Details for: PROCR

Gene ID: 10544

Symbol: PROCR

Ensembl ID: ENSG00000101000

Description: protein C receptor

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 2.4
    Marker Score: 769
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 2.39
    Marker Score: 1,350
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 2.36
    Marker Score: 1,551
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.58
    Marker Score: 1,149
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.54
    Marker Score: 15,518
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.54
    Marker Score: 6,638
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168,874
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.44
    Marker Score: 2,875
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 1.42
    Marker Score: 344
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.41
    Marker Score: 1,702
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 1.38
    Marker Score: 1,187
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.36
    Marker Score: 1,828
  • Cell Name: basophil (CL0000767)
    Fold Change: 1.33
    Marker Score: 632
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.31
    Marker Score: 7,767
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 1.3
    Marker Score: 3,379
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.29
    Marker Score: 1,213
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 1.14
    Marker Score: 459
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.09
    Marker Score: 270
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.09
    Marker Score: 251
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251,769
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,790
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,013
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,406
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 499
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 454
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,409
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.94
    Marker Score: 212
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.92
    Marker Score: 537
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.91
    Marker Score: 1,325
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 0.91
    Marker Score: 212
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,728
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.9
    Marker Score: 909
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.89
    Marker Score: 863
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 319
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.88
    Marker Score: 5,011
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 0.87
    Marker Score: 474
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,275
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.82
    Marker Score: 516
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.81
    Marker Score: 2,212
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.81
    Marker Score: 461
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.79
    Marker Score: 774
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.79
    Marker Score: 3,296
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.78
    Marker Score: 594
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,259
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.77
    Marker Score: 310
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 390
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.75
    Marker Score: 686
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.75
    Marker Score: 1,954
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.71
    Marker Score: 7,993
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.7
    Marker Score: 438
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.7
    Marker Score: 408
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.7
    Marker Score: 629
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.69
    Marker Score: 1,636
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.69
    Marker Score: 250
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2,859
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.66
    Marker Score: 823
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.65
    Marker Score: 1,098
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 0.64
    Marker Score: 232
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.63
    Marker Score: 569
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.63
    Marker Score: 16,231
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.63
    Marker Score: 141
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.62
    Marker Score: 349
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.62
    Marker Score: 150
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.62
    Marker Score: 987
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.61
    Marker Score: 720
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 0.61
    Marker Score: 223
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.6
    Marker Score: 189
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.59
    Marker Score: 168
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.58
    Marker Score: 9,092
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.57
    Marker Score: 507
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.57
    Marker Score: 221
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.57
    Marker Score: 992
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.56
    Marker Score: 252
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 440
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.55
    Marker Score: 174
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.55
    Marker Score: 266
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.54
    Marker Score: 1,184
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.54
    Marker Score: 224
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.53
    Marker Score: 1,011
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.51
    Marker Score: 3,047
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.51
    Marker Score: 160
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 0.5
    Marker Score: 124
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.5
    Marker Score: 1,021
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.49
    Marker Score: 245
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 0.48
    Marker Score: 196
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.48
    Marker Score: 278
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.48
    Marker Score: 198
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.48
    Marker Score: 588
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.48
    Marker Score: 104
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.47
    Marker Score: 1,115
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.46
    Marker Score: 159
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 0.46
    Marker Score: 236
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 0.44
    Marker Score: 245
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.44
    Marker Score: 139
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.43
    Marker Score: 302
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 0.43
    Marker Score: 185
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.43
    Marker Score: 2,590
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.43
    Marker Score: 280

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PROCR is a transmembrane receptor that belongs to the immunoglobulin superfamily. It is primarily expressed on the surface of endothelial cells, which are responsible for maintaining the integrity of the vascular wall. PROCR is characterized by its ability to bind protein C, a zymogen that is activated to its active form, activated protein C (APC). This binding event triggers a cascade of signaling events that ultimately lead to the inhibition of coagulation and inflammation. PROCR is also involved in regulating the expression of other genes involved in coagulation and inflammation. **Pathways and Functions:** The protein C pathway, in which PROCR plays a central role, is a complex network of signaling events that regulate coagulation and inflammation. The pathway involves the binding of protein C to PROCR, which triggers the activation of protein C to APC. APC then activates various target proteins, including factor X, factor Va, and factor VIII, leading to the inhibition of coagulation. Beyond its role in coagulation, PROCR is also involved in regulating inflammation by modulating the expression of genes involved in the inflammatory response. Additionally, PROCR has been implicated in the regulation of angiogenesis, a process by which new blood vessels form from pre-existing vessels. **Clinical Significance:** Dysregulation of the protein C pathway, including mutations in the PROCR gene, has been implicated in various clinical conditions, including: 1. **Thrombophilia**: A condition characterized by an increased risk of blood clots due to genetic mutations that disrupt the protein C pathway. 2. **Antiphospholipid syndrome**: A condition characterized by the presence of antiphospholipid antibodies, which can lead to blood clots and other cardiovascular complications. 3. **Cardiovascular disease**: PROCR has been implicated in the regulation of cardiovascular disease, including atherosclerosis and myocardial infarction. 4. **Pregnancy complications**: PROCR has been implicated in the regulation of pregnancy complications, including preeclampsia and placental abruption. In conclusion, the protein C receptor (PROCR) is a critical component in the regulation of coagulation and inflammation. Its dysregulation has been implicated in various clinical conditions, highlighting the importance of PROCR in maintaining vascular homeostasis. Further research is needed to elucidate the mechanisms by which PROCR regulates coagulation and inflammation, and to explore its potential as a therapeutic target for the treatment of cardiovascular and other diseases.

Genular Protein ID: 3849184369

Symbol: EPCR_HUMAN

Name: Endothelial protein C receptor

UniProtKB Accession Codes:

Q9UNN8 B2RC04 Q14218 Q6IB56 Q96CB3 Q9ULX1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CPTAC 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 EMBL 10 EMDB 1 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 16 PDBsum 12 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7929370

Title: Identification, cloning, and regulation of a novel endothelial cell protein C/activated protein C receptor.

PubMed ID: 7929370

DOI: 10.1016/s0021-9258(18)47220-1

PubMed ID: 10397730

Title: Structural and functional implications of the intron/exon organization of the human endothelial cell protein C/activated protein C receptor (EPCR) gene: comparison with the structure of CD1/major histocompatibility complex alpha1 and alpha2 domains.

PubMed ID: 10397730

PubMed ID: 10570964

Title: Organization and chromosomal localization of the human endothelial protein C receptor gene.

PubMed ID: 10570964

DOI: 10.1016/s0378-1119(99)00360-1

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10681599

Title: Metalloproteolytic release of endothelial cell protein C receptor.

PubMed ID: 10681599

DOI: 10.1074/jbc.275.8.6038

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 12034704

Title: The crystal structure of the endothelial protein C receptor and a bound phospholipid.

PubMed ID: 12034704

DOI: 10.1074/jbc.c200163200

Sequence Information:

  • Length: 238
  • Mass: 26671
  • Checksum: EA7F0658CD19695C
  • Sequence:
    • MLTTLLPILL LSGWAFCSQD ASDGLQRLHM LQISYFRDPY HVWYQGNASL GGHLTHVLEG 
PDTNTTIIQL QPLQEPESWA RTQSGLQSYL LQFHGLVRLV HQERTLAFPL TIRCFLGCEL 
PPEGSRAHVF FEVAVNGSSF VSFRPERALW QADTQVTSGV VTFTLQQLNA YNRTRYELRE 
FLEDTCVQYV QKHISAENTK GSQTSRSYTS LVLGVLVGSF IIAGVAVGIF LCTGGRRC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.