Details for: ARPC1A

Gene ID: 10552

Symbol: ARPC1A

Ensembl ID: ENSG00000241685

Description: actin related protein 2/3 complex subunit 1A

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 2.5
    Marker Score: 1,763
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 2.44
    Marker Score: 15,581
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.3
    Marker Score: 19,823
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.27
    Marker Score: 1,789
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 2.25
    Marker Score: 10,807
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 2.25
    Marker Score: 660
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.04
    Marker Score: 70,594
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.98
    Marker Score: 7,792
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.98
    Marker Score: 3,723
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.96
    Marker Score: 2,096
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.91
    Marker Score: 3,068
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.9
    Marker Score: 4,306
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.89
    Marker Score: 14,787
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 1.89
    Marker Score: 1,343
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.87
    Marker Score: 8,080
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.87
    Marker Score: 2,100
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 1.84
    Marker Score: 1,763
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.84
    Marker Score: 2,703
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.78
    Marker Score: 6,858
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.78
    Marker Score: 2,911
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.74
    Marker Score: 15,085
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.73
    Marker Score: 11,248
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.72
    Marker Score: 4,209
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 1.71
    Marker Score: 1,526
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.69
    Marker Score: 3,534
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.66
    Marker Score: 479
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 1.64
    Marker Score: 2,529
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.64
    Marker Score: 2,714
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.63
    Marker Score: 683
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.63
    Marker Score: 3,710
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.63
    Marker Score: 2,882
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.62
    Marker Score: 1,711
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.62
    Marker Score: 3,841
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 1.61
    Marker Score: 976
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.58
    Marker Score: 1,053
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.56
    Marker Score: 5,761
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 1.55
    Marker Score: 2,244
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.55
    Marker Score: 439
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.53
    Marker Score: 8,051
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.53
    Marker Score: 787
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 1.52
    Marker Score: 20,482
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.52
    Marker Score: 3,729
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.5
    Marker Score: 1,414
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.49
    Marker Score: 2,972
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.48
    Marker Score: 556
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.46
    Marker Score: 852
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.46
    Marker Score: 1,537
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 1.45
    Marker Score: 461
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.4
    Marker Score: 86,203
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.4
    Marker Score: 15,749
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.39
    Marker Score: 518
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.38
    Marker Score: 1,153
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1.36
    Marker Score: 5,245
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.35
    Marker Score: 12,855
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.35
    Marker Score: 12,656
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.34
    Marker Score: 3,157
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.34
    Marker Score: 2,541
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.34
    Marker Score: 13,798
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 1.33
    Marker Score: 3,379
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.32
    Marker Score: 2,227
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.31
    Marker Score: 308
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.31
    Marker Score: 2,088
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.31
    Marker Score: 11,239
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 1.31
    Marker Score: 450
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.3
    Marker Score: 463
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.3
    Marker Score: 743
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.3
    Marker Score: 418
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 1.3
    Marker Score: 854
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.29
    Marker Score: 1,312
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 1.28
    Marker Score: 558
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 1.28
    Marker Score: 5,343
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.28
    Marker Score: 2,699
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 1.28
    Marker Score: 509
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.27
    Marker Score: 1,965
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.27
    Marker Score: 1,322
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.25
    Marker Score: 846
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.25
    Marker Score: 615
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 1.23
    Marker Score: 298
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.23
    Marker Score: 1,899
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.23
    Marker Score: 2,499
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.23
    Marker Score: 1,413
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.22
    Marker Score: 493
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.22
    Marker Score: 4,997
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.22
    Marker Score: 671
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.21
    Marker Score: 1,156
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.21
    Marker Score: 44,673
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 1.21
    Marker Score: 643
  • Cell Name: pericyte (CL0000669)
    Fold Change: 1.21
    Marker Score: 704
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 1.2
    Marker Score: 396
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 1.2
    Marker Score: 269
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.19
    Marker Score: 748
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 1.19
    Marker Score: 1,020
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 1.17
    Marker Score: 994
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.16
    Marker Score: 23,020
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 1.15
    Marker Score: 1,238
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 1.15
    Marker Score: 1,158
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 1.15
    Marker Score: 279
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 1.15
    Marker Score: 640
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 1.15
    Marker Score: 348
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 1.15
    Marker Score: 593

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** ARPC1A is a 37-kDa protein that belongs to the family of actin-related proteins, which are essential for the formation and maintenance of the actin cytoskeleton. It is a subunit of the Arp2/3 complex, which is composed of seven subunits (ARC1A, ARC2, ARC3, ARC4, ARP2, ARP3, and ARP6). The Arp2/3 complex is responsible for the nucleation of actin filaments, a process that is critical for cell movement, phagocytosis, and the formation of cellular protrusions. ARPC1A is highly conserved across species, with high sequence identity to its murine and feline homologues. It is also highly expressed in immune cells, including monocytes and macrophages, where it plays a critical role in the regulation of actin dynamics during phagocytosis. **Pathways and Functions** The Arp2/3 complex, including ARPC1A, is involved in various cellular processes, including: 1. **Actin cytoskeleton organization**: ARPC1A is essential for the nucleation of actin filaments, which is critical for the formation and maintenance of the actin cytoskeleton. 2. **Phagocytosis**: The Arp2/3 complex, including ARPC1A, plays a critical role in the regulation of actin dynamics during phagocytosis, a process that is essential for the clearance of pathogens and dead cells. 3. **Cell migration**: The Arp2/3 complex, including ARPC1A, is involved in the regulation of actin dynamics during cell migration, a process that is critical for tissue development and repair. 4. **Axon guidance**: ARPC1A is also involved in the regulation of actin dynamics during axon guidance, a process that is essential for the formation of the nervous system. **Clinical Significance** Dysregulation of ARPC1A has been implicated in several diseases, including: 1. **Infectious diseases**: ARPC1A has been shown to play a critical role in the regulation of actin dynamics during phagocytosis, and its dysregulation has been implicated in the pathogenesis of infectious diseases, such as Leishmania infection. 2. **Autoimmune disorders**: The Arp2/3 complex, including ARPC1A, has been implicated in the regulation of immune cell function, and its dysregulation has been implicated in the pathogenesis of autoimmune disorders, such as rheumatoid arthritis. 3. **Cancer**: ARPC1A has been shown to play a critical role in the regulation of actin dynamics during cell migration and invasion, and its dysregulation has been implicated in the pathogenesis of cancer. In summary, ARPC1A is a critical component of the Arp2/3 complex, a multifunctional molecular machine that plays a vital role in various cellular processes, including actin cytoskeleton organization, phagocytosis, and cell migration. Its dysregulation has been implicated in several diseases, including infectious diseases, autoimmune disorders, and cancer.

Genular Protein ID: 774546655

Symbol: ARC1A_HUMAN

Name: Actin-related protein 2/3 complex subunit 1A

UniProtKB Accession Codes:

Q92747 A4D276 B4DLQ7 D6W5S1 Q7Z5U8 Q86WU5 Q8IXQ0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 ComplexPortal 4 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 EMDB 1 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIRSF 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 5 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8978670

Title: Fission yeast Sop2p: a novel and evolutionarily conserved protein that interacts with Arp3p and modulates profilin function.

PubMed ID: 8978670

DOI: 10.1002/j.1460-2075.1996.tb01034.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 370
  • Mass: 41569
  • Checksum: 57FA5AC69997636E
  • Sequence:
    • MSLHQFLLEP ITCHAWNRDR TQIALSPNNH EVHIYKKNGS QWVKAHELKE HNGHITGIDW 
APKSDRIVTC GADRNAYVWS QKDGVWKPTL VILRINRAAT FVKWSPLENK FAVGSGARLI 
SVCYFESEND WWVSKHIKKP IRSTVLSLDW HPNNVLLAAG SCDFKCRVFS AYIKEVDEKP 
ASTPWGSKMP FGQLMSEFGG SGTGGWVHGV SFSASGSRLA WVSHDSTVSV ADASKSVQVS 
TLKTEFLPLL SVSFVSENSV VAAGHDCCPM LFNYDDRGCL TFVSKLDIPK QSIQRNMSAM 
ERFRNMDKRA TTEDRNTALE TLHQNSITQV SIYEVDKQDC RKFCTTGIDG AMTIWDFKTL 
ESSIQGLRIM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.