Genular: Defining Cellular Identity and Function

Details for: ARL6IP5

Gene ID: 10550

Symbol: ARL6IP5

Ensembl ID: ENSG00000144746

Description: ADP ribosylation factor like GTPase 6 interacting protein 5

Associated with

Glutamate neurotransmitter release cycle
(R-HSA-210500)
Neuronal system
(R-HSA-112316)
Neurotransmitter release cycle
(R-HSA-112310)
Transmission across chemical synapses
(R-HSA-112315)
Cellular response to organic cyclic compound
(GO:0071407)
Cellular response to oxidative stress
(GO:0034599)
Cytoskeleton
(GO:0005856)
Endoplasmic reticulum membrane
(GO:0005789)
Glutathione metabolic process
(GO:0006749)
Intrinsic apoptotic signaling pathway in response to oxidative stress
(GO:0008631)
L-glutamate import across plasma membrane
(GO:0098712)
L-glutamate transmembrane transport
(GO:0015813)
Learning or memory
(GO:0007611)
Membrane
(GO:0016020)
Molecular_function
(GO:0003674)
Negative regulation of l-glutamate import across plasma membrane
(GO:0002037)
Negative regulation of mitochondrial membrane potential
(GO:0010917)
Negative regulation of transport
(GO:0051051)
Plasma membrane
(GO:0005886)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
(GO:0043280)
Positive regulation of stress-activated mapk cascade
(GO:0032874)
Presynaptic cytosol
(GO:0099523)
Protein binding
(GO:0005515)
Protein localization to plasma membrane
(GO:0072659)
Protein transport
(GO:0015031)

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: mature T cell (CL0002419)
Fold Change: 3.75
Marker Score: 37,162
Cell Name: blood cell (CL0000081)
Fold Change: 3.34
Marker Score: 38,805
Cell Name: T-helper 22 cell (CL0001042)
Fold Change: 3.16
Marker Score: 13,532
Cell Name: double negative T regulatory cell (CL0011024)
Fold Change: 3.11
Marker Score: 3,010
Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
Fold Change: 3.01
Marker Score: 2,640
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 2.98
Marker Score: 157,434
Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: 2.95
Marker Score: 9,318
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 2.95
Marker Score: 1,730
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 2.85
Marker Score: 8,001
Cell Name: fibroblast of lung (CL0002553)
Fold Change: 2.83
Marker Score: 7,399
Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
Fold Change: 2.82
Marker Score: 4,146
Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
Fold Change: 2.76
Marker Score: 8,057
Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
Fold Change: 2.71
Marker Score: 5,305
Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 2.69
Marker Score: 7,438
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 2.68
Marker Score: 17,139
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 2.58
Marker Score: 144,446
Cell Name: intraepithelial lymphocyte (CL0002496)
Fold Change: 2.57
Marker Score: 2,861
Cell Name: retinal rod cell (CL0000604)
Fold Change: 2.56
Marker Score: 7,297
Cell Name: type I NK T cell (CL0000921)
Fold Change: 2.55
Marker Score: 2,001
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 2.54
Marker Score: 756
Cell Name: basophil (CL0000767)
Fold Change: 2.53
Marker Score: 1,202
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 2.49
Marker Score: 595
Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: 2.49
Marker Score: 1,073
Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 2.47
Marker Score: 2,078
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 2.46
Marker Score: 5,611
Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
Fold Change: 2.46
Marker Score: 2,301
Cell Name: memory regulatory T cell (CL0002678)
Fold Change: 2.45
Marker Score: 856
Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
Fold Change: 2.44
Marker Score: 1,786
Cell Name: class switched memory B cell (CL0000972)
Fold Change: 2.44
Marker Score: 2,290
Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
Fold Change: 2.43
Marker Score: 5,923
Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
Fold Change: 2.42
Marker Score: 4,329
Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
Fold Change: 2.4
Marker Score: 1,327
Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
Fold Change: 2.4
Marker Score: 4,115
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 2.39
Marker Score: 4,864
Cell Name: stromal cell (CL0000499)
Fold Change: 2.39
Marker Score: 2,804
Cell Name: lung macrophage (CL1001603)
Fold Change: 2.38
Marker Score: 2,728
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 2.38
Marker Score: 1,187
Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: 2.36
Marker Score: 732
Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
Fold Change: 2.36
Marker Score: 1,712
Cell Name: regulatory T cell (CL0000815)
Fold Change: 2.36
Marker Score: 2,609
Cell Name: exhausted T cell (CL0011025)
Fold Change: 2.34
Marker Score: 1,347
Cell Name: Kupffer cell (CL0000091)
Fold Change: 2.34
Marker Score: 2,341
Cell Name: alveolar macrophage (CL0000583)
Fold Change: 2.34
Marker Score: 59,836
Cell Name: double negative thymocyte (CL0002489)
Fold Change: 2.34
Marker Score: 3,223
Cell Name: adventitial cell (CL0002503)
Fold Change: 2.33
Marker Score: 576
Cell Name: naive T cell (CL0000898)
Fold Change: 2.33
Marker Score: 1,500
Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
Fold Change: 2.32
Marker Score: 4,523
Cell Name: CD4-positive helper T cell (CL0000492)
Fold Change: 2.31
Marker Score: 2,517
Cell Name: memory B cell (CL0000787)
Fold Change: 2.31
Marker Score: 1,745
Cell Name: oocyte (CL0000023)
Fold Change: 2.3
Marker Score: 568
Cell Name: Unknown (CL0000548)
Fold Change: 2.27
Marker Score: 1,656
Cell Name: decidual cell (CL2000002)
Fold Change: 2.26
Marker Score: 9,738
Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 2.26
Marker Score: 4,000
Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
Fold Change: 2.26
Marker Score: 1,635
Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: 2.26
Marker Score: 1,916
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 2.24
Marker Score: 2,260
Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: 2.24
Marker Score: 1,993
Cell Name: dendritic cell (CL0000451)
Fold Change: 2.24
Marker Score: 1,537
Cell Name: early pro-B cell (CL0002046)
Fold Change: 2.23
Marker Score: 22,596
Cell Name: reticular cell (CL0000432)
Fold Change: 2.23
Marker Score: 813
Cell Name: gamma-delta T cell (CL0000798)
Fold Change: 2.23
Marker Score: 1,498
Cell Name: natural T-regulatory cell (CL0000903)
Fold Change: 2.22
Marker Score: 1,143
Cell Name: bronchial epithelial cell (CL0002328)
Fold Change: 2.22
Marker Score: 587
Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 2.2
Marker Score: 8,129
Cell Name: unswitched memory B cell (CL0000970)
Fold Change: 2.19
Marker Score: 1,285
Cell Name: cell in vitro (CL0001034)
Fold Change: 2.19
Marker Score: 75,817
Cell Name: B-1 B cell (CL0000819)
Fold Change: 2.19
Marker Score: 3,814
Cell Name: kidney loop of Henle epithelial cell (CL1000909)
Fold Change: 2.19
Marker Score: 1,371
Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
Fold Change: 2.18
Marker Score: 1,788
Cell Name: glycinergic amacrine cell (CL4030028)
Fold Change: 2.18
Marker Score: 2,053
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 2.16
Marker Score: 905
Cell Name: lung secretory cell (CL1000272)
Fold Change: 2.16
Marker Score: 1,930
Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
Fold Change: 2.16
Marker Score: 1,330
Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
Fold Change: 2.16
Marker Score: 1,905
Cell Name: non-classical monocyte (CL0000875)
Fold Change: 2.16
Marker Score: 5,214
Cell Name: microglial cell (CL0000129)
Fold Change: 2.16
Marker Score: 3,926
Cell Name: keratocyte (CL0002363)
Fold Change: 2.16
Marker Score: 496
Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
Fold Change: 2.15
Marker Score: 1,555
Cell Name: smooth muscle cell (CL0000192)
Fold Change: 2.15
Marker Score: 1,415
Cell Name: bronchus fibroblast of lung (CL2000093)
Fold Change: 2.15
Marker Score: 2,956
Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
Fold Change: 2.15
Marker Score: 5,570
Cell Name: large intestine goblet cell (CL1000320)
Fold Change: 2.14
Marker Score: 568
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 2.14
Marker Score: 3,155
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 2.14
Marker Score: 2,288
Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: 2.14
Marker Score: 491
Cell Name: progenitor cell of endocrine pancreas (CL0002351)
Fold Change: 2.14
Marker Score: 465
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 2.13
Marker Score: 8,372
Cell Name: pro-T cell (CL0000827)
Fold Change: 2.13
Marker Score: 8,715
Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
Fold Change: 2.12
Marker Score: 712
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 2.11
Marker Score: 2,549
Cell Name: small pre-B-II cell (CL0000954)
Fold Change: 2.11
Marker Score: 2,534
Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
Fold Change: 2.11
Marker Score: 555
Cell Name: supporting cell (CL0000630)
Fold Change: 2.11
Marker Score: 3,957
Cell Name: epidermal cell (CL0000362)
Fold Change: 2.1
Marker Score: 591
Cell Name: pro-B cell (CL0000826)
Fold Change: 2.1
Marker Score: 2,030
Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
Fold Change: 2.1
Marker Score: 557
Cell Name: type II pneumocyte (CL0002063)
Fold Change: 2.09
Marker Score: 13,638
Cell Name: starburst amacrine cell (CL0004232)
Fold Change: 2.09
Marker Score: 593
Cell Name: type I pneumocyte (CL0002062)
Fold Change: 2.06
Marker Score: 2,482
Cell Name: naive B cell (CL0000788)
Fold Change: 2.06
Marker Score: 1,839

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

**Key Characteristics:** ARL6IP5 is a protein that interacts with ADP ribosylation factor-like GTPases, which are involved in various cellular processes, including cell signaling, cytoskeleton dynamics, and membrane trafficking. The protein's ability to regulate the activity of these GTPases suggests that it may play a key role in modulating cellular responses to stress, including oxidative stress and apoptosis. Additionally, ARL6IP5's involvement in neurotransmission, particularly in the regulation of glutamate release, highlights its potential role in neurological disorders. **Pathways and Functions:** ARL6IP5 is involved in multiple cellular pathways, including: 1. **Cellular response to oxidative stress:** ARL6IP5 regulates the activity of stress-activated MAPK cascades, which are crucial in mediating cellular responses to oxidative stress. 2. **Cytoskeleton dynamics:** ARL6IP5 interacts with GTPases that regulate cytoskeleton dynamics, which is essential for maintaining cellular shape and integrity. 3. **Neurotransmission:** ARL6IP5 regulates the release of glutamate, an excitatory neurotransmitter, which is critical for neuronal function and communication. 4. **Apoptosis:** ARL6IP5 promotes apoptosis, or programmed cell death, by regulating the activity of cysteine-type endopeptidases involved in the apoptotic process. **Clinical Significance:** The dysregulation of ARL6IP5 has been implicated in various diseases, including: 1. **Neurological disorders:** ARL6IP5's involvement in neurotransmission and glutamate release suggests that dysregulation of this protein may contribute to neurological disorders, such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). 2. **Immune disorders:** ARL6IP5's role in regulating immune cell function, particularly in T cells and macrophages, highlights its potential involvement in immune-related disorders, such as multiple sclerosis and rheumatoid arthritis. 3. **Cancer:** ARL6IP5's ability to regulate apoptosis and stress-activated signaling pathways suggests that dysregulation of this protein may contribute to cancer development and progression. In conclusion, ARL6IP5 is a multifunctional protein that plays a crucial role in regulating cellular stress response, neurotransmission, and immune function. Further research is necessary to fully elucidate the mechanisms by which ARL6IP5 regulates these processes and to explore its potential therapeutic applications in various diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

PRA1 family protein 3

Genular Protein ID: 773061878

Symbol: PRAF3_HUMAN

Name: PRA1 family protein 3

UniProtKB Accession Codes:

O75915 B2R6V5 Q53ES3 Q5KU08

Database IDs:

Citations:

PubMed ID: 12438930

Title: Identification of addicsin/GTRAP3-18 as a chronic morphine-augumented gene in amygdala.

PubMed ID: 12438930

DOI: 10.1097/00001756-200211150-00018

PubMed ID: 15757671

Title: JM4 is a four-transmembrane protein binding to the CCR5 receptor.

PubMed ID: 15757671

DOI: 10.1016/j.febslet.2005.02.037

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 12761501

Title: Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways.

PubMed ID: 12761501

DOI: 10.1038/sj.onc.1206406

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 14761432

Title: Effect of differentiation inducer and heat stress on the expression of JWA protein and Hsp70 of K562 cells.

PubMed ID: 14761432

PubMed ID: 16481131

Title: Genomic organization, expression profile, and characterization of the new protein PRA1 domain family, member 2 (PRAF2).

PubMed ID: 16481131

DOI: 10.1016/j.gene.2005.12.009

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

Length: 188
Mass: 21615
Checksum: 3AA708C6D0901B44
Sequence:

MDVNIAPLRA WDDFFPGSDR FARPDFRDIS KWNNRVVSNL LYYQTNYLVV AAMMISIVGF 
LSPFNMILGG IVVVLVFTGF VWAAHNKDVL RRMKKRYPTT FVMVVMLASY FLISMFGGVM 
VFVFGITFPL LLMFIHASLR LRNLKNKLEN KMEGIGLKRT PMGIVLDALE QQEEGINRLT 
DYISKVKE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: ARL6IP5

Associated with

Cells (max top 100)

Other Information

Identification of addicsin/GTRAP3-18 as a chronic morphine-augumented gene in amygdala. PubMed ID: 12438930

JM4 is a four-transmembrane protein binding to the CCR5 receptor. PubMed ID: 15757671

Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. PubMed ID: 11042152

Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. PubMed ID: 12761501

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. PubMed ID: 12665801

Effect of differentiation inducer and heat stress on the expression of JWA protein and Hsp70 of K562 cells. PubMed ID: 14761432

Genomic organization, expression profile, and characterization of the new protein PRA1 domain family, member 2 (PRAF2). PubMed ID: 16481131

Initial characterization of the human central proteome. PubMed ID: 21269460

Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features. PubMed ID: 22223895

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712