Details for: CEBPG

Gene ID: 1054

Symbol: CEBPG

Ensembl ID: ENSG00000153879

Description: CCAAT enhancer binding protein gamma

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 184.1908
    Cell Significance Index: -28.6500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 111.1403
    Cell Significance Index: -28.1900
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 80.5199
    Cell Significance Index: -33.1700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 68.7533
    Cell Significance Index: -32.4600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 62.4046
    Cell Significance Index: -32.1000
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 48.4783
    Cell Significance Index: -32.5300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 24.9644
    Cell Significance Index: -30.7800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 11.1167
    Cell Significance Index: -29.7800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.9307
    Cell Significance Index: -31.3000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.3134
    Cell Significance Index: -16.3200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.2173
    Cell Significance Index: -9.2300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.7546
    Cell Significance Index: 47.7600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.7164
    Cell Significance Index: 186.6900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.3562
    Cell Significance Index: 39.0800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.2595
    Cell Significance Index: 57.0900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.1712
    Cell Significance Index: 17.5500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.1429
    Cell Significance Index: 1031.9900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.1016
    Cell Significance Index: 15.0300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.0778
    Cell Significance Index: 55.9900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.7919
    Cell Significance Index: 56.0100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.7718
    Cell Significance Index: 341.2200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.6962
    Cell Significance Index: 85.6000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6399
    Cell Significance Index: 44.2600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.6340
    Cell Significance Index: 13.7400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.5232
    Cell Significance Index: 67.6000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5203
    Cell Significance Index: 93.7900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.4992
    Cell Significance Index: 23.4600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.4877
    Cell Significance Index: 13.9800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4662
    Cell Significance Index: 93.5100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.3921
    Cell Significance Index: 10.4700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.3900
    Cell Significance Index: 29.0700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3247
    Cell Significance Index: 64.4300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3229
    Cell Significance Index: 20.8400
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.2810
    Cell Significance Index: 4.9700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2572
    Cell Significance Index: 140.4400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2475
    Cell Significance Index: 47.1100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2035
    Cell Significance Index: 4.3400
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.1948
    Cell Significance Index: 3.1300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1873
    Cell Significance Index: 31.9800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1850
    Cell Significance Index: 21.8200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.1787
    Cell Significance Index: 2.0300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1690
    Cell Significance Index: 16.7200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1335
    Cell Significance Index: 18.3400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1023
    Cell Significance Index: 4.7700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0993
    Cell Significance Index: 16.1500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0986
    Cell Significance Index: 35.3700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0916
    Cell Significance Index: 2.5600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0893
    Cell Significance Index: 5.6300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0393
    Cell Significance Index: 27.1800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0206
    Cell Significance Index: 28.0600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.0095
    Cell Significance Index: 0.1800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0068
    Cell Significance Index: 5.1300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0041
    Cell Significance Index: 0.1300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0020
    Cell Significance Index: 0.2500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0029
    Cell Significance Index: -2.1300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0088
    Cell Significance Index: -16.5300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0094
    Cell Significance Index: -1.0800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0110
    Cell Significance Index: -6.8600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0167
    Cell Significance Index: -30.7500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0187
    Cell Significance Index: -1.9100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0190
    Cell Significance Index: -29.2400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0280
    Cell Significance Index: -20.5400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0310
    Cell Significance Index: -17.5000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0430
    Cell Significance Index: -27.3300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0616
    Cell Significance Index: -27.9700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0619
    Cell Significance Index: -17.8100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0692
    Cell Significance Index: -14.5700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0862
    Cell Significance Index: -9.8800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0927
    Cell Significance Index: -10.8000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1076
    Cell Significance Index: -0.6500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1307
    Cell Significance Index: -2.1900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1625
    Cell Significance Index: -8.5300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1855
    Cell Significance Index: -26.9700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1898
    Cell Significance Index: -10.6500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2547
    Cell Significance Index: -8.8500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2560
    Cell Significance Index: -6.4000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2783
    Cell Significance Index: -21.3600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2832
    Cell Significance Index: -19.0400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2991
    Cell Significance Index: -13.2300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3018
    Cell Significance Index: -31.4200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3263
    Cell Significance Index: -12.3600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.3290
    Cell Significance Index: -3.0300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3547
    Cell Significance Index: -28.0900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3634
    Cell Significance Index: -22.2800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3669
    Cell Significance Index: -7.6800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.3776
    Cell Significance Index: -11.0900
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.3838
    Cell Significance Index: -3.1300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4009
    Cell Significance Index: -24.6400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4244
    Cell Significance Index: -10.9100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4338
    Cell Significance Index: -11.6100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.4371
    Cell Significance Index: -4.5300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.4387
    Cell Significance Index: -22.1700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4851
    Cell Significance Index: -12.7600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.5176
    Cell Significance Index: -13.8700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.5640
    Cell Significance Index: -9.5000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.5679
    Cell Significance Index: -13.1200
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.5963
    Cell Significance Index: -3.7100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.6046
    Cell Significance Index: -24.7700
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.6130
    Cell Significance Index: -10.3100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.6846
    Cell Significance Index: -25.1300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CEBPG is a member of the CCAAT/enhancer-binding protein (C/EBP) family, which consists of three main subfamilies: C/EBPα, C/EBPβ, and C/EBPγ. CEBPG is characterized by its ability to bind to specific DNA sequences, known as C/EBP-binding elements, which are present in the promoter regions of target genes. This binding facilitates the recruitment of coactivators and the activation of transcription. CEBPG is also known for its ability to form homodimers and heterodimers with other C/EBP family members, which modulates its transcriptional activity. **Pathways and Functions:** CEBPG is involved in several key pathways, including: 1. **Integrated Stress Response (ISR):** CEBPG is activated in response to endoplasmic reticulum stress, leading to the expression of genes involved in protein folding and degradation. 2. **Cellular Response to Nutrient Deficiencies:** CEBPG is activated in response to amino acid and heme deficiencies, leading to the expression of genes involved in nutrient sensing and metabolism. 3. **Immune Regulation:** CEBPG is expressed in immune cells, including monocytes and natural killer cells, and regulates the expression of genes involved in immune response and cytokine production. 4. **Cell Differentiation:** CEBPG is involved in the regulation of cell differentiation, particularly in the development of epithelial cells and stem cells. **Clinical Significance:** Dysregulation of CEBPG has been implicated in several human diseases, including: 1. **Autoimmune Disorders:** CEBPG has been shown to play a role in the regulation of immune responses, and its dysregulation may contribute to autoimmune disorders, such as rheumatoid arthritis and lupus. 2. **Cancer:** CEBPG has been implicated in the regulation of cell growth and differentiation, and its dysregulation may contribute to the development of cancer. 3. **Neurological Disorders:** CEBPG has been shown to play a role in the regulation of neuronal development and function, and its dysregulation may contribute to neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, CEBPG is a critical transcription factor that plays a key role in regulating cellular stress response, immune regulation, and development. Its dysregulation has been implicated in several human diseases, highlighting the importance of further research into the mechanisms of CEBPG and its role in human health and disease.

Genular Protein ID: 2498218559

Symbol: CEBPG_HUMAN

Name: CCAAT/enhancer-binding protein gamma

UniProtKB Accession Codes:

P53567 B2R946 Q5U052

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 ComplexPortal 7 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 3 GO 27 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7665092

Title: Cloning of the cDNA encoding human C/EBP gamma, a protein binding to the PRE-I enhancer element of the human interleukin-4 promoter.

PubMed ID: 7665092

DOI: 10.1016/0378-1119(95)00271-7

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 150
  • Mass: 16408
  • Checksum: 630D1C1F92A00186
  • Sequence:
    • MSKISQQNST PGVNGISVIH TQAHASGLQQ VPQLVPAGPG GGGKAVAPSK QSKKSSPMDR 
NSDEYRQRRE RNNMAVKKSR LKSKQKAQDT LQRVNQLKEE NERLEAKIKL LTKELSVLKD 
LFLEHAHNLA DNVQSISTEN TTADGDNAGQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.