Details for: LAMTOR5

Gene ID: 10542

Symbol: LAMTOR5

Ensembl ID: ENSG00000134248

Description: late endosomal/lysosomal adaptor, MAPK and MTOR activator 5

Associated with

Other Information

Genular Protein ID: 1770993514

Symbol: LTOR5_HUMAN

Name: Ragulator complex protein LAMTOR5

UniProtKB Accession Codes:

O43504 A0A0C4DGV4 Q6IBD8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DNASU 1 DisGeNET 1 EMBL 7 EMDB 12 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 22 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 53 PDBsum 25 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 7 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9499022

Title: Cloning and characterization of a novel hepatitis B virus x binding protein that inhibits viral replication.

PubMed ID: 9499022

DOI: 10.1128/jvi.72.3.1737-1743.1998

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12773388

Title: HBXIP functions as a cofactor of survivin in apoptosis suppression.

PubMed ID: 12773388

DOI: 10.1093/emboj/cdg263

PubMed ID: 16176273

Title: Human ATP-dependent RNA/DNA helicase hSuv3p interacts with the cofactor of survivin HBXIP.

PubMed ID: 16176273

DOI: 10.1111/j.1742-4658.2005.04910.x

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22980980

Title: Ragulator is a GEF for the Rag GTPases that signal amino acid levels to mTORC1.

PubMed ID: 22980980

DOI: 10.1016/j.cell.2012.07.032

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25561175

Title: SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1.

PubMed ID: 25561175

DOI: 10.1038/nature14107

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 25567906

Title: Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1.

PubMed ID: 25567906

DOI: 10.1126/science.1257132

PubMed ID: 30181260

Title: Ragulator and SLC38A9 activate the Rag GTPases through noncanonical GEF mechanisms.

PubMed ID: 30181260

DOI: 10.1073/pnas.1811727115

PubMed ID: 21059355

Title: Structural characterization of HBXIP: the protein that interacts with the anti-apoptotic protein survivin and the oncogenic viral protein HBx.

PubMed ID: 21059355

DOI: 10.1016/j.jmb.2010.10.046

PubMed ID: 29285400

Title: Structural insight into the Ragulator complex which anchors mTORC1 to the lysosomal membrane.

PubMed ID: 29285400

DOI: 10.1038/celldisc.2017.49

PubMed ID: 29107538

Title: Hybrid Structure of the RagA/C-Ragulator mTORC1 Activation Complex.

PubMed ID: 29107538

DOI: 10.1016/j.molcel.2017.10.016

PubMed ID: 29123114

Title: Structural basis for Ragulator functioning as a scaffold in membrane-anchoring of Rag GTPases and mTORC1.

PubMed ID: 29123114

DOI: 10.1038/s41467-017-01567-4

PubMed ID: 29158492

Title: Structural basis for the assembly of the Ragulator-Rag GTPase complex.

PubMed ID: 29158492

DOI: 10.1038/s41467-017-01762-3

PubMed ID: 28935770

Title: Crystal structure of the human lysosomal mTORC1 scaffold complex and its impact on signaling.

PubMed ID: 28935770

DOI: 10.1126/science.aao1583

PubMed ID: 31704029

Title: Cryo-EM structure of the human FLCN-FNIP2-Rag-Ragulator complex.

PubMed ID: 31704029

DOI: 10.1016/j.cell.2019.10.036

PubMed ID: 31314152

Title: C7orf59/LAMTOR4 phosphorylation and structural flexibility modulate Ragulator assembly.

PubMed ID: 31314152

DOI: 10.1002/2211-5463.12700

PubMed ID: 31601708

Title: Structural basis for the docking of mTORC1 on the lysosomal surface.

PubMed ID: 31601708

DOI: 10.1126/science.aay0166

PubMed ID: 31672913

Title: Structural mechanism of a Rag GTPase activation checkpoint by the lysosomal folliculin complex.

PubMed ID: 31672913

DOI: 10.1126/science.aax0364

PubMed ID: 32868926

Title: Structural mechanism for amino acid-dependent Rag GTPase nucleotide state switching by SLC38A9.

PubMed ID: 32868926

DOI: 10.1038/s41594-020-0490-9

PubMed ID: 35338845

Title: Cryo-EM structures of the human GATOR1-Rag-Ragulator complex reveal a spatial-constraint regulated GAP mechanism.

PubMed ID: 35338845

DOI: 10.1016/j.molcel.2022.03.002

PubMed ID: 36103527

Title: Structural basis for FLCN RagC GAP activation in MiT-TFE substrate-selective mTORC1 regulation.

PubMed ID: 36103527

DOI: 10.1126/sciadv.add2926

PubMed ID: 36697823

Title: Structure of the lysosomal mTORC1-TFEB-Rag-Ragulator megacomplex.

PubMed ID: 36697823

DOI: 10.1038/s41586-022-05652-7

Sequence Information:

  • Length: 91
  • Mass: 9614
  • Checksum: 01D9E762ABC63980
  • Sequence:
    • MEATLEQHLE DTMKNPSIVG VLCTDSQGLN LGCRGTLSDE HAGVISVLAQ QAAKLTSDPT 
DIPVVCLESD NGNIMIQKHD GITVAVHKMA S

Genular Protein ID: 3125767232

Symbol: A0A8Z5A536_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A8Z5A536

Database IDs:

ARBA 5 CTD 1 EMBL 1 EPD 1 Ensembl 2 GO 3 Gene3D 1 GeneTree 1 HGNC 1 InterPro 1 KEGG 1 MaxQB 1 NCBI Taxonomy 1 PANTHER 2 PRINTS 1 Pfam 1 Proteomes 2 RefSeq 1 SMR 1

Citations:

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

Sequence Information:

  • Length: 173
  • Mass: 18159
  • Checksum: 75B3AA133363A336
  • Sequence:
    • MEPGAGHLDG HRAGSPSLRQ ALCDGSAVMF SSKERGRCTV INFVPLEAPL RSTPRSRQVT 
EACGGEGRAV PLGSEPEWSV GGMEATLEQH LEDTMKNPSI VGVLCTDSQG LNLGCRGTLS 
DEHAGVISVL AQQAAKLTSD PTDIPVVCLE SDNGNIMIQK HDGITVAVHK MAS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.