Details for: ATG7

Gene ID: 10533

Symbol: ATG7

Ensembl ID: ENSG00000197548

Description: autophagy related 7

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 2.88
    Marker Score: 1,041
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.87
    Marker Score: 61,245
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 2.75
    Marker Score: 2,437
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.68
    Marker Score: 3,041
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 2.63
    Marker Score: 6,594
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 2.54
    Marker Score: 1,674
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.52
    Marker Score: 50,093
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.41
    Marker Score: 10,103
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.4
    Marker Score: 35,883
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.36
    Marker Score: 89,801
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.31
    Marker Score: 85,209
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 2.27
    Marker Score: 3,059
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 2.27
    Marker Score: 662
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.22
    Marker Score: 9,210
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 2.15
    Marker Score: 1,496
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 2.15
    Marker Score: 1,416
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.14
    Marker Score: 20,147
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 2.14
    Marker Score: 675
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 2.12
    Marker Score: 1,053
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.09
    Marker Score: 16,000
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 2.05
    Marker Score: 3,950
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 2.05
    Marker Score: 860
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 2.05
    Marker Score: 4,506
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 2.05
    Marker Score: 2,553
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.04
    Marker Score: 125,506
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 2.04
    Marker Score: 1,760
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 2.03
    Marker Score: 2,243
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.01
    Marker Score: 35,733
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 2
    Marker Score: 2,424
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.97
    Marker Score: 2,272
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.97
    Marker Score: 7,603
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.96
    Marker Score: 9,085
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.93
    Marker Score: 5,499
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.88
    Marker Score: 19,440
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.88
    Marker Score: 3,155
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.87
    Marker Score: 17,722
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.85
    Marker Score: 3,224
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.84
    Marker Score: 1,073
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.8
    Marker Score: 1,055
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.8
    Marker Score: 15,469
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.79
    Marker Score: 1,069
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.78
    Marker Score: 940
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 1.76
    Marker Score: 954
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 1.68
    Marker Score: 935
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.68
    Marker Score: 3,412
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 1.67
    Marker Score: 1,374
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.66
    Marker Score: 564
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.65
    Marker Score: 517
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1.64
    Marker Score: 1,265
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.61
    Marker Score: 2,479
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.6
    Marker Score: 2,322
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.59
    Marker Score: 25,558
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.59
    Marker Score: 434
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.59
    Marker Score: 6,464
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.58
    Marker Score: 884
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.56
    Marker Score: 3,733
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.56
    Marker Score: 34,837
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.51
    Marker Score: 435
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167,526
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 1.46
    Marker Score: 1,096
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.45
    Marker Score: 1,565
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 1.43
    Marker Score: 5,970
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.42
    Marker Score: 361
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.41
    Marker Score: 1,226
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 1.4
    Marker Score: 511
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 1.38
    Marker Score: 437
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.37
    Marker Score: 1,311
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 1.32
    Marker Score: 342
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.29
    Marker Score: 416
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.27
    Marker Score: 42,738
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.25
    Marker Score: 19,610
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.25
    Marker Score: 701
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.25
    Marker Score: 2,935
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.2
    Marker Score: 4,272
  • Cell Name: oocyte (CL0000023)
    Fold Change: 1.2
    Marker Score: 297
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.18
    Marker Score: 1,429
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.17
    Marker Score: 1,449
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.16
    Marker Score: 422
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 1.15
    Marker Score: 502
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.15
    Marker Score: 425
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.15
    Marker Score: 1,624
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.14
    Marker Score: 430
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 1.1
    Marker Score: 1,552
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.1
    Marker Score: 605
  • Cell Name: granule cell (CL0000120)
    Fold Change: 1.09
    Marker Score: 8,190
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 1.08
    Marker Score: 557
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 1.04
    Marker Score: 3,393
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.03
    Marker Score: 1,107
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 1.03
    Marker Score: 2,375
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 1.03
    Marker Score: 5,548
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.02
    Marker Score: 6,565
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.02
    Marker Score: 1,020
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.02
    Marker Score: 611
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.02
    Marker Score: 380
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 1.01
    Marker Score: 267
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 1.01
    Marker Score: 6,051
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 1.01
    Marker Score: 203
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1
    Marker Score: 1,052
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,709
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,935

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** ATG7 is a ubiquitin-like modifier-activating enzyme that catalyzes the activation of ubiquitin-like proteins, such as ATG12, which are essential for the formation of autophagosomes. The ATG7 gene is characterized by its ability to interact with various cellular components, including ATG12, LC3, and Beclin-1, which are key players in the autophagy pathway. ATG7 also exhibits homodimerization activity, suggesting its ability to form complexes with itself and other proteins. **Pathways and Functions** The ATG7 gene is involved in several key pathways, including: 1. **Autophagy**: ATG7 plays a central role in the regulation of autophagy, a process that involves the degradation and recycling of cellular components. 2. **Antigen processing: ubiquitination & proteasome degradation**: ATG7 is involved in the ubiquitination of proteins, which is essential for their degradation by the proteasome. 3. **Atg8 activating enzyme activity**: ATG7 activates ATG8, a ubiquitin-like protein that is involved in the formation of autophagosomes. 4. **Atg12 activating enzyme activity**: ATG7 activates ATG12, a ubiquitin-like protein that is involved in the formation of autophagosomes. 5. **Autophagosome assembly**: ATG7 is involved in the assembly of autophagosomes, which are structures that engulf and degrade cellular components. 6. **Mitophagy**: ATG7 is involved in the regulation of mitophagy, a process that involves the degradation of mitochondria. **Clinical Significance** Dysregulation of the ATG7 gene has been implicated in various diseases, including: 1. **Autophagy-related disorders**: Mutations in the ATG7 gene have been associated with autophagy-related disorders, such as type 2 diabetes and cancer. 2. **Neurodegenerative diseases**: ATG7 has been implicated in the regulation of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 3. **Cancer**: ATG7 has been shown to play a role in cancer development and progression, particularly in the regulation of autophagy and antigen processing. 4. **Infectious diseases**: ATG7 has been implicated in the regulation of the immune response to infections, particularly in the regulation of autophagy and antigen processing. In conclusion, the ATG7 gene plays a critical role in the regulation of autophagy and various cellular pathways. Its dysregulation has been implicated in various diseases, highlighting the importance of this gene in maintaining cellular homeostasis and regulating the immune response.

Genular Protein ID: 430809665

Symbol: ATG7_HUMAN

Name: Ubiquitin-like modifier-activating enzyme ATG7

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10233149

Title: Glucose-induced autophagy of peroxisomes in Pichia pastoris requires a unique E1-like protein.

PubMed ID: 10233149

DOI: 10.1091/mbc.10.5.1353

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 11096062

Title: The human homolog of Saccharomyces cerevisiae Apg7p is a Protein-activating enzyme for multiple substrates including human Apg12p, GATE-16, GABARAP, and MAP-LC3.

PubMed ID: 11096062

DOI: 10.1074/jbc.c000752200

PubMed ID: 11890701

Title: Murine Apg12p has a substrate preference for murine Apg7p over three Apg8p homologs.

PubMed ID: 11890701

DOI: 10.1006/bbrc.2002.6645

PubMed ID: 11825910

Title: Human Apg3p/Aut1p homologue is an authentic E2 enzyme for multiple substrates, GATE-16, GABARAP, and MAP-LC3, and facilitates the conjugation of hApg12p to hApg5p.

PubMed ID: 11825910

DOI: 10.1074/jbc.m200385200

PubMed ID: 16303767

Title: Phosphatidylserine in addition to phosphatidylethanolamine is an in vitro target of the mammalian Atg8 modifiers, LC3, GABARAP, and GATE-16.

PubMed ID: 16303767

DOI: 10.1074/jbc.m505888200

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19124466

Title: Regulation of autophagy by the p300 acetyltransferase.

PubMed ID: 19124466

DOI: 10.1074/jbc.m807135200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20543840

Title: Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity.

PubMed ID: 20543840

DOI: 10.1038/ncb2069

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22170151

Title: The FAP motif within human ATG7, an autophagy-related E1-like enzyme, is essential for the E2-substrate reaction of LC3 lipidation.

PubMed ID: 22170151

DOI: 10.4161/auto.8.1.18339

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 23386620

Title: Heat shock factor 1 (HSF1) controls chemoresistance and autophagy through transcriptional regulation of autophagy-related protein 7 (ATG7).

PubMed ID: 23386620

DOI: 10.1074/jbc.m112.422071

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 34161705

Title: Developmental Consequences of Defective ATG7-Mediated Autophagy in Humans.

PubMed ID: 34161705

DOI: 10.1056/nejmoa1915722

Sequence Information:

  • Length: 703
  • Mass: 77960
  • Checksum: ABBD1A29A6C58356
  • Sequence:
  • MAAATGDPGL SKLQFAPFSS ALDVGFWHEL TQKKLNEYRL DEAPKDIKGY YYNGDSAGLP 
    ARLTLEFSAF DMSAPTPARC CPAIGTLYNT NTLESFKTAD KKLLLEQAAN EIWESIKSGT 
    ALENPVLLNK FLLLTFADLK KYHFYYWFCY PALCLPESLP LIQGPVGLDQ RFSLKQIEAL 
    ECAYDNLCQT EGVTALPYFL IKYDENMVLV SLLKHYSDFF QGQRTKITIG VYDPCNLAQY 
    PGWPLRNFLV LAAHRWSSSF QSVEVVCFRD RTMQGARDVA HSIIFEVKLP EMAFSPDCPK 
    AVGWEKNQKG GMGPRMVNLS ECMDPKRLAE SSVDLNLKLM CWRLVPTLDL DKVVSVKCLL 
    LGAGTLGCNV ARTLMGWGVR HITFVDNAKI SYSNPVRQPL YEFEDCLGGG KPKALAAADR 
    LQKIFPGVNA RGFNMSIPMP GHPVNFSSVT LEQARRDVEQ LEQLIESHDV VFLLMDTRES 
    RWLPAVIAAS KRKLVINAAL GFDTFVVMRH GLKKPKQQGA GDLCPNHPVA SADLLGSSLF 
    ANIPGYKLGC YFCNDVVAPG DSTRDRTLDQ QCTVSRPGLA VIAGALAVEL MVSVLQHPEG 
    GYAIASSSDD RMNEPPTSLG LVPHQIRGFL SRFDNVLPVS LAFDKCTACS SKVLDQYERE 
    GFNFLAKVFN SSHSFLEDLT GLTLLHQETQ AAEIWDMSDD ETI

Genular Protein ID: 3610867477

Symbol: B3KQM6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 16303743

Title: Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.

PubMed ID: 16303743

DOI: 10.1093/dnares/12.2.117

Sequence Information:

  • Length: 703
  • Mass: 77946
  • Checksum: ABB08A36A6C58349
  • Sequence:
  • MAAATGDPGL SKLQFAPFSS ALDVGFWHEL TQKKLNEYRL DEAPKDIKGY YYNGDSAGLP 
    ARLTLEFSAF DMSAPTPARC CPAIGTLYNT NTLESFKTAD KKLLLEQAAN EIWESIKSGT 
    ALENPVLLNK FLLLTFADLK KYHFYYWFCY PALCLPESLP LIQGPVGLDQ RFSLKQIEAL 
    ECAYDNLCQT EGVTALPYFL IKYDENMVLV SLLKHYSDFF QGQRTKITIG VYDPCNLAQY 
    PGWPLRNFLV LAAHRWSSSF QSVEVVCFRD RTMQGARDVA HSIIFEVKLP EMAFSPDCPK 
    AVGWEKNQKG GMGPRMVNLS ECMDPKRLAE SSVDLNLKLM CWRLVPTLDL DKVVSVKCLL 
    LGAGTLGCNV ARTLMGWGVR HITFVDNAKI SYSNPVRQPL YEFEDCLGGG KPKALAAADR 
    LQKIFPGVNA RGFNMSIPMP GHPVNFSSVT LEQARRDVEQ LEQLIESHDV VFLLMDTRES 
    RWLPAVIAAS KRKLVINAAL GFDTFVVMRH GLKKPKQQGA GDLCPNHPVA SADLLGSSLF 
    ANIPGYKLGC YFCNDVVAPG DSTRDRTLDQ QCTVSRPGLA VVAGALAVEL MVSVLQHPEG 
    GYAIASSSDD RMNEPPTSLG LVPHQIRGFL SRFDNVLPVS LAFDKCTACS SKVLDQYERE 
    GFNFLAKVFN SSHSFLEDLT GLTLLHQETQ AAEIWDMSDD ETI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.