Details for: TM9SF1

Gene ID: 10548

Symbol: TM9SF1

Ensembl ID: ENSG00000100926

Description: transmembrane 9 superfamily member 1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 1.89
    Marker Score: 5,345
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 1.72
    Marker Score: 505
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.31
    Marker Score: 1,741
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.3
    Marker Score: 6,402
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1.23
    Marker Score: 2,554
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.09
    Marker Score: 37,078
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.01
    Marker Score: 1,757
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,769
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,993
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,403
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 0.97
    Marker Score: 590
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,406
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 487
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 443
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.93
    Marker Score: 939
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.92
    Marker Score: 646
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5,198
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,723
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 0.9
    Marker Score: 603
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,285
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.87
    Marker Score: 589
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 311
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.86
    Marker Score: 476
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.83
    Marker Score: 334
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.8
    Marker Score: 285
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.79
    Marker Score: 772
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.78
    Marker Score: 700
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.78
    Marker Score: 221
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,259
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.74
    Marker Score: 310
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.73
    Marker Score: 379
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.72
    Marker Score: 553
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.72
    Marker Score: 287
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.71
    Marker Score: 254
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.7
    Marker Score: 640
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.7
    Marker Score: 395
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.69
    Marker Score: 864
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2,859
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 172
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.63
    Marker Score: 2,613
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.62
    Marker Score: 650
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.62
    Marker Score: 1,682
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 0.6
    Marker Score: 210
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.6
    Marker Score: 3,904
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.59
    Marker Score: 543
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.58
    Marker Score: 186
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.55
    Marker Score: 595
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.55
    Marker Score: 3,528
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.55
    Marker Score: 4,084
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.55
    Marker Score: 372
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 437
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.53
    Marker Score: 134
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.52
    Marker Score: 656
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.5
    Marker Score: 825
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5
    Marker Score: 321
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.5
    Marker Score: 159
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.49
    Marker Score: 226
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.49
    Marker Score: 4,295
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.49
    Marker Score: 358
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.49
    Marker Score: 238
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.48
    Marker Score: 225
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.48
    Marker Score: 408
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.47
    Marker Score: 313
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.46
    Marker Score: 4,677
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.46
    Marker Score: 663
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.46
    Marker Score: 459
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.46
    Marker Score: 280
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.46
    Marker Score: 159
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.45
    Marker Score: 332
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.45
    Marker Score: 455
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.44
    Marker Score: 109
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.43
    Marker Score: 286
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.43
    Marker Score: 368
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.43
    Marker Score: 459
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.43
    Marker Score: 186
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.42
    Marker Score: 165
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.42
    Marker Score: 223
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.41
    Marker Score: 4,807
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.41
    Marker Score: 221
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.41
    Marker Score: 633
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.41
    Marker Score: 108
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.41
    Marker Score: 142
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.4
    Marker Score: 406
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.4
    Marker Score: 129
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.4
    Marker Score: 3,436
  • Cell Name: bronchial smooth muscle cell (CL0002598)
    Fold Change: 0.4
    Marker Score: 112
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.4
    Marker Score: 80
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.39
    Marker Score: 246
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.39
    Marker Score: 221
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.39
    Marker Score: 912
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.39
    Marker Score: 444
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.38
    Marker Score: 380
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.38
    Marker Score: 121
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.38
    Marker Score: 424
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.38
    Marker Score: 925
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.37
    Marker Score: 514
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.37
    Marker Score: 280
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.37
    Marker Score: 185
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.37
    Marker Score: 106
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.36
    Marker Score: 152

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TM9SF1 is a transmembrane protein, consisting of a single transmembrane domain, with an intracellular cytoplasmic tail. Its expression is predominantly found in cells of the immune system, such as plasmablasts, tracheal goblet cells, and myoepithelial cells of the mammary gland. Additionally, TM9SF1 is also expressed in various non-immune cells, including kidney proximal convoluted tubule epithelial cells, fibroblasts of the mammary gland, and germ cells. **Pathways and Functions:** TM9SF1 is involved in multiple cellular processes, including: 1. **Autophagy**: TM9SF1 has been implicated in the regulation of autophagy, a process critical for maintaining cellular homeostasis. Autophagy involves the degradation of damaged or dysfunctional cellular components, and TM9SF1 may play a role in modulating this process. 2. **Cell Signaling**: TM9SF1 has been shown to interact with other proteins, influencing cell signaling pathways, including those involved in immune responses and cell growth. 3. **Membrane Trafficking**: TM9SF1 is involved in the regulation of membrane trafficking, including endocytosis and exocytosis, which are essential for cellular communication and function. **Clinical Significance:** TM9SF1 has been implicated in various human diseases, including: 1. **Autoimmune Disorders**: TM9SF1 has been linked to autoimmune diseases, such as lupus and rheumatoid arthritis, where it may contribute to the regulation of immune responses. 2. **Cancer**: TM9SF1 has been found to be overexpressed in certain types of cancer, including breast and lung cancer, where it may play a role in tumor progression and metastasis. 3. **Neurological Disorders**: TM9SF1 has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease, where it may contribute to the regulation of neuronal function and survival. In conclusion, TM9SF1 is a multifunctional transmembrane protein with a wide range of tissue-specific expression. Its involvement in autophagy, cell signaling, and membrane trafficking has significant implications for our understanding of human disease. Further research is needed to fully elucidate the function and clinical significance of TM9SF1, but its potential as a therapeutic target for autoimmune and cancer diseases is an exciting area of investigation.

Genular Protein ID: 2518938489

Symbol: TM9S1_HUMAN

Name: Transmembrane 9 superfamily member 1

UniProtKB Accession Codes:

O15321 D3DS65 Q86SZ6 Q96FI8

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DNASU 1 EMBL 9 EPD 1 Ensembl 4 ExpressionAtlas 1 GO 6 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 3 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 2 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9332367

Title: Cloning of a human multispanning membrane protein cDNA: evidence for a new protein family.

PubMed ID: 9332367

DOI: 10.1016/s0378-1119(97)00263-1

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19029833

Title: High-throughput functional screening for autophagy-related genes and identification of TM9SF1 as an autophagosome-inducing gene.

PubMed ID: 19029833

DOI: 10.4161/auto.5.1.7247

Sequence Information:

  • Length: 606
  • Mass: 68861
  • Checksum: 7E0E790B5C1451B9
  • Sequence:
    • MTVVGNPRSW SCQWLPILIL LLGTGHGPGV EGVTHYKAGD PVILYVNKVG PYHNPQETYH 
YYQLPVCCPE KIRHKSLSLG EVLDGDRMAE SLYEIRFREN VEKRILCHMQ LSSAQVEQLR 
QAIEELYYFE FVVDDLPIRG FVGYMEESGF LPHSHKIGLW THLDFHLEFH GDRIIFANVS 
VRDVKPHSLD GLRPDEFLGL THTYSVRWSE TSVERRSDRR RGDDGGFFPR TLEIHWLSII 
NSMVLVFLLV GFVAVILMRV LRNDLARYNL DEETTSAGSG DDFDQGDNGW KIIHTDVFRF 
PPYRGLLCAV LGVGAQFLAL GTGIIVMALL GMFNVHRHGA INSAAILLYA LTCCISGYVS 
SHFYRQIGGE RWVWNIILTT SLFSVPFFLT WSVVNSVHWA NGSTQALPAT TILLLLTVWL 
LVGFPLTVIG GIFGKNNASP FDAPCRTKNI AREIPPQPWY KSTVIHMTVG GFLPFSAISV 
ELYYIFATVW GREQYTLYGI LFFVFAILLS VGACISIALT YFQLSGEDYR WWWRSVLSVG 
STGLFIFLYS VFYYARRSNM SGAVQTVEFF GYSLLTGYVF FLMLGTISFF SSLKFIRYIY 
VNLKMD

Genular Protein ID: 235390112

Symbol: B4E3A9_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4E3A9

Database IDs:

ARBA 9 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 GO 1 GenomeRNAi 1 InterPro 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 1 RefSeq 1 RuleBase 1

Sequence Information:

  • Length: 519
  • Mass: 59184
  • Checksum: 4871439B59DB68FB
  • Sequence:
    • MAESLYEIRF RENVEKRILC HMQLSSAQVE QLRQAIEELY YFEFVVDDLP IRGFVGYMEE 
SGFLPHSHKI GLWTHLDFHL EFHGDRIMFA NVSVRDVKPH SLDGLRPDEF LGLTHTYSVR 
WSETSVERRS DRRRGDDGGF FPRTLEIHWL SIINSMVLVF LLVGFVAVIL MRVLRNDLAR 
YNLDEETTSA GSGDDFDQGD NGWKIIHTDV FRFPPYRGLL CAVLGVGAQF LALGTGIIVM 
ALLGMFNVHR HGAINSAAIL LYALTCCISG YVSSHFYRQI GGERWVWNII LTTSLFSVPF 
FLTWSVVNSV HWANGSTQAL PATTILLLLT VWLLVGFPLT VIGGIFGKNN ASPFDAPCRT 
KNIAREIPPQ PWYKSTVIHM TVGGFLPFSA ISVELYYIFA TVWGREQYTL YGILFFVFAI 
LLSVGACISI ALTYFQLSGE DYRWWWRSVL SVGSTGLFIF LYSVFYYARR SNMSGAVQTV 
EFFGYSLLTG YVFFLMLGTI SFFSSLKFIR YIYVNLKMD

Genular Protein ID: 120859419

Symbol: G3V1B9_HUMAN

Name: N/A

UniProtKB Accession Codes:

G3V1B9

Database IDs:

ARBA 9 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 3 Ensembl 2 GO 1 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 1 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 RuleBase 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

Sequence Information:

  • Length: 519
  • Mass: 59165
  • Checksum: 371C3EE4E5B01D3D
  • Sequence:
    • MAESLYEIRF RENVEKRILC HMQLSSAQVE QLRQAIEELY YFEFVVDDLP IRGFVGYMEE 
SGFLPHSHKI GLWTHLDFHL EFHGDRIIFA NVSVRDVKPH SLDGLRPDEF LGLTHTYSVR 
WSETSVERRS DRRRGDDGGF FPRTLEIHWL SIINSMVLVF LLVGFVAVIL MRVLRNDLAR 
YNLDEETTSA GSGDDFDQGD NGWKIIHTDV FRFPPYRGLL CAVLGVGAQF LALGTGIIVM 
ALLGMFNVHR HGAINSAAIL LYALTCCISG YVSSHFYRQI GGERWVWNII LTTSLFSVPF 
FLTWSVVNSV HWANGSTQAL PATTILLLLT VWLLVGFPLT VIGGIFGKNN ASPFDAPCRT 
KNIAREIPPQ PWYKSTVIHM TVGGFLPFSA ISVELYYIFA TVWGREQYTL YGILFFVFAI 
LLSVGACISI ALTYFQLSGE DYRWWWRSVL SVGSTGLFIF LYSVFYYARR SNMSGAVQTV 
EFFGYSLLTG YVFFLMLGTI SFFSSLKFIR YIYVNLKMD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.