Genular: Defining Cellular Identity and Function

Details for: PRDX4

Gene ID: 10549

Symbol: PRDX4

Ensembl ID: ENSG00000123131

Description: peroxiredoxin 4

Associated with

Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Neutrophil degranulation
(R-HSA-6798695)
Cell redox homeostasis
(GO:0045454)
Cellular oxidant detoxification
(GO:0098869)
Cellular response to stress
(GO:0033554)
Cytosol
(GO:0005829)
Endoplasmic reticulum
(GO:0005783)
Extracellular exosome
(GO:0070062)
Extracellular matrix organization
(GO:0030198)
Extracellular region
(GO:0005576)
Ficolin-1-rich granule lumen
(GO:1904813)
Hydrogen peroxide catabolic process
(GO:0042744)
I-kappab phosphorylation
(GO:0007252)
Identical protein binding
(GO:0042802)
Male gonad development
(GO:0008584)
Molecular adaptor activity
(GO:0060090)
Molecular sequestering activity
(GO:0140313)
Negative regulation of male germ cell proliferation
(GO:2000255)
Nucleus
(GO:0005634)
Protein binding
(GO:0005515)
Protein maturation by protein folding
(GO:0022417)
Response to oxidative stress
(GO:0006979)
Secretory granule lumen
(GO:0034774)
Spermatogenesis
(GO:0007283)
Thioredoxin peroxidase activity
(GO:0008379)

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: epithelial cell of exocrine pancreas (CL1001433)
Fold Change: 3.39
Marker Score: 1,910
Cell Name: IgA plasma cell (CL0000987)
Fold Change: 3.26
Marker Score: 2,778
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 3.12
Marker Score: 999
Cell Name: oogonial cell (CL0000024)
Fold Change: 2.7
Marker Score: 3,877
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: 2.63
Marker Score: 2,739
Cell Name: serous secreting cell (CL0000313)
Fold Change: 2.4
Marker Score: 958
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 2.37
Marker Score: 5,405
Cell Name: decidual cell (CL2000002)
Fold Change: 2.34
Marker Score: 10,100
Cell Name: Sertoli cell (CL0000216)
Fold Change: 2.3
Marker Score: 13,643
Cell Name: oocyte (CL0000023)
Fold Change: 2.29
Marker Score: 567
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 2.25
Marker Score: 14,609
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 2.24
Marker Score: 4,737
Cell Name: preosteoblast (CL0007010)
Fold Change: 2.23
Marker Score: 633
Cell Name: fibroblast of breast (CL4006000)
Fold Change: 2.16
Marker Score: 1,233
Cell Name: peptic cell (CL0000155)
Fold Change: 2.15
Marker Score: 902
Cell Name: cell in vitro (CL0001034)
Fold Change: 2.11
Marker Score: 73,260
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 2.1
Marker Score: 8,259
Cell Name: lung secretory cell (CL1000272)
Fold Change: 2.09
Marker Score: 1,866
Cell Name: bronchus fibroblast of lung (CL2000093)
Fold Change: 2.09
Marker Score: 2,875
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 2.06
Marker Score: 23,147
Cell Name: mesodermal cell (CL0000222)
Fold Change: 2.05
Marker Score: 26,998
Cell Name: Leydig cell (CL0000178)
Fold Change: 2.03
Marker Score: 2,189
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 2.01
Marker Score: 3,093
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 1.94
Marker Score: 4,059
Cell Name: migratory enteric neural crest cell (CL0002607)
Fold Change: 1.94
Marker Score: 1,827
Cell Name: IgG plasma cell (CL0000985)
Fold Change: 1.94
Marker Score: 845
Cell Name: pneumocyte (CL0000322)
Fold Change: 1.93
Marker Score: 3,098
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 1.9
Marker Score: 16,409
Cell Name: eukaryotic cell (CL0000255)
Fold Change: 1.84
Marker Score: 945
Cell Name: neural cell (CL0002319)
Fold Change: 1.83
Marker Score: 881
Cell Name: fibroblast of lung (CL0002553)
Fold Change: 1.82
Marker Score: 4,769
Cell Name: stem cell (CL0000034)
Fold Change: 1.82
Marker Score: 4,314
Cell Name: neural crest cell (CL0011012)
Fold Change: 1.8
Marker Score: 1,926
Cell Name: mucous neck cell (CL0000651)
Fold Change: 1.8
Marker Score: 4,085
Cell Name: pancreatic stellate cell (CL0002410)
Fold Change: 1.78
Marker Score: 1,125
Cell Name: type A enteroendocrine cell (CL0002067)
Fold Change: 1.78
Marker Score: 717
Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: 1.74
Marker Score: 1,096
Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 1.74
Marker Score: 3,085
Cell Name: respiratory goblet cell (CL0002370)
Fold Change: 1.72
Marker Score: 498
Cell Name: respiratory epithelial cell (CL0002368)
Fold Change: 1.72
Marker Score: 948
Cell Name: kidney cell (CL1000497)
Fold Change: 1.72
Marker Score: 1,145
Cell Name: IgG plasmablast (CL0000982)
Fold Change: 1.71
Marker Score: 472
Cell Name: theca cell (CL0000503)
Fold Change: 1.7
Marker Score: 1,219
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.69
Marker Score: 2,483
Cell Name: male germ cell (CL0000015)
Fold Change: 1.68
Marker Score: 485
Cell Name: keratinocyte (CL0000312)
Fold Change: 1.68
Marker Score: 1,403
Cell Name: epithelial cell (CL0000066)
Fold Change: 1.68
Marker Score: 2,670
Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 1.67
Marker Score: 4,551
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: 1.66
Marker Score: 1,761
Cell Name: duct epithelial cell (CL0000068)
Fold Change: 1.66
Marker Score: 777
Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 1.66
Marker Score: 6,145
Cell Name: endothelial cell of sinusoid (CL0002262)
Fold Change: 1.64
Marker Score: 398
Cell Name: granulosa cell (CL0000501)
Fold Change: 1.63
Marker Score: 16,435
Cell Name: Unknown (CL0002371)
Fold Change: 1.61
Marker Score: 1,715
Cell Name: type EC enteroendocrine cell (CL0000577)
Fold Change: 1.61
Marker Score: 1,520
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 1.61
Marker Score: 54,865
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.61
Marker Score: 3,926
Cell Name: bronchial goblet cell (CL1000312)
Fold Change: 1.61
Marker Score: 792
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 1.6
Marker Score: 1,666
Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 1.6
Marker Score: 11,912
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 1.59
Marker Score: 1,695
Cell Name: osteoclast (CL0000092)
Fold Change: 1.59
Marker Score: 790
Cell Name: PP cell (CL0000696)
Fold Change: 1.59
Marker Score: 357
Cell Name: hepatocyte (CL0000182)
Fold Change: 1.57
Marker Score: 1,072
Cell Name: secretory cell (CL0000151)
Fold Change: 1.57
Marker Score: 2,865
Cell Name: Hofbauer cell (CL3000001)
Fold Change: 1.56
Marker Score: 861
Cell Name: paneth cell (CL0000510)
Fold Change: 1.56
Marker Score: 1,086
Cell Name: primordial germ cell (CL0000670)
Fold Change: 1.56
Marker Score: 1,957
Cell Name: proerythroblast (CL0000547)
Fold Change: 1.55
Marker Score: 1,054
Cell Name: plasmablast (CL0000980)
Fold Change: 1.55
Marker Score: 2,059
Cell Name: IgM plasma cell (CL0000986)
Fold Change: 1.53
Marker Score: 533
Cell Name: mesothelial cell of epicardium (CL0011019)
Fold Change: 1.53
Marker Score: 491
Cell Name: mammary gland epithelial cell (CL0002327)
Fold Change: 1.53
Marker Score: 542
Cell Name: stromal cell (CL0000499)
Fold Change: 1.48
Marker Score: 1,739
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 1.47
Marker Score: 7,705
Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 1.46
Marker Score: 2,912
Cell Name: mural cell (CL0008034)
Fold Change: 1.45
Marker Score: 166,333
Cell Name: vein endothelial cell (CL0002543)
Fold Change: 1.44
Marker Score: 1,304
Cell Name: pro-T cell (CL0000827)
Fold Change: 1.44
Marker Score: 5,906
Cell Name: tracheobronchial serous cell (CL0019001)
Fold Change: 1.44
Marker Score: 527
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: 1.44
Marker Score: 11,226
Cell Name: lung ciliated cell (CL1000271)
Fold Change: 1.44
Marker Score: 682
Cell Name: acinar cell (CL0000622)
Fold Change: 1.41
Marker Score: 998
Cell Name: alveolar macrophage (CL0000583)
Fold Change: 1.41
Marker Score: 36,047
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 1.4
Marker Score: 1,421
Cell Name: smooth muscle cell of large intestine (CL1000279)
Fold Change: 1.39
Marker Score: 525
Cell Name: pancreatic D cell (CL0000173)
Fold Change: 1.38
Marker Score: 601
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 1.38
Marker Score: 5,324
Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 1.38
Marker Score: 3,247
Cell Name: glandular cell of esophagus (CL0002657)
Fold Change: 1.38
Marker Score: 436
Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
Fold Change: 1.36
Marker Score: 11,853
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 1.36
Marker Score: 24,198
Cell Name: nephron tubule epithelial cell (CL1000494)
Fold Change: 1.36
Marker Score: 319
Cell Name: mucus secreting cell (CL0000319)
Fold Change: 1.36
Marker Score: 346
Cell Name: elicited macrophage (CL0000861)
Fold Change: 1.36
Marker Score: 8,239
Cell Name: myofibroblast cell (CL0000186)
Fold Change: 1.34
Marker Score: 1,660
Cell Name: adventitial cell (CL0002503)
Fold Change: 1.33
Marker Score: 329
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 1.32
Marker Score: 2,682
Cell Name: type II pneumocyte (CL0002063)
Fold Change: 1.32
Marker Score: 8,577
Cell Name: basal cell (CL0000646)
Fold Change: 1.31
Marker Score: 1,695

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

**Key Characteristics:** PRDX4 is a small, cytosolic enzyme with a molecular weight of approximately 15 kDa. It contains two cysteine residues that are essential for its catalytic activity, which involves the reduction of hydrogen peroxide and other ROS. PRDX4 is highly expressed in cells that are exposed to oxidative stress, such as immune cells and reproductive cells. It has been shown to be a key regulator of cellular redox balance, and its activity is essential for maintaining cellular homeostasis. **Pathways and Functions:** PRDX4 is involved in several cellular pathways, including: 1. **Cellular Redox Homeostasis:** PRDX4 plays a crucial role in maintaining the balance between ROS production and detoxification. It reduces hydrogen peroxide and other ROS, which helps to prevent oxidative damage to cellular components. 2. **Cellular Stress Response:** PRDX4 is activated in response to cellular stress, such as hypoxia and oxidative stress. It helps to regulate cellular signaling pathways that activate stress response mechanisms. 3. **Immune Function:** PRDX4 is essential for the activation of immune cells, such as neutrophils and macrophages. It helps to regulate the production of ROS, which is necessary for the killing of pathogens. 4. **Cell Signaling:** PRDX4 is involved in the regulation of cell signaling pathways, including the PI3K/Akt and MAPK pathways. It helps to modulate the activity of these pathways, which is necessary for cell growth, differentiation, and survival. **Clinical Significance:** Dysregulation of PRDX4 has been implicated in several diseases, including: 1. **Oxidative Stress-Related Diseases:** PRDX4 deficiency has been linked to an increased risk of oxidative stress-related diseases, such as cancer, atherosclerosis, and neurodegenerative diseases. 2. **Immune System Disorders:** PRDX4 is essential for the activation of immune cells, and its dysfunction has been implicated in immune system disorders, such as autoimmune diseases and immunodeficiency diseases. 3. **Reproductive Diseases:** PRDX4 is involved in the regulation of reproductive cell development and function. Its dysregulation has been linked to reproductive diseases, such as infertility and miscarriage. In conclusion, PRDX4 is a vital enzyme that plays a crucial role in maintaining cellular redox balance and immune function. Its dysregulation has been implicated in several diseases, highlighting the importance of PRDX4 in human health and disease. Further research is needed to fully understand the mechanisms of PRDX4 and its role in human disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Peroxiredoxin-4

Genular Protein ID: 3079861958

Symbol: PRDX4_HUMAN

Name: Peroxiredoxin-4

UniProtKB Accession Codes:

Q13162 Q6FHT3

Database IDs:

Citations:

PubMed ID: 9388242

Title: Regulatory role for a novel human thioredoxin peroxidase in NF-kappaB activation.

PubMed ID: 9388242

DOI: 10.1074/jbc.272.49.30952

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19892738

Title: Global profiling of protease cleavage sites by chemoselective labeling of protein N-termini.

PubMed ID: 19892738

DOI: 10.1073/pnas.0908958106

PubMed ID: 12059788

Title: A method for detection of overoxidation of cysteines: peroxiredoxins are oxidized in vivo at the active-site cysteine during oxidative stress.

PubMed ID: 12059788

DOI: 10.1042/bj20020525

PubMed ID: 18052930

Title: Peroxiredoxin IV is an endoplasmic reticulum-localized enzyme forming oligomeric complexes in human cells.

PubMed ID: 18052930

DOI: 10.1042/bj20071428

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 21994946

Title: Crystal structure of reduced and of oxidized peroxiredoxin IV enzyme reveals a stable oxidized decamer and a non-disulfide-bonded intermediate in the catalytic cycle.

PubMed ID: 21994946

DOI: 10.1074/jbc.m111.298810

PubMed ID: 21916849

Title: Structural insights into the peroxidase activity and inactivation of human peroxiredoxin 4.

PubMed ID: 21916849

DOI: 10.1042/bj20110380

Sequence Information:

Length: 271
Mass: 30540
Checksum: 7E56B580049FC60F
Sequence:

MEALPLLAAT TPDHGRHRRL LLLPLLLFLL PAGAVQGWET EERPRTREEE CHFYAGGQVY 
PGEASRVSVA DHSLHLSKAK ISKPAPYWEG TAVIDGEFKE LKLTDYRGKY LVFFFYPLDF 
TFVCPTEIIA FGDRLEEFRS INTEVVACSV DSQFTHLAWI NTPRRQGGLG PIRIPLLSDL 
THQISKDYGV YLEDSGHTLR GLFIIDDKGI LRQITLNDLP VGRSVDETLR LVQAFQYTDK 
HGEVCPAGWK PGSETIIPDP AGKLKYFDKL N

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: PRDX4

Associated with

Cells (max top 100)

Other Information

Regulatory role for a novel human thioredoxin peroxidase in NF-kappaB activation. PubMed ID: 9388242

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Global profiling of protease cleavage sites by chemoselective labeling of protein N-termini. PubMed ID: 19892738

A method for detection of overoxidation of cysteines: peroxiredoxins are oxidized in vivo at the active-site cysteine during oxidative stress. PubMed ID: 12059788

Peroxiredoxin IV is an endoplasmic reticulum-localized enzyme forming oligomeric complexes in human cells. PubMed ID: 18052930

Initial characterization of the human central proteome. PubMed ID: 21269460

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Crystal structure of reduced and of oxidized peroxiredoxin IV enzyme reveals a stable oxidized decamer and a non-disulfide-bonded intermediate in the catalytic cycle. PubMed ID: 21994946

Structural insights into the peroxidase activity and inactivation of human peroxiredoxin 4. PubMed ID: 21916849