Details for: RNASEH2A

Gene ID: 10535

Symbol: RNASEH2A

Ensembl ID: ENSG00000104889

Description: ribonuclease H2 subunit A

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: germ cell (CL0000586)
    Fold Change: 2.89
    Marker Score: 5,041
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.44
    Marker Score: 1,534
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.37
    Marker Score: 2,322
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.33
    Marker Score: 1,768
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.31
    Marker Score: 5,374
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 1.3
    Marker Score: 972
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.26
    Marker Score: 1,809
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.23
    Marker Score: 1,548
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 1.19
    Marker Score: 949
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.15
    Marker Score: 4,505
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.02
    Marker Score: 3,018
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 1.01
    Marker Score: 537
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1
    Marker Score: 2,718
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,765
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,989
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,403
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.97
    Marker Score: 477
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.97
    Marker Score: 3,576
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,405
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 485
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 440
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5,193
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,720
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.89
    Marker Score: 356
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,261
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.87
    Marker Score: 586
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 310
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.85
    Marker Score: 2,327
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.8
    Marker Score: 198
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.79
    Marker Score: 437
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1,252
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.76
    Marker Score: 770
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.76
    Marker Score: 216
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.74
    Marker Score: 540
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.74
    Marker Score: 405
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.73
    Marker Score: 379
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.71
    Marker Score: 645
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.7
    Marker Score: 536
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.7
    Marker Score: 438
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.69
    Marker Score: 10,787
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2,858
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.68
    Marker Score: 356
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.67
    Marker Score: 633
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 171
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.66
    Marker Score: 443
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.65
    Marker Score: 413
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.64
    Marker Score: 22,274
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.64
    Marker Score: 314
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.61
    Marker Score: 3,977
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.59
    Marker Score: 970
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.59
    Marker Score: 627
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.58
    Marker Score: 655
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.58
    Marker Score: 754
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.58
    Marker Score: 332
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.58
    Marker Score: 166
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.56
    Marker Score: 181
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.56
    Marker Score: 197
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.55
    Marker Score: 1,046
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 439
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.54
    Marker Score: 271
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.54
    Marker Score: 144
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.54
    Marker Score: 385
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.53
    Marker Score: 1,117
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.53
    Marker Score: 7,045
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.53
    Marker Score: 340
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.52
    Marker Score: 122
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.51
    Marker Score: 262
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.51
    Marker Score: 212
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.5
    Marker Score: 544
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.5
    Marker Score: 485
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.5
    Marker Score: 5,838
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.49
    Marker Score: 700
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 0.49
    Marker Score: 244
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.48
    Marker Score: 340
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 0.48
    Marker Score: 154
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 0.47
    Marker Score: 1,304
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 0.47
    Marker Score: 353
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.47
    Marker Score: 505
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.46
    Marker Score: 213
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.46
    Marker Score: 932
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.46
    Marker Score: 408
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.45
    Marker Score: 401
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.45
    Marker Score: 887
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.45
    Marker Score: 1,064
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 0.45
    Marker Score: 302
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.45
    Marker Score: 2,674
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.45
    Marker Score: 324
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.45
    Marker Score: 466
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.44
    Marker Score: 1,093
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.44
    Marker Score: 214
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.44
    Marker Score: 3,835
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.44
    Marker Score: 530
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.44
    Marker Score: 4,382
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.43
    Marker Score: 410
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.43
    Marker Score: 470
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.43
    Marker Score: 2,750
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.43
    Marker Score: 404
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.43
    Marker Score: 84
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.42
    Marker Score: 3,115
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.42
    Marker Score: 303

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** RNASEH2A is a single-copy gene that codes for a 24-kDa protein. It is highly conserved across species, with a high degree of sequence similarity to its counterparts in other organisms. The RNASEH2A protein is a subunit of the RNase H2 complex, which is a heterodimeric enzyme composed of RNASEH1 and RNASEH2A subunits. This complex is responsible for the hydrolysis of RNA-DNA hybrids, which are essential for DNA replication, repair, and recombination. **Pathways and Functions** RNASEH2A is involved in several cellular pathways, including: 1. **DNA replication**: RNASEH2A plays a crucial role in the removal of RNA primers during DNA replication, ensuring the accurate and efficient progression of the replication process. 2. **Mismatch repair**: RNASEH2A is involved in the correction of DNA mismatch errors, which can arise during DNA replication and repair. 3. **Metal ion binding**: RNASEH2A has a metal ion-binding domain, which is essential for the catalytic activity of the RNase H2 complex. 4. **RNA catabolism**: RNASEH2A is involved in the degradation of RNA-DNA hybrids, which is essential for the removal of excess RNA molecules and the maintenance of genome stability. 5. **Immune responses**: RNASEH2A has been implicated in the regulation of immune responses, particularly in the context of immunodeficiency disorders. **Clinical Significance** Dysregulation of RNASEH2A has been implicated in several human diseases, including: 1. **Immunodeficiency disorders**: Mutations in the RNASEH2A gene have been associated with severe immunodeficiency disorders, such as severe combined immunodeficiency (SCID). 2. **Cancer**: RNASEH2A has been implicated in the development and progression of various cancers, including lymphoma and leukemia. 3. **Neurological conditions**: RNASEH2A has been implicated in the regulation of neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). 4. **Reproductive disorders**: RNASEH2A has been implicated in the regulation of reproductive processes, including meiosis and fertilization. In conclusion, RNASEH2A is a critical gene involved in the regulation of RNA and DNA interactions during various cellular processes. Its dysregulation has been implicated in several human diseases, highlighting the importance of this gene in maintaining genome stability and promoting proper cellular function.

Genular Protein ID: 534322942

Symbol: RNH2A_HUMAN

Name: Ribonuclease H2 subunit A

UniProtKB Accession Codes:

O75792 B2RCY1 Q96F11

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTC 1 CTD 1 ChEBI 5 ChiTaRS 1 ComplexPortal 1 DNASU 1 DisGeNET 1 EC 2 EMBL 4 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 11 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 2 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9789007

Title: Cloning of the cDNA encoding the large subunit of human RNase HI, a homologue of the prokaryotic RNase HII.

PubMed ID: 9789007

DOI: 10.1073/pnas.95.22.12872

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 21177858

Title: The structural and biochemical characterization of human RNase H2 complex reveals the molecular basis for substrate recognition and Aicardi-Goutieres syndrome defects.

PubMed ID: 21177858

DOI: 10.1074/jbc.m110.181974

PubMed ID: 16845400

Title: Mutations in genes encoding ribonuclease H2 subunits cause Aicardi-Goutieres syndrome and mimic congenital viral brain infection.

PubMed ID: 16845400

DOI: 10.1038/ng1842

PubMed ID: 17846997

Title: Clinical and molecular phenotype of Aicardi-Goutieres syndrome.

PubMed ID: 17846997

DOI: 10.1086/521373

PubMed ID: 20131292

Title: Expanding the phenotypic spectrum of lupus erythematosus in Aicardi-Goutieres syndrome.

PubMed ID: 20131292

DOI: 10.1002/art.27367

Sequence Information:

  • Length: 299
  • Mass: 33395
  • Checksum: 34992FE85130157B
  • Sequence:
    • MDLSELERDN TGRCRLSSPV PAVCRKEPCV LGVDEAGRGP VLGPMVYAIC YCPLPRLADL 
EALKVADSKT LLESERERLF AKMEDTDFVG WALDVLSPNL ISTSMLGRVK YNLNSLSHDT 
ATGLIQYALD QGVNVTQVFV DTVGMPETYQ ARLQQSFPGI EVTVKAKADA LYPVVSAASI 
CAKVARDQAV KKWQFVEKLQ DLDTDYGSGY PNDPKTKAWL KEHVEPVFGF PQFVRFSWRT 
AQTILEKEAE DVIWEDSASE NQEGLRKITS YFLNEGSQAR PRSSHRYFLE RGLESATSL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.