Details for: ANP32B

Gene ID: 10541

Symbol: ANP32B

Ensembl ID: ENSG00000136938

Description: acidic nuclear phosphoprotein 32 family member B

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 3.28
    Marker Score: 173,670
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 3.28
    Marker Score: 43,315
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 3.17
    Marker Score: 1,928
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 3.17
    Marker Score: 2,389
  • Cell Name: blood cell (CL0000081)
    Fold Change: 3.15
    Marker Score: 36,635
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 3.1
    Marker Score: 3,238
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 3.07
    Marker Score: 41,286
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 3.04
    Marker Score: 13,052
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 3
    Marker Score: 5,352
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.97
    Marker Score: 8,822
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 2.93
    Marker Score: 4,143
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 2.9
    Marker Score: 2,279
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 2.9
    Marker Score: 1,449
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.84
    Marker Score: 18,447
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 2.83
    Marker Score: 28,046
  • Cell Name: centroblast (CL0009112)
    Fold Change: 2.82
    Marker Score: 1,391
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 2.71
    Marker Score: 2,538
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.7
    Marker Score: 11,054
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 2.68
    Marker Score: 1,940
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 2.67
    Marker Score: 2,627
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 2.66
    Marker Score: 4,643
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 2.62
    Marker Score: 1,579
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 2.6
    Marker Score: 1,880
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.57
    Marker Score: 89,091
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 2.56
    Marker Score: 2,470
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 2.55
    Marker Score: 2,395
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 2.53
    Marker Score: 1,579
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.52
    Marker Score: 140,970
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 2.52
    Marker Score: 3,037
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 2.51
    Marker Score: 1,576
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 2.51
    Marker Score: 7,915
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.51
    Marker Score: 2,678
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 2.5
    Marker Score: 886
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 2.49
    Marker Score: 2,661
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.49
    Marker Score: 84,608
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 2.45
    Marker Score: 2,305
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 2.44
    Marker Score: 2,460
  • Cell Name: Unknown (CL0000548)
    Fold Change: 2.44
    Marker Score: 1,779
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.44
    Marker Score: 15,572
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.43
    Marker Score: 5,080
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.42
    Marker Score: 6,575
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.4
    Marker Score: 574
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 2.4
    Marker Score: 837
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 2.4
    Marker Score: 4,698
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 2.4
    Marker Score: 4,109
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 2.38
    Marker Score: 1,534
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 2.38
    Marker Score: 553
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 2.37
    Marker Score: 5,587
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 2.37
    Marker Score: 1,796
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 2.36
    Marker Score: 2,107
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 2.35
    Marker Score: 3,989
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 2.34
    Marker Score: 4,400
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 2.34
    Marker Score: 1,371
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.34
    Marker Score: 59,809
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.33
    Marker Score: 3,814
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 2.31
    Marker Score: 560
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 2.29
    Marker Score: 4,065
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 2.29
    Marker Score: 1,133
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 2.28
    Marker Score: 1,892
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.27
    Marker Score: 25,525
  • Cell Name: Unknown (CL0002371)
    Fold Change: 2.26
    Marker Score: 2,404
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 2.25
    Marker Score: 4,389
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 2.23
    Marker Score: 3,434
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 2.22
    Marker Score: 2,397
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 2.22
    Marker Score: 5,415
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 2.22
    Marker Score: 688
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 2.22
    Marker Score: 839
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 2.21
    Marker Score: 2,440
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 2.2
    Marker Score: 1,292
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 2.2
    Marker Score: 14,338
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 2.2
    Marker Score: 769
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 2.19
    Marker Score: 5,969
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 2.19
    Marker Score: 1,847
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 2.19
    Marker Score: 1,604
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 2.19
    Marker Score: 6,132
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.16
    Marker Score: 5,275
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 2.15
    Marker Score: 691
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.15
    Marker Score: 16,035
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 2.15
    Marker Score: 7,960
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 2.15
    Marker Score: 3,084
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 2.14
    Marker Score: 2,332
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 2.14
    Marker Score: 4,492
  • Cell Name: muscle precursor cell (CL0000680)
    Fold Change: 2.14
    Marker Score: 555
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 2.14
    Marker Score: 1,905
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.14
    Marker Score: 18,406
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 2.13
    Marker Score: 2,518
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 2.13
    Marker Score: 1,216
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.13
    Marker Score: 21,390
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.12
    Marker Score: 8,343
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.12
    Marker Score: 3,122
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 2.12
    Marker Score: 643
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.1
    Marker Score: 21,310
  • Cell Name: stem cell (CL0000034)
    Fold Change: 2.09
    Marker Score: 4,967
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 2.08
    Marker Score: 16,217
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.07
    Marker Score: 8,948
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 2.07
    Marker Score: 1,394
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.07
    Marker Score: 1,382
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 2.07
    Marker Score: 548
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 2.07
    Marker Score: 1,190
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 2.06
    Marker Score: 679

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ANP32B is a member of the acidic nuclear phosphoprotein 32 family, characterized by its acidic and leucine-rich amino acid sequence. It is a nuclear protein that has been shown to be dynamically regulated by post-translational modifications, such as phosphorylation. ANP32B is highly expressed in cells involved in immune responses, including T cells, B cells, and hematopoietic stem cells. Its expression is also elevated in malignant cells, suggesting a potential role in cancer progression. **Pathways and Functions:** ANP32B is involved in multiple cellular pathways, including: 1. **Apoptosis regulation**: ANP32B has been shown to modulate the apoptotic process by interacting with pro-apoptotic proteins and regulating the activity of caspases. 2. **Cell differentiation**: ANP32B plays a crucial role in regulating cell differentiation, particularly in the context of immune cell development. 3. **Protein export**: ANP32B has been implicated in the regulation of protein export from the nucleus, which is essential for cellular function and survival. 4. **Histone binding**: ANP32B interacts with histones, which is critical for chromatin remodeling and gene expression regulation. 5. **Nucleosome assembly**: ANP32B is involved in the assembly of nucleosomes, which is essential for maintaining chromatin structure and function. **Clinical Significance:** The clinical significance of ANP32B is multifaceted: 1. **Immune system disorders**: Alterations in ANP32B expression have been linked to various immune system disorders, including autoimmune diseases and cancer. 2. **Cancer progression**: ANP32B has been shown to promote cancer progression by regulating cell proliferation, apoptosis, and metastasis. 3. **Neurological disorders**: ANP32B has been implicated in neurological disorders, including Alzheimer's disease and Parkinson's disease, where it regulates protein aggregation and clearance. 4. **Regulatory T cells**: ANP32B has been shown to play a crucial role in the development and function of regulatory T cells, which are essential for maintaining immune homeostasis. In conclusion, ANP32B is a multifunctional gene that plays a critical role in various cellular processes, including apoptosis, cell differentiation, and protein export. Its clinical significance extends to immune system disorders, cancer progression, neurological disorders, and regulatory T cell function. Further research is needed to fully elucidate the mechanisms by which ANP32B regulates cellular processes and its potential therapeutic applications.

Genular Protein ID: 2340007723

Symbol: AN32B_HUMAN

Name: Acidic protein rich in leucines

UniProtKB Accession Codes:

Q92688 B2R9C7 O00655 P78458 P78459

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CPTAC 1 CTD 1 CarbonylDB 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 EPD 1 Ensembl 1 EvolutionaryTrace 1 GO 15 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 1 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 2 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9473664

Title: Expression analysis and chromosomal mapping of a novel human gene, APRIL, encoding an acidic protein rich in leucines.

PubMed ID: 9473664

DOI: 10.1016/s0167-4781(97)00165-6

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 15895553

Title: The Anp32 family of proteins containing leucine-rich repeats.

PubMed ID: 15895553

DOI: 10.1080/14734220410019020

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 17178712

Title: Analysis of nucleocytoplasmic trafficking of the HuR ligand APRIL and its influence on CD83 expression.

PubMed ID: 17178712

DOI: 10.1074/jbc.m608849200

PubMed ID: 18318008

Title: Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.

PubMed ID: 18318008

DOI: 10.1002/pmic.200700884

PubMed ID: 18039846

Title: Promoter region-specific histone incorporation by the novel histone chaperone ANP32B and DNA-binding factor KLF5.

PubMed ID: 18039846

DOI: 10.1128/mcb.01396-07

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 20015864

Title: Downregulation of ANP32B, a novel substrate of caspase-3, enhances caspase-3 activation and apoptosis induction in myeloid leukemic cells.

PubMed ID: 20015864

DOI: 10.1093/carcin/bgp320

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 21159877

Title: Foamy virus nuclear RNA export is distinct from that of other retroviruses.

PubMed ID: 21159877

DOI: 10.1128/jvi.01518-10

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24823948

Title: ANP32B is a nuclear target of henipavirus M proteins.

PubMed ID: 24823948

DOI: 10.1371/journal.pone.0097233

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 31217244

Title: ANP32 Proteins Are Essential for Influenza Virus Replication in Human Cells.

PubMed ID: 31217244

DOI: 10.1128/jvi.00217-19

PubMed ID: 31793855

Title: Interaction of host cellular factor ANP32B with matrix proteins of different paramyxoviruses.

PubMed ID: 31793855

DOI: 10.1099/jgv.0.001362

PubMed ID: 33045004

Title: Selective usage of ANP32 proteins by influenza B virus polymerase: Implications in determination of host range.

PubMed ID: 33045004

DOI: 10.1371/journal.ppat.1008989

PubMed ID: 20538007

Title: Solution structure of histone chaperone ANP32B: interaction with core histones H3-H4 through its acidic concave domain.

PubMed ID: 20538007

DOI: 10.1016/j.jmb.2010.06.005

Sequence Information:

  • Length: 251
  • Mass: 28788
  • Checksum: 93A1AADF8EDE7D53
  • Sequence:
    • MDMKRRIHLE LRNRTPAAVR ELVLDNCKSN DGKIEGLTAE FVNLEFLSLI NVGLISVSNL 
PKLPKLKKLE LSENRIFGGL DMLAEKLPNL THLNLSGNKL KDISTLEPLK KLECLKSLDL 
FNCEVTNLND YRESVFKLLP QLTYLDGYDR EDQEAPDSDA EVDGVDEEEE DEEGEDEEDE 
DDEDGEEEEF DEEDDEDEDV EGDEDDDEVS EEEEEFGLDE EDEDEDEDEE EEEGGKGEKR 
KRETDDEGED D

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.