVEL MVSVLQHPEG GYAIASSSDD RMNEPPTSLG LVPHQIRGFL SRFDNVLPVS LAFDKCTACS SKVLDQYERE GFNFLAKVFN SSHSFLEDLT GLTLLHQETQ AAEIWDMSDD ETI
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.