Details for: LAMTOR5

Gene ID: 10542

Symbol: LAMTOR5

Ensembl ID: ENSG00000134248

Description: late endosomal/lysosomal adaptor, MAPK and MTOR activator 5

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 3.39
    Marker Score: 12,048
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 3.04
    Marker Score: 5,553
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 2.84
    Marker Score: 1,512
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 2.79
    Marker Score: 1,030
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.79
    Marker Score: 6,809
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.78
    Marker Score: 10,736
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 2.76
    Marker Score: 6,962
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 2.76
    Marker Score: 17,980
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.75
    Marker Score: 2,165
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.74
    Marker Score: 95,049
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 2.72
    Marker Score: 36,570
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 2.71
    Marker Score: 2,825
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.68
    Marker Score: 4,302
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 2.67
    Marker Score: 4,117
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 2.65
    Marker Score: 4,223
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 2.65
    Marker Score: 7,091
  • Cell Name: centroblast (CL0009112)
    Fold Change: 2.61
    Marker Score: 1,286
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 2.58
    Marker Score: 13,565
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.56
    Marker Score: 2,736
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 2.56
    Marker Score: 2,005
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 2.52
    Marker Score: 19,708
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 2.5
    Marker Score: 4,152
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.48
    Marker Score: 10,709
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.45
    Marker Score: 2,957
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.43
    Marker Score: 4,935
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.41
    Marker Score: 9,870
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 2.41
    Marker Score: 31,739
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.4
    Marker Score: 20,693
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 2.39
    Marker Score: 2,133
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 2.38
    Marker Score: 2,413
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 2.37
    Marker Score: 20,594
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 2.36
    Marker Score: 2,326
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.36
    Marker Score: 4,921
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.35
    Marker Score: 60,155
  • Cell Name: club cell (CL0000158)
    Fold Change: 2.35
    Marker Score: 2,741
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.35
    Marker Score: 6,963
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 2.34
    Marker Score: 6,690
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 2.34
    Marker Score: 2,212
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 2.33
    Marker Score: 823
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 2.32
    Marker Score: 1,322
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 2.31
    Marker Score: 1,391
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.3
    Marker Score: 1,534
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 2.3
    Marker Score: 4,002
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.28
    Marker Score: 77,590
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 2.28
    Marker Score: 1,082
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 2.27
    Marker Score: 3,217
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2.27
    Marker Score: 4,532
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 2.26
    Marker Score: 4,013
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 2.26
    Marker Score: 743
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 2.26
    Marker Score: 4,239
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.25
    Marker Score: 2,523
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.24
    Marker Score: 8,819
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 2.24
    Marker Score: 930
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 2.24
    Marker Score: 2,372
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 2.23
    Marker Score: 6,171
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 2.23
    Marker Score: 3,162
  • Cell Name: blood cell (CL0000081)
    Fold Change: 2.23
    Marker Score: 25,943
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 2.23
    Marker Score: 10,691
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 2.23
    Marker Score: 768
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 2.21
    Marker Score: 2,357
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.19
    Marker Score: 24,657
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 2.18
    Marker Score: 1,326
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 2.17
    Marker Score: 13,860
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 2.16
    Marker Score: 3,104
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 2.16
    Marker Score: 2,281
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.15
    Marker Score: 21,823
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.14
    Marker Score: 119,932
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 2.14
    Marker Score: 963
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 2.13
    Marker Score: 5,018
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 2.13
    Marker Score: 1,172
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 2.12
    Marker Score: 4,820
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 2.12
    Marker Score: 21,023
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 2.12
    Marker Score: 1,093
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 2.12
    Marker Score: 3,607
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 2.12
    Marker Score: 5,280
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.11
    Marker Score: 15,703
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 2.11
    Marker Score: 2,123
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 2.11
    Marker Score: 713
  • Cell Name: oocyte (CL0000023)
    Fold Change: 2.1
    Marker Score: 520
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.09
    Marker Score: 13,364
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 2.08
    Marker Score: 1,079
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 2.08
    Marker Score: 6,527
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.07
    Marker Score: 13,483
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 2.07
    Marker Score: 7,666
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 2.07
    Marker Score: 1,300
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 2.06
    Marker Score: 2,589
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 2.06
    Marker Score: 1,303
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.06
    Marker Score: 493
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 2.06
    Marker Score: 842
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 2.06
    Marker Score: 800
  • Cell Name: stem cell (CL0000034)
    Fold Change: 2.06
    Marker Score: 4,890
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.06
    Marker Score: 2,167
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 2.06
    Marker Score: 1,838
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 2.05
    Marker Score: 2,421
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.05
    Marker Score: 3,021
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 2.05
    Marker Score: 2,051
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 2.05
    Marker Score: 884
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 2.05
    Marker Score: 2,464
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 2.04
    Marker Score: 3,884
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 2.04
    Marker Score: 1,923

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** LAMTOR5 is a 94-kDa protein that belongs to the LAMTOR family of proteins. It is characterized by its ability to interact with various proteins, including the Ragulator complex, mTORC1, and AMPK. LAMTOR5 is predominantly expressed in epithelial cells, including those of the proximal tubule, secretory cells, and renal intercalated cells. Its expression is also observed in other cell types, such as radial glial cells, basal cells of prostate epithelium, and progenitor cells of mammary luminal epithelium. **Pathways and Functions:** LAMTOR5 is involved in several key cellular pathways, including: 1. **Autophagy:** LAMTOR5 interacts with ATG14L and ATG7 to regulate the activity of mTORC1, which in turn modulates autophagy. 2. **mTOR Signaling:** LAMTOR5 is a key component of the Ragulator complex, which activates mTORC1 in response to growth factors, nutrients, and energy levels. 3. **Stress Response:** LAMTOR5 is involved in the regulation of stress response pathways, including the unfolded protein response (UPR) and the heat shock response. 4. **Cytosol and Lysosome Regulation:** LAMTOR5 regulates the activity of cytosolic and lysosomal proteins, including the regulation of protein localization to the nucleus and the lysosome. 5. **Amino Acid Regulation:** LAMTOR5 is involved in the regulation of amino acid metabolism, including the regulation of protein synthesis and autophagy. **Clinical Significance:** Dysregulation of LAMTOR5 has been implicated in various diseases, including: 1. **Cancer:** Overexpression of LAMTOR5 has been observed in various types of cancer, including breast, lung, and prostate cancer. 2. **Neurodegenerative Diseases:** LAMTOR5 has been implicated in the regulation of autophagy in neurodegenerative diseases, such as Alzheimer's and Parkinson's disease. 3. **Metabolic Disorders:** LAMTOR5 is involved in the regulation of glucose and lipid metabolism, making it a potential target for the treatment of metabolic disorders, such as type 2 diabetes and obesity. 4. **Infectious Diseases:** LAMTOR5 has been implicated in the regulation of viral genome replication, making it a potential target for the treatment of viral infections. In conclusion, LAMTOR5 is a multifunctional protein that plays a critical role in various cellular processes, including autophagy, mTOR signaling, and stress response. Its dysregulation has been implicated in various diseases, making it a potential target for the development of novel therapeutic strategies.

Genular Protein ID: 1770993514

Symbol: LTOR5_HUMAN

Name: Ragulator complex protein LAMTOR5

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9499022

Title: Cloning and characterization of a novel hepatitis B virus x binding protein that inhibits viral replication.

PubMed ID: 9499022

DOI: 10.1128/jvi.72.3.1737-1743.1998

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12773388

Title: HBXIP functions as a cofactor of survivin in apoptosis suppression.

PubMed ID: 12773388

DOI: 10.1093/emboj/cdg263

PubMed ID: 16176273

Title: Human ATP-dependent RNA/DNA helicase hSuv3p interacts with the cofactor of survivin HBXIP.

PubMed ID: 16176273

DOI: 10.1111/j.1742-4658.2005.04910.x

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22980980

Title: Ragulator is a GEF for the Rag GTPases that signal amino acid levels to mTORC1.

PubMed ID: 22980980

DOI: 10.1016/j.cell.2012.07.032

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25561175

Title: SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1.

PubMed ID: 25561175

DOI: 10.1038/nature14107

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 25567906

Title: Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1.

PubMed ID: 25567906

DOI: 10.1126/science.1257132

PubMed ID: 30181260

Title: Ragulator and SLC38A9 activate the Rag GTPases through noncanonical GEF mechanisms.

PubMed ID: 30181260

DOI: 10.1073/pnas.1811727115

PubMed ID: 21059355

Title: Structural characterization of HBXIP: the protein that interacts with the anti-apoptotic protein survivin and the oncogenic viral protein HBx.

PubMed ID: 21059355

DOI: 10.1016/j.jmb.2010.10.046

PubMed ID: 29285400

Title: Structural insight into the Ragulator complex which anchors mTORC1 to the lysosomal membrane.

PubMed ID: 29285400

DOI: 10.1038/celldisc.2017.49

PubMed ID: 29107538

Title: Hybrid Structure of the RagA/C-Ragulator mTORC1 Activation Complex.

PubMed ID: 29107538

DOI: 10.1016/j.molcel.2017.10.016

PubMed ID: 29123114

Title: Structural basis for Ragulator functioning as a scaffold in membrane-anchoring of Rag GTPases and mTORC1.

PubMed ID: 29123114

DOI: 10.1038/s41467-017-01567-4

PubMed ID: 29158492

Title: Structural basis for the assembly of the Ragulator-Rag GTPase complex.

PubMed ID: 29158492

DOI: 10.1038/s41467-017-01762-3

PubMed ID: 28935770

Title: Crystal structure of the human lysosomal mTORC1 scaffold complex and its impact on signaling.

PubMed ID: 28935770

DOI: 10.1126/science.aao1583

PubMed ID: 31704029

Title: Cryo-EM structure of the human FLCN-FNIP2-Rag-Ragulator complex.

PubMed ID: 31704029

DOI: 10.1016/j.cell.2019.10.036

PubMed ID: 31314152

Title: C7orf59/LAMTOR4 phosphorylation and structural flexibility modulate Ragulator assembly.

PubMed ID: 31314152

DOI: 10.1002/2211-5463.12700

PubMed ID: 31601708

Title: Structural basis for the docking of mTORC1 on the lysosomal surface.

PubMed ID: 31601708

DOI: 10.1126/science.aay0166

PubMed ID: 31672913

Title: Structural mechanism of a Rag GTPase activation checkpoint by the lysosomal folliculin complex.

PubMed ID: 31672913

DOI: 10.1126/science.aax0364

PubMed ID: 32868926

Title: Structural mechanism for amino acid-dependent Rag GTPase nucleotide state switching by SLC38A9.

PubMed ID: 32868926

DOI: 10.1038/s41594-020-0490-9

PubMed ID: 35338845

Title: Cryo-EM structures of the human GATOR1-Rag-Ragulator complex reveal a spatial-constraint regulated GAP mechanism.

PubMed ID: 35338845

DOI: 10.1016/j.molcel.2022.03.002

PubMed ID: 36103527

Title: Structural basis for FLCN RagC GAP activation in MiT-TFE substrate-selective mTORC1 regulation.

PubMed ID: 36103527

DOI: 10.1126/sciadv.add2926

PubMed ID: 36697823

Title: Structure of the lysosomal mTORC1-TFEB-Rag-Ragulator megacomplex.

PubMed ID: 36697823

DOI: 10.1038/s41586-022-05652-7

Sequence Information:

  • Length: 91
  • Mass: 9614
  • Checksum: 01D9E762ABC63980
  • Sequence:
  • MEATLEQHLE DTMKNPSIVG VLCTDSQGLN LGCRGTLSDE HAGVISVLAQ QAAKLTSDPT 
    DIPVVCLESD NGNIMIQKHD GITVAVHKMA S

Genular Protein ID: 3125767232

Symbol: A0A8Z5A536_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

Sequence Information:

  • Length: 173
  • Mass: 18159
  • Checksum: 75B3AA133363A336
  • Sequence:
  • MEPGAGHLDG HRAGSPSLRQ ALCDGSAVMF SSKERGRCTV INFVPLEAPL RSTPRSRQVT 
    EACGGEGRAV PLGSEPEWSV GGMEATLEQH LEDTMKNPSI VGVLCTDSQG LNLGCRGTLS 
    DEHAGVISVL AQQAAKLTSD PTDIPVVCLE SDNGNIMIQK HDGITVAVHK MAS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.