Details for: LAMTOR5
Associated with
Cells (max top 100)
(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 3.39
Marker Score: 12,048 - Cell Name: secretory cell (CL0000151)
Fold Change: 3.04
Marker Score: 5,553 - Cell Name: renal intercalated cell (CL0005010)
Fold Change: 2.84
Marker Score: 1,512 - Cell Name: radial glial cell (CL0000681)
Fold Change: 2.79
Marker Score: 1,030 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 2.79
Marker Score: 6,809 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 2.78
Marker Score: 10,736 - Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 2.76
Marker Score: 6,962 - Cell Name: type II pneumocyte (CL0002063)
Fold Change: 2.76
Marker Score: 17,980 - Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 2.75
Marker Score: 2,165 - Cell Name: cell in vitro (CL0001034)
Fold Change: 2.74
Marker Score: 95,049 - Cell Name: malignant cell (CL0001064)
Fold Change: 2.72
Marker Score: 36,570 - Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: 2.71
Marker Score: 2,825 - Cell Name: pneumocyte (CL0000322)
Fold Change: 2.68
Marker Score: 4,302 - Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 2.67
Marker Score: 4,117 - Cell Name: epithelial cell (CL0000066)
Fold Change: 2.65
Marker Score: 4,223 - Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 2.65
Marker Score: 7,091 - Cell Name: centroblast (CL0009112)
Fold Change: 2.61
Marker Score: 1,286 - Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 2.58
Marker Score: 13,565 - Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 2.56
Marker Score: 2,736 - Cell Name: thyroid follicular cell (CL0002258)
Fold Change: 2.56
Marker Score: 2,005 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: 2.52
Marker Score: 19,708 - Cell Name: kidney collecting duct intercalated cell (CL1001432)
Fold Change: 2.5
Marker Score: 4,152 - Cell Name: decidual cell (CL2000002)
Fold Change: 2.48
Marker Score: 10,709 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 2.45
Marker Score: 2,957 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 2.43
Marker Score: 4,935 - Cell Name: pro-T cell (CL0000827)
Fold Change: 2.41
Marker Score: 9,870 - Cell Name: mesodermal cell (CL0000222)
Fold Change: 2.41
Marker Score: 31,739 - Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 2.4
Marker Score: 20,693 - Cell Name: lung secretory cell (CL1000272)
Fold Change: 2.39
Marker Score: 2,133 - Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 2.38
Marker Score: 2,413 - Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
Fold Change: 2.37
Marker Score: 20,594 - Cell Name: IgG-negative class switched memory B cell (CL0002117)
Fold Change: 2.36
Marker Score: 2,326 - Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 2.36
Marker Score: 4,921 - Cell Name: alveolar macrophage (CL0000583)
Fold Change: 2.35
Marker Score: 60,155 - Cell Name: club cell (CL0000158)
Fold Change: 2.35
Marker Score: 2,741 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 2.35
Marker Score: 6,963 - Cell Name: retinal rod cell (CL0000604)
Fold Change: 2.34
Marker Score: 6,690 - Cell Name: glycinergic amacrine cell (CL4030028)
Fold Change: 2.34
Marker Score: 2,212 - Cell Name: transitional stage B cell (CL0000818)
Fold Change: 2.33
Marker Score: 823 - Cell Name: fibroblast of breast (CL4006000)
Fold Change: 2.32
Marker Score: 1,322 - Cell Name: IgG memory B cell (CL0000979)
Fold Change: 2.31
Marker Score: 1,391 - Cell Name: kidney cell (CL1000497)
Fold Change: 2.3
Marker Score: 1,534 - Cell Name: B-1 B cell (CL0000819)
Fold Change: 2.3
Marker Score: 4,002 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 2.28
Marker Score: 77,590 - Cell Name: lung ciliated cell (CL1000271)
Fold Change: 2.28
Marker Score: 1,082 - Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 2.27
Marker Score: 3,217 - Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 2.27
Marker Score: 4,532 - Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 2.26
Marker Score: 4,013 - Cell Name: fetal cardiomyocyte (CL0002495)
Fold Change: 2.26
Marker Score: 743 - Cell Name: supporting cell (CL0000630)
Fold Change: 2.26
Marker Score: 4,239 - Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: 2.25
Marker Score: 2,523 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 2.24
Marker Score: 8,819 - Cell Name: ventricular cardiac muscle cell (CL2000046)
Fold Change: 2.24
Marker Score: 930 - Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 2.24
Marker Score: 2,372 - Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 2.23
Marker Score: 6,171 - Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
Fold Change: 2.23
Marker Score: 3,162 - Cell Name: blood cell (CL0000081)
Fold Change: 2.23
Marker Score: 25,943 - Cell Name: enterocyte (CL0000584)
Fold Change: 2.23
Marker Score: 10,691 - Cell Name: type G enteroendocrine cell (CL0000508)
Fold Change: 2.23
Marker Score: 768 - Cell Name: neural crest cell (CL0011012)
Fold Change: 2.21
Marker Score: 2,357 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 2.19
Marker Score: 24,657 - Cell Name: germinal center B cell (CL0000844)
Fold Change: 2.18
Marker Score: 1,326 - Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 2.17
Marker Score: 13,860 - Cell Name: oogonial cell (CL0000024)
Fold Change: 2.16
Marker Score: 3,104 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: 2.16
Marker Score: 2,281 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 2.15
Marker Score: 21,823 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 2.14
Marker Score: 119,932 - Cell Name: chondrocyte (CL0000138)
Fold Change: 2.14
Marker Score: 963 - Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 2.13
Marker Score: 5,018 - Cell Name: Hofbauer cell (CL3000001)
Fold Change: 2.13
Marker Score: 1,172 - Cell Name: mucous neck cell (CL0000651)
Fold Change: 2.12
Marker Score: 4,820 - Cell Name: mature T cell (CL0002419)
Fold Change: 2.12
Marker Score: 21,023 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: 2.12
Marker Score: 1,093 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: 2.12
Marker Score: 3,607 - Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 2.12
Marker Score: 5,280 - Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 2.11
Marker Score: 15,703 - Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 2.11
Marker Score: 2,123 - Cell Name: stem cell of epidermis (CL1000428)
Fold Change: 2.11
Marker Score: 713 - Cell Name: oocyte (CL0000023)
Fold Change: 2.1
Marker Score: 520 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 2.09
Marker Score: 13,364 - Cell Name: enteroendocrine cell (CL0000164)
Fold Change: 2.08
Marker Score: 1,079 - Cell Name: colon epithelial cell (CL0011108)
Fold Change: 2.08
Marker Score: 6,527 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 2.07
Marker Score: 13,483 - Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 2.07
Marker Score: 7,666 - Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: 2.07
Marker Score: 1,300 - Cell Name: primordial germ cell (CL0000670)
Fold Change: 2.06
Marker Score: 2,589 - Cell Name: pancreatic stellate cell (CL0002410)
Fold Change: 2.06
Marker Score: 1,303 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 2.06
Marker Score: 493 - Cell Name: eurydendroid cell (CL0000253)
Fold Change: 2.06
Marker Score: 842 - Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: 2.06
Marker Score: 800 - Cell Name: stem cell (CL0000034)
Fold Change: 2.06
Marker Score: 4,890 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 2.06
Marker Score: 2,167 - Cell Name: naive B cell (CL0000788)
Fold Change: 2.06
Marker Score: 1,838 - Cell Name: late pro-B cell (CL0002048)
Fold Change: 2.05
Marker Score: 2,421 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 2.05
Marker Score: 3,021 - Cell Name: Kupffer cell (CL0000091)
Fold Change: 2.05
Marker Score: 2,051 - Cell Name: myelocyte (CL0002193)
Fold Change: 2.05
Marker Score: 884 - Cell Name: type I pneumocyte (CL0002062)
Fold Change: 2.05
Marker Score: 2,464 - Cell Name: multi-ciliated epithelial cell (CL0005012)
Fold Change: 2.04
Marker Score: 3,884 - Cell Name: type EC enteroendocrine cell (CL0000577)
Fold Change: 2.04
Marker Score: 1,923
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 1770993514
Symbol: LTOR5_HUMAN
Name: Ragulator complex protein LAMTOR5
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9499022
Title: Cloning and characterization of a novel hepatitis B virus x binding protein that inhibits viral replication.
PubMed ID: 9499022
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 12773388
Title: HBXIP functions as a cofactor of survivin in apoptosis suppression.
PubMed ID: 12773388
DOI: 10.1093/emboj/cdg263
PubMed ID: 16176273
Title: Human ATP-dependent RNA/DNA helicase hSuv3p interacts with the cofactor of survivin HBXIP.
PubMed ID: 16176273
PubMed ID: 17525332
Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.
PubMed ID: 17525332
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 22980980
Title: Ragulator is a GEF for the Rag GTPases that signal amino acid levels to mTORC1.
PubMed ID: 22980980
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25561175
Title: SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1.
PubMed ID: 25561175
DOI: 10.1038/nature14107
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 25567906
Title: Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1.
PubMed ID: 25567906
PubMed ID: 30181260
Title: Ragulator and SLC38A9 activate the Rag GTPases through noncanonical GEF mechanisms.
PubMed ID: 30181260
PubMed ID: 21059355
Title: Structural characterization of HBXIP: the protein that interacts with the anti-apoptotic protein survivin and the oncogenic viral protein HBx.
PubMed ID: 21059355
PubMed ID: 29285400
Title: Structural insight into the Ragulator complex which anchors mTORC1 to the lysosomal membrane.
PubMed ID: 29285400
PubMed ID: 29107538
Title: Hybrid Structure of the RagA/C-Ragulator mTORC1 Activation Complex.
PubMed ID: 29107538
PubMed ID: 29123114
Title: Structural basis for Ragulator functioning as a scaffold in membrane-anchoring of Rag GTPases and mTORC1.
PubMed ID: 29123114
PubMed ID: 29158492
Title: Structural basis for the assembly of the Ragulator-Rag GTPase complex.
PubMed ID: 29158492
PubMed ID: 28935770
Title: Crystal structure of the human lysosomal mTORC1 scaffold complex and its impact on signaling.
PubMed ID: 28935770
PubMed ID: 31704029
Title: Cryo-EM structure of the human FLCN-FNIP2-Rag-Ragulator complex.
PubMed ID: 31704029
PubMed ID: 31314152
Title: C7orf59/LAMTOR4 phosphorylation and structural flexibility modulate Ragulator assembly.
PubMed ID: 31314152
PubMed ID: 31601708
Title: Structural basis for the docking of mTORC1 on the lysosomal surface.
PubMed ID: 31601708
PubMed ID: 31672913
Title: Structural mechanism of a Rag GTPase activation checkpoint by the lysosomal folliculin complex.
PubMed ID: 31672913
PubMed ID: 32868926
Title: Structural mechanism for amino acid-dependent Rag GTPase nucleotide state switching by SLC38A9.
PubMed ID: 32868926
PubMed ID: 35338845
Title: Cryo-EM structures of the human GATOR1-Rag-Ragulator complex reveal a spatial-constraint regulated GAP mechanism.
PubMed ID: 35338845
PubMed ID: 36103527
Title: Structural basis for FLCN RagC GAP activation in MiT-TFE substrate-selective mTORC1 regulation.
PubMed ID: 36103527
PubMed ID: 36697823
Title: Structure of the lysosomal mTORC1-TFEB-Rag-Ragulator megacomplex.
PubMed ID: 36697823
Sequence Information:
- Length: 91
- Mass: 9614
- Checksum: 01D9E762ABC63980
- Sequence:
MEATLEQHLE DTMKNPSIVG VLCTDSQGLN LGCRGTLSDE HAGVISVLAQ QAAKLTSDPT DIPVVCLESD NGNIMIQKHD GITVAVHKMA S
Genular Protein ID: 3125767232
Symbol: A0A8Z5A536_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
Sequence Information:
- Length: 173
- Mass: 18159
- Checksum: 75B3AA133363A336
- Sequence:
MEPGAGHLDG HRAGSPSLRQ ALCDGSAVMF SSKERGRCTV INFVPLEAPL RSTPRSRQVT EACGGEGRAV PLGSEPEWSV GGMEATLEQH LEDTMKNPSI VGVLCTDSQG LNLGCRGTLS DEHAGVISVL AQQAAKLTSD PTDIPVVCLE SDNGNIMIQK HDGITVAVHK MAS
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.