Details for: AGR2

Gene ID: 10551

Symbol: AGR2

Ensembl ID: ENSG00000106541

Description: anterior gradient 2, protein disulphide isomerase family member

Associated with

  • Digestive tract morphogenesis
    (GO:0048546)
  • Dystroglycan binding
    (GO:0002162)
  • Endoplasmic reticulum
    (GO:0005783)
  • Epidermal growth factor receptor binding
    (GO:0005154)
  • Extracellular region
    (GO:0005576)
  • Extracellular space
    (GO:0005615)
  • Identical protein binding
    (GO:0042802)
  • Inflammatory response
    (GO:0006954)
  • Lung goblet cell differentiation
    (GO:0060480)
  • Mucus secretion
    (GO:0070254)
  • Positive regulation of cell-substrate adhesion
    (GO:0010811)
  • Positive regulation of developmental growth
    (GO:0048639)
  • Positive regulation of epidermal growth factor receptor signaling pathway
    (GO:0045742)
  • Positive regulation of gene expression
    (GO:0010628)
  • Positive regulation of ire1-mediated unfolded protein response
    (GO:1903896)
  • Positive regulation of perk-mediated unfolded protein response
    (GO:1903899)
  • Positive regulation of protein localization to plasma membrane
    (GO:1903078)
  • Protein binding
    (GO:0005515)
  • Response to endoplasmic reticulum stress
    (GO:0034976)

Other Information

Genular Protein ID: 3266025709

Symbol: AGR2_HUMAN

Name: Anterior gradient protein 2 homolog

UniProtKB Accession Codes:

O95994

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTAC 2 CTD 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 EMBL 9 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 17 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9790916

Title: hAG-2, the human homologue of the Xenopus laevis cement gland gene XAG-2, is coexpressed with estrogen receptor in breast cancer cell lines.

PubMed ID: 9790916

DOI: 10.1006/bbrc.1998.9440

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 12592373

Title: hAG-2 and hAG-3, human homologues of genes involved in differentiation, are associated with oestrogen receptor-positive breast tumours and interact with metastasis gene C4.4a and dystroglycan.

PubMed ID: 12592373

DOI: 10.1038/sj.bjc.6600740

PubMed ID: 15834940

Title: AGR2, an androgen-inducible secretory protein overexpressed in prostate cancer.

PubMed ID: 15834940

DOI: 10.1002/gcc.20188

PubMed ID: 18199544

Title: The adenocarcinoma-associated antigen, AGR2, promotes tumor growth, cell migration, and cellular transformation.

PubMed ID: 18199544

DOI: 10.1158/0008-5472.can-07-2930

PubMed ID: 19359471

Title: The protein disulfide isomerase AGR2 is essential for production of intestinal mucus.

PubMed ID: 19359471

DOI: 10.1073/pnas.0808722106

PubMed ID: 23274113

Title: Metastasis-promoting anterior gradient 2 protein has a dimeric thioredoxin fold structure and a role in cell adhesion.

PubMed ID: 23274113

DOI: 10.1016/j.jmb.2012.12.009

PubMed ID: 34952832

Title: A disorder clinically resembling cystic fibrosis caused by biallelic variants in the AGR2 gene.

PubMed ID: 34952832

DOI: 10.1136/jmedgenet-2021-108150

PubMed ID: 34237462

Title: Human AGR2 Deficiency Causes Mucus Barrier Dysfunction and Infantile Inflammatory Bowel Disease.

PubMed ID: 34237462

DOI: 10.1016/j.jcmgh.2021.07.001

Sequence Information:

  • Length: 175
  • Mass: 19979
  • Checksum: F271B1BD377BEE11
  • Sequence:
    • MEKIPVSAFL LLVALSYTLA RDTTVKPGAK KDTKDSRPKL PQTLSRGWGD QLIWTQTYEE 
ALYKSKTSNK PLMIIHHLDE CPHSQALKKV FAENKEIQKL AEQFVLLNLV YETTDKHLSP 
DGQYVPRIMF VDPSLTVRAD ITGRYSNRLY AYEPADTALL LDNMKKALKL LKTEL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.