PRDX4 | ENSG00000123131 | NCBI 10549

Details for: PRDX4

Gene ID: 10549

Symbol: PRDX4

Ensembl ID: ENSG00000123131

Description: peroxiredoxin 4

Associated with

Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Neutrophil degranulation
(R-HSA-6798695)
Cell redox homeostasis
(GO:0045454)
Cellular oxidant detoxification
(GO:0098869)
Cellular response to stress
(GO:0033554)
Cytosol
(GO:0005829)
Endoplasmic reticulum
(GO:0005783)
Extracellular exosome
(GO:0070062)
Extracellular matrix organization
(GO:0030198)
Extracellular region
(GO:0005576)
Ficolin-1-rich granule lumen
(GO:1904813)
Hydrogen peroxide catabolic process
(GO:0042744)
I-kappab phosphorylation
(GO:0007252)
Identical protein binding
(GO:0042802)
Male gonad development
(GO:0008584)
Molecular adaptor activity
(GO:0060090)
Molecular sequestering activity
(GO:0140313)
Negative regulation of male germ cell proliferation
(GO:2000255)
Nucleus
(GO:0005634)
Protein binding
(GO:0005515)
Protein maturation by protein folding
(GO:0022417)
Response to oxidative stress
(GO:0006979)
Secretory granule lumen
(GO:0034774)
Spermatogenesis
(GO:0007283)
Thioredoxin peroxidase activity
(GO:0008379)

Other Information

Proteins

Peroxiredoxin-4

Genular Protein ID: 3079861958

Symbol: PRDX4_HUMAN

Name: Peroxiredoxin-4

UniProtKB Accession Codes:

Q13162 Q6FHT3

Database IDs:

Citations:

PubMed ID: 9388242

Title: Regulatory role for a novel human thioredoxin peroxidase in NF-kappaB activation.

PubMed ID: 9388242

DOI: 10.1074/jbc.272.49.30952

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19892738

Title: Global profiling of protease cleavage sites by chemoselective labeling of protein N-termini.

PubMed ID: 19892738

DOI: 10.1073/pnas.0908958106

PubMed ID: 12059788

Title: A method for detection of overoxidation of cysteines: peroxiredoxins are oxidized in vivo at the active-site cysteine during oxidative stress.

PubMed ID: 12059788

DOI: 10.1042/bj20020525

PubMed ID: 18052930

Title: Peroxiredoxin IV is an endoplasmic reticulum-localized enzyme forming oligomeric complexes in human cells.

PubMed ID: 18052930

DOI: 10.1042/bj20071428

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 21994946

Title: Crystal structure of reduced and of oxidized peroxiredoxin IV enzyme reveals a stable oxidized decamer and a non-disulfide-bonded intermediate in the catalytic cycle.

PubMed ID: 21994946

DOI: 10.1074/jbc.m111.298810

PubMed ID: 21916849

Title: Structural insights into the peroxidase activity and inactivation of human peroxiredoxin 4.

PubMed ID: 21916849

DOI: 10.1042/bj20110380

Sequence Information:

Length: 271
Mass: 30540
Checksum: 7E56B580049FC60F
Sequence:

MEALPLLAAT TPDHGRHRRL LLLPLLLFLL PAGAVQGWET EERPRTREEE CHFYAGGQVY 
PGEASRVSVA DHSLHLSKAK ISKPAPYWEG TAVIDGEFKE LKLTDYRGKY LVFFFYPLDF 
TFVCPTEIIA FGDRLEEFRS INTEVVACSV DSQFTHLAWI NTPRRQGGLG PIRIPLLSDL 
THQISKDYGV YLEDSGHTLR GLFIIDDKGI LRQITLNDLP VGRSVDETLR LVQAFQYTDK 
HGEVCPAGWK PGSETIIPDP AGKLKYFDKL N

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: PRDX4

Associated with

Other Information

Regulatory role for a novel human thioredoxin peroxidase in NF-kappaB activation. PubMed ID: 9388242

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Global profiling of protease cleavage sites by chemoselective labeling of protein N-termini. PubMed ID: 19892738

A method for detection of overoxidation of cysteines: peroxiredoxins are oxidized in vivo at the active-site cysteine during oxidative stress. PubMed ID: 12059788

Peroxiredoxin IV is an endoplasmic reticulum-localized enzyme forming oligomeric complexes in human cells. PubMed ID: 18052930

Initial characterization of the human central proteome. PubMed ID: 21269460

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Crystal structure of reduced and of oxidized peroxiredoxin IV enzyme reveals a stable oxidized decamer and a non-disulfide-bonded intermediate in the catalytic cycle. PubMed ID: 21994946

Structural insights into the peroxidase activity and inactivation of human peroxiredoxin 4. PubMed ID: 21916849